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Flutamide Medication: Uses, Dosage, and Side Effects Explained
Summary or Key Points
Flutamide is a nonsteroidal antiandrogen medication used to treat conditions related to hormone imbalances, such as prostate cancer, hirsutism, and polycystic ovary syndrome (PCOS). It works by blocking the effects of androgens (male hormones) in the body. Always consult your healthcare provider before starting or adjusting your dose. If you need assistance, schedule a telemedicine appointment with one of our providers today.
Names of Medication
US Brand Name: Eulexin (Flutamide)
The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. In this case, Flutamide is the generic name.
Pharmacologic Category
Nonsteroidal Antiandrogen (NSAA)
Other medications in this category include bicalutamide and nilutamide, which also block the effects of male hormones in the body.
Flutamide Dosage
Flutamide is prescribed for various conditions, and the dosage depends on the specific condition being treated. Always consult your healthcare provider before changing your dose or starting treatment. You can also speak with one of our telemedicine providers for personalized advice.
Flutamide for Prostate Cancer
Adult Dose: 250 mg orally every 8 hours (three times a day). Treatment is typically long-term and may be combined with other medications, such as luteinizing hormone-releasing hormone (LHRH) agonists.
Flutamide for Hirsutism
Adult Dose: 250 mg orally twice a day. The duration of treatment may vary based on individual response and the severity of symptoms.
Flutamide for Polycystic Ovary Syndrome (PCOS)
Adult Dose: 250 mg orally twice a day. Treatment is often long-term but should be regularly reviewed by your healthcare provider.
Flutamide for Male Pattern Baldness
Adult Dose: 250 mg orally twice a day. The duration of treatment depends on the response and progression of hair loss.
Flutamide for Endometriosis
Adult Dose: 250 mg orally twice a day. The length of treatment may vary, and regular follow-up with your healthcare provider is recommended.
Flutamide for Breast Cancer
Adult Dose: 250 mg orally three times a day. Treatment is often long-term and may be part of a combination therapy.
Flutamide for Hormone-Sensitive Tumors
Adult Dose: 250 mg orally three times a day. The duration of treatment depends on the type and progression of the tumor.
Flutamide for Acne
Adult Dose: 250 mg orally twice a day. The length of treatment may vary based on the severity of acne and response to the medication.
Flutamide for Hyperandrogenism
Adult Dose: 250 mg orally twice a day. The duration of treatment depends on the severity of symptoms and response to therapy.
Flutamide for Infertility
Adult Dose: 250 mg orally twice a day. The length of treatment may vary depending on the underlying cause of infertility and response to treatment.
Dosage Forms and Strengths
Flutamide is available in tablet form.
Strength: 250 mg tablets.
Administration Instructions for Flutamide
Flutamide should be taken orally, typically with a full glass of water. It can be taken with or without food, though taking it with food may help reduce stomach upset. To maintain consistent levels of the medication in your body, take it at the same time each day. Do not crush or chew the tablets. Always follow your healthcare provider’s instructions. If you miss a dose, take it as soon as you remember, but do not double up on doses.
Flutamide Side Effects and Adverse Reactions
Like all medications, Flutamide can cause side effects. Some are common, while others are rare but more serious. If you experience any side effects, contact your healthcare provider immediately. You can also schedule a telemedicine visit with one of our providers for further guidance.
Common Flutamide Side Effects:
- Diarrhea: Loose or watery stools.
- Nausea: A sensation of needing to vomit.
- Fatigue: Feeling unusually tired or weak.
Less Common Side Effects:
- Liver Toxicity: Symptoms may include yellowing of the skin or eyes, dark urine, or severe abdominal pain.
- Gynecomastia: Enlargement of breast tissue in males.
Rare but Serious Side Effects:
- Allergic Reactions: Symptoms may include rash, itching, swelling, or difficulty breathing.
- Severe Liver Damage: Symptoms include jaundice, dark urine, and persistent nausea or vomiting.
Contraindications for Flutamide
A contraindication is a specific situation or condition where a medication should not be used because it may cause harm. For Flutamide, there are certain conditions where it is not safe or recommended.
Severe liver disease: Flutamide is processed by the liver, and taking it with severe liver problems can lead to toxic levels of the medication, worsening liver function.
Allergy to Flutamide: If you have had an allergic reaction to Flutamide in the past, taking it again could cause serious allergic reactions, including rash, swelling, or difficulty breathing.
Pregnancy: Flutamide is not safe for use during pregnancy as it can harm the developing fetus (see more details in the pregnancy section below).
Severe kidney disease: Since the kidneys help eliminate Flutamide, impaired kidney function can lead to dangerous levels of the drug in the bloodstream.
