Mupirocin Ointment: Uses, Dosage & Side Effects Explained

Summary of Key Points

Mupirocin is a topical antibiotic commonly used to treat various skin infections, such as impetigo, folliculitis, and wound infections. It works by inhibiting bacterial growth on the skin. Available in both ointment and cream forms, Mupirocin is applied directly to the affected area. Always follow your healthcare provider’s instructions when using this medication. If you have any questions or concerns, feel free to consult one of our providers through telemedicine.

Names of Medication

US Brand Name: Bactroban (Mupirocin)

US Brand Name: Centany (Mupirocin)

The generic name refers to the active ingredient in the medication, which in this case is “Mupirocin.”

Pharmacologic Category

Topical Antibiotic

Mupirocin Dosing Guidelines

Mupirocin is used to treat a variety of skin infections. Below are the recommended doses for adults. Always consult your healthcare provider before making any changes to your dosage. If needed, you can schedule a telemedicine appointment with us for further guidance.

1. Impetigo: Apply a small amount of Mupirocin ointment to the affected area three times daily for 5 to 10 days.
2. Folliculitis: Apply a small amount of Mupirocin ointment to the affected area three times daily for 5 to 10 days.
3. Furuncles and Carbuncles: Apply a small amount of Mupirocin ointment to the affected area three times daily for 5 to 10 days.
4. Secondary Skin Infections: Apply a small amount of Mupirocin ointment to the affected area three times daily for 10 days.
5. Staphylococcal and Streptococcal Infections: Apply a small amount of Mupirocin ointment to the affected area three times daily for 10 days.
6. Wound Infections: Apply a small amount of Mupirocin ointment to the affected area three times daily for 10 days.
7. Nasal Colonization of MRSA: Apply a small amount of Mupirocin nasal ointment inside each nostril twice daily for 5 days.
8. Eczema with Secondary Infection: Apply a small amount of Mupirocin ointment to the affected area three times daily for 5 to 10 days.

Dosage Forms and Strengths of Mupirocin

1. Mupirocin 2% Ointment
2. Mupirocin 2% Cream
3. Mupirocin 2% Nasal Ointment

How to Use Mupirocin Ointment and Cream

Before applying Mupirocin, clean and dry the affected area thoroughly. Apply a small amount of the medication and gently rub it in. If your healthcare provider advises, you may cover the area with a bandage or gauze. Be sure to wash your hands after applying the medication, unless you are treating your hands. Avoid contact with your eyes, nose, or mouth unless you are using the nasal ointment. If accidental contact occurs, rinse the area thoroughly with water.

Contraindications for Mupirocin

A contraindication is a specific condition where a medication should not be used due to potential risks. If you have any of the following conditions, Mupirocin may not be safe for you. Always consult your healthcare provider before starting any new medication.

1. Allergy to Mupirocin: If you are allergic to Mupirocin or any of its ingredients, using this medication can lead to severe allergic reactions, such as rash, itching, swelling, or difficulty breathing.
2. Severe Kidney Disease: Mupirocin contains polyethylene glycol, which can be absorbed through the skin. In individuals with severe kidney disease, this ingredient may accumulate and cause harm. Therefore, it is contraindicated in these patients.
3. Open Wounds or Large Areas of Broken Skin: Applying Mupirocin to large areas of broken skin or open wounds can increase absorption into the bloodstream, potentially leading to side effects, particularly in individuals with kidney issues.

Drug Interactions with Mupirocin

Mupirocin is generally safe to use with most medications, but some interactions may occur. Always inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements.

1. Chlorhexidine (Hibiclens): Using Mupirocin alongside chlorhexidine, an antiseptic, may reduce the effectiveness of Mupirocin. Avoid using these products together unless directed by your healthcare provider.
2. Silver Sulfadiazine (Silvadene): This topical antibiotic may interfere with Mupirocin’s action. If you are prescribed both medications, consult your healthcare provider to determine the best treatment plan.

Mupirocin Use During Pregnancy

Is it safe to take Mupirocin during pregnancy?

