Dihydrotachysterol: Uses, Dosage, and Side Effects Explained

Summary of Key Points

Dihydrotachysterol is a synthetic form of vitamin D, specifically a vitamin D analog, used to manage conditions associated with low calcium levels, such as hypoparathyroidism, rickets, and osteomalacia. It works by regulating calcium and phosphate levels in the body, which supports healthy bone development. It is essential to follow your healthcare provider’s instructions carefully, as the dihydrotachysterol dosage may vary depending on the condition being treated. Consult with one of our telemedicine providers to determine if this medication is appropriate for you.

Names of Medication

US Brand Name: DHT

Generic Name: Dihydrotachysterol

The generic name refers to the active ingredient in the medication. It is typically listed in parentheses next to the brand name.

Pharmacologic Category

Vitamin D Analog

Dihydrotachysterol belongs to a class of medications known as vitamin D analogs, which are used to treat conditions related to imbalances in calcium and phosphate levels.

Dihydrotachysterol Dosage

The dihydrotachysterol dosage depends on the specific condition being treated. Always adhere to your healthcare provider’s instructions and consult them before making any changes to your dose. You can also schedule a telemedicine appointment with one of our providers for personalized advice.

1. Rickets: Initial dose: 0.5 to 1 mg daily. Maintenance dose: 0.2 to 0.5 mg daily.
2. Osteomalacia: Initial dose: 0.5 to 1 mg daily. Maintenance dose: 0.2 to 0.5 mg daily.
3. Hypoparathyroidism: Initial dose: 0.5 to 2 mg daily. Maintenance dose: 0.2 to 1 mg daily.
4. Renal Osteodystrophy: Initial dose: 0.5 to 1 mg daily. Maintenance dose: 0.2 to 0.5 mg daily.
5. Osteoporosis: Initial dose: 0.5 to 1 mg daily. Maintenance dose: 0.2 to 0.5 mg daily.
6. Vitamin D Deficiency: Initial dose: 0.5 to 1 mg daily. Maintenance dose: 0.2 to 0.5 mg daily.
7. Paget’s Disease: Initial dose: 0.5 to 1 mg daily. Maintenance dose: 0.2 to 0.5 mg daily.
8. Hypophosphatemic Rickets: Initial dose: 0.5 to 1 mg daily. Maintenance dose: 0.2 to 0.5 mg daily.
9. Malabsorption Syndromes: Initial dose: 0.5 to 1 mg daily. Maintenance dose: 0.2 to 0.5 mg daily.
10. Osteogenesis Imperfecta: Initial dose: 0.5 to 1 mg daily. Maintenance dose: 0.2 to 0.5 mg daily.

Dosage Forms and Strengths

Dihydrotachysterol is available in the following forms:

1. Oral solution: 0.2 mg/mL
2. Oral tablet: 0.25 mg, 0.5 mg, 1 mg

Administration Instructions

Dihydrotachysterol is typically taken by mouth, either as a tablet or liquid solution. It can be taken with or without food. It is crucial to take this medication exactly as prescribed by your healthcare provider. Do not skip doses or take more than the recommended amount. If you miss a dose, take it as soon as you remember, but avoid doubling up on doses. Regular monitoring of calcium and phosphate levels may be necessary while using this medication.

Dihydrotachysterol Side Effects

As with any medication, dihydrotachysterol may cause side effects. While most are mild, some can be more serious. If you experience any of the following, contact your healthcare provider immediately or schedule a telemedicine appointment with us.

Common Side Effects

1. Nausea
2. Vomiting
3. Constipation
4. Loss of appetite

These side effects are generally mild and may improve as your body adjusts to the medication.

Less Common Side Effects

1. Increased thirst
2. Frequent urination
3. Dry mouth

These symptoms may indicate elevated calcium levels and should be reported to your doctor.

Serious Side Effects

1. Severe weakness
2. Confusion
3. Irregular heartbeat

These side effects are rare but serious and require immediate medical attention.

Contraindications

A contraindication is a specific condition or situation where a particular medication should not be used because it may cause harm. If you have any of the following conditions, dihydrotachysterol may not be safe for you. Always consult your healthcare provider before starting any new medication. If you’re unsure, you can schedule a telemedicine appointment with one of our providers.

1. Hypercalcemia (High Blood Calcium Levels): Dihydrotachysterol increases calcium absorption, so if you already have elevated calcium levels, taking this medication could worsen the condition and lead to complications such as kidney stones or heart problems.
2. Vitamin D Toxicity: Since dihydrotachysterol is a form of vitamin D, taking it when you already have excessive vitamin D in your body could result in dangerously high calcium levels, leading to symptoms like nausea, vomiting, and even kidney damage.
3. Hypersensitivity to Dihydrotachysterol: If you have had an allergic reaction to dihydrotachysterol in the past, you should not take it again, as it could trigger severe allergic reactions, including difficulty breathing or swelling.
4. Severe Renal Impairment: If you have significant kidney disease, your body may not be able to process dihydrotachysterol effectively, which could lead to dangerously high calcium levels or other complications.

