Ferrous Sulfate: Uses, Dosage, and Side Effects Explained

Key Points About Ferrous Sulfate

Ferrous sulfate is an iron supplement commonly used to treat or prevent low iron levels, such as in cases of iron deficiency anemia or during pregnancy. It plays a crucial role in the production of red blood cells and helps maintain healthy iron levels. Always consult your healthcare provider before starting or adjusting your dose. Our telemedicine providers are available to assist you with any questions or concerns.

Names of Ferrous Sulfate Medication

US Brand Names: Feosol, Fer-In-Sol, Slow Fe

Ferrous sulfate is the generic name for these medications. The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. The generic name is typically listed in parentheses.

Pharmacologic Category of Ferrous Sulfate

Iron Supplement

Hematopoietic Agent

Ferrous Sulfate Dosage and Treatment

Ferrous sulfate is used to treat a variety of conditions related to low iron levels. The dosage may vary depending on the specific condition being treated. Always consult your doctor before making any changes to your dose. You can also schedule a telemedicine appointment for personalized guidance.

Iron Deficiency Anemia: 300-325 mg taken orally once daily or divided into 2-3 doses per day. Treatment typically lasts 3-6 months or until iron levels return to normal.

Anemia of Chronic Disease: 300-325 mg taken orally once daily. The duration of treatment depends on the underlying condition and how well you respond to therapy.

Sideroblastic Anemia: 300-325 mg taken orally once daily. Treatment may be long-term, depending on the severity of the condition.

Pregnancy-Related Anemia: 300-325 mg taken orally once daily. Treatment usually continues throughout pregnancy and may extend into the postpartum period if necessary.

Menorrhagia (Heavy Menstrual Bleeding): 300-325 mg taken orally once daily. The length of treatment depends on the severity of the bleeding and how well you respond to therapy.

Gastrointestinal Bleeding: 300-325 mg taken orally once daily. The duration of treatment depends on the cause of the bleeding and your response to therapy.

Malabsorption Syndromes: 300-325 mg taken orally once daily. The length of treatment varies based on the underlying cause of the malabsorption.

Chronic Kidney Disease: 300-325 mg taken orally once daily. Treatment may be long-term, depending on the severity of the anemia.

Post-Surgical Anemia: 300-325 mg taken orally once daily. The duration of treatment depends on your recovery and iron levels.

Nutritional Anemia: 300-325 mg taken orally once daily. Treatment typically lasts 3-6 months or until iron levels normalize.

Dosage Forms and Strengths of Ferrous Sulfate

Tablets: 300 mg, 325 mg

Liquid: 75 mg/0.6 mL, 125 mg/5 mL

Extended-release tablets: 160 mg

How to Take Ferrous Sulfate: Administration Instructions

Take ferrous sulfate with a full glass of water. It is best absorbed on an empty stomach, but if it causes stomach discomfort, you can take it with food. Avoid consuming dairy products, antacids, or calcium supplements at the same time, as they can interfere with iron absorption. If you miss a dose, take it as soon as you remember, but do not take two doses at once to make up for a missed dose.

Contraindications for Ferrous Sulfate

A contraindication is a specific situation where a medication should not be used because it may cause harm. For ferrous sulfate, certain conditions may make it unsafe. Be sure to discuss your medical history with your healthcare provider before starting this medication.

Hemochromatosis: This condition causes your body to absorb too much iron. Taking ferrous sulfate can lead to iron overload, which may damage organs such as the liver and heart.

Hemolytic Anemia: In this type of anemia, red blood cells are destroyed faster than they can be replaced. Ferrous sulfate may not be effective and could lead to iron buildup, worsening the condition.

Ulcerative Colitis or Crohn’s Disease: These inflammatory bowel diseases can be aggravated by ferrous sulfate, as it may irritate the gastrointestinal tract and worsen symptoms like diarrhea or abdominal pain.

Allergy to Iron Supplements: If you have had an allergic reaction to iron supplements in the past, avoid ferrous sulfate, as it could trigger a serious allergic response.

Repeated Blood Transfusions: Frequent transfusions may already provide sufficient iron, and taking ferrous sulfate could result in iron overload.

Ferrous Sulfate Drug Interactions

Ferrous sulfate can interact with other medications, potentially reducing its effectiveness or increasing the risk of side effects. Be sure to inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements. Some common medications that may interact with ferrous sulfate include:

Antacids (e.g., Tums, Maalox): These can reduce the absorption of ferrous sulfate, making it less effective.

Levothyroxine (brand name: Synthroid): Iron can decrease the absorption of this thyroid medication, potentially reducing its effectiveness.

