Nifedipine: Uses, Dosage, Side Effects & Interactions Explained

Summary of Key Points

Nifedipine is a medication commonly used to manage high blood pressure (hypertension), chest pain (angina), and other heart-related conditions. It works by relaxing the blood vessels, which helps the heart pump blood more easily. Nifedipine is available in both immediate-release and extended-release forms. Always consult your healthcare provider before starting or adjusting your dose. Our telemedicine providers are available to assist with any questions you may have.

Nifedipine Brand Names and Generic Name

US Brand Names: Adalat CC, Procardia, Procardia XL

Generic Name: Nifedipine

The generic name refers to the active ingredient in the medication. It is typically listed in parentheses next to the brand name.

Pharmacologic Category of Nifedipine

Calcium Channel Blocker (Dihydropyridine)

Nifedipine belongs to a class of medications known as calcium channel blockers, specifically the dihydropyridine subclass. Other medications in this group include amlodipine, felodipine, and nicardipine.

Nifedipine Dosage and Administration

Nifedipine is prescribed for a variety of conditions, and the dosage and frequency depend on the specific condition being treated. Always follow your healthcare provider’s instructions carefully, and never adjust your dose without consulting them first. If you need guidance, our telemedicine providers are available to help.

Nifedipine for Hypertension (High Blood Pressure)

Initial dose: 30 mg to 60 mg once daily (extended-release form)

Maintenance dose: 30 mg to 90 mg once daily

Length of treatment: Ongoing, as directed by your healthcare provider

Nifedipine for Angina (Chest Pain)

Immediate-release: 10 mg to 20 mg three times daily

Extended-release: 30 mg to 60 mg once daily

Length of treatment: Ongoing, as directed by your healthcare provider

Nifedipine for Raynaud’s Phenomenon

Immediate-release: 10 mg to 20 mg three times daily

Length of treatment: As directed by your healthcare provider

Nifedipine for Coronary Artery Disease

Extended-release: 30 mg to 60 mg once daily

Length of treatment: Ongoing, as directed by your healthcare provider

Nifedipine for Heart Failure

Extended-release: 30 mg to 60 mg once daily

Length of treatment: Ongoing, as directed by your healthcare provider

Nifedipine for Atrial Fibrillation

Extended-release: 30 mg to 60 mg once daily

Length of treatment: Ongoing, as directed by your healthcare provider

Nifedipine for Peripheral Vascular Disease

Extended-release: 30 mg to 60 mg once daily

Length of treatment: Ongoing, as directed by your healthcare provider

Nifedipine for Pulmonary Hypertension

Extended-release: 30 mg to 60 mg once daily

Length of treatment: Ongoing, as directed by your healthcare provider

Nifedipine for Myocardial Infarction (Heart Attack)

Extended-release: 30 mg to 60 mg once daily

Length of treatment: Ongoing, as directed by your healthcare provider

Nifedipine for Tachycardia (Fast Heart Rate)

Extended-release: 30 mg to 60 mg once daily

Length of treatment: Ongoing, as directed by your healthcare provider

Nifedipine Dosage Forms and Strengths

Immediate-release tablets: 10 mg, 20 mg

Extended-release tablets: 30 mg, 60 mg, 90 mg

Capsules: 10 mg, 20 mg

Contraindications for Nifedipine

A contraindication is a specific situation where a medication should not be used because it may cause harm. Before starting Nifedipine, it is essential to be aware of any conditions or circumstances that could make taking this medication unsafe.

Key Contraindications for Nifedipine

Severe Aortic Stenosis: Nifedipine can cause a significant drop in blood pressure, which may worsen symptoms in individuals with severe narrowing of the aortic valve (aortic stenosis).

Allergy to Nifedipine: If you have a known allergy to Nifedipine or any of its components, you should not take this medication. Allergic reactions can range from mild skin rashes to severe, life-threatening anaphylaxis.

Cardiogenic Shock: This is a condition where the heart is unable to pump enough blood to meet the body’s needs. Nifedipine can further lower blood pressure, potentially worsening this condition.

Recent Myocardial Infarction (Heart Attack): Nifedipine may increase the risk of complications in patients who have recently experienced a heart attack, particularly within the first two weeks.

Nifedipine Drug Interactions

Nifedipine can interact with other medications, which may increase the risk of side effects or reduce the effectiveness of either drug. It is important to inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs and supplements.

Medications that Interact with Nifedipine

Rifampin (Rifadin): This antibiotic can reduce the effectiveness of Nifedipine by increasing its breakdown in the liver.

Phenytoin (Dilantin): This anti-seizure medication can lower the levels of Nifedipine in your bloodstream, making it less effective.

Digoxin (Lanoxin): Nifedipine can increase the levels of digoxin in your blood, which may lead to toxicity.

Beta-blockers (e.g., Metoprolol, Atenolol): Taking Nifedipine with beta-blockers can cause an excessive drop in blood pressure or heart rate.

Grapefruit Juice: Grapefruit juice can increase the levels of Nifedipine in your blood, raising the risk of side effects.

