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Diclofenac: Uses, Dosage, Side Effects & Gel Application Guide
Summary of Key Points
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to alleviate pain and reduce inflammation in conditions such as arthritis, gout, and tendinitis. It is available in various forms, including oral tablets, topical gels, and injections. Diclofenac works by inhibiting substances in the body that cause inflammation. It is important to consult a healthcare provider before starting or adjusting your dose. You can schedule a telemedicine appointment with one of our providers today for personalized advice.
Names of Diclofenac Medications
Voltaren (Diclofenac)
Cambia (Diclofenac)
Zorvolex (Diclofenac)
Flector (Diclofenac)
Dyloject (Diclofenac)
Diclofenac is the generic name, while the brand names listed above are specific to the companies that manufacture the drug. The generic name refers to the active ingredient, while the brand name is the commercial name given by the manufacturer.
Pharmacologic Category: NSAIDs Similar to Diclofenac
Ibuprofen (Advil, Motrin)
Naproxen (Aleve)
Meloxicam (Mobic)
Indomethacin (Indocin)
Diclofenac Dosage and Administration
Diclofenac is prescribed for a variety of conditions, with the dosage and frequency tailored to the specific condition being treated. Always follow your healthcare provider’s instructions and consult them before making any changes to your dose. If you have any questions about your treatment plan, you can schedule a telemedicine appointment with us for further guidance.
Diclofenac Dosage for Osteoarthritis
Oral: 50 mg two to three times daily or 75 mg twice daily. Extended-release: 100 mg once daily.
Diclofenac Dosage for Rheumatoid Arthritis
Oral: 50 mg three to four times daily or 75 mg twice daily. Extended-release: 100 mg once daily.
Diclofenac Dosage for Ankylosing Spondylitis
Oral: 25 mg four times daily, with an additional 25 mg dose at bedtime if needed.
Diclofenac Dosage for Gout
Oral: 50 mg three times daily during acute attacks.
Diclofenac Dosage for Tendinitis and Bursitis
Oral: 50 mg two to three times daily.
Diclofenac Dosage for Pain and Inflammation
Oral: 50 mg every 8 hours as needed.
Diclofenac Dosage for Dysmenorrhea (Menstrual Pain)
Oral: 50 mg three times daily at the onset of pain.
Diclofenac Dosage for Postoperative Pain
Oral: 50 mg every 6 to 8 hours as needed.
Diclofenac Dosage Forms and Strengths
Oral Tablets: 25 mg, 50 mg, 75 mg
Extended-Release Tablets: 100 mg
Topical Gel: 1%, 3%
Topical Patch: 1.3%
Injection: 37.5 mg/mL
How to Take Diclofenac: Administration Instructions
Diclofenac should be taken with food or milk to help reduce the risk of stomach upset. For topical gel, apply it to clean, dry skin, avoiding any open wounds or contact with the eyes. Do not apply heat or bandages to the treated area. Injections are administered by a healthcare provider. Always follow the instructions provided by your healthcare provider or pharmacist to ensure safe and effective use.
Diclofenac Side Effects and Adverse Reactions
Like all medications, Diclofenac may cause side effects. Some are more common and tend to be mild, while others are rare but potentially serious. If you experience any side effects, contact your healthcare provider immediately. You can also schedule a telemedicine visit with one of our providers for further assistance.
Common Diclofenac Side Effects: Nausea, indigestion, diarrhea, and headache. These side effects are generally mild and often resolve on their own.
Less Common Diclofenac Side Effects: Dizziness, drowsiness, and skin rash. If these symptoms persist or worsen, consult your healthcare provider.
Serious Diclofenac Side Effects: Stomach ulcers, bleeding, and liver or kidney problems are rare but serious. Seek immediate medical attention if you notice black stools, severe stomach pain, or yellowing of the skin or eyes.
Diclofenac Contraindications
A contraindication is a specific condition in which a medication should not be used because it may cause harm. Diclofenac has several contraindications. If you have any of the following conditions, avoid taking Diclofenac and consult one of our telemedicine providers for alternative treatment options.
Allergy to NSAIDs: If you have had an allergic reaction to NSAIDs like ibuprofen or aspirin, Diclofenac may cause a similar reaction, such as hives, swelling, or difficulty breathing.
History of Asthma: Diclofenac can trigger asthma attacks in individuals with a history of asthma, particularly if they are sensitive to aspirin or other NSAIDs.
Active or History of Stomach Ulcers or Bleeding: Diclofenac can irritate the stomach lining and increase the risk of ulcers or gastrointestinal bleeding, especially in those with a history of these conditions.
Severe Heart, Kidney, or Liver Disease: Diclofenac can worsen heart failure, kidney function, or liver function in individuals with pre-existing conditions.
Recent Heart Surgery (CABG): Diclofenac is contraindicated in patients who have recently undergone coronary artery bypass graft (CABG) surgery, as it can increase the risk of heart attack or stroke.
