Ertapenem: Uses, Dosage, and Side Effects Explained

Summary of Key Points

Ertapenem is an antibiotic used to treat a range of serious bacterial infections, including pneumonia, intra-abdominal infections, and skin infections. It works by stopping the growth of bacteria. Ertapenem is typically administered by injection and is often prescribed when other antibiotics are not effective. Always consult your healthcare provider before starting or changing your treatment. You can easily connect with one of our providers via telemedicine for more information.

Names of Medication

US Brand Name: Invanz

Generic Name: Ertapenem

The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. In this case, Ertapenem is the generic name.

Pharmacologic Category

Ertapenem belongs to the carbapenem class of antibiotics. Other medications in this category include:

1. Imipenem
2. Meropenem
3. Doripenem

Ertapenem Dosage

Ertapenem is used to treat various infections in adults. The dosage depends on the specific condition being treated. Always follow your healthcare provider’s instructions and consult them before making any changes to your dose. You can schedule a telemedicine appointment with one of our providers to discuss your treatment plan.

Community-Acquired Pneumonia

1 gram (g) intravenously (IV) or intramuscularly (IM) once daily for 7 to 14 days.

Intra-Abdominal Infections

1 g IV or IM once daily for 5 to 14 days.

Skin and Soft Tissue Infections

1 g IV or IM once daily for 7 to 14 days.

Urinary Tract Infections (UTIs)

1 g IV or IM once daily for 3 to 10 days, depending on the severity of the infection.

Pelvic Inflammatory Disease

1 g IV or IM once daily for 3 to 14 days.

Diabetic Foot Infections

1 g IV or IM once daily for 5 to 14 days.

Bacteremia

1 g IV or IM once daily for 7 to 14 days.

Bone and Joint Infections

1 g IV or IM once daily for 4 to 6 weeks.

Meningitis

1 g IV once daily for 7 to 21 days, depending on the severity and response to treatment.

Endocarditis

1 g IV once daily for 4 to 6 weeks.

Dosage Forms and Strengths

Ertapenem is available in the following form and strength:

1. Injection: 1 g vial for reconstitution

Administration Instructions for Ertapenem

Ertapenem is administered either intravenously (IV) or intramuscularly (IM). It is typically given by a healthcare professional in a hospital or clinic setting. If prescribed for home use, your healthcare provider will provide detailed instructions on how to prepare and administer the injection. Always follow these instructions carefully to ensure the medication’s effectiveness. If you have any questions or concerns, consult one of our providers through telemedicine for guidance.

Ertapenem Side Effects and Adverse Reactions

Like all medications, Ertapenem can cause side effects. Some are common, while others are rare but more serious. If you experience any side effects, contact your healthcare provider immediately. You can also schedule a telemedicine visit with one of our providers to discuss any concerns.

Common Side Effects

1. Nausea and Vomiting: Feeling nauseous or vomiting is a common side effect.
2. Diarrhea: Loose or frequent stools may occur during treatment.
3. Headache: Some patients report mild to moderate headaches.
4. Injection Site Reactions: Redness, swelling, or pain at the injection site may occur.

Serious Side Effects

1. Allergic Reactions: Symptoms may include rash, itching, swelling, severe dizziness, or difficulty breathing. Seek immediate medical attention if these occur.
2. Seizures: Rare but serious, especially in individuals with a history of seizures or neurological conditions.
3. Severe Diarrhea (Clostridium difficile-associated diarrhea): This can occur during or after treatment and may require medical attention.

Contraindications for Ertapenem

A contraindication is a specific condition where a medication should not be used because it may cause harm. If you have any of the following conditions, avoid taking Ertapenem. Always consult your healthcare provider to discuss your medical history and ensure Ertapenem is safe for you.

1. Allergy to Ertapenem or other beta-lactam antibiotics: If you are allergic to Ertapenem or other beta-lactam antibiotics (such as penicillins or cephalosporins), taking this medication could trigger a severe, potentially life-threatening allergic reaction.
2. Severe allergic reactions to any carbapenem antibiotics:Ertapenem is part of the carbapenem class. If you have had a severe allergic reaction to any carbapenem antibiotic, you should not take Ertapenem, as it may cause a similar reaction.
3. Severe kidney disease:Ertapenem is processed by the kidneys. If you have severe kidney disease or are on dialysis, your body may not clear the drug effectively, leading to a buildup and potential toxicity.
4. History of seizures:Ertapenem can lower the seizure threshold, increasing the risk of seizures in individuals with a history of epilepsy or other seizure disorders.