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Nifedipine in Pregnancy

Is it safe to take Nifedipine when pregnant?

Nifedipine is generally considered safe during pregnancy, particularly for managing high blood pressure or preterm labor. However, it is classified as a Category C drug by the FDA, meaning that while animal studies have shown potential risks to the fetus, there are no well-controlled studies in humans. Your healthcare provider will carefully weigh the benefits and risks before prescribing Nifedipine during pregnancy. If you are pregnant or planning to become pregnant, it’s important to consult with one of our telemedicine providers to ensure the safest treatment plan for both you and your baby.

Nifedipine while Breastfeeding

Is it safe to take Nifedipine while breastfeeding?

Nifedipine is considered safe to use while breastfeeding, as only small amounts of the drug pass into breast milk. Studies have not shown significant adverse effects on breastfed infants. However, it’s always best to consult your healthcare provider before starting any new medication while breastfeeding. Our telemedicine providers are available to help you make informed decisions about your treatment options.

Estimated Cost of Nifedipine Medication

The cost of a 30-day supply of Nifedipine can vary depending on the dosage and the pharmacy. With a GoodRx coupon, the estimated cost for a 30-day supply of generic Nifedipine without insurance typically ranges from $10 to $20. Brand-name versions, such as Procardia, may be significantly more expensive. Be sure to check with your pharmacy for the most accurate pricing.

Possible Alternatives to Nifedipine

If Nifedipine is not suitable for you or causes unwanted side effects, there are alternative treatments available for the conditions it addresses. Always consult your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with us to discuss these alternatives in more detail.

Alternatives for Hypertension (High Blood Pressure)

1. Other calcium channel blockers, such as Amlodipine (Norvasc)
2. ACE inhibitors, like Lisinopril (Zestril)
3. Beta-blockers, such as Metoprolol (Lopressor)
4. Lifestyle changes: Reducing salt intake, engaging in regular exercise, and managing weight

Alternatives for Angina (Chest Pain)

1. Beta-blockers, such as Atenolol (Tenormin)
2. Nitrates, like Nitroglycerin (Nitrostat)
3. Lifestyle changes: Quitting smoking, reducing stress, and following a heart-healthy diet

Alternatives for Raynaud’s Phenomenon

1. Other calcium channel blockers, such as Amlodipine (Norvasc)
2. Alpha-blockers, like Prazosin (Minipress)
3. Lifestyle changes: Keeping hands and feet warm, avoiding stress, and quitting smoking

Alternatives for Coronary Artery Disease

1. Statins, such as Atorvastatin (Lipitor)
2. Beta-blockers, like Carvedilol (Coreg)
3. Lifestyle changes: Eating a heart-healthy diet, exercising regularly, and managing cholesterol levels

Alternatives for Heart Failure

1. ACE inhibitors, such as Enalapril (Vasotec)
2. Diuretics, like Furosemide (Lasix)
3. Lifestyle changes: Reducing salt intake, managing fluid intake, and staying physically active

Alternatives for Atrial Fibrillation

1. Antiarrhythmic drugs, such as Amiodarone (Pacerone)
2. Beta-blockers, like Metoprolol (Lopressor)
3. Lifestyle changes: Reducing caffeine and alcohol intake, managing stress, and engaging in regular exercise

Alternatives for Peripheral Vascular Disease

1. Antiplatelet drugs, such as Clopidogrel (Plavix)
2. Statins, like Simvastatin (Zocor)
3. Lifestyle changes: Quitting smoking, engaging in regular physical activity, and maintaining a healthy diet

Alternatives for Pulmonary Hypertension

1. Endothelin receptor antagonists, such as Bosentan (Tracleer)
2. Phosphodiesterase inhibitors, like Sildenafil (Revatio)
3. Lifestyle changes: Avoiding high altitudes, managing stress, and staying active within your limits

Alternatives for Myocardial Infarction (Heart Attack)

1. Antiplatelet drugs, such as Aspirin
2. Beta-blockers, like Metoprolol (Lopressor)
3. Lifestyle changes: Quitting smoking, following a heart-healthy diet, and engaging in regular exercise

Alternatives for Tachycardia (Fast Heart Rate)

1. Beta-blockers, such as Propranolol (Inderal)
2. Calcium channel blockers, like Verapamil (Calan)
3. Lifestyle changes: Reducing caffeine and alcohol intake, managing stress, and engaging in regular exercise

Recent Updates on Nifedipine Research

Recent studies have explored the long-term effects of Nifedipine in managing chronic conditions like hypertension and angina. A 2022 study published in the Journal of Hypertension found that Nifedipine continues to be an effective and well-tolerated option for controlling blood pressure, particularly in patients with coexisting conditions such as diabetes. Additionally, ongoing research is investigating the potential benefits of Nifedipine in treating pulmonary hypertension, with early findings suggesting improvements in exercise capacity and symptom relief.

Staying informed about the latest research is important, and discussing any new findings with your healthcare provider can help ensure your treatment plan remains up to date. If you have questions about how these updates might affect your care, our telemedicine providers are available to guide you through your options.

James Kingsley

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