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Granisetron Medication: Uses, Dosage, Side Effects & Nausea Relief
Summary of Key Points
Granisetron is a prescription medication used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, surgery, and other conditions. It works by blocking serotonin, a natural substance that can trigger nausea. Granisetron is available in various forms, including tablets, injections, and patches. Always consult your healthcare provider before starting or adjusting your dose. Our telemedicine team is also available to assist you.
Names of Medication
US Brand Name: Sancuso (Granisetron)
The generic name refers to the chemical composition of the medication, while the brand name is given by the manufacturer. In this article, the generic name is listed in parentheses.
Pharmacologic Category
5-HT3 Receptor Antagonists
Other medications in this category include Ondansetron, Dolasetron, and Palonosetron.
Granisetron Dosage
Granisetron is used to treat various types of nausea and vomiting. The dosage depends on the condition being treated. Always follow your healthcare provider’s instructions, and consult with one of our telemedicine providers before making any changes to your dose.
Granisetron for Chemotherapy-Induced Nausea and Vomiting (CINV)
Oral: 2 mg once daily or 1 mg twice daily, starting 1 hour before chemotherapy.
IV: 10 mcg/kg administered 30 minutes before chemotherapy.
Patch: Apply 24 to 48 hours before chemotherapy; remove at least 24 hours after chemotherapy is completed.
Granisetron for Radiation-Induced Nausea and Vomiting
Oral: 2 mg once daily, starting 1 hour before radiation therapy.
Granisetron for Postoperative Nausea and Vomiting
IV: 1 mg administered before anesthesia or immediately after surgery.
Granisetron for Motion Sickness
Oral: 1 mg taken 1 hour before travel, then as needed.
Granisetron for Hyperemesis Gravidarum (Severe Nausea and Vomiting in Pregnancy)
Oral: 1 mg twice daily, as directed by your healthcare provider.
Granisetron for Gastroenteritis (Stomach Flu)
Oral: 1 mg twice daily, as needed.
Granisetron for Pancreatitis-Associated Nausea
IV: 1 mg administered as needed.
Granisetron for Migraine-Associated Nausea
Oral: 1 mg taken at the onset of nausea, as needed.
Dosage Forms and Strengths of Granisetron
Oral Tablets: 1 mg, 2 mg
Injection (IV): 1 mg/mL
Transdermal Patch: 3.1 mg/24 hours
Administration Instructions for Granisetron
Granisetron can be taken orally, applied as a patch, or administered via injection. If using the patch, apply it to clean, dry skin on your upper arm. Do not cut the patch. For tablets, take them with or without food, as directed by your healthcare provider. If receiving an injection, it will be administered by a healthcare professional. Always follow your doctor’s instructions carefully.
Granisetron Side Effects and Adverse Reactions
Like all medications, Granisetron can cause side effects. Most are mild, but some may be serious. Contact your healthcare provider if you experience any of the following:
Common Side Effects: Headache, constipation, and fatigue. These are generally mild and resolve on their own.
Less Common Side Effects: Dizziness, diarrhea, or trouble sleeping. If these persist or worsen, consult your doctor.
Serious Side Effects: Allergic reactions (rash, itching, swelling), chest pain, or irregular heartbeat. Seek immediate medical attention if you experience any of these.
Contraindications for Granisetron
A contraindication is a specific condition where a medication should not be used due to potential harm. Inform your healthcare provider if you have any of the following conditions before starting Granisetron.
Allergy to Granisetron or similar medications: If you have had an allergic reaction to Granisetron or other 5-HT3 receptor antagonists (such as ondansetron), taking this medication could cause a serious allergic reaction, including difficulty breathing, rash, or swelling.
Severe liver disease: Granisetron is metabolized by the liver. If you have severe liver disease, the medication may not be processed properly, leading to increased side effects or toxicity.
Prolonged QT interval: Granisetron can affect the heart’s electrical system, potentially prolonging the QT interval, which can lead to dangerous heart rhythms. If you have a history of QT prolongation or are taking medications that affect the QT interval, Granisetron may not be safe for you.
Drug Interactions with Granisetron
Granisetron can interact with other medications, increasing the risk of side effects or reducing the effectiveness of either drug. Inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements.
Amiodarone (Pacerone): This medication can increase the risk of QT prolongation when taken with Granisetron.
Fluoxetine (Prozac): Taking Granisetron with selective serotonin reuptake inhibitors (SSRIs) like fluoxetine can increase the risk of serotonin syndrome, a potentially life-threatening condition.