Antibiotics (e.g., Ciprofloxacin, Doxycycline): Iron can interfere with the absorption of these antibiotics, making them less effective.

Proton Pump Inhibitors (e.g., Omeprazole, Prilosec): These medications reduce stomach acid, which is necessary for proper iron absorption.

Calcium Supplements: Calcium can interfere with the absorption of ferrous sulfate, reducing its effectiveness.

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Ferrous Sulfate in Pregnancy

Is it safe to take ferrous sulfate when pregnant?

Yes, ferrous sulfate is generally considered safe during pregnancy, particularly if you have iron deficiency anemia. Pregnant women often require additional iron to support the growing baby and placenta. However, it’s essential to follow the recommended dosage, as excessive iron intake can be harmful. Always consult your healthcare provider before starting any new medication during pregnancy to ensure it’s appropriate for your specific needs.

Ferrous Sulfate While Breastfeeding

Is it safe to take ferrous sulfate while breastfeeding?

Yes, ferrous sulfate is typically safe to use while breastfeeding. Iron is a vital nutrient, and breastfeeding mothers may need extra iron, especially if their levels were low during pregnancy. Ferrous sulfate does not significantly alter the iron content of breast milk, making it safe for your baby. However, it’s always best to consult your healthcare provider before starting any new medication while breastfeeding.

Estimated Cost of Ferrous Sulfate

The cost of a 30-day supply of ferrous sulfate without insurance can vary depending on the pharmacy and location. With a GoodRx coupon, the price for a 30-day supply of ferrous sulfate (325 mg tablets) typically ranges from $5 to $10. Be sure to check with your local pharmacy for the most accurate pricing.

Possible Alternatives to Ferrous Sulfate

If ferrous sulfate isn’t the right option for you, there are alternative treatments and lifestyle adjustments that can help manage iron deficiency and related conditions. Always discuss any changes with your healthcare provider or consider scheduling a telemedicine appointment to explore your options.

Iron Deficiency Anemia

Alternatives include other iron supplements, such as ferrous gluconate or ferrous fumarate. Additionally, dietary changes—like increasing your intake of iron-rich foods such as red meat, spinach, and lentils—can also be beneficial.

Anemia of Chronic Disease

Treatment often focuses on managing the underlying condition. In some cases, erythropoiesis-stimulating agents (ESAs) or intravenous iron may be recommended to address anemia.

Sideroblastic Anemia

Treatment for sideroblastic anemia may involve vitamin B6 (pyridoxine) supplements, as this type of anemia is often associated with a deficiency in this vitamin.

Pregnancy-Related Anemia

In addition to iron supplements, your healthcare provider may recommend folic acid and vitamin B12. Eating iron-rich foods and taking prenatal vitamins can also help manage anemia during pregnancy.

Menorrhagia (Heavy Menstrual Bleeding)

Treatment for heavy menstrual bleeding may include hormonal therapies, such as birth control pills or intrauterine devices (IUDs). Iron supplements may still be necessary to address any resulting anemia.

Gastrointestinal Bleeding

The first step in treating anemia caused by gastrointestinal bleeding is addressing the source of the bleeding. Iron supplements or intravenous iron may be recommended to restore iron levels.

Malabsorption Syndromes

If your body has difficulty absorbing iron, intravenous iron or other treatments may be required. It’s also important to treat the underlying cause of the malabsorption to improve iron levels.

Chronic Kidney Disease

For patients with chronic kidney disease, intravenous iron or ESAs may be necessary to manage anemia. Oral iron supplements like ferrous sulfate may not be effective in more advanced stages of the disease.

Post-Surgical Anemia

Depending on the severity of the anemia, iron supplements or blood transfusions may be recommended after surgery. A diet rich in iron and protein can also support recovery.

Nutritional Anemia

Improving your diet by incorporating more iron-rich foods, such as lean meats, beans, and fortified cereals, can help manage nutritional anemia. In some cases, additional vitamin and mineral supplements may be necessary.

Recent Updates on Ferrous Sulfate Research

Recent studies have focused on enhancing the absorption and tolerability of iron supplements like ferrous sulfate. One area of research involves developing new formulations that reduce common gastrointestinal side effects, such as nausea and constipation, which are often associated with traditional iron supplements. Additionally, ongoing research is examining the effectiveness of ferrous sulfate in specific populations, including those with chronic kidney disease and inflammatory bowel disease, to optimize treatment for these groups.

Researchers are also exploring the potential benefits of iron supplementation in managing fatigue and cognitive function in individuals with mild iron deficiency, even before anemia develops. Early findings suggest that iron supplementation may improve energy levels and mental clarity in some patients, though further research is needed to confirm these results.

James Kingsley

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