Estrone Hormone: Uses, Dosage, and Menopause Relief

Summary of Key Points

Estrone is a type of estrogen, a hormone commonly used to treat conditions related to hormone imbalances. It is often prescribed to manage symptoms of menopause, prevent osteoporosis, and in some cases, treat certain cancers. Estrone can help relieve symptoms such as hot flashes, vaginal dryness, and bone loss. Always consult your healthcare provider before starting or adjusting your dosage. Our telemedicine providers are available to assist with any questions or concerns you may have.

Names of Medication

US Brand Name: Estrone (generic name: Estrone)

The generic name refers to the active ingredient in the medication, while the brand name is assigned by the manufacturer. In this case, the generic name is listed in parentheses.

Pharmacologic Category

Estrogen Derivatives

Dosing Information for Estrone

Estrone is prescribed for various conditions, and the dosage will depend on the specific condition being treated. Always follow your doctor’s instructions and consult them before making any changes to your dose. You can also schedule a telemedicine appointment with one of our providers for personalized guidance.

1. Menopause Symptoms: 0.3 mg to 2 mg orally once daily. The duration of treatment depends on the severity of symptoms and how well you respond to therapy.
2. Osteoporosis Prevention: 0.3 mg to 2 mg orally once daily. Treatment is typically long-term to help maintain bone density.
3. Hypoestrogenism: 1.25 mg orally once daily. The length of treatment depends on the underlying cause of estrogen deficiency.
4. Breast Cancer (Palliative Treatment): 10 mg orally three times daily for at least three months.
5. Prostate Cancer (Palliative Treatment): 1.25 mg to 2.5 mg orally three times daily.
6. Endometriosis: 1.25 mg orally once daily. Treatment duration varies based on symptom control.
7. Uterine Bleeding: 1.25 mg orally once daily for 7 to 10 days.
8. Hot Flashes: 0.3 mg to 2 mg orally once daily. The length of treatment depends on the severity of symptoms and response to therapy.
9. Vaginal Atrophy: 0.3 mg to 2 mg orally once daily. Treatment duration depends on symptom relief.
10. Hormone Replacement Therapy (HRT): 0.3 mg to 2 mg orally once daily. The duration of treatment depends on individual needs and response.

Dosage Forms and Strengths of Estrone

Oral Tablets: 0.3 mg, 0.625 mg, 1.25 mg, 2 mg

Administration Instructions for Estrone

Take Estrone by mouth, with or without food, as directed by your healthcare provider. It is important to take the medication at the same time each day to maintain consistent hormone levels. If you miss a dose, take it as soon as you remember, unless it’s close to your next scheduled dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once.

Adverse Reactions and Side Effects of Estrone

Like all medications, Estrone may cause side effects. Some are more common, while others are rare but potentially serious. If you experience any side effects, contact your healthcare provider immediately. You can also schedule a telemedicine consultation with one of our providers for further advice.

Common Side Effects of Estrone

1. Headache: Mild to moderate headaches may occur as your body adjusts to the medication.
2. Nausea: Some patients may experience an upset stomach, particularly when starting treatment.
3. Breast Tenderness: Sensitivity or discomfort in the breast area may occur.
4. Weight Changes: Some individuals may experience weight gain or loss while taking Estrone.

Less Common but Serious Side Effects of Estrone

1. Blood Clots: Estrone may increase the risk of blood clots, which can lead to conditions like deep vein thrombosis (DVT) or pulmonary embolism.
2. Stroke: There is a small risk of stroke, particularly in individuals with other risk factors such as high blood pressure or smoking.
3. Breast Cancer: Long-term use of estrogen therapy may increase the risk of developing breast cancer.
4. Liver Problems: Symptoms such as yellowing of the skin or eyes (jaundice) may indicate liver issues.

Contraindications for Estrone Use

A contraindication is a specific situation where a medication should not be used because it may be harmful. If you have any of the following conditions, taking Estrone may not be safe. Always consult your healthcare provider before starting any new medication. If you have concerns, you can schedule a telemedicine appointment with one of our providers.

1. Pregnancy: Estrone should not be used during pregnancy, as it can harm the developing fetus. Estrogen medications like Estrone can increase the risk of birth defects or other complications.
2. Breastfeeding: Estrone is not recommended while breastfeeding, as it can pass into breast milk and may affect the baby’s development or milk production.
3. History of Blood Clots: If you have a history of blood clots (such as deep vein thrombosis or pulmonary embolism), Estrone may increase your risk of developing more clots. Estrogen can make blood more likely to clot, leading to serious complications.
4. Breast or Uterine Cancer: Estrone is contraindicated in individuals with a history of estrogen-dependent cancers, such as breast or uterine cancer, as it can stimulate the growth of these cancers.
5. Liver Disease: If you have liver disease, your body may not process Estrone properly, leading to increased side effects or complications.
6. Unexplained Vaginal Bleeding: Estrone should not be used if you have unexplained vaginal bleeding, as this could be a sign of a more serious condition that requires evaluation by a healthcare provider.

