Medroxyprogesterone: Uses, Dosage, Side Effects & More

Summary or Key Points

Medroxyprogesterone is a synthetic form of the hormone progesterone, commonly used to manage hormone-related conditions. It is often prescribed for menstrual disorders, abnormal uterine bleeding, and as part of hormone replacement therapy. Additionally, Medroxyprogesterone is used for contraception and to prevent endometrial hyperplasia. Always consult your healthcare provider before starting or adjusting your dose. You can also connect with one of our providers through telemedicine for personalized advice.

Names of Medication

US Brand Name: Provera, Depo-Provera

Generic Name: Medroxyprogesterone

The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. In this case, Medroxyprogesterone is the generic name.

Pharmacologic Category

Progestins

Hormonal Contraceptives

Antineoplastics (for certain cancers)

Medroxyprogesterone Dosage

Medroxyprogesterone is prescribed for a variety of conditions, and the dosage will depend on the specific condition being treated. Always follow your healthcare provider’s instructions and consult them before making any changes to your dose. You can also schedule a telemedicine appointment with us for further guidance.

Endometrial Hyperplasia

Dosage: 5 to 10 mg orally once daily for 12 to 14 consecutive days per month.

Endometriosis

Dosage: 104 mg injected subcutaneously every 3 months.

Abnormal Uterine Bleeding

Dosage: 5 to 10 mg orally once daily for 5 to 10 days, starting on day 16 or 21 of the menstrual cycle.

Amenorrhea (Absence of Menstrual Periods)

Dosage: 5 to 10 mg orally once daily for 5 to 10 days.

Medroxyprogesterone for Birth Control (Contraception)

Dosage: 150 mg injected intramuscularly every 3 months.

Hormone Replacement Therapy (HRT)

Dosage: 5 to 10 mg orally for 12 to 14 days per month, in combination with estrogen.

Uterine Cancer

Dosage: 400 to 1000 mg injected intramuscularly once a week.

Menstrual Disorders

Dosage: 5 to 10 mg orally once daily for 5 to 10 days.

Premenstrual Syndrome (PMS)

Dosage: 5 to 10 mg orally once daily for 10 days, starting on day 16 of the menstrual cycle.

Osteoporosis Prevention

Dosage: 150 mg injected intramuscularly every 3 months.

Dosage Forms and Strengths

Tablets: 2.5 mg, 5 mg, 10 mg

Injectable Suspension: 150 mg/mL (intramuscular), 104 mg/0.65 mL (subcutaneous)

Administration Instructions for Medroxyprogesterone

Medroxyprogesterone can be taken orally or administered via injection, depending on the condition being treated. If taking the oral form, it’s recommended to take it at the same time each day, with or without food. For injections, a healthcare provider will administer the medication. If you miss a dose, take it as soon as you remember, but do not double up on doses. Always follow your healthcare provider’s instructions carefully.

Contraindications

A contraindication is a specific situation where a medication should not be used because it may be harmful. Understanding these contraindications is essential to ensure your safety when taking Medroxyprogesterone.

Who Should Not Take Medroxyprogesterone?

Pregnancy: Medroxyprogesterone is not recommended during pregnancy as it may harm the developing fetus. If you are pregnant or planning to become pregnant, consult your healthcare provider for alternatives.

History of Blood Clots: If you have a history of blood clots (such as deep vein thrombosis or pulmonary embolism), Medroxyprogesterone may increase your risk of developing additional clots.

Severe Liver Disease: Medroxyprogesterone is processed by the liver, so if you have severe liver disease, your body may not metabolize the medication properly, leading to potential toxicity.

Breast Cancer or Other Hormone-Sensitive Cancers: Medroxyprogesterone can affect hormone levels, which may worsen hormone-sensitive conditions like breast cancer.

Unexplained Vaginal Bleeding: If you have abnormal vaginal bleeding that has not been diagnosed, Medroxyprogesterone should not be used until the cause is identified, as it could mask underlying conditions.

Allergic Reactions: If you have had an allergic reaction to Medroxyprogesterone or any of its ingredients, you should avoid taking it.

Drug to Drug Interactions

Medroxyprogesterone can interact with other medications, which may affect its effectiveness or increase the risk of side effects. Always inform your healthcare provider of all medications you are taking, including over-the-counter drugs and supplements.

Common Medications That May Interact with Medroxyprogesterone

Rifampin (Rifadin): This antibiotic can reduce the effectiveness of Medroxyprogesterone by speeding up its breakdown in the body.

