Iron Sucrose Injection: Uses, Dosage, and Side Effects Explained

Summary of Key Points

Iron sucrose is a medication used to treat iron deficiency anemia and other conditions that require increased iron levels. It is commonly prescribed for individuals with chronic kidney disease, anemia from various causes, and those undergoing hemodialysis. Administered intravenously, iron sucrose helps replenish the body’s iron stores. Always consult your healthcare provider before starting or adjusting your treatment.

Names of Medication

US Brand Name: Venofer (Iron sucrose)

The generic name refers to the active ingredient in the medication, listed in parentheses. Generic names describe the drug’s chemical composition, while brand names are created by the manufacturer.

Pharmacologic Category

Iron Preparations

Parenteral Iron Supplements

Iron Sucrose Dosing Guidelines

Iron sucrose is used to treat various conditions related to iron deficiency. The dosage and frequency depend on the specific condition being treated. Always consult your doctor before making any changes to your dose. You can also schedule a telemedicine appointment with one of our providers for personalized advice.

Iron Deficiency Anemia

Adults: 100-200 mg intravenously (IV) per session, typically administered 1-3 times per week, depending on the severity of anemia. The duration of treatment varies based on iron levels.

Chronic Kidney Disease (CKD)

Adults: 100 mg IV during each dialysis session, with a total cumulative dose of up to 1,000 mg over several weeks. The frequency and duration depend on iron levels and the patient’s response to treatment.

Anemia of Chronic Disease

Adults: 100-200 mg IV per session, 1-3 times per week, depending on the severity of anemia. The treatment duration is based on individual needs.

Gastrointestinal Bleeding

Adults: 200 mg IV per session, typically administered 1-3 times per week. The length of treatment depends on the severity of bleeding and iron levels.

Menorrhagia (Heavy Menstrual Bleeding)

Adults: 200 mg IV per session, 1-2 times per week, depending on the severity of iron deficiency. The duration of treatment varies based on the response to therapy.

Iron Sucrose for Anemia in Pregnancy

Adults: 100-200 mg IV per session, 1-2 times per week. The treatment duration depends on iron levels and the stage of pregnancy.

Malnutrition

Adults: 100-200 mg IV per session, 1-3 times per week. The length of treatment depends on the severity of iron deficiency and the patient’s nutritional status.

Hemodialysis-Related Anemia

Adults: 100 mg IV during each dialysis session, with a total cumulative dose of up to 1,000 mg over several weeks. The frequency and duration depend on iron levels and the patient’s response to treatment.

Post-Surgical Anemia

Adults: 200 mg IV per session, 1-3 times per week. The length of treatment depends on the severity of anemia and iron levels.

Cancer-Related Anemia

Adults: 100-200 mg IV per session, 1-3 times per week. The duration of treatment varies based on iron levels and the patient’s response to therapy.

Dosage Forms and Strengths

Injection, solution: 100 mg/5 mL (20 mg/mL)

Administration Instructions for Iron Sucrose Injection

Iron sucrose is administered intravenously, meaning it is injected directly into a vein. It is typically given in a healthcare setting, such as a clinic or hospital, by a trained healthcare professional. The infusion usually takes about 15-30 minutes. Follow your doctor’s instructions closely and attend all scheduled appointments to monitor your response to treatment. If you experience any unusual symptoms during or after the infusion, contact your healthcare provider immediately.

Iron Sucrose Side Effects and Adverse Reactions

Like all medications, iron sucrose can cause side effects. Most are mild, but some can be more serious. If you experience any side effects, contact your healthcare provider promptly. You can also schedule a telemedicine appointment with one of our providers for further guidance.

Common Side Effects (1-10%): Headache, nausea, vomiting, muscle cramps, joint pain, and dizziness. These symptoms are usually mild and tend to resolve on their own.

Less Common Side Effects (0.1-1%): Low blood pressure, swelling at the injection site, and rash. These may require medical attention if they persist or worsen.

Rare but Serious Side Effects (<0.1%): Severe allergic reactions (anaphylaxis), chest pain, shortness of breath, and fainting. These require immediate medical attention.

Contraindications for Iron Sucrose

A contraindication is a specific situation where a medication should not be used because it may cause harm. For Iron Sucrose, several conditions make its use unsafe. Below is a list of contraindications and reasons why Iron Sucrose may not be recommended:

Known hypersensitivity to iron sucrose or any of its components: If you have had an allergic reaction to iron sucrose or similar iron products, taking this medication could cause a severe allergic reaction, including life-threatening anaphylaxis.

Non-iron deficiency anemia: Iron sucrose is only effective for treating anemia caused by iron deficiency. If your anemia is due to other causes, such as vitamin B12 deficiency or chronic disease, using iron sucrose could lead to iron overload and other complications.