Drug to Drug Interactions

Certain medications can interact with Ertapenem, potentially reducing its effectiveness or increasing the likelihood of side effects. It is essential to inform your healthcare provider about all medications you are currently taking, including over-the-counter drugs and supplements. Below are some known drug interactions:

Valproic Acid (Depakote):Ertapenem can lower the blood levels of valproic acid, a medication used to control seizures. This interaction may increase the risk of seizures in individuals taking valproic acid.

Probenecid (Benemid): Probenecid can raise Ertapenem levels in the blood, which may increase the risk of side effects.

Ertapenem in Pregnancy

Is it Safe to Take Ertapenem When Pregnant?

There is limited information on the use of Ertapenem during pregnancy. While animal studies have not shown harm to the fetus, no well-controlled studies have been conducted in pregnant women. Ertapenem should only be used during pregnancy if the potential benefits outweigh the risks. If you are pregnant or planning to become pregnant, consult your healthcare provider to determine whether Ertapenem is the right option for you. Our telemedicine providers are available to help you make an informed decision.

Ertapenem While Breastfeeding

Is it Safe to Take Ertapenem While Breastfeeding?

Ertapenem is excreted in breast milk in small amounts. Although no adverse effects have been reported in breastfed infants, the possibility of side effects in a nursing baby cannot be completely ruled out. If you are breastfeeding, discuss the potential risks and benefits of taking Ertapenem with your healthcare provider. They may recommend monitoring your baby for any signs of side effects, such as diarrhea or rash.

Estimated Cost of Ertapenem Medication

The estimated cost of a 30-day supply of Ertapenem without insurance ranges from $500 to $700, depending on the pharmacy. Using a GoodRx coupon, you may be able to reduce the price to around $450. Prices can vary, so it’s a good idea to check with your pharmacy or use a discount service like GoodRx for the most up-to-date pricing.

Possible Alternatives to Ertapenem

If Ertapenem is not suitable for you, or if you are looking for alternative treatments, other medications and lifestyle changes may be helpful. Always consult your healthcare provider before making any changes to your treatment plan. Our telemedicine providers can assist you in exploring these options.

1. Community-acquired pneumonia: Alternatives include antibiotics such as azithromycin (Zithromax), doxycycline, or levofloxacin (Levaquin). Lifestyle changes, such as quitting smoking and getting vaccinated against pneumonia and the flu, can also help prevent future infections.
2. Intra-abdominal infections: Other antibiotics like piperacillin-tazobactam (Zosyn) or metronidazole (Flagyl) may be used. Practicing good hygiene and proper food handling can help prevent infections.
3. Skin and soft tissue infections: Alternatives include clindamycin, trimethoprim-sulfamethoxazole (Bactrim), or doxycycline. Keeping wounds clean and dry is essential for preventing infections.
4. Urinary tract infections: Common alternatives include nitrofurantoin (Macrobid), trimethoprim-sulfamethoxazole (Bactrim), or ciprofloxacin (Cipro). Drinking plenty of water and urinating frequently can help flush out bacteria.
5. Pelvic inflammatory disease: Alternatives include doxycycline, metronidazole (Flagyl), or ceftriaxone (Rocephin). Practicing safe sex and getting regular STI screenings can help prevent PID.
6. Diabetic foot infections: Alternatives may include amoxicillin-clavulanate (Augmentin) or clindamycin. Proper foot care, including regular inspections and wound care, is crucial for preventing infections in people with diabetes.
7. Bacteremia: Depending on the bacteria involved, alternatives may include vancomycin or ceftriaxone (Rocephin). Prompt treatment of infections and maintaining good hygiene can help prevent bacteremia.
8. Bone and joint infections: Other antibiotics like vancomycin or cefazolin may be used. Keeping wounds clean and treating infections early can help prevent bone and joint infections.
9. Meningitis: Alternatives may include ceftriaxone (Rocephin) or vancomycin. Vaccination and prompt treatment of ear or sinus infections can help prevent meningitis.
10. Endocarditis: Depending on the bacteria involved, alternatives may include vancomycin or ceftriaxone (Rocephin). Good oral hygiene and regular dental checkups can help prevent endocarditis, especially in individuals with heart conditions.

Recent Updates on Ertapenem Research

Recent studies have focused on Ertapenem for treating multidrug-resistant infections, particularly in hospital settings. Research indicates that Ertapenem remains effective against many resistant bacteria, making it a valuable option for complicated infections. Ongoing studies are exploring its use in combination with other antibiotics to enhance effectiveness and reduce the risk of resistance. Additionally, researchers are investigating shorter treatment courses with Ertapenem, which may help reduce side effects and improve patient outcomes.

James Kingsley

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