Ergocalciferol (Vitamin D2): Benefits, Dosage & Side Effects

Summary of Key Points

Ergocalciferol, commonly known as Vitamin D2, is a form of Vitamin D used to treat or prevent conditions caused by Vitamin D deficiency, such as rickets, osteomalacia, and certain parathyroid disorders. It plays a crucial role in helping the body absorb calcium and phosphorus, which are essential for maintaining strong bones. Always consult your healthcare provider before starting or adjusting your dose. You can schedule a telemedicine appointment with one of our providers for personalized advice on Ergocalciferol dosage and usage.

Names of Medication

US Brand Name: Drisdol (Ergocalciferol)

The generic name refers to the active ingredient in the medication, which is listed in parentheses after the brand name.

Pharmacologic Category

Category: Vitamin D Analog

Ergocalciferol Dosage Guidelines

Ergocalciferol is prescribed to treat various conditions related to Vitamin D deficiency. Below are the recommended doses for adults. Always consult your doctor before making any changes to your medication. You can easily schedule a telemedicine visit with one of our providers for guidance on the appropriate Ergocalciferol dosage for your condition.

Rickets

Dose: 12,000 to 500,000 IU/day, depending on severity

Frequency: Once daily

Length of Treatment: Typically 6 to 12 months, or as directed by your doctor

Osteomalacia

Dose: 50,000 IU once weekly

Frequency: Once weekly

Length of Treatment: 6 to 12 weeks, followed by maintenance therapy

Hypoparathyroidism

Dose: 50,000 to 200,000 IU/day

Frequency: Once daily

Length of Treatment: Long-term, as directed by your healthcare provider

Vitamin D Deficiency

Dose: 50,000 IU once weekly

Frequency: Once weekly

Length of Treatment: 6 to 8 weeks, followed by maintenance therapy

Osteoporosis

Dose: 50,000 IU once monthly

Frequency: Once monthly

Length of Treatment: Long-term, as part of an osteoporosis management plan

Chronic Kidney Disease

Dose: 50,000 IU once weekly

Frequency: Once weekly

Length of Treatment: As directed by your healthcare provider

Malabsorption Syndromes

Dose: 10,000 to 50,000 IU/day

Frequency: Once daily

Length of Treatment: Long-term, depending on the severity of malabsorption

Cystic Fibrosis

Dose: 50,000 IU once weekly

Frequency: Once weekly

Length of Treatment: As directed by your healthcare provider

Liver Disease

Dose: 50,000 IU once weekly

Frequency: Once weekly

Length of Treatment: As directed by your healthcare provider

Hyperparathyroidism

Dose: 50,000 IU once weekly

Frequency: Once weekly

Length of Treatment: As directed by your healthcare provider

Dosage Forms and Strengths

Ergocalciferol is available in the following forms and strengths:

1. Capsules: 50,000 IU
2. Oral Solution: 8000 IU/mL
3. Tablets: 400 IU

How to Take Ergocalciferol

Take Ergocalciferol exactly as prescribed by your healthcare provider. It can be taken with or without food. If using the liquid form, be sure to use a special measuring device to ensure the correct dose. Avoid using a household spoon, as it may not provide an accurate measurement. If you miss a dose, take it as soon as you remember, but do not take two doses at once to make up for a missed one.

Contraindications for Ergocalciferol

A contraindication is a specific condition where a medication should not be used because it may cause harm. If you have any of the following conditions, Ergocalciferol may not be safe for you. Always consult your healthcare provider before starting any new medication. If you’re unsure, one of our telemedicine providers can assist you.

1. Hypercalcemia (high calcium levels in the blood): Ergocalciferol increases calcium absorption. If you already have high calcium levels, this medication could worsen your condition, potentially leading to complications like kidney stones or heart issues.
2. Hypervitaminosis D (excess vitamin D): If you have elevated levels of vitamin D, taking Ergocalciferol could lead to toxicity, which may cause symptoms such as nausea, vomiting, and even kidney damage.
3. Allergic reactions: If you are allergic to Ergocalciferol or any of its components, taking this medication could trigger an allergic reaction, which may include rash, itching, or difficulty breathing.
4. Malabsorption syndromes: If you have a condition that affects nutrient absorption (such as Crohn’s disease or celiac disease), Ergocalciferol may not be absorbed properly, and alternative treatments may be necessary.

