Dimenhydrinate: Motion Sickness Medication & Dosage Guide

Summary of Key Points

Dimenhydrinate is an over-the-counter medication commonly used to prevent and treat nausea, vomiting, dizziness, and motion sickness. It is also effective in managing vertigo and certain inner ear disorders. Dimenhydrinate works by blocking specific signals in the brain that trigger nausea and dizziness. Always consult a healthcare provider before starting or adjusting your dose. You can easily schedule a telemedicine appointment with one of our providers for personalized care.

Names of Medication

US Brand Name: Dramamine

Generic Name: Dimenhydrinate

The generic name refers to the active ingredient in the medication, while the brand name is assigned by the manufacturer. In this case, Dimenhydrinate is the generic name.

Pharmacologic Category

Antiemetic: Helps prevent nausea and vomiting

Antihistamine: Blocks histamine receptors

Dimenhydrinate Dosage

Dimenhydrinate is used to treat various conditions. Below are the recommended dosages for adults. Always consult your doctor before adjusting your dose, and you can connect with one of our telemedicine providers for guidance.

Motion Sickness

50-100 mg taken 30 to 60 minutes before travel

Repeat every 4 to 6 hours as needed

Do not exceed 400 mg in 24 hours

Nausea and Vomiting

50-100 mg every 4 to 6 hours as needed

Do not exceed 400 mg in 24 hours

Vertigo and Inner Ear Disorders

50-100 mg every 4 to 6 hours as needed

Do not exceed 400 mg in 24 hours

Seasickness and Travel Sickness

50-100 mg taken 30 to 60 minutes before travel

Repeat every 4 to 6 hours as needed

Do not exceed 400 mg in 24 hours

Migraine-Associated Nausea

50-100 mg every 4 to 6 hours as needed

Do not exceed 400 mg in 24 hours

Postoperative Nausea

50-100 mg every 4 to 6 hours as needed

Do not exceed 400 mg in 24 hours

Dosage Forms and Strengths

Tablets: 50 mg

Chewable Tablets: 50 mg

Liquid: 12.5 mg/5 mL

Suppositories: 50 mg

Administration Instructions

Dimenhydrinate can be taken with or without food. If you experience stomach discomfort, taking it with food or milk may help. For motion sickness, it is best to take the medication 30 to 60 minutes before travel. Always follow your healthcare provider’s instructions on how to take this medication, and do not exceed the recommended dose. If you have any questions about how to take Dimenhydrinate, our telemedicine providers are available to assist you.

Dimenhydrinate Side Effects and Adverse Reactions

Like all medications, Dimenhydrinate can cause side effects. Most are mild, but some may be more serious. If you experience any concerning symptoms, contact your healthcare provider immediately.

1. Drowsiness (Very Common): Feeling unusually sleepy or fatigued.
2. Dry Mouth (Common): A dry sensation in the mouth or throat.
3. Dizziness (Common): Feeling lightheaded or unsteady.
4. Blurred Vision (Less Common): Difficulty focusing or seeing clearly.
5. Headache (Less Common): Pain or discomfort in the head.
6. Confusion (Rare): Difficulty thinking clearly or remembering things.
7. Allergic Reaction (Rare): Rash, itching, swelling, or difficulty breathing. Seek immediate medical attention if this occurs.

Contraindications

A contraindication is a specific situation where a medication should not be used because it may be harmful. If you have any of the following conditions, avoid taking Dimenhydrinate. Always consult your healthcare provider before starting or stopping any medication.

1. Allergy to Dimenhydrinate or Diphenhydramine: If you have a known allergy to Dimenhydrinate or its active ingredient, Diphenhydramine, taking this medication could cause a serious allergic reaction, including rash, swelling, or difficulty breathing.
2. Severe Asthma or Chronic Obstructive Pulmonary Disease (COPD): Dimenhydrinate can thicken mucus and make breathing more difficult, worsening symptoms in people with severe asthma or COPD.
3. Glaucoma: Dimenhydrinate can increase pressure in the eyes, which may worsen glaucoma, a condition that damages the optic nerve and can lead to vision loss.
4. Enlarged Prostate (Benign Prostatic Hyperplasia): Dimenhydrinate can cause urinary retention, which may worsen symptoms in men with an enlarged prostate.
5. Seizure Disorders: Dimenhydrinate can lower the seizure threshold, increasing the likelihood of seizures in those with epilepsy or other seizure disorders.

