Mecasermin: Uses, Dosage, and Key Side Effects Explained

Summary of Key Points

Mecasermin is a prescription medication used to treat growth failure in both children and adults with conditions such as growth hormone deficiency and Laron syndrome. It works by replacing insulin-like growth factor-1 (IGF-1), a hormone that plays a crucial role in growth. Mecasermin is administered through an injection and should always be used under the guidance of a healthcare provider. It is important to consult your doctor before making any changes to your dosage or treatment plan.

Names of Medication

US Brand Name: Increlex

Generic Name: Mecasermin

The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. In this case, Mecasermin is the generic name.

Pharmacologic Category

Insulin-like Growth Factor-1 (IGF-1) Agonist

Mecasermin Dosing Guidelines

Mecasermin is prescribed for various conditions that cause growth failure. The dosage is tailored to the specific condition and the individual patient’s needs. Always follow your doctor’s instructions carefully and consult them before making any adjustments to your dose. For personalized advice, one of our telemedicine providers is available to assist you.

Growth Hormone Deficiency

Dosage: 0.04 to 0.12 mg/kg injected under the skin twice daily

Frequency: Twice daily

Length of Treatment: Long-term, as directed by your healthcare provider

Laron Syndrome

Dosage: 0.04 to 0.12 mg/kg injected under the skin twice daily

Frequency: Twice daily

Length of Treatment: Long-term, as directed by your healthcare provider

Short Stature

Dosage: 0.04 to 0.12 mg/kg injected under the skin twice daily

Frequency: Twice daily

Length of Treatment: Long-term, as directed by your healthcare provider

Turner Syndrome

Dosage: 0.04 to 0.12 mg/kg injected under the skin twice daily

Frequency: Twice daily

Length of Treatment: Long-term, as directed by your healthcare provider

Prader-Willi Syndrome

Dosage: 0.04 to 0.12 mg/kg injected under the skin twice daily

Frequency: Twice daily

Length of Treatment: Long-term, as directed by your healthcare provider

Chronic Kidney Disease

Dosage: 0.04 to 0.12 mg/kg injected under the skin twice daily

Frequency: Twice daily

Length of Treatment: Long-term, as directed by your healthcare provider

Idiopathic Short Stature

Dosage: 0.04 to 0.12 mg/kg injected under the skin twice daily

Frequency: Twice daily

Length of Treatment: Long-term, as directed by your healthcare provider

Hypopituitarism

Dosage: 0.04 to 0.12 mg/kg injected under the skin twice daily

Frequency: Twice daily

Length of Treatment: Long-term, as directed by your healthcare provider

Skeletal Dysplasia

Dosage: 0.04 to 0.12 mg/kg injected under the skin twice daily

Frequency: Twice daily

Length of Treatment: Long-term, as directed by your healthcare provider

Congenital Growth Hormone Receptor Deficiency

Dosage: 0.04 to 0.12 mg/kg injected under the skin twice daily

Frequency: Twice daily

Length of Treatment: Long-term, as directed by your healthcare provider

Dosage Forms and Strengths

Injection, solution: 10 mg/1 mL

Administration Instructions for Mecasermin

Mecasermin is given as a subcutaneous injection. It is important to rotate injection sites to prevent skin irritation. The medication should be administered 20 minutes before or after a meal to reduce the risk of hypoglycemia. If you are unsure how to properly administer the injection, consult your healthcare provider or one of our telemedicine specialists for guidance.

Contraindications for Mecasermin

A contraindication is a condition where a medication should not be used because it may cause harm. If you have any of the following conditions, Mecasermin may not be safe for you. Always discuss your medical history with your healthcare provider before starting any new medication.

1. Active or suspected cancer: Mecasermin promotes growth, and if you have cancer or a tumor, it could accelerate the growth of cancer cells.
2. Closed growth plates: Mecasermin is intended for children whose bones are still growing. If your growth plates have closed (typically after puberty), Mecasermin will not be effective and could potentially cause harm.
3. Hypoglycemia (low blood sugar): Mecasermin can lower blood sugar levels. If you have a history of hypoglycemia, it could worsen the condition, leading to dangerously low blood sugar levels.
4. Allergic reaction to Mecasermin or its ingredients: If you have previously experienced an allergic reaction to Mecasermin, taking it again could result in a severe, potentially life-threatening allergic response.

