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Mecasermin Rinfabate: IGF-1 Therapy for Growth Hormone Deficiency
Summary of Key Points
Mecasermin rinfabate is a medication used to treat growth failure in both children and adults with specific conditions, such as growth hormone deficiency and Turner syndrome. It works by stimulating growth in individuals who are unable to produce sufficient insulin-like growth factor-1 (IGF-1) naturally. This medication is typically administered as an injection under the skin. Always consult your healthcare provider before starting or adjusting your dose.
Names of Medication
US Brand Name: Iplex
Generic Name: Mecasermin rinfabate
The generic name refers to the chemical composition of the active ingredient. In this case, Mecasermin rinfabate is the generic name.
Pharmacologic Category
Insulin-like Growth Factor-1 (IGF-1) Agonist
Mecasermin Rinfabate Dosing Guidelines
Mecasermin rinfabate is prescribed to treat various conditions related to growth failure. The dosage may vary depending on the specific condition being treated. Always follow your healthcare provider’s instructions carefully and consult them before making any changes to your dose. If you need to speak with a healthcare provider, you can schedule a telemedicine appointment with us today.
Growth Hormone Deficiency
Adult Dose: 0.5 mg/kg injected under the skin twice daily. Treatment is typically long-term, depending on the patient’s response and growth progress.
Turner Syndrome
Adult Dose: 0.5 mg/kg injected under the skin twice daily. The duration of treatment may vary based on the patient’s growth response and overall clinical condition.
Prader-Willi Syndrome
Adult Dose: 0.5 mg/kg injected under the skin twice daily. Treatment is usually long-term, but the exact duration should be determined by your healthcare provider.
Chronic Kidney Disease
Adult Dose: 0.5 mg/kg injected under the skin twice daily. The length of treatment depends on the patient’s response to therapy and overall health condition.
Idiopathic Short Stature
Adult Dose: 0.5 mg/kg injected under the skin twice daily. The duration of treatment may vary depending on the patient’s growth response.
Hypoglycemia
Adult Dose: 0.5 mg/kg injected under the skin twice daily. The length of treatment is determined by the patient’s clinical response to the medication.
Short Stature Due to Growth Hormone Insensitivity
Adult Dose: 0.5 mg/kg injected under the skin twice daily. Treatment is typically long-term, depending on the patient’s growth progress.
Skeletal Dysplasia
Adult Dose: 0.5 mg/kg injected under the skin twice daily. The duration of treatment varies based on the patient’s growth and response to therapy.
Congenital Growth Hormone Deficiency
Adult Dose: 0.5 mg/kg injected under the skin twice daily. Treatment is usually long-term, depending on the patient’s growth and development.
Malnutrition-Related Growth Failure
Adult Dose: 0.5 mg/kg injected under the skin twice daily. The length of treatment depends on the patient’s nutritional status and response to therapy.
Dosage Forms and Strengths
Injection: 10 mg/mL solution in a single-use vial
Administration Instructions for Mecasermin Rinfabate
Mecasermin rinfabate is administered as a subcutaneous injection. Your healthcare provider will guide you on how to properly inject the medication at home. It is important to rotate injection sites to prevent skin irritation. Avoid injecting into areas that are red, swollen, or irritated. Always follow the dosing schedule prescribed by your doctor, and do not skip a dose unless advised by your healthcare provider. If you miss a dose, contact your provider for further instructions.
Mecasermin Rinfabate Side Effects and Adverse Reactions
Like all medications, Mecasermin rinfabate may cause side effects. Some are common and mild, while others can be more serious. If you experience any side effects, contact your healthcare provider immediately. You can also schedule a telemedicine appointment with one of our providers to discuss your symptoms.
Common Side Effects: These may include headache, dizziness, and mild nausea. These effects are usually temporary and may subside as your body adjusts to the medication.
Hypoglycemia (Low Blood Sugar): This is a common side effect and may cause symptoms such as shakiness, sweating, and confusion. It is important to eat a meal or snack before taking your dose to help prevent low blood sugar.
Injection Site Reactions: Some patients may experience redness, swelling, or discomfort at the injection site. These reactions are generally mild and tend to resolve on their own.
Allergic Reactions: In rare cases, some patients may experience an allergic reaction, which can include symptoms such as rash, itching, swelling, or difficulty breathing. Seek medical attention immediately if you experience any of these symptoms.
Severe Hypoglycemia: In rare instances, patients may experience severe low blood sugar, which can lead to unconsciousness or seizures. This is a medical emergency and requires immediate attention.
Contraindications for Mecasermin Rinfabate
A contraindication is a specific situation or condition where a particular medication should not be used because it may be harmful to the patient. Before starting Mecasermin rinfabate, it’s important to know if you have any conditions that make it unsafe for you to take this medication.
Allergy to Mecasermin Rinfabate: If you have a known allergy to Mecasermin rinfabate or any of its ingredients, you should not take this medication. Allergic reactions can be severe and may include symptoms such as rash, swelling, or difficulty breathing.
Active or Suspected Cancer: Mecasermin rinfabate should not be used if you have active cancer or a history of cancer. This is because the medication promotes cell growth, which could potentially worsen cancerous conditions.