Diclofenac Drug Interactions
Diclofenac can interact with other medications, potentially leading to harmful side effects or reduced effectiveness. It is important to inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements. Below are some common medications that may interact with Diclofenac:
Blood thinners (anticoagulants): Warfarin (Coumadin), Apixaban (Eliquis), Rivaroxaban (Xarelto) – Diclofenac can increase the risk of bleeding when taken with blood thinners.
Diuretics (water pills): Furosemide (Lasix), Hydrochlorothiazide (Microzide) – Diclofenac may reduce the effectiveness of diuretics, potentially leading to fluid retention or worsening kidney function.
ACE inhibitors or ARBs: Lisinopril (Zestril), Losartan (Cozaar) – These blood pressure medications may be less effective when taken with Diclofenac, and the combination may increase the risk of kidney problems.
Other NSAIDs: Ibuprofen (Advil), Naproxen (Aleve) – Taking multiple NSAIDs together increases the risk of stomach ulcers and bleeding.
SSRIs (antidepressants): Sertraline (Zoloft), Fluoxetine (Prozac) – These medications can increase the risk of bleeding when taken with Diclofenac.
Diclofenac in Pregnancy
Is it safe to take Diclofenac when pregnant?
Diclofenac is generally not recommended during pregnancy, especially in the third trimester. Taking Diclofenac in the later stages of pregnancy can affect the baby’s heart and kidneys, potentially leading to complications during delivery. If you are pregnant or planning to become pregnant, it’s important to discuss alternative pain management options with your healthcare provider. Our telemedicine providers are available to help you find safer alternatives to Diclofenac for pain relief.
Diclofenac While Breastfeeding
Is it safe to take Diclofenac while breastfeeding?
Diclofenac is typically not advised while breastfeeding, as small amounts of the drug can pass into breast milk. Although the risk to the baby is considered low, it’s essential to carefully weigh the benefits and risks with your healthcare provider. If you are breastfeeding and need pain relief, there may be safer alternatives available. Speak with one of our telemedicine providers to explore your pain management options while breastfeeding.
Estimated Cost of Diclofenac Medication
The estimated cost of a 30-day supply of generic Diclofenac without insurance ranges from $10 to $30, depending on the dosage and pharmacy. For example, the price of Diclofenac sodium 75 mg may vary. With a GoodRx coupon, you could lower the cost to around $10 to $15 for a 30-day supply. Be sure to check with your pharmacy for the most accurate pricing on Diclofenac sodium or other forms of the medication.
Possible Alternatives to Diclofenac
If Diclofenac is not suitable due to contraindications or side effects, several alternative treatments and lifestyle changes may help manage your condition. Always consult your healthcare provider before making any changes to your treatment plan. Our telemedicine providers are available to help you explore these options.
- Osteoarthritis: Acetaminophen (Tylenol) is often recommended as a first-line treatment. Physical therapy, weight management, and low-impact exercises like swimming or walking can also help reduce pain and improve joint function.
- Rheumatoid arthritis: Disease-modifying antirheumatic drugs (DMARDs) like Methotrexate (Trexall) or biologics like Adalimumab (Humira) may slow disease progression. Regular exercise and a diet rich in anti-inflammatory foods can also be beneficial.
- Ankylosing spondylitis: TNF inhibitors like Etanercept (Enbrel) or physical therapy may be recommended. Maintaining good posture and engaging in stretching exercises can help manage symptoms.
- Gout: Medications like Allopurinol (Zyloprim) or Colchicine (Colcrys) are often used to lower uric acid levels. Reducing purine-rich foods, such as red meat and alcohol, can help prevent flare-ups.
- Tendinitis: Rest, ice, and physical therapy are commonly recommended. In some cases, corticosteroid injections may be used to reduce inflammation.
- Bursitis: Rest, ice, and over-the-counter pain relievers like acetaminophen may help. Physical therapy and stretching exercises can also be beneficial.
- Pain and Inflammation: Acetaminophen or other NSAIDs like ibuprofen may be used as alternatives. Heat or cold therapy, along with gentle exercise, can help manage pain and inflammation.
- Dysmenorrhea (Menstrual Pain): Ibuprofen or naproxen may be used as alternatives. Lifestyle changes, such as regular exercise, a healthy diet, and stress management techniques, can also help reduce menstrual pain.
- Postoperative Pain: Acetaminophen or prescription opioids may be used for short-term pain relief after surgery. Follow your surgeon’s recommendations for pain management and recovery.
Recent Updates on Diclofenac Research
Recent studies have highlighted the cardiovascular risks associated with Diclofenac use. A large-scale study published in 2018 found that Diclofenac may increase the risk of heart attack and stroke, particularly in patients with pre-existing heart conditions. As a result, healthcare providers are more cautious when prescribing Diclofenac, especially for long-term use. Ongoing research is also exploring new formulations of Diclofenac, such as Diclofenac gel and patches, which may reduce gastrointestinal side effects.
If you have concerns about the risks associated with Diclofenac, including potential cardiovascular or gastrointestinal issues, our telemedicine providers can help you evaluate whether this medication is right for you or suggest safer alternatives. Whether you’re considering Diclofenac versus ibuprofen for pain relief or exploring other NSAIDs, we can guide you through your options.
