Histidine Benefits: Essential Amino Acid for Immune & Tissue Health

Summary of Key Points

Histidine is an essential amino acid that plays a crucial role in various bodily functions, including supporting the immune system, aiding in tissue repair, and contributing to the production of important molecules like hemoglobin. It is commonly used to manage conditions such as allergic rhinitis, asthma, and anemia. However, it’s important to consult your healthcare provider before starting or adjusting your histidine dosage. If you need personalized advice, you can schedule a telemedicine appointment with one of our providers.

Names of Medication

US Brand Name: No specific brand name (Histidine)

The generic name refers to the active ingredient in the medication, while the brand name is assigned by the manufacturer. In this case, histidine is the generic name.

Pharmacologic Category

Amino acids

Dietary supplements

Histidine Dosing Guidelines

Histidine is used to treat a variety of conditions. Below are typical dosages for adults. Always consult your healthcare provider before making any changes to your dose. If you need assistance, our telemedicine providers are available to help.

1. Allergic rhinitis: 4-5 grams daily, taken in divided doses. The duration of treatment may vary depending on the severity of symptoms.
2. Asthma: 4-6 grams daily, divided into multiple doses. The length of treatment depends on the severity of the condition.
3. Atopic dermatitis: 4-5 grams daily, in divided doses. Treatment duration varies based on how well the patient responds to therapy.
4. Cystic fibrosis: 4-6 grams daily, taken in divided doses. This is typically a long-term treatment that should be monitored by a healthcare provider.
5. Chronic obstructive pulmonary disease (COPD): 4-6 grams daily, divided into multiple doses. The length of treatment depends on the progression of the disease.
6. Anemia: 4-5 grams daily, divided into multiple doses. The duration of treatment varies depending on the underlying cause of the anemia.
7. Malnutrition: 4-6 grams daily, in divided doses. The length of treatment depends on the severity of the malnutrition.
8. Muscle wasting: 4-6 grams daily, divided into multiple doses. This is generally a long-term treatment.
9. Liver disease: 4-6 grams daily, taken in divided doses. The length of treatment depends on the severity of the liver condition.
10. Kidney disease: 4-6 grams daily, divided into multiple doses. This is usually a long-term treatment that should be closely monitored by a healthcare provider.

Dosage Forms and Strengths of Histidine

Histidine supplements are available in several forms and strengths:

1. Oral capsules: 500 mg, 1000 mg
2. Powder form: 1 gram per scoop
3. Intravenous (IV) solution: Available in clinical settings

Administration Instructions for Histidine

Histidine can be taken with or without food. If you are using the powder form, mix it with water or juice as directed by your healthcare provider. For intravenous administration, histidine should only be administered by a healthcare professional in a clinical setting. Always follow your healthcare provider’s instructions carefully, and do not adjust your dose without consulting them. If you have any questions, our telemedicine providers are available to offer guidance.

Adverse Reactions and Side Effects of Histidine

As with any medication, histidine may cause side effects. While not everyone will experience them, it’s important to be aware of potential reactions. If you experience any severe side effects, contact your healthcare provider immediately.

Common side effects:

1. Headache: Mild headaches may occur, particularly when starting the medication.
2. Nausea: Some individuals may experience mild nausea, which typically improves over time.

Less common side effects:

1. Fatigue: Some patients report feeling unusually tired or weak.
2. Digestive issues: Mild stomach discomfort or diarrhea may occur.

Rare side effects:

1. Allergic reactions: Symptoms may include rash, itching, or swelling, particularly of the face, tongue, or throat.
2. Severe dizziness or difficulty breathing: These are rare but serious side effects that require immediate medical attention.

Contraindications for Histidine Use

A contraindication is a specific situation where a medication should not be used because it may cause harm. If you have any of the following conditions, avoid taking histidine, as it may negatively impact your health or interact poorly with your body.

1. Allergic reactions to histidine or other amino acids: If you have a known allergy to histidine or other amino acids, taking this supplement could trigger an allergic reaction, which may include symptoms like rash, itching, swelling, or difficulty breathing.
2. Severe liver disease: Histidine is metabolized in the liver. If you have severe liver disease, your body may not process the supplement properly, leading to a buildup of harmful byproducts.
3. Severe kidney disease: Histidine is filtered by the kidneys. If your kidneys are not functioning well, taking histidine could result in an accumulation of the supplement in your body, potentially worsening kidney function.
4. Pregnancy and breastfeeding: While histidine is a naturally occurring amino acid, its safety in supplemental form during pregnancy and breastfeeding has not been thoroughly studied. It is best to avoid taking it unless specifically recommended by a healthcare provider.

