Isradipine Medication: Uses, Dosage, and Side Effects Explained

Summary of Key Points

Isradipine is a medication primarily used to manage high blood pressure (hypertension) and other heart-related conditions. It belongs to a class of drugs known as calcium channel blockers, which help relax blood vessels, making it easier for the heart to circulate blood. This medication is typically taken orally and may be prescribed for long-term use. Always consult your healthcare provider before making any changes to your medication regimen.

Names of Medication

Generic Name: Isradipine

US Brand Name: Dynacirc

The generic name refers to the active ingredient in the medication, while the brand name is assigned by the manufacturer. In this case, Isradipine is the generic name.

Pharmacologic Category

Calcium Channel Blocker

Other medications in this category include amlodipine, nifedipine, and diltiazem. These drugs work by relaxing the muscles of the heart and blood vessels, improving blood flow and reducing the heart’s workload.

Isradipine Dosage

Isradipine is prescribed for various conditions, including hypertension, angina, and heart failure. The dosage may vary depending on the specific condition being treated. Always follow your healthcare provider’s instructions and consult them before making any changes to your dose. If you need to speak with a provider, you can schedule a telemedicine appointment with us today.

Isradipine for Hypertension (High Blood Pressure)

Initial Dose: 2.5 mg twice daily

Maintenance Dose: 5-10 mg per day, divided into two doses

Length of Treatment: Long-term, as directed by your doctor

Isradipine for Angina (Chest Pain)

Initial Dose: 2.5 mg twice daily

Maintenance Dose: 5-10 mg per day, divided into two doses

Length of Treatment: As needed, depending on symptoms

Isradipine for Heart Failure

Initial Dose: 2.5 mg twice daily

Maintenance Dose: Adjusted based on response, typically 5-10 mg per day

Length of Treatment: Long-term, as directed by your doctor

Isradipine for Atrial Fibrillation

Initial Dose: 2.5 mg twice daily

Maintenance Dose: Adjusted based on response, typically 5-10 mg per day

Length of Treatment: Long-term, as directed by your doctor

Isradipine for Coronary Artery Disease

Initial Dose: 2.5 mg twice daily

Maintenance Dose: Adjusted based on response, typically 5-10 mg per day

Length of Treatment: Long-term, as directed by your doctor

Isradipine for Peripheral Vascular Disease

Initial Dose: 2.5 mg twice daily

Maintenance Dose: Adjusted based on response, typically 5-10 mg per day

Length of Treatment: Long-term, as directed by your doctor

Isradipine for Stroke Prevention

Initial Dose: 2.5 mg twice daily

Maintenance Dose: Adjusted based on response, typically 5-10 mg per day

Length of Treatment: Long-term, as directed by your doctor

Isradipine for Myocardial Infarction (Heart Attack)

Initial Dose: 2.5 mg twice daily

Maintenance Dose: Adjusted based on response, typically 5-10 mg per day

Length of Treatment: Long-term, as directed by your doctor

Isradipine for Arrhythmia

Initial Dose: 2.5 mg twice daily

Maintenance Dose: Adjusted based on response, typically 5-10 mg per day

Length of Treatment: Long-term, as directed by your doctor

Isradipine for Hypertensive Crisis

Initial Dose: 5 mg, followed by additional doses as needed

Maintenance Dose: Adjusted based on response

Length of Treatment: Short-term, until blood pressure is controlled

Dosage Forms and Strengths

Capsules: 2.5 mg, 5 mg

Administration Instructions for Isradipine

Isradipine is typically taken orally, with or without food. It’s important to take the medication at the same time each day to maintain consistent levels in your bloodstream. Do not crush or chew the capsules. If you miss a dose, take it as soon as you remember, but skip it if it’s almost time for your next dose. Never double up on doses. Always follow your doctor’s instructions and consult them if you have any questions.

Isradipine Contraindications

A contraindication is a specific condition where a medication should not be used because it may cause harm. If you have any of the following conditions, Isradipine may not be safe for you. Always consult your healthcare provider before starting or stopping any medication.

Severe Aortic Stenosis: Isradipine is contraindicated in patients with severe aortic stenosis, a condition where the heart’s aortic valve is narrowed. This is because Isradipine can lower blood pressure, which may reduce blood flow through the narrowed valve, leading to serious complications.

Allergy to Isradipine or Similar Medications: If you have a known allergy to Isradipine or other calcium channel blockers, taking this medication could cause an allergic reaction, which may be life-threatening.

Severe Hypotension (Low Blood Pressure): Since Isradipine lowers blood pressure, it is contraindicated in individuals with already low blood pressure, as it could cause dangerously low levels, leading to dizziness, fainting, or shock.

Cardiogenic Shock: This is a condition where the heart is unable to pump enough blood to meet the body’s needs. Isradipine can worsen this condition by further lowering blood pressure.

Unstable Angina: In patients with unstable angina (chest pain due to reduced blood flow to the heart), Isradipine may increase the risk of heart attack or other severe complications.