Drug to Drug Interactions

Estrone can interact with other medications, potentially reducing its effectiveness or increasing the risk of side effects. It’s important to inform your healthcare provider about all medications you are currently taking, including over-the-counter drugs and supplements. Below are some common medications that may interact with Estrone:

1. Rifampin (Rifadin): This antibiotic can decrease Estrone’s effectiveness by accelerating estrogen breakdown in the liver.
2. Carbamazepine (Tegretol): This anti-seizure medication can lower Estrone levels, reducing its effectiveness.
3. Phenytoin (Dilantin): Another anti-seizure medication, Phenytoin, can also diminish Estrone’s effectiveness.
4. St. John’s Wort: This herbal supplement may reduce Estrone’s effectiveness by speeding up its metabolism in the liver.
5. Warfarin (Coumadin): Estrone may interfere with Warfarin’s blood-thinning effects, potentially increasing the risk of blood clots.

Estrone in Pregnancy

Is it Safe to Take Estrone During Pregnancy?

No, Estrone is not safe to use during pregnancy. Estrogen medications like Estrone can harm a developing fetus, potentially leading to birth defects and other complications. If you are pregnant or planning to become pregnant, consult your healthcare provider about alternative treatments. If you suspect you are pregnant while taking Estrone, stop the medication and contact your healthcare provider immediately.

Estrone While Breastfeeding

Is it Safe to Take Estrone While Breastfeeding?

No, Estrone is not recommended while breastfeeding. It can pass into breast milk and may affect your baby’s development or interfere with milk production. If you are breastfeeding and require hormone therapy, discuss safer alternatives with your healthcare provider. You can also schedule a telemedicine appointment with one of our providers to explore your options.

Estimated Cost of Estrone Medication

The cost of a 30-day supply of Estrone without insurance can vary depending on the pharmacy and location. However, with a GoodRx coupon, the estimated cost typically ranges from $40 to $60. Prices may fluctuate, so it’s a good idea to check with your pharmacy or use a coupon service like GoodRx for the most up-to-date pricing.

Possible Alternatives to Estrone

If Estrone is not suitable for you, there are alternative treatments and lifestyle changes that may help manage the conditions for which Estrone is commonly prescribed. Always consult your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to discuss these alternatives.

1. Menopause Symptoms: Non-hormonal medications such as selective serotonin reuptake inhibitors (SSRIs), lifestyle changes like regular exercise, and dietary adjustments, including increasing soy intake, may help manage symptoms.
2. Osteoporosis: Bisphosphonates (e.g., Alendronate, Fosamax) or selective estrogen receptor modulators (SERMs) like Raloxifene (Evista) can help strengthen bones. Weight-bearing exercises and calcium/vitamin D supplements may also be beneficial.
3. Hypoestrogenism: Hormone replacement therapy (HRT) with other forms of estrogen, such as estradiol, or non-hormonal treatments like vaginal moisturizers for specific symptoms may be considered.
4. Breast Cancer: Tamoxifen or aromatase inhibitors like Anastrozole (Arimidex) are often used in hormone-sensitive breast cancer. Consult your oncologist to determine the best treatment plan for your situation.
5. Prostate Cancer: Androgen deprivation therapy (ADT) or medications like Leuprolide (Lupron) are commonly used. Discuss your options with your oncologist for a personalized treatment plan.
6. Endometriosis: GnRH agonists like Leuprolide (Lupron) or progestin-only treatments may be effective alternatives. Lifestyle changes, such as adopting an anti-inflammatory diet, may also help manage symptoms.
7. Uterine Bleeding: Non-hormonal options like Tranexamic acid (Lysteda) or hormonal IUDs may help control bleeding. In severe cases, surgical options may be considered.
8. Hot Flashes: Non-hormonal medications like Gabapentin (Neurontin) or lifestyle changes, such as avoiding triggers (e.g., spicy foods, alcohol) and practicing relaxation techniques, may provide relief.
9. Vaginal Atrophy: Vaginal moisturizers, lubricants, or non-hormonal treatments like DHEA (Intrarosa) may effectively manage symptoms.
10. Hormone Replacement Therapy (HRT): Other forms of HRT, such as estradiol or combination estrogen-progestin therapy, may be suitable alternatives. Discuss with your healthcare provider to find the best option for you.

Recent Updates on Estrone Research

Recent studies have focused on the long-term safety of estrogen therapy, including Estrone, particularly in postmenopausal women. Research indicates that while estrogen therapy can effectively manage menopause symptoms and help prevent osteoporosis, it may increase the risk of certain conditions, such as blood clots and breast cancer, in some individuals. Ongoing studies are exploring ways to minimize these risks, such as using lower doses of estrogen or combining it with other medications. If you have concerns about the safety of Estrone, discuss them with your healthcare provider. You can also schedule a telemedicine appointment with one of our providers to review the latest research and determine if Estrone is the right choice for you.

James Kingsley

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