Drug Interactions with Mecasermin

Certain medications can interact with Mecasermin, either reducing its effectiveness or increasing the risk of side effects. Be sure to inform your healthcare provider about all medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements. Below are some medications that may interact with Mecasermin:

1. Insulin or other diabetes medications: (e.g., Humalog [insulin lispro], Glucophage [metformin]) — Mecasermin can lower blood sugar, and using it alongside insulin or other diabetes medications may increase the risk of hypoglycemia.
2. Corticosteroids: (e.g., Prednisone [prednisone], Medrol [methylprednisolone]) — These medications may reduce Mecasermin’s effectiveness by interfering with its ability to promote growth.

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Mecasermin in Pregnancy

Is it safe to take Mecasermin when pregnant?

There is currently not enough research to determine whether Mecasermin is safe to use during pregnancy. If you are pregnant or planning to become pregnant, it is essential to have a detailed conversation with your healthcare provider. They will help you weigh the potential benefits of continuing Mecasermin against any possible risks to your baby.

Mecasermin while Breastfeeding

Is it safe to take Mecasermin while breastfeeding?

It is unclear whether Mecasermin passes into breast milk. Given the potential risks to a nursing infant, it is important to consult your healthcare provider before using Mecasermin while breastfeeding. Together, you can decide whether to continue breastfeeding or explore alternative treatments that may be safer for your baby.

Estimated Cost of Mecasermin

The cost of Mecasermin can vary depending on your location and insurance coverage. Without insurance, a 30-day supply of Mecasermin, when using a GoodRx coupon, is estimated to cost between $20,000 and $25,000. Be sure to check with your pharmacy and healthcare provider for more accurate pricing, and explore any available financial assistance programs that may help reduce the cost.

Possible Alternatives to Mecasermin

If Mecasermin is not the right option for you, there are other treatments available. Below are some alternatives for conditions commonly treated with Mecasermin. Always consult your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to discuss your options in more detail.

1. Growth hormone deficiency: Synthetic growth hormone (e.g., Genotropin [somatropin]) is a common alternative. Additionally, lifestyle changes such as proper nutrition and regular exercise may help improve growth outcomes.
2. Laron syndrome: While Mecasermin is typically used, some patients may benefit from supportive therapies like nutritional support and physical therapy to manage symptoms.
3. Short stature: Growth hormone therapy (e.g., Norditropin [somatropin]) is a frequently used alternative. Addressing underlying health conditions or improving diet and exercise may also contribute to better growth outcomes.
4. Turner syndrome: Growth hormone therapy is often prescribed to promote growth in children with Turner syndrome. Estrogen replacement therapy may also be recommended to support development during puberty.
5. Prader-Willi syndrome: Growth hormone therapy is commonly used to improve growth and body composition. Lifestyle changes, such as a carefully managed diet and regular physical activity, are also key to managing this condition.
6. Chronic kidney disease: In children with growth failure due to chronic kidney disease, growth hormone therapy may be considered. Managing kidney function through diet, medication, and dialysis is also critical for overall health.
7. Idiopathic short stature: Growth hormone therapy is often the first-line treatment. Improving nutrition and addressing any underlying health issues may also help support growth.
8. Hypopituitarism: Growth hormone replacement therapy is commonly used. Treating the underlying pituitary condition, if possible, is also important for managing symptoms effectively.
9. Skeletal dysplasia: Treatment options may include physical therapy, orthopedic interventions, and, in some cases, growth hormone therapy. Genetic counseling may also be recommended for families affected by this condition.
10. Congenital growth hormone receptor deficiency: Mecasermin is typically the treatment of choice, but other supportive therapies, such as nutritional support and physical therapy, may also be beneficial in managing symptoms.

Recent Updates on Mecasermin Research

Ongoing research continues to explore the long-term safety and effectiveness of Mecasermin in treating growth disorders. Recent studies have focused on its use in patients with severe growth hormone resistance, such as those with Laron syndrome. Researchers are also investigating Mecasermin’s potential to improve metabolic outcomes in patients with growth disorders. While these findings are promising, more research is needed to fully understand the long-term benefits and risks of Mecasermin. If you have questions about the latest research, consider scheduling a telemedicine appointment with one of our providers to discuss how these developments may affect your treatment plan.

James Kingsley

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