Hemochromatosis or other iron overload syndromes: These are conditions where the body stores too much iron. Taking iron sucrose could worsen iron overload, leading to damage to organs like the liver and heart.

Active infection: Iron can promote bacterial growth. If you have an active infection, iron sucrose could potentially worsen the infection.

Drug to Drug Interactions

Iron sucrose can interact with other medications, potentially reducing its effectiveness or increasing the risk of side effects. It is important to inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter products, and supplements. Some known interactions include:

1. ACE inhibitors (e.g., lisinopril, enalapril): These medications, commonly used to manage high blood pressure, may increase the risk of allergic reactions when taken with iron sucrose.
2. Oral iron supplements (e.g., ferrous sulfate, ferrous gluconate): Taking oral iron supplements alongside iron sucrose can lead to iron overload, which may damage organs such as the liver and heart.
3. Antacids (e.g., calcium carbonate, magnesium hydroxide): These can interfere with iron absorption, making iron sucrose less effective.
4. Levodopa (e.g., Sinemet): Iron can reduce the absorption of levodopa, a medication used to treat Parkinson’s disease, potentially decreasing its effectiveness.

Iron Sucrose in Pregnancy

Is Iron Sucrose Safe During Pregnancy?

Iron sucrose is generally considered safe during pregnancy when prescribed by a healthcare provider. It is often used to treat iron deficiency in pregnant women, as untreated iron deficiency anemia can pose risks to both the mother and baby. However, it is essential to discuss the benefits and potential risks with your healthcare provider before starting treatment. If you are pregnant and have been diagnosed with iron deficiency anemia, our telemedicine providers can help determine if iron sucrose is the right option for you.

Iron Sucrose while Breastfeeding

Is Iron Sucrose Safe While Breastfeeding?

Yes, iron sucrose is generally considered safe while breastfeeding. Only small amounts of iron pass into breast milk, making it unlikely to harm a nursing infant. However, as with any medication, it is important to consult your healthcare provider before starting iron sucrose to ensure it is the best choice for you and your baby. Our telemedicine providers are available to discuss your treatment options and address any concerns you may have while breastfeeding.

Estimated Cost of Iron Sucrose

The cost of iron sucrose can vary depending on your location and pharmacy. Without insurance, the estimated cost of a 30-day supply using a GoodRx coupon is approximately $40 to $60. Prices may differ, so it’s a good idea to check with your pharmacy or use a discount service like GoodRx to find the best price available.

Possible Alternatives to Iron Sucrose

Depending on the condition being treated, alternative treatments or lifestyle changes may help manage your symptoms. Always consult your healthcare provider before making any changes to your treatment plan. Here are some possible alternatives for common conditions treated with iron sucrose:

1. Iron deficiency anemia: Oral iron supplements (e.g., ferrous sulfate, ferrous gluconate), dietary changes to increase iron-rich foods (e.g., red meat, spinach, lentils), and vitamin C supplements to enhance iron absorption.
2. Chronic kidney disease: Erythropoiesis-stimulating agents (ESAs), dietary modifications to support kidney health, and phosphate binders.
3. Anemia of chronic disease: Managing the underlying chronic condition, ESAs, and anti-inflammatory medications.
4. Gastrointestinal bleeding: Treating the source of bleeding (e.g., ulcers, polyps), proton pump inhibitors (PPIs), and dietary adjustments.
5. Menorrhagia (heavy menstrual bleeding): Hormonal treatments (e.g., birth control pills), nonsteroidal anti-inflammatory drugs (NSAIDs), and surgical options such as endometrial ablation.
6. Pregnancy-related anemia: Prenatal vitamins with iron, dietary changes, and oral iron supplements.
7. Malnutrition: Nutritional supplements, dietary changes, and addressing the underlying causes of malnutrition.
8. Hemodialysis-related anemia: ESAs, iron supplements, and managing dialysis-related complications.
9. Post-surgical anemia: Blood transfusions, oral or IV iron supplements, and ensuring adequate nutrition to support recovery.
10. Cancer-related anemia: ESAs, blood transfusions, and treating the underlying cancer.

If you are considering any of these alternatives, our telemedicine providers are available to help you make informed decisions about your treatment plan.

Recent Updates on Iron Sucrose Research

Recent studies have focused on improving the delivery and effectiveness of iron sucrose, particularly in patients with chronic kidney disease and those undergoing hemodialysis. New formulations of intravenous iron, including iron sucrose, are being developed to reduce the frequency of doses and improve patient outcomes. Additionally, research is ongoing to better understand the long-term safety of iron sucrose in pregnant women and breastfeeding mothers.

As our understanding of iron deficiency and its treatment continues to evolve, staying informed about the latest research is important. If you have questions about how new findings may impact your treatment, our telemedicine providers are here to guide you through the latest developments and ensure you receive the best care possible.

James Kingsley

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