Drug Interactions with Ergocalciferol

Ergocalciferol can interact with other medications, potentially affecting its effectiveness or increasing the risk of side effects. Be sure to inform your healthcare provider about all medications you’re taking, including over-the-counter drugs and supplements. Known interactions include:

1. Cholestyramine (Prevalite, Questran): This medication can reduce the absorption of Ergocalciferol, making it less effective.
2. Orlistat (Alli, Xenical): Orlistat can decrease the absorption of fat-soluble vitamins, including vitamin D, reducing Ergocalciferol’s effectiveness.
3. Phenytoin (Dilantin) and Barbiturates: These medications can increase the breakdown of vitamin D in the liver, reducing its effectiveness.
4. Thiazide diuretics (Hydrochlorothiazide): These medications can raise calcium levels in the blood, and when combined with Ergocalciferol, may increase the risk of hypercalcemia.

Ergocalciferol in Pregnancy

Is it safe to take Ergocalciferol when pregnant?

Yes, Ergocalciferol (Vitamin D2) is generally considered safe during pregnancy, but it should always be taken under the guidance of a healthcare provider. Vitamin D plays a crucial role in both maternal and fetal health by supporting calcium absorption and promoting healthy bone development. However, excessive intake of vitamin D can lead to complications, so it’s important to adhere to the recommended dosage. If you’re uncertain about your vitamin D needs during pregnancy, consult your healthcare provider or one of our telemedicine specialists for personalized advice.

Ergocalciferol while Breastfeeding

Is it safe to take Ergocalciferol while breastfeeding?

Yes, Ergocalciferol is generally safe to use while breastfeeding. Vitamin D is essential for both the mother and baby, contributing to bone health and supporting the immune system. However, it’s important to monitor your dosage, as high levels of vitamin D can pass into breast milk and potentially affect your baby. Always consult your healthcare provider before taking Ergocalciferol while breastfeeding to ensure you’re using the appropriate amount.

Estimated Cost of Ergocalciferol Medication

The estimated cost of a 30-day supply of Ergocalciferol (50,000 IU capsules) without insurance typically ranges from $10 to $15 when using a GoodRx coupon. Prices may vary depending on the pharmacy and location, so it’s a good idea to compare prices at different pharmacies near you.

Possible Alternatives to Ergocalciferol

For certain conditions, alternative treatments or lifestyle changes may help manage your health. Always discuss any changes to your treatment plan with your healthcare provider. If you need guidance, our telemedicine providers are available to assist you.

1. Rickets: In addition to Ergocalciferol, increasing sunlight exposure and consuming foods rich in vitamin D (such as fortified milk and fish) may be beneficial. Calcium and phosphorus supplements may also be recommended.
2. Osteomalacia: Similar to rickets, increasing dietary vitamin D and calcium, along with safe sun exposure, can help. Your doctor may also suggest other forms of vitamin D, such as cholecalciferol (Vitamin D3).
3. Hypoparathyroidism: Calcium and vitamin D supplements are commonly used. In some cases, synthetic parathyroid hormone (PTH) may be prescribed.
4. Vitamin D deficiency: Besides Ergocalciferol, you can increase vitamin D levels through dietary changes (such as eating fatty fish and fortified foods) and safe sun exposure. Cholecalciferol (Vitamin D3) is another option.
5. Osteoporosis: Weight-bearing exercises, calcium supplements, and medications like bisphosphonates (e.g., Alendronate) may be recommended alongside vitamin D supplementation.
6. Chronic kidney disease: Active forms of vitamin D (such as calcitriol) may be necessary, as the kidneys may not convert Ergocalciferol into its active form. Your doctor may also recommend dietary changes and phosphate binders.
7. Malabsorption syndromes: In cases where the body cannot absorb vitamin D properly, higher doses or injectable forms may be required. A healthcare provider may also suggest dietary modifications.
8. Cystic fibrosis: Patients may need higher doses of vitamin D due to malabsorption. Pancreatic enzyme replacement therapy and a high-calorie, high-fat diet may also be recommended.
9. Liver disease: Since the liver helps convert vitamin D to its active form, patients with liver disease may require higher doses or active forms of vitamin D, such as calcitriol.
10. Hyperparathyroidism: Treatment may include surgery to remove the overactive parathyroid gland(s), along with calcium and vitamin D supplementation to support bone health.

Recent Updates on Ergocalciferol Research

Recent studies have explored the role of vitamin D in immune function, particularly in relation to respiratory infections and autoimmune diseases. Some research suggests that maintaining adequate vitamin D levels may reduce the risk of severe respiratory infections, including COVID-19. However, more research is needed to confirm these findings. Additionally, ongoing studies are investigating the potential benefits of vitamin D supplementation in preventing chronic conditions such as heart disease and diabetes.

As always, consult your healthcare provider before making any changes to your vitamin D intake. If you have questions about how Ergocalciferol fits into your treatment plan, our telemedicine providers are available to help you make informed decisions about your health.

James Kingsley

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