Carbamazepine (Tegretol): This anti-seizure medication may decrease the effectiveness of Medroxyprogesterone, leading to reduced contraceptive protection or hormone regulation.

Phenytoin (Dilantin): Another anti-seizure medication that can lower Medroxyprogesterone levels in your body, potentially making it less effective.

St. John’s Wort: This herbal supplement can interfere with Medroxyprogesterone by increasing its breakdown, which may reduce its effectiveness.

Medroxyprogesterone in Pregnancy

Is it Safe to Take Medroxyprogesterone When Pregnant?

No, Medroxyprogesterone is not considered safe during pregnancy. It may pose risks to the developing fetus, including an increased chance of birth defects. If you are pregnant or suspect you might be, discontinue Medroxyprogesterone immediately and contact your healthcare provider. If you need assistance managing your condition during pregnancy, our telemedicine providers can help you explore safer alternatives.

Medroxyprogesterone While Breastfeeding

Is it Safe to Take Medroxyprogesterone While Breastfeeding?

Medroxyprogesterone is generally regarded as safe while breastfeeding. Although small amounts of the medication may pass into breast milk, there is no evidence to suggest it harms nursing infants. However, it’s always a good idea to discuss any concerns with your healthcare provider, especially if you are breastfeeding a newborn or a premature baby. Our telemedicine providers can help you weigh the benefits and risks based on your individual circumstances.

Estimated Cost of Medroxyprogesterone

The cost of Medroxyprogesterone can vary depending on the pharmacy and location. With a GoodRx coupon, a 30-day supply of Medroxyprogesterone (10 mg tablets) typically ranges from $10 to $15 without insurance. Prices may fluctuate, so it’s a good idea to check with your local pharmacy or use a coupon service to find the best available price.

Possible Alternatives to Medroxyprogesterone

If Medroxyprogesterone is not suitable for you, there are alternative treatments and lifestyle changes that may help manage your condition. Always consult your healthcare provider before making any changes to your treatment plan. Our telemedicine providers are available to help you explore these options.

Endometrial Hyperplasia

Alternatives may include other progestins, such as norethindrone, or lifestyle changes like weight loss and diabetes management, which can reduce the risk of hyperplasia.

Endometriosis

Non-hormonal treatments, such as NSAIDs (e.g., ibuprofen) for pain relief, or hormonal alternatives like oral contraceptives, may be considered. In more severe cases, surgery may be an option.

Abnormal Uterine Bleeding

Hormonal birth control pills or an intrauterine device (IUD) may help regulate bleeding. In some cases, surgical options like endometrial ablation may be recommended.

Amenorrhea

Lifestyle changes, such as maintaining a healthy weight, managing stress, and ensuring proper nutrition, can help. Hormonal treatments, including estrogen therapy, may also be considered.

Contraception

Alternatives include oral contraceptive pills, IUDs, contraceptive implants, or barrier methods like condoms.

Hormone Replacement Therapy (HRT)

Other forms of HRT, such as estrogen patches or gels, may be considered. Lifestyle changes, including regular exercise and a balanced diet, can also help manage menopause symptoms.

Uterine Cancer

Treatment options may include surgery, radiation, or chemotherapy, depending on the stage of the cancer. Hormonal treatments, such as tamoxifen, may also be considered.

Menstrual Disorders

Lifestyle changes, such as stress management, regular exercise, and maintaining a healthy weight, can help. Hormonal treatments, like birth control pills, may also help regulate your cycle.

Premenstrual Syndrome (PMS)

Lifestyle changes, including regular exercise, a balanced diet, and stress management, can help alleviate symptoms. Some individuals may benefit from antidepressants or hormonal treatments.

Osteoporosis Prevention

Calcium and vitamin D supplements, along with weight-bearing exercises, can help strengthen bones. Bisphosphonates, such as alendronate (Fosamax), may also be considered to support bone health.

Recent Updates on Medroxyprogesterone Research

Recent studies have focused on the long-term safety of Medroxyprogesterone, particularly for contraception and hormone replacement therapy. Research indicates that while Medroxyprogesterone is effective, prolonged use may increase the risk of bone density loss, especially in younger women. This has led to recommendations for monitoring bone health in long-term users. Additionally, ongoing studies are investigating a potential link between Medroxyprogesterone and an increased risk of breast cancer, though current evidence remains inconclusive. It’s important to discuss any concerns with your healthcare provider, and our telemedicine team is here to help you stay informed about the latest research.

James Kingsley

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