Drug to Drug Interactions

Isradipine can interact with other medications, potentially leading to harmful effects or reducing the effectiveness of either drug. It is crucial to inform your healthcare provider about all medications you are currently taking, including prescription drugs, over-the-counter medications, and supplements. Below are some medications that may interact with Isradipine:

1. Beta-blockers: (e.g., Atenolol, Metoprolol, Propranolol) – Combining Isradipine with beta-blockers can cause an excessive drop in blood pressure and heart rate.
2. Digoxin: (Lanoxin) – Isradipine can increase the levels of Digoxin in the blood, which may lead to toxicity.
3. Fentanyl: (Duragesic, Sublimaze) – This combination can result in severe hypotension (low blood pressure).
4. Cimetidine: (Tagamet) – Cimetidine can raise blood levels of Isradipine, increasing the risk of side effects.
5. Rifampin: (Rifadin) – Rifampin may reduce the effectiveness of Isradipine by speeding up its breakdown in the liver.
6. Grapefruit Juice: – Grapefruit juice can elevate Isradipine concentrations in the blood, potentially leading to more pronounced side effects.

Isradipine in Pregnancy

The safety of Isradipine during pregnancy has not been well-established. It is classified as an FDA pregnancy category C drug, meaning animal studies have shown some risk to the fetus, but there are no well-controlled studies in humans. If you are pregnant or planning to become pregnant, it is important to discuss the potential risks and benefits of Isradipine with your healthcare provider to determine if it is the right option for you.

Isradipine while Breastfeeding

There is limited information on whether Isradipine passes into breast milk. Due to the potential for adverse effects in a nursing infant, it is generally recommended to either avoid breastfeeding while taking Isradipine or discuss alternative medications with your healthcare provider. If you are breastfeeding, consult with one of our telemedicine providers to explore the safest options for both you and your baby.

Estimated Cost of Isradipine Medication

The cost of a 30-day supply of Isradipine without insurance can vary depending on the pharmacy and location. With a GoodRX coupon, the price typically ranges from $20 to $40 for a 30-day supply of 2.5 mg or 5 mg tablets. Prices may fluctuate, so it’s advisable to check with your local pharmacy or use a discount service like GoodRX to find the best available price.

Possible Alternatives to Isradipine

If Isradipine is not suitable for you, there are alternative treatments and lifestyle changes that may help manage your condition. Always discuss these options with your healthcare provider before making any changes to your treatment plan. Our telemedicine providers are available to help you explore these alternatives.

1. Hypertension: Alternatives include other calcium channel blockers (e.g., Amlodipine), ACE inhibitors (e.g., Lisinopril), or lifestyle changes such as reducing salt intake, engaging in regular exercise, and managing weight.
2. Angina: Other treatment options include beta-blockers (e.g., Metoprolol), nitrates (e.g., Nitroglycerin), or lifestyle changes like quitting smoking and managing stress.
3. Heart Failure: ACE inhibitors, beta-blockers, or diuretics (e.g., Furosemide) may be considered. Lifestyle changes such as reducing sodium intake and monitoring fluid levels can also be beneficial.
4. Atrial Fibrillation: Medications like beta-blockers or anticoagulants (e.g., Warfarin) may be used. Procedural alternatives include cardioversion or catheter ablation.
5. Coronary Artery Disease: Statins (e.g., Atorvastatin) and antiplatelet medications (e.g., Aspirin) are common alternatives. Lifestyle changes, including a heart-healthy diet and regular exercise, are also essential.
6. Peripheral Vascular Disease: Antiplatelet agents (e.g., Clopidogrel) or lifestyle changes such as smoking cessation and regular walking exercises may help improve symptoms.
7. Stroke: Anticoagulants (e.g., Warfarin) or antiplatelet medications (e.g., Aspirin) are often used. Managing risk factors such as high blood pressure and diabetes is crucial for prevention.
8. Myocardial Infarction (Heart Attack): Beta-blockers, ACE inhibitors, or antiplatelet medications may be prescribed. Lifestyle changes, including quitting smoking and adopting a heart-healthy diet, are vital for recovery and prevention.
9. Arrhythmia: Medications like beta-blockers or antiarrhythmic drugs (e.g., Amiodarone) may be used. In some cases, a pacemaker may be recommended.
10. Hypertensive Crisis: Immediate treatment with intravenous medications (e.g., Nitroprusside) may be necessary. Long-term management typically includes lifestyle changes and oral antihypertensive medications.

Recent Updates on Isradipine Research

Recent studies have explored the potential neuroprotective effects of Isradipine, particularly in Parkinson’s disease. Early research suggests that Isradipine may help slow the progression of Parkinson’s by protecting dopamine-producing neurons. However, larger clinical trials are still needed to confirm these findings. If you have Parkinson’s disease and are considering Isradipine, consult with your healthcare provider to discuss the latest research and whether this medication might be appropriate for you.

James Kingsley

Learn More