Mupirocin is classified as a Category B medication for pregnancy by the FDA, meaning animal studies have not shown harm to the fetus, but there are no well-controlled studies in pregnant women. While Mupirocin is generally considered safe during pregnancy, it should only be used if clearly necessary and prescribed by your healthcare provider. If you are pregnant or planning to become pregnant, discuss the potential risks and benefits of using Mupirocin with your healthcare provider.

Mupirocin While Breastfeeding

Is it safe to use Mupirocin while breastfeeding?

Mupirocin is generally considered safe to use during breastfeeding, but it’s important to exercise caution. If you apply Mupirocin ointment to the breast area, make sure to wash it off thoroughly before nursing to prevent your baby from accidentally ingesting it. Always consult your healthcare provider before using Mupirocin while breastfeeding to ensure it’s the right choice for your situation.

Estimated Cost of Mupirocin Ointment

The cost of a 30-day supply of Mupirocin without insurance can vary depending on the pharmacy and location. However, with a GoodRx coupon, a 15-gram tube of Mupirocin ointment typically costs between $5 and $15. Prices may fluctuate, so it’s a good idea to check with your local pharmacy or use a discount service like GoodRx for the most up-to-date pricing.

Possible Alternatives to Mupirocin

If Mupirocin isn’t suitable for you or if you’re considering other treatment options, there are several alternatives available. Always discuss these options with your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to determine the best course of action for your condition.

Alternatives for Common Skin Infections

1. Impetigo: Alternatives include topical antibiotics like Retapamulin (Altabax) or oral antibiotics such as Cephalexin (Keflex). Maintaining good hygiene, including washing the affected area with soap and water, can also help manage impetigo.
2. Folliculitis: Mild cases may resolve with proper hygiene and the use of warm compresses. For more severe cases, topical antiseptics like benzoyl peroxide or oral antibiotics such as Doxycycline (Vibramycin) may be prescribed.
3. Furuncles and Carbuncles: Warm compresses and good hygiene can help small boils drain naturally. Larger or more painful boils may require incision and drainage by a healthcare provider. Oral antibiotics like Clindamycin (Cleocin) may also be recommended.
4. Secondary Skin Infections: Treatment depends on the underlying cause, but oral antibiotics like Amoxicillin-Clavulanate (Augmentin) or topical antiseptics such as hydrogen peroxide may be advised.
5. Staphylococcal Infections: Oral antibiotics such as Dicloxacillin or Cephalexin are commonly used. In some cases, topical antiseptics and proper wound care may also be beneficial.
6. Streptococcal Infections: Oral antibiotics like Penicillin or Amoxicillin are often the first-line treatment. Keeping the skin clean and dry can help prevent further infection.
7. Wound Infections: Proper wound care, including cleaning and dressing, is essential. For more serious infections, oral antibiotics like Cephalexin (Keflex) or Clindamycin (Cleocin) may be prescribed.
8. Nasal Colonization of MRSA: Mupirocin is often used to treat MRSA colonization, but alternatives include nasal antiseptics like povidone-iodine or oral antibiotics such as Doxycycline (Vibramycin) in more severe cases.
9. Eczema: Moisturizers, topical corticosteroids, and avoiding triggers like harsh soaps or allergens can help manage eczema. In some cases, oral antihistamines or immunosuppressants may be recommended.

Recent Updates on Mupirocin Research

Recent studies have highlighted the growing resistance of certain bacteria to topical antibiotics, including Mupirocin. Research published in 2022 noted that while Mupirocin remains effective for most patients, there is increasing concern about Mupirocin-resistant strains of Staphylococcus aureus, particularly in hospital settings. Ongoing research is exploring new formulations and combination therapies to combat resistance and improve the effectiveness of topical treatments like Mupirocin.

Additionally, there is emerging interest in using Mupirocin to prevent surgical site infections, especially in patients who are carriers of MRSA. Some studies suggest that preoperative nasal decolonization with Mupirocin may reduce the risk of postoperative infections. However, more research is needed to confirm these findings and establish standardized guidelines.

It’s important to stay informed about the latest research and discuss any concerns with your healthcare provider. If you have questions about your treatment with Mupirocin, you can schedule a telemedicine appointment with one of our providers for personalized advice.

James Kingsley

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