Drug Interactions with Dihydrotachysterol

Dihydrotachysterol, a Vitamin D analog, can interact with other medications, potentially reducing its effectiveness or increasing the risk of side effects. It is important to inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter products, and supplements. Below are some common medications that may interact with Dihydrotachysterol:

1. Thiazide Diuretics (e.g., Hydrochlorothiazide): These medications can raise calcium levels in the blood, which may lead to hypercalcemia when combined with Dihydrotachysterol.
2. Calcium Supplements (e.g., Caltrate): Taking calcium supplements alongside Dihydrotachysterol may cause calcium levels to rise too high, increasing the risk of hypercalcemia.
3. Digoxin (e.g., Lanoxin): Elevated calcium levels from Dihydrotachysterol can heighten the risk of digoxin toxicity, which may result in serious heart complications.
4. Magnesium-containing Antacids (e.g., Maalox): These can increase magnesium levels, which may lead to complications when taken with Dihydrotachysterol.
5. Phenytoin (e.g., Dilantin): This anti-seizure medication can reduce the effectiveness of Dihydrotachysterol by speeding up its breakdown in the liver.

Dihydrotachysterol and Pregnancy

Is it safe to take Dihydrotachysterol during pregnancy? The safety of Dihydrotachysterol during pregnancy has not been well studied. It is classified as a pregnancy category C drug, meaning there is insufficient research to determine its safety. If you are pregnant or planning to become pregnant, it is essential to discuss the potential risks and benefits of Dihydrotachysterol with your healthcare provider. You can also schedule a telemedicine appointment with one of our providers to review your treatment options.

Dihydrotachysterol and Breastfeeding

Is it safe to take Dihydrotachysterol while breastfeeding? It is unclear whether Dihydrotachysterol passes into breast milk. Due to the potential for serious side effects in a nursing infant, it is important to consult your healthcare provider before using Dihydrotachysterol while breastfeeding. If you are breastfeeding and need to take this medication, a telemedicine consultation with one of our providers can help you weigh the risks and benefits.

Estimated Cost of Dihydrotachysterol Medication

The estimated cost of a 30-day supply of Dihydrotachysterol without insurance can vary. Using a GoodRx coupon, prices typically range from $30 to $50, depending on the pharmacy. It’s a good idea to compare prices at different pharmacies and use available discounts to help lower your out-of-pocket costs.

Possible Alternatives to Dihydrotachysterol

If Dihydrotachysterol is not the right option for you, alternative treatments and lifestyle changes may help manage your condition. Always discuss any changes to your treatment plan with your healthcare provider before making adjustments. You can also consult with one of our providers through telemedicine to explore these options.

1. Rickets: Alternatives may include vitamin D2 (ergocalciferol) or vitamin D3 (cholecalciferol) supplements, along with calcium and phosphorus supplements. Sunlight exposure can also help naturally boost vitamin D levels.
2. Osteomalacia: Treatment often involves vitamin D and calcium supplementation. In some cases, addressing underlying conditions like malabsorption or kidney disease may be necessary.
3. Hypoparathyroidism: Calcium and active forms of vitamin D (such as calcitriol) are commonly used. Parathyroid hormone replacement therapy may also be an option for some patients.
4. Renal Osteodystrophy: Management typically involves controlling phosphate levels, using phosphate binders, and supplementing with active vitamin D analogs.
5. Osteoporosis: Alternatives include bisphosphonates (e.g., alendronate), selective estrogen receptor modulators (SERMs), and lifestyle changes such as weight-bearing exercise and ensuring adequate calcium and vitamin D intake.
6. Vitamin D Deficiency: Vitamin D3 (cholecalciferol) or vitamin D2 (ergocalciferol) supplements are commonly used. Sunlight exposure and dietary changes can also help improve vitamin D levels.
7. Paget’s Disease: Bisphosphonates (e.g., alendronate, risedronate) are the first-line treatment. Calcitonin may also be used in some cases.
8. Hypophosphatemic Rickets: Treatment typically involves phosphate supplements and active forms of vitamin D, such as calcitriol.
9. Malabsorption Syndromes: Addressing the underlying cause of malabsorption is key. This may involve dietary changes, enzyme supplements, or other medications to improve nutrient absorption.
10. Osteogenesis Imperfecta: Bisphosphonates are often used to strengthen bones. Physical therapy and lifestyle changes to reduce fracture risk are also important.

Recent Updates on Dihydrotachysterol Research

Recent research on Dihydrotachysterol has focused on its role in managing calcium and phosphate balance in patients with hypoparathyroidism and other metabolic bone diseases. While Dihydrotachysterol has been used for many years, newer vitamin D analogs like calcitriol are being studied for their potentially improved safety profiles, especially in patients with kidney disease. Ongoing studies are also examining the long-term effects of vitamin D analogs on bone health and cardiovascular outcomes. If you are interested in learning more about the latest research or discussing alternative treatments, our telemedicine providers are available to guide you through your options.

James Kingsley

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