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Digoxin Medication: Uses, Dosage, and Safety Guidelines
Summary of Key Points
Digoxin is a prescription medication used to treat various heart conditions, including heart failure and abnormal heart rhythms. It helps the heart pump more effectively and controls heart rate. Digoxin is available in different forms, such as tablets or liquid. Always follow your healthcare provider’s instructions carefully when taking this medication. If you have any questions, feel free to consult one of our providers through telemedicine.
Names of Medication
US Brand Name: Lanoxin
Generic Name: Digoxin
The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. In this article, the generic name is listed in parentheses.
Pharmacologic Category
Digoxin belongs to the Cardiac Glycosides category.
Other medications in this category include digitoxin and ouabain.
Digoxin Dosage
Digoxin is used to treat several heart conditions. The dose and frequency depend on the condition being treated, as well as factors such as the patient’s age, weight, kidney function, and overall health. Always consult your doctor before making any changes to your dosage. Our telemedicine providers are available to assist with managing your medication.
Digoxin for Heart Failure
Initial dose: 0.125 mg to 0.25 mg once daily
Maintenance dose: 0.125 mg to 0.5 mg once daily, depending on response and kidney function
Digoxin is typically prescribed for long-term management of heart failure. Your doctor will monitor your progress and adjust the dose as necessary.
Digoxin for Atrial Fibrillation and Atrial Flutter
Initial dose: 0.25 mg once daily
Maintenance dose: 0.125 mg to 0.375 mg once daily, depending on response
Digoxin is used to control heart rate in patients with atrial fibrillation or atrial flutter. The duration of treatment will vary based on the individual’s condition.
Digoxin for Supraventricular Tachycardia
Initial dose: 0.25 mg once daily
Maintenance dose: 0.125 mg to 0.375 mg once daily
Digoxin helps manage rapid heartbeats caused by supraventricular tachycardia. Your doctor will determine the appropriate length of treatment.
Digoxin for Congestive Heart Failure
Initial dose: 0.125 mg to 0.25 mg once daily
Maintenance dose: 0.125 mg to 0.5 mg once daily
Digoxin improves heart function in patients with congestive heart failure. It is usually taken long-term under close medical supervision.
Digoxin for Cardiomyopathy
Initial dose: 0.125 mg to 0.25 mg once daily
Maintenance dose: 0.125 mg to 0.5 mg once daily
Digoxin may be prescribed to help the heart pump more effectively in patients with cardiomyopathy. The dose will be adjusted based on response and kidney function.
Digoxin for Myocardial Infarction (Heart Attack)
Initial dose: 0.125 mg to 0.25 mg once daily
Maintenance dose: 0.125 mg to 0.5 mg once daily
Digoxin may be used after a heart attack to support heart function. Your doctor will monitor your condition and adjust the dose as needed.
Digoxin for Ventricular Tachycardia
Initial dose: 0.25 mg once daily
Maintenance dose: 0.125 mg to 0.375 mg once daily
Digoxin helps control abnormal heart rhythms, such as ventricular tachycardia. The length of treatment will depend on your specific condition.
Digoxin for Arrhythmia
Initial dose: 0.25 mg once daily
Maintenance dose: 0.125 mg to 0.375 mg once daily
Digoxin is used to manage various types of arrhythmias. Your doctor will determine the appropriate dose and treatment duration.
Digoxin for Heart Block
Initial dose: 0.125 mg to 0.25 mg once daily
Maintenance dose: 0.125 mg to 0.5 mg once daily
In some cases, Digoxin may be used to manage heart block. Your doctor will monitor your heart function and adjust the dose as needed.
Dosage Forms and Strengths of Digoxin
Digoxin is available in the following forms and strengths:
- Tablets: 0.0625 mg, 0.125 mg, 0.25 mg
- Oral solution: 0.05 mg/mL
- Injection: 0.25 mg/mL
Administration Instructions for Digoxin
Take Digoxin exactly as prescribed by your healthcare provider. It is usually taken once daily, with or without food. If you miss a dose, take it as soon as you remember, unless it’s almost time for your next dose. Do not take two doses at once. Always consult your doctor before making any changes to your medication regimen. If you have concerns, our telemedicine providers are available to assist you.
Contraindications for Digoxin
A contraindication is a condition or factor that makes the use of a particular medication unsafe or inappropriate. If you have any of the following conditions, you should not take Digoxin, as it may cause harmful effects or worsen your condition.
Ventricular Fibrillation: Digoxin is contraindicated in patients with ventricular fibrillation, a type of irregular heartbeat. This is because Digoxin can worsen this condition by affecting the heart’s electrical signals.
Hypersensitivity to Digoxin: If you have had an allergic reaction to Digoxin or any of its components, you should not take this medication. Allergic reactions can range from mild rashes to severe, life-threatening conditions like anaphylaxis.
Advanced Heart Block: In patients with advanced heart block (a condition where the heart’s electrical signals are delayed or blocked), Digoxin can slow the heart rate further, potentially leading to dangerous complications.