Drug to Drug Interactions
Flutamide can interact with other medications, potentially leading to harmful effects or reducing the effectiveness of either Flutamide or the other drugs. It’s important to inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements.
Warfarin (Coumadin): Flutamide may increase the effects of warfarin, a blood thinner, which can raise the risk of bleeding.
Theophylline (Elixophyllin, Theochron): Flutamide may elevate the levels of theophylline in your blood, potentially causing side effects such as nausea, vomiting, or seizures.
Leuprolide (Lupron): Flutamide is often used in combination with leuprolide for prostate cancer treatment. However, this combination can increase the risk of liver toxicity, so regular monitoring of liver function is recommended.
Anti-seizure medications (e.g., Phenytoin, Carbamazepine): These drugs may reduce the effectiveness of Flutamide by speeding up its breakdown in the liver.
Flutamide in Pregnancy
Is it Safe to Take Flutamide During Pregnancy?
No, Flutamide is not safe during pregnancy. It is classified as a pregnancy category D medication, meaning there is evidence of potential harm to the fetus. Flutamide can interfere with the development of male genitalia in a male fetus, potentially leading to birth defects. If you are pregnant or planning to become pregnant, avoid taking Flutamide. Always consult your healthcare provider for safer alternatives.
Flutamide While Breastfeeding
Is it Safe to Take Flutamide While Breastfeeding?
No, Flutamide is not recommended while breastfeeding. It is unclear whether Flutamide passes into breast milk, but due to the potential for serious side effects in a nursing infant, it is advised to avoid this medication. Speak with your healthcare provider to explore alternative treatments if you are breastfeeding.
Estimated Cost of Flutamide Medication
The cost of a 30-day supply of Flutamide without insurance can vary depending on the pharmacy and location. However, with a GoodRX coupon, the price typically ranges from $30 to $50 for a 30-day supply of 250 mg tablets. Prices may fluctuate, so it’s a good idea to check with your pharmacy or use a coupon service like GoodRX for the most up-to-date pricing.
Possible Alternatives to Flutamide
Depending on the condition being treated, alternative medications or lifestyle changes may help manage your symptoms. Always discuss any changes to your treatment plan with your healthcare provider, and consider scheduling a telemedicine visit with one of our providers to explore your options.
- Prostate cancer: Alternatives to Flutamide include other anti-androgens like bicalutamide (Casodex) or enzalutamide (Xtandi). Hormone therapy, radiation, or surgery may also be considered depending on the stage of the cancer.
- Hirsutism: For excessive hair growth, medications such as spironolactone or oral contraceptives may be prescribed. Non-medication options like laser hair removal or electrolysis can also be effective.
- Polycystic ovary syndrome (PCOS): Lifestyle changes such as weight loss and exercise can help manage PCOS symptoms. Medications like metformin or oral contraceptives may also help regulate hormones.
- Male pattern baldness: Alternatives include finasteride (Propecia) or minoxidil (Rogaine). Hair transplant surgery may also be an option for some patients.
- Endometriosis: Hormonal treatments like oral contraceptives or GnRH agonists (e.g., leuprolide) are common alternatives. Surgery may be considered for more severe cases.
- Breast cancer: Depending on the type of breast cancer, alternatives may include tamoxifen, aromatase inhibitors, or chemotherapy. Surgery and radiation are also common treatments.
- Hormone-sensitive tumors: Other hormone-blocking therapies, such as GnRH agonists or aromatase inhibitors, may be considered as alternatives to Flutamide.
- Acne: For acne related to hormone imbalances, oral contraceptives or spironolactone may be alternatives. Topical treatments like benzoyl peroxide or retinoids can also be helpful.
- Hyperandrogenism: Spironolactone or oral contraceptives may help manage high androgen levels. Lifestyle changes, such as weight loss and dietary adjustments, can also be beneficial.
- Infertility: Depending on the cause of infertility, treatments may include medications like clomiphene or letrozole to stimulate ovulation, or assisted reproductive technologies like IVF.
Recent Updates on Flutamide Research
Recent studies have focused on the long-term safety of Flutamide, particularly its impact on liver function. Researchers are investigating whether lower doses of Flutamide can effectively treat prostate cancer while reducing the risk of liver toxicity. Additionally, ongoing research is examining Flutamide’s use for conditions like hirsutism and PCOS. Some studies suggest it may help manage symptoms when combined with other treatments, though more research is needed to confirm these findings.
It’s important to stay informed about new research and discuss any concerns with your healthcare provider. If you have questions about how recent studies might affect your treatment plan, consider scheduling a telemedicine appointment with one of our providers today.
