Dexlansoprazole: Uses, Dosage, and Side Effects Overview

Summary of Key Points

Dexlansoprazole is a medication used to manage conditions caused by excessive stomach acid, such as gastroesophageal reflux disease (GERD) and erosive esophagitis. It works by decreasing the amount of acid produced in the stomach. Typically, Dexlansoprazole is taken once daily and is available in various strengths. Always consult your healthcare provider before starting or adjusting your dose. You can also schedule a telemedicine appointment with one of our providers to discuss your treatment options.

Names of Medication

US Brand Name: Dexilant

Generic Name: Dexlansoprazole

The generic name refers to the active ingredient in the medication, while the brand name is assigned by the manufacturer. The generic name is listed in parentheses.

Pharmacologic Category

Dexlansoprazole belongs to a class of medications known as Proton Pump Inhibitors (PPIs).

Other medications in this category include:

1. Omeprazole (Prilosec)
2. Esomeprazole (Nexium)
3. Lansoprazole (Prevacid)
4. Pantoprazole (Protonix)

Dexlansoprazole Dosage

Dexlansoprazole is used to treat various conditions related to excess stomach acid. The dosage and duration of treatment depend on the specific condition being treated. Always follow your doctor’s instructions and consult them before making any changes to your dose. You can also schedule a telemedicine visit with one of our providers to discuss your dosage.

Gastroesophageal Reflux Disease (GERD)

Dosage: 30 mg once daily for 4 weeks.

Erosive Esophagitis

Dosage: 60 mg once daily for up to 8 weeks. After healing, 30 mg once daily may be used to prevent recurrence.

Zollinger-Ellison Syndrome

Dosage: 60 mg twice daily. The length of treatment varies based on the patient’s response and condition.

Peptic Ulcer Disease

Dosage: 30 mg once daily for 4 to 8 weeks.

Non-Erosive Gastroesophageal Reflux Disease (NERD)

Dosage: 30 mg once daily for 4 weeks.

Barrett’s Esophagus

Dosage: 30 mg once daily. The duration of treatment depends on the patient’s condition and response.

Dyspepsia (Indigestion)

Dosage: 30 mg once daily for 4 weeks.

Gastritis

Dosage: 30 mg once daily for 4 to 8 weeks.

Esophageal Ulcers

Dosage: 60 mg once daily for 8 weeks.

Stomach Ulcers

Dosage: 30 mg once daily for 4 to 8 weeks.

Dosage Forms and Strengths

Dexlansoprazole is available in delayed-release capsules in the following strengths:

1. 30 mg
2. 60 mg

Administration Instructions

Take Dexlansoprazole exactly as prescribed by your healthcare provider. It can be taken with or without food. Swallow the capsule whole; do not crush or chew it. If you have difficulty swallowing, you may open the capsule and sprinkle the contents on a tablespoon of applesauce. Be sure to consume the mixture immediately without chewing. Always follow your doctor’s instructions carefully, and if you have any questions, consult one of our telemedicine providers.

Dexlansoprazole Side Effects

Like all medications, Dexlansoprazole may cause side effects. Most are mild, but some can be more serious. If you experience severe symptoms, contact your healthcare provider immediately.

Common Side Effects (affecting more than 1 in 10 people)

1. Diarrhea: Loose or watery stools.
2. Nausea: Feeling sick to your stomach.
3. Stomach pain: Discomfort or cramping in the abdomen.

Less Common Side Effects (affecting 1 in 100 to 1 in 1,000 people)

1. Headache: Mild to moderate pain in the head.
2. Flatulence: Excess gas in the digestive system.
3. Dizziness: Feeling lightheaded or unsteady.

Rare Side Effects (affecting fewer than 1 in 1,000 people)

1. Severe allergic reactions: Rash, itching, swelling, or difficulty breathing.
2. Bone fractures: Long-term use of PPIs may increase the risk of fractures.
3. Low magnesium levels: Symptoms may include muscle cramps, seizures, or an irregular heartbeat.

Contraindications

A contraindication is a specific condition where a medication should not be used because it may cause harm. If you have any of the following conditions, do not take Dexlansoprazole unless your healthcare provider specifically recommends it. These contraindications are important to discuss with your provider, and you can always consult with one of our telemedicine providers for personalized advice.

1. Allergic reactions to Dexlansoprazole or other proton pump inhibitors (PPIs): If you have had an allergic reaction to Dexlansoprazole or other PPIs (such as omeprazole or lansoprazole), taking this medication could lead to serious allergic reactions, including rash, swelling, or difficulty breathing.
2. Severe liver disease: Dexlansoprazole is processed by the liver. If you have severe liver disease, your body may not process the medication properly, leading to increased side effects or toxicity.
3. Low magnesium levels (hypomagnesemia): Long-term use of Dexlansoprazole can lower magnesium levels in your blood, which can cause serious health issues like muscle spasms, irregular heartbeats, or seizures. If you already have low magnesium, this medication may not be safe for you.