Wolff-Parkinson-White Syndrome: Digoxin should not be used in patients with this syndrome, as it can increase the risk of rapid heart rates and other serious arrhythmias.
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Drug to Drug Interactions
Digoxin can interact with various medications, potentially increasing side effects or reducing its effectiveness. It’s important to inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements. Below are some common medications that may interact with Digoxin:
- Amiodarone (Pacerone): This antiarrhythmic can elevate Digoxin levels in the blood, increasing the risk of toxicity.
- Verapamil (Calan, Verelan): A calcium channel blocker used for high blood pressure and arrhythmias, Verapamil can raise Digoxin levels, leading to toxicity.
- Quinidine (Quinidex): This antiarrhythmic significantly increases Digoxin levels, heightening the risk of adverse effects.
- Spironolactone (Aldactone): A diuretic often prescribed for heart failure, Spironolactone can raise Digoxin levels, increasing the risk of toxicity.
- Diuretics (Furosemide, Lasix): Diuretics that cause potassium loss can heighten the risk of Digoxin toxicity, as low potassium levels make the heart more sensitive to Digoxin.
- Antacids (Maalox, Mylanta): These medications can reduce Digoxin absorption, making it less effective.
Digoxin in Pregnancy
Is it Safe to Take Digoxin When Pregnant?
Digoxin is classified as a Category C medication for pregnancy, meaning there is not enough well-controlled research in humans to confirm its safety. However, Digoxin has been used in pregnant women to treat heart conditions when the benefits outweigh the risks. If you are pregnant or planning to become pregnant, it’s essential to discuss with your healthcare provider whether Digoxin is the right option for you. Our telemedicine providers are available to help you make an informed decision.
Digoxin While Breastfeeding
Is it Safe to Take Digoxin While Breastfeeding?
Digoxin passes into breast milk in very small amounts. Most studies suggest it is generally safe to use while breastfeeding, as the levels in breast milk are unlikely to harm the baby. However, it’s important to consult your healthcare provider before continuing Digoxin while breastfeeding. If you have concerns, our telemedicine providers can guide you through the decision-making process.
Estimated Cost of Digoxin Medication
The estimated cost of a 30-day supply of Digoxin (0.125 mg) without insurance is approximately $10 to $15 when using a GoodRx coupon. Prices may vary depending on the pharmacy and location, so it’s a good idea to compare options to find the best deal.
Possible Alternatives to Digoxin
If Digoxin is not the right medication for you, or if you are seeking alternative treatments, several options are available depending on the condition being treated. Always consult your healthcare provider before making any changes to your treatment plan. Our telemedicine providers are available to discuss these alternatives with you.
Heart Failure
Alternatives include ACE inhibitors (such as Lisinopril), beta-blockers (like Metoprolol), and lifestyle changes such as reducing sodium intake and engaging in regular exercise.
Atrial Fibrillation
Beta-blockers (such as Atenolol) or calcium channel blockers (like Diltiazem) are often used. Blood thinners like Warfarin may also be prescribed to reduce the risk of stroke.
Atrial Flutter
Similar to atrial fibrillation, beta-blockers and calcium channel blockers may be used. In some cases, procedures like electrical cardioversion are considered.
Supraventricular Tachycardia
Medications such as beta-blockers or calcium channel blockers can help manage this condition. In some cases, catheter ablation may be recommended.
Congestive Heart Failure
Diuretics (such as Furosemide), ACE inhibitors, and lifestyle changes like quitting smoking and reducing alcohol intake are common alternatives.
Cardiomyopathy
Treatment options include beta-blockers, ACE inhibitors, and lifestyle changes such as weight management and reducing alcohol consumption.
Myocardial Infarction (Heart Attack)
After a heart attack, medications like beta-blockers, statins (such as Atorvastatin), and aspirin are often prescribed. Lifestyle changes, including a heart-healthy diet and regular physical activity, are also important.
Ventricular Tachycardia
Antiarrhythmic medications (such as Amiodarone) or procedures like catheter ablation may be considered.
Arrhythmia
Depending on the type of arrhythmia, medications like beta-blockers or calcium channel blockers may be used. In some cases, a pacemaker may be necessary.
Heart Block
Treatment often involves the use of a pacemaker to regulate the heart’s rhythm.
Recent Updates on Digoxin Research
Recent studies have focused on Digoxin’s role in treating heart failure and atrial fibrillation. Some research suggests that while Digoxin can be effective, it may increase mortality risk in certain populations, particularly at higher doses. Ongoing studies aim to optimize Digoxin dosing to maximize benefits while minimizing risks. Additionally, there is growing interest in understanding how Digoxin interacts with other heart medications, which could lead to more personalized treatment plans in the future.
If you have questions about whether Digoxin is right for you, or if you want to explore other treatment options, our telemedicine providers are available to assist you. Schedule an appointment today to discuss your heart health and medication needs.
