Dihydrotestosterone (DHT): Uses, Dosage, and Side Effects

Summary of Key Points

Dihydrotestosterone (DHT) is a hormone essential for male development and overall health. It is commonly prescribed to treat conditions such as androgen deficiency, benign prostatic hyperplasia (BPH), and male pattern baldness. DHT is available in various forms and strengths, and it’s important to follow your healthcare provider’s instructions carefully. Always consult your doctor before making any changes to your dosage.

Names of Medication

US Brand Name: Androstanolone

Generic Name: Dihydrotestosterone (DHT)

The generic name refers to the active ingredient in the medication, while the brand name is assigned by the manufacturer. In this case, the generic name (Dihydrotestosterone) is provided in parentheses.

Pharmacologic Category

Androgens

Testosterone derivatives

Dosing Information for Dihydrotestosterone (DHT)

Dihydrotestosterone is used to manage a variety of conditions in adults. The dosage and frequency depend on the specific condition being treated. Always consult your healthcare provider before adjusting your dose. You can also schedule a telemedicine appointment with one of our providers for personalized guidance.

Common DHT Dosages by Condition

1. Androgen Deficiency: 25-50 mg applied topically once daily. The duration of treatment may vary based on your healthcare provider’s recommendations.
2. Benign Prostatic Hyperplasia (BPH): 50 mg applied topically once daily. The length of treatment depends on the severity of symptoms and response to therapy.
3. Male Pattern Baldness (Alopecia): 2.5-5 mg applied topically to the scalp once daily. Treatment may be long-term to maintain hair growth.
4. Hypogonadism: 25-50 mg applied topically once daily. Treatment is typically ongoing to sustain testosterone levels.
5. Prostate Cancer: Dosing is individualized based on the stage of cancer and other treatments. Consult your doctor for specific dosing instructions.
6. Erectile Dysfunction: 25-50 mg applied topically once daily. The duration of treatment depends on the underlying cause.
7. Infertility: 25-50 mg applied topically once daily. Treatment duration varies depending on fertility goals and response to therapy.
8. Osteoporosis: 25-50 mg applied topically once daily. Long-term treatment may be necessary to improve bone density.
9. Metabolic Syndrome: 25-50 mg applied topically once daily. The length of treatment depends on the response to therapy and improvements in metabolic markers.

Dosage Forms and Strengths of DHT

Dihydrotestosterone is available in the following forms:

1. Topical Gel: 25 mg, 50 mg
2. Topical Cream: 2.5 mg, 5 mg

Administration Instructions for DHT

Dihydrotestosterone is typically applied topically to the skin. Follow these steps to ensure proper use:

1. Wash your hands before and after applying the medication.
2. Apply the prescribed amount to clean, dry skin.
3. Avoid applying the medication to broken or irritated skin.
4. Allow the medication to fully absorb before dressing.
5. Do not wash the application area for at least 2 hours after applying.

Always follow your healthcare provider’s instructions. If you have any questions or concerns, schedule a telemedicine appointment with one of our providers for further guidance.

Adverse Reactions and Side Effects of DHT

As with any medication, Dihydrotestosterone can cause side effects. Some are more common, while others are rare but potentially serious. If you experience any side effects, contact your healthcare provider promptly.

Common Side Effects of DHT

1. Skin irritation: Redness, itching, or rash at the application site.
2. Increased hair growth: Hair growth may increase in areas where the medication is applied.
3. Acne: Some patients may develop acne due to increased oil production.

Less Common Side Effects of DHT

1. Headache: Some patients report mild to moderate headaches.
2. Fatigue: A feeling of unusual tiredness or weakness.

Serious Side Effects of DHT (Rare)

1. Liver issues: Symptoms may include yellowing of the skin or eyes, dark urine, or severe abdominal pain.
2. Heart problems: Chest pain, shortness of breath, or an irregular heartbeat may occur.
3. Prostate issues: Difficulty urinating or blood in the urine could indicate a problem.

Contraindications for Dihydrotestosterone (DHT)

A contraindication is a specific situation where a medication should not be used because it may cause harm. Before starting any new medication, it’s important to be aware of conditions or circumstances that make its use unsafe. Below are the contraindications for Dihydrotestosterone (DHT).

Conditions Where DHT is Contraindicated

1. Prostate Cancer: Dihydrotestosterone can stimulate the growth of prostate tissue, potentially worsening prostate cancer. If you have or are at risk for prostate cancer, this medication is not recommended.
2. Severe Liver Disease: DHT is processed by the liver. If you have severe liver disease, your body may not metabolize the medication properly, increasing the risk of side effects or toxicity.
3. Heart Disease: DHT can elevate the risk of cardiovascular problems, including heart attacks and strokes. Patients with a history of heart disease should avoid this medication.
4. Allergic Reactions: If you are allergic to Dihydrotestosterone or any of its components, taking this medication could lead to serious allergic reactions, including anaphylaxis.
5. Pregnancy and Breastfeeding: DHT is contraindicated in women who are pregnant or breastfeeding due to the potential risk of harm to the baby (see more details below).