Closed Growth Plates: If your growth plates (the areas of growing tissue near the ends of the long bones in children and adolescents) have closed, Mecasermin rinfabate will not be effective and should not be used. This medication works by promoting growth, which is no longer possible once the growth plates have closed.
Hypoglycemia (Low Blood Sugar): Mecasermin rinfabate can lower blood sugar levels, so it should not be used if you are prone to severe hypoglycemia. This medication can make it more difficult to manage blood sugar levels, especially in individuals with diabetes or other conditions that affect blood sugar.
Drug Interactions with Mecasermin Rinfabate
It’s crucial to inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and supplements. Certain drugs may interact with Mecasermin rinfabate, potentially affecting its effectiveness or increasing the likelihood of side effects.
Insulin or Other Diabetes Medications
Medications such as Humalog (insulin lispro) and Glucophage (metformin) can interact with Mecasermin rinfabate. Since Mecasermin rinfabate lowers blood sugar levels, using it alongside insulin or other diabetes medications may heighten the risk of hypoglycemia (low blood sugar).
Corticosteroids
Drugs like Prednisone (prednisone) and Medrol (methylprednisolone) may reduce the growth-promoting effects of Mecasermin rinfabate, potentially diminishing its overall effectiveness. If you are taking corticosteroids, it’s important to discuss this with your healthcare provider.
Mecasermin Rinfabate and Pregnancy
There is limited information regarding the safety of Mecasermin rinfabate during pregnancy. While animal studies suggest some potential risks, there is not enough data to determine its safety in pregnant women. If you are pregnant or planning to become pregnant, it’s essential to discuss the potential risks and benefits of IGF-1 therapy with your healthcare provider. In some cases, the benefits may outweigh the risks, but this decision should be made with careful consideration.
Mecasermin Rinfabate While Breastfeeding
It is unclear whether Mecasermin rinfabate passes into breast milk. Since many medications can be transferred to a baby through breastfeeding, it’s important to consult your healthcare provider if you are breastfeeding or planning to breastfeed while taking this medication. Your provider can help you weigh the potential risks and benefits and determine whether to continue the medication or breastfeeding.
Estimated Cost of Mecasermin Rinfabate
The cost of Mecasermin rinfabate can vary depending on the pharmacy and location. Without insurance, the estimated cost for a 30-day supply using a GoodRx coupon ranges from approximately $10,000 to $15,000. Prices may fluctuate, so it’s a good idea to check with your pharmacy or use a coupon service like GoodRx to find the best available price.
Possible Alternatives to Mecasermin Rinfabate
If Mecasermin rinfabate is not suitable for you, other treatment options or lifestyle changes may help manage your condition. Always consult your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to explore these alternatives further.
Growth Hormone Deficiency
Other treatments include synthetic growth hormone therapy, such as Genotropin (somatropin), which can stimulate growth. Additionally, lifestyle changes like maintaining a balanced diet and engaging in regular exercise may support overall health.
Turner Syndrome
Growth hormone therapy is commonly used for Turner syndrome, and estrogen replacement therapy may be recommended to assist with development during puberty. Regular monitoring and supportive care are essential for managing this condition effectively.
Prader-Willi Syndrome
Growth hormone therapy can improve growth and body composition in individuals with Prader-Willi syndrome. A specialized diet and physical therapy may also provide significant benefits.
Chronic Kidney Disease
Managing the underlying kidney condition is critical for individuals with chronic kidney disease. In some cases, growth hormone therapy may be used, but addressing nutritional deficiencies and maintaining a healthy lifestyle are also important components of care.
Idiopathic Short Stature
Growth hormone therapy is an option for idiopathic short stature, but it’s important to discuss the potential benefits and risks with your healthcare provider. In some cases, no treatment may be necessary if the short stature is not associated with other health concerns.
Hypoglycemia
Managing blood sugar levels through diet, medication, and regular monitoring is key for individuals with hypoglycemia. Mecasermin rinfabate may not be appropriate if you experience frequent episodes of low blood sugar.
Short Stature Due to Growth Hormone Insensitivity
Mecasermin rinfabate is often used in cases of growth hormone insensitivity. Other options may include nutritional support and managing any underlying health conditions.
Skeletal Dysplasia
Treatment options for skeletal dysplasia depend on the specific type. In some cases, physical therapy, orthopedic surgery, or other interventions may be recommended to address the condition.
Congenital Growth Hormone Deficiency
Synthetic growth hormone therapy is the standard treatment for congenital growth hormone deficiency. Early diagnosis and treatment are crucial for achieving the best outcomes.
Malnutrition-Related Growth Failure
Addressing the underlying cause of malnutrition through dietary changes, supplements, and medical care is essential. In some cases, growth hormone therapy may be considered if malnutrition has significantly impacted growth.
Recent Updates on Mecasermin Rinfabate Research
Recent studies have focused on the long-term safety and effectiveness of Mecasermin rinfabate in treating growth disorders. Ongoing research is exploring its use in a broader range of growth-related conditions, as well as its potential benefits for children with growth hormone insensitivity. Some studies are also investigating optimal dosing strategies to minimize side effects, such as hypoglycemia. While the research is promising, it’s important to stay informed about new findings and discuss any updates with your healthcare provider. You can also schedule a telemedicine appointment with one of our providers to review the latest research and how it may apply to your treatment plan.