Drug-to-Drug Interactions

Certain medications can interact with Dimenhydrinate, potentially increasing side effects or reducing the effectiveness of either drug. If you are taking any of the following medications, talk to your healthcare provider before using Dimenhydrinate:

1. Central Nervous System Depressants: These include medications like benzodiazepines (e.g., Valium [diazepam], Xanax [alprazolam]) and opioids (e.g., OxyContin [oxycodone], Vicodin [hydrocodone/acetaminophen]). Taking Dimenhydrinate with these drugs can increase drowsiness and sedation.
2. Anticholinergic Medications: Drugs like Benadryl (diphenhydramine) or Atrovent (ipratropium) can increase the risk of side effects such as dry mouth, constipation, and difficulty urinating when taken with Dimenhydrinate.
3. Monoamine Oxidase Inhibitors (MAOIs): Medications like Nardil (phenelzine) or Parnate (tranylcypromine) can increase the risk of serious side effects, including high blood pressure and seizures, when combined with Dimenhydrinate.
4. Alcohol: Drinking alcohol while taking Dimenhydrinate can increase drowsiness and impair your ability to think clearly or operate machinery.

Dimenhydrinate in Pregnancy

Is it safe to take Dimenhydrinate when pregnant?

Dimenhydrinate, commonly used to treat motion sickness, is classified as a Category B drug by the FDA. This means that animal studies have not shown harm to the fetus, but there are no well-controlled studies in pregnant women. It is generally considered safe for short-term use to manage nausea and vomiting during pregnancy, such as morning sickness. However, it’s essential to consult your healthcare provider before taking Dimenhydrinate while pregnant to ensure it’s appropriate for your specific situation.

Dimenhydrinate while Breastfeeding

Is it safe to take Dimenhydrinate while breastfeeding?

Dimenhydrinate can pass into breast milk in small amounts. Occasional use is unlikely to harm a breastfeeding infant, but frequent or high doses may cause drowsiness or irritability in the baby. If you are breastfeeding and considering Dimenhydrinate, it’s important to discuss the potential risks and benefits with your healthcare provider. They can help you determine the best course of action for both you and your baby.

Estimated Cost of Dimenhydrinate

The estimated cost of a 30-day supply of Dimenhydrinate (50 mg tablets, taken as needed) without insurance is approximately $10 to $15 when using a GoodRx coupon. Prices may vary depending on the pharmacy and location. Be sure to check GoodRx or other discount programs for the most up-to-date pricing information.

Possible Alternatives to Dimenhydrinate

If Dimenhydrinate is not suitable for you, or if you are exploring alternative treatments, there are other options available. Always discuss any changes to your treatment plan with your healthcare provider. You can also schedule a telemedicine appointment with one of our providers for personalized advice.

Motion Sickness

Alternatives to Dimenhydrinate for motion sickness include other antihistamines like Meclizine (brand name: Bonine) or non-medication options such as acupressure wristbands, ginger supplements, or behavioral techniques like focusing on the horizon while traveling.

Nausea and Vomiting

Depending on the cause, alternatives may include medications like Ondansetron (brand name: Zofran) or lifestyle adjustments, such as eating smaller, more frequent meals and avoiding strong odors or spicy foods.

Vertigo

Other medications, such as Meclizine, or vestibular rehabilitation exercises may help manage vertigo symptoms. Your healthcare provider can help determine the most appropriate treatment for you.

Seasickness

In addition to Dimenhydrinate, non-medication options like ginger, acupressure bands, or focusing on a stable object can help prevent seasickness. Prescription scopolamine patches are another effective option.

Dizziness

Treatment for dizziness depends on the underlying cause. Staying hydrated, avoiding sudden movements, and managing stress may help. In some cases, medications like Meclizine may be recommended.

Inner Ear Disorders

Depending on the specific condition, treatments may include physical therapy, medications like Betahistine, or surgery. Consult your healthcare provider for a personalized approach.

Migraine-Associated Nausea

Medications like Sumatriptan (brand name: Imitrex) for migraines, along with anti-nausea medications like Ondansetron, may be effective. Lifestyle changes, such as avoiding known migraine triggers, can also help.

Postoperative Nausea

Medications like Ondansetron or Scopolamine patches are commonly used to prevent nausea after surgery. Your surgeon or anesthesiologist can recommend the best option for you.

Travel Sickness

In addition to Dimenhydrinate, other options include Meclizine, scopolamine patches, or non-medication strategies like sitting in the front seat of a car or using acupressure bands.

Recent Updates on Dimenhydrinate Research

Recent studies have explored the effectiveness of Dimenhydrinate in treating nausea and vomiting in various settings, including postoperative care and chemotherapy-induced nausea. Some research has also examined the potential benefits of combining Dimenhydrinate with other anti-nausea medications to improve outcomes. Additionally, ongoing research is investigating the long-term safety of Dimenhydrinate use, particularly in pregnant women and children. While Dimenhydrinate remains a widely used and effective option for nausea and motion sickness, staying informed about new findings is important. Be sure to discuss any concerns or questions with your healthcare provider, and remember that you can consult one of our telemedicine providers for the latest information and personalized advice.

James Kingsley

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