Drug to Drug Interactions with Dihydrotestosterone (DHT)

Certain medications can interact with Dihydrotestosterone (DHT), potentially leading to harmful effects or reducing the effectiveness of either drug. It’s important to inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements. Below are some medications that may interact with DHT:

1. Warfarin (Coumadin): DHT may increase the risk of bleeding when taken with blood thinners like Warfarin.
2. Insulin: DHT can affect blood sugar levels, which may interfere with insulin or other diabetes medications.
3. Corticosteroids (Prednisone): Taking DHT with corticosteroids can raise the risk of fluid retention and heart complications.
4. Cyclosporine (Neoral, Sandimmune): DHT may elevate cyclosporine levels in your body, increasing the risk of kidney damage.
5. Finasteride (Propecia, Proscar): Finasteride is used to lower DHT levels, so taking both medications may reduce each other’s effectiveness.

Dihydrotestosterone (DHT) in Pregnancy

Is it Safe to Take Dihydrotestosterone During Pregnancy?

No, Dihydrotestosterone is not safe during pregnancy. DHT is a potent androgen hormone that can cause serious harm to a developing fetus, including abnormal genital development. It is classified as a Category X drug, meaning it should not be used during pregnancy under any circumstances. If you are pregnant or planning to become pregnant, consult your healthcare provider immediately to discuss alternative treatments.

Dihydrotestosterone (DHT) While Breastfeeding

Is it Safe to Take Dihydrotestosterone While Breastfeeding?

No, Dihydrotestosterone is not safe while breastfeeding. DHT can pass into breast milk and may harm a nursing infant. Women who are breastfeeding should avoid this medication. If you are breastfeeding and require treatment, consult your healthcare provider for safer alternatives.

Estimated Cost of Dihydrotestosterone Medication

The cost of a 30-day supply of Dihydrotestosterone without insurance can vary depending on the pharmacy and location. However, with a GoodRX coupon, the estimated cost typically ranges from $50 to $150 for a 30-day supply. Check with your local pharmacy for the most accurate pricing.

Possible Alternatives to Dihydrotestosterone (DHT)

If Dihydrotestosterone is not suitable for you, other treatment options are available for the conditions it is commonly prescribed for. Always discuss these alternatives with your healthcare provider before making any changes to your treatment plan. Our telemedicine providers are available to help you explore these options.

1. Androgen Deficiency: Alternatives include testosterone replacement therapy (TRT) in the form of gels, patches, or injections. Lifestyle changes, such as regular exercise and a balanced diet, may also help alleviate symptoms.
2. Benign Prostatic Hyperplasia (BPH): Medications like Tamsulosin (Flomax) or Finasteride (Proscar) are commonly used. Minimally invasive surgical options may also be considered.
3. Male Pattern Baldness: Finasteride (Propecia) and Minoxidil (Rogaine) are popular alternatives. Hair transplant surgery is another option for some patients.
4. Hypogonadism: Testosterone replacement therapy (TRT) is the primary alternative. Lifestyle changes, including weight loss and resistance training, may also improve symptoms.
5. Alopecia: Minoxidil (Rogaine) and corticosteroid injections are common alternatives. In some cases, light therapy or hair transplant surgery may be considered.
6. Prostate Cancer: Hormonal therapies like Leuprolide (Lupron) or surgical options may be recommended. Radiation therapy is another common treatment.
7. Erectile Dysfunction: PDE5 inhibitors like Sildenafil (Viagra) or Tadalafil (Cialis) are often prescribed. Lifestyle changes, such as quitting smoking and regular exercise, can also help.
8. Infertility: Clomiphene (Clomid) or hormone injections may be prescribed. Lifestyle changes, such as reducing stress and maintaining a healthy weight, can also improve fertility.
9. Osteoporosis: Bisphosphonates like Alendronate (Fosamax) or hormone replacement therapy (HRT) may be used. Weight-bearing exercises and calcium-rich diets can also help strengthen bones.
10. Metabolic Syndrome: Lifestyle changes, including a healthy diet, regular exercise, and weight loss, are the first line of treatment. Medications like Metformin (Glucophage) may also be prescribed to manage blood sugar levels.

Recent Updates on Dihydrotestosterone (DHT) Research

Recent studies continue to explore Dihydrotestosterone’s role in various conditions, particularly prostate health and male pattern baldness. A 2022 study found that DHT levels may be linked to prostate cancer progression, prompting researchers to investigate new ways to block DHT in patients with advanced prostate cancer. Additionally, ongoing research is examining the potential for topical DHT formulations to treat hair loss with fewer systemic side effects. However, more clinical trials are needed to confirm these findings. As always, consult your healthcare provider to discuss the latest research and how it may impact your treatment plan.

James Kingsley

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