Ondansetron (Zofran): Both medications belong to the same class (5-HT3 receptor antagonists), and taking them together may increase the risk of side effects such as QT prolongation.
Ketoconazole (Nizoral): This antifungal medication can increase the levels of Granisetron in your blood, raising the risk of side effects.
Tramadol (Ultram): Combining Granisetron with tramadol can increase the risk of seizures or serotonin syndrome.
Granisetron in Pregnancy
Is it safe to take Granisetron during pregnancy? The safety of Granisetron during pregnancy has not been fully established. While animal studies have not shown harm to the fetus, research involving pregnant women is limited. If you are pregnant or planning to become pregnant, it is crucial to discuss the potential risks and benefits of using Granisetron with your healthcare provider. They will help you weigh the risks of untreated nausea and vomiting against any potential risks associated with the medication.
Granisetron While Breastfeeding
Is it safe to take Granisetron while breastfeeding? There is limited information available regarding the use of Granisetron during breastfeeding. It is not known whether Granisetron passes into breast milk, so caution is advised. If you are breastfeeding, consult your healthcare provider before taking Granisetron to determine whether the benefits outweigh any potential risks to your baby.
Estimated Cost of Granisetron Medication
The estimated cost of a 30-day supply of Granisetron without insurance, using a GoodRX coupon, ranges from $30 to $60, depending on the pharmacy and dosage. Prices can vary, so it’s a good idea to check with your local pharmacy or use a medication discount service like GoodRX to find the best price for Granisetron.
Possible Alternatives to Granisetron
If Granisetron is not the right option for you, there are alternative treatments available for various conditions. Always discuss these alternatives with your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to explore these options.
Nausea and Vomiting
Alternatives include other anti-nausea medications such as ondansetron (Zofran) or prochlorperazine (Compazine). Lifestyle changes, like eating smaller, more frequent meals and avoiding strong odors, may also help alleviate symptoms.
Chemotherapy-Induced Nausea
Other medications, such as aprepitant (Emend) or dexamethasone (Decadron), may be used. Complementary treatments like acupuncture and ginger supplements have also been suggested. While Granisetron is commonly used for chemotherapy-induced nausea, these alternatives may be considered if Granisetron is not suitable for you.
Radiation-Induced Nausea
Similar to chemotherapy-induced nausea, medications like ondansetron or dexamethasone may be prescribed. Your healthcare provider may also recommend adjusting your radiation schedule to better manage nausea.
Postoperative Nausea
Alternatives include scopolamine patches (Transderm Scop) or metoclopramide (Reglan). Non-medication options, such as deep breathing exercises and staying hydrated, may also provide relief. While Granisetron is an option for postoperative nausea, these alternatives may be considered based on your individual needs.
Motion Sickness
Over-the-counter options like dimenhydrinate (Dramamine) or meclizine (Antivert) are commonly used for motion sickness. Behavioral techniques, such as focusing on the horizon or sitting in the front seat of a vehicle, may also help alleviate symptoms.
Hyperemesis Gravidarum
This severe form of nausea during pregnancy may require hospitalization and intravenous fluids. Medications like ondansetron or vitamin B6 supplements may also be recommended. In some cases, Granisetron may be considered, but always consult your healthcare provider before starting any treatment.
Gastroenteritis
Rehydration is key in managing gastroenteritis. Oral rehydration solutions (ORS) and anti-nausea medications like ondansetron may help. Avoiding dairy and fatty foods can also reduce symptoms. In some cases, Granisetron may be used to manage nausea.
Pancreatitis
Treatment for pancreatitis focuses on managing pain and nausea. Intravenous fluids and fasting may be recommended to allow the pancreas to heal. Anti-nausea medications like promethazine (Phenergan) may also be used. Granisetron can be considered as part of the treatment plan for nausea relief.
Migraine-Associated Nausea
Triptans, such as sumatriptan (Imitrex), can help with both headache and nausea. Anti-nausea medications like metoclopramide or prochlorperazine may also be used. In some cases, Granisetron may be an option for managing nausea associated with migraines.
Recent Updates on Granisetron Research
Recent studies have explored the use of Granisetron in combination with other anti-nausea medications to enhance its effectiveness in treating chemotherapy-induced nausea and vomiting. Research has also investigated the potential of Granisetron for managing nausea in patients with chronic conditions like gastroparesis. Ongoing clinical trials are examining Granisetron patches, which may offer a more convenient and longer-lasting option for patients who have difficulty swallowing pills. As research continues, staying informed about new developments is important. You can always consult one of our telemedicine providers to discuss the latest findings and how they may impact your treatment plan.