Drug to Drug Interactions

Histidine may interact with certain medications, potentially diminishing their effectiveness or increasing the risk of side effects. If you are currently taking any of the following medications, it’s important to consult your healthcare provider before starting Histidine supplements:

Immunosuppressants: Medications such as cyclosporine (Neoral, Sandimmune) or tacrolimus (Prograf) may interact with Histidine, potentially altering immune system function.

Antihistamines: Since Histidine is a precursor to histamine, a compound involved in allergic reactions, taking antihistamines like diphenhydramine (Benadryl) or loratadine (Claritin) alongside Histidine supplements could reduce the effectiveness of the antihistamine.

Levodopa (Sinemet): Histidine may interfere with the absorption of levodopa, a medication used to manage Parkinson’s disease, potentially reducing its effectiveness.

Histidine in Pregnancy

Is it safe to take Histidine during pregnancy?

There is limited research on the safety of Histidine supplements during pregnancy. While Histidine is a naturally occurring essential amino acid found in many foods, the effects of taking it in supplement form are not well understood. It is generally recommended to avoid Histidine supplements during pregnancy unless specifically advised by your healthcare provider. If you are pregnant and considering Histidine, we encourage you to consult one of our telemedicine providers to discuss your individual situation.

Histidine while Breastfeeding

Is it safe to take Histidine while breastfeeding?

As with pregnancy, there is insufficient research to confirm the safety of Histidine supplements while breastfeeding. Since Histidine is naturally present in the body and in many foods, it is likely safe when consumed in dietary amounts. However, the effects of taking it in higher doses as a supplement remain unclear. It is best to avoid supplementation unless recommended by a healthcare provider. If you are breastfeeding and considering Histidine, we encourage you to schedule a telemedicine appointment with one of our providers to discuss your options.

Estimated Cost of Histidine Supplements

The cost of a 30-day supply of Histidine supplements can vary depending on the brand and dosage. With a GoodRX coupon, the estimated cost for a 30-day supply of Histidine without insurance ranges from approximately $10 to $20. Prices may vary by location and pharmacy, so it’s always a good idea to compare prices before making a purchase.

Possible Alternatives to Histidine

Depending on the condition you are managing, there may be alternative treatments or lifestyle changes that could be more appropriate. Always consult your healthcare provider before making any changes to your treatment plan. Below are some alternatives for specific conditions:

1. Allergic rhinitis: Alternatives include antihistamines (e.g., cetirizine [Zyrtec], fexofenadine [Allegra]), nasal corticosteroids (e.g., fluticasone [Flonase]), and lifestyle modifications such as avoiding allergens.
2. Asthma: Inhaled corticosteroids (e.g., budesonide [Pulmicort]), bronchodilators (e.g., albuterol [ProAir]), and lifestyle changes like avoiding triggers and improving air quality can help manage asthma symptoms.
3. Atopic dermatitis: Common alternatives include topical corticosteroids, moisturizers, and avoiding irritants. In more severe cases, phototherapy may be recommended.
4. Cystic fibrosis: Treatments may include airway clearance techniques, pancreatic enzyme supplements, and medications like ivacaftor (Kalydeco). Lifestyle changes, such as maintaining a high-calorie diet, can also be beneficial.
5. Chronic obstructive pulmonary disease (COPD): Bronchodilators, inhaled corticosteroids, and pulmonary rehabilitation are common treatments. Quitting smoking and improving air quality can also significantly improve outcomes.
6. Anemia: Depending on the type of anemia, treatments may include iron supplements, vitamin B12 injections, or folic acid. Dietary changes to increase iron-rich foods may also be helpful.
7. Malnutrition: Nutritional supplements, a balanced diet, and working with a dietitian can help improve nutritional intake. In severe cases, enteral or parenteral nutrition may be necessary.
8. Muscle wasting: Resistance training, protein supplements, and medications like anabolic steroids (under medical supervision) may be considered. Ensuring adequate caloric intake is also crucial.
9. Liver disease: Treatment depends on the underlying cause but may include antiviral medications, lifestyle changes such as reducing alcohol intake, and managing complications like ascites or hepatic encephalopathy.
10. Kidney disease: Managing blood pressure, controlling blood sugar levels, and making dietary changes (e.g., reducing sodium and protein intake) are key. In advanced stages, dialysis or kidney transplantation may be necessary.

Recent Updates on Histidine Research

Recent studies have explored the potential role of Histidine in various health conditions, including its anti-inflammatory and antioxidant properties. Some research suggests that Histidine supplementation may help reduce oxidative stress, which is associated with conditions like cardiovascular disease and diabetes. Additionally, ongoing studies are investigating Histidine’s potential to improve immune function and support muscle recovery in athletes. However, more research is needed to confirm these benefits and determine the appropriate dosing for different conditions.

If you are interested in learning more about the potential health benefits of Histidine and how it might support your specific health needs, we recommend scheduling a telemedicine appointment with one of our providers. They can discuss the latest research and how it may apply to your situation.

James Kingsley

Learn More