Drug to Drug Interactions

Dexlansoprazole can interact with other medications, potentially affecting their effectiveness or increasing the risk of side effects. Inform your healthcare provider about all the medications you are taking, including over-the-counter drugs, vitamins, and supplements. The following are some medications that may interact with Dexlansoprazole:

1. Clopidogrel (Plavix): Dexlansoprazole may reduce the effectiveness of clopidogrel, a blood thinner used to prevent heart attacks and strokes.
2. Warfarin (Coumadin, Jantoven): Dexlansoprazole may increase the risk of bleeding when taken with warfarin, a blood thinner.
3. Digoxin (Lanoxin): Dexlansoprazole can increase digoxin levels in your blood, which may lead to toxicity.
4. Ketoconazole (Nizoral): Dexlansoprazole can reduce the absorption of ketoconazole, an antifungal medication, making it less effective.
5. Atazanavir (Reyataz): Dexlansoprazole may reduce the effectiveness of atazanavir, a medication used to treat HIV.

Dexlansoprazole in Pregnancy

Is it safe to take Dexlansoprazole during pregnancy?

There is limited information regarding the safety of Dexlansoprazole in pregnancy. While animal studies have not shown harm to the fetus, there are no well-controlled studies in pregnant women. Dexlansoprazole should only be used during pregnancy if the potential benefits outweigh the risks. If you are pregnant or planning to become pregnant, it is important to consult your healthcare provider before starting this medication. You can also schedule a telemedicine appointment with one of our providers to discuss your options.

Dexlansoprazole While Breastfeeding

Is it safe to take Dexlansoprazole while breastfeeding?

It is not known whether Dexlansoprazole passes into breast milk. Due to the potential for serious side effects in a nursing infant, it is essential to consult your healthcare provider before using this medication while breastfeeding. If you are breastfeeding and need treatment for acid reflux or other conditions, our telemedicine providers can help you explore safer alternatives.

Estimated Cost of Dexlansoprazole

The cost of a 30-day supply of Dexlansoprazole without insurance can vary. With a GoodRx coupon, the estimated price ranges from $150 to $250, depending on the pharmacy and dosage. Be sure to check with your local pharmacy or use a discount program to find the best available price.

Possible Alternatives to Dexlansoprazole

If Dexlansoprazole is not suitable for you, or if you’re exploring other treatment options, there are alternative medications and lifestyle changes that may help manage your condition. Always discuss these alternatives with your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine consultation with one of our providers to explore these options.

Alternative Treatments for GERD

Gastroesophageal reflux disease (GERD): Alternatives include other proton pump inhibitors (PPIs) like omeprazole (Prilosec) or H2 blockers such as ranitidine (Zantac). Lifestyle modifications, such as avoiding trigger foods, eating smaller meals, and elevating the head of your bed, may also provide relief.

Alternative Treatments for Erosive Esophagitis

Erosive esophagitis: Other PPIs, such as esomeprazole (Nexium) or pantoprazole (Protonix), may be effective. Additionally, avoiding acidic foods and quitting smoking can help improve symptoms.

Alternative Treatments for Zollinger-Ellison Syndrome

Zollinger-Ellison syndrome: High doses of PPIs, such as lansoprazole (Prevacid) or rabeprazole (Aciphex), may be required. In some cases, surgery or other treatments may be necessary, depending on the severity of the condition.

Alternative Treatments for Peptic Ulcer Disease

Peptic ulcer disease: Alternatives include H2 blockers like famotidine (Pepcid) or antibiotics if the ulcer is caused by an H. pylori infection. Reducing NSAID use and avoiding alcohol can also help manage symptoms.

Alternative Treatments for Non-Erosive GERD (NERD)

Non-erosive gastroesophageal reflux disease (NERD): H2 blockers or lifestyle changes, such as weight loss, dietary adjustments, and stress management, may be effective in managing symptoms.

Alternative Treatments for Barrett’s Esophagus

Barrett’s esophagus: Long-term use of PPIs, such as omeprazole (Prilosec), may be recommended. Regular monitoring through endoscopy is also important to track any changes in the esophagus.

Alternative Treatments for Dyspepsia

Dyspepsia: Antacids like calcium carbonate (Tums) or H2 blockers may be used to relieve symptoms. Avoiding spicy foods, caffeine, and alcohol can also help reduce discomfort.

Alternative Treatments for Gastritis

Gastritis: H2 blockers or PPIs may be prescribed. Avoiding NSAIDs, alcohol, and spicy foods can help manage symptoms and prevent flare-ups.

Alternative Treatments for Esophageal Ulcers

Esophageal ulcers: PPIs, such as pantoprazole (Protonix) or esomeprazole (Nexium), may be used to promote healing. Avoiding smoking and alcohol can help prevent further damage to the esophagus.

Alternative Treatments for Stomach Ulcers

Stomach ulcers: PPIs or H2 blockers may be used to reduce stomach acid and promote healing. If an H. pylori infection is present, antibiotics are necessary. Reducing NSAID use and avoiding alcohol can also aid in recovery.

Recent Updates on Dexlansoprazole Research

Recent studies have examined the long-term safety of proton pump inhibitors (PPIs) like Dexlansoprazole. Some research suggests that prolonged use of PPIs may be linked to an increased risk of kidney disease, bone fractures, and vitamin B12 deficiency. However, these risks are generally considered low, and the benefits of using Dexlansoprazole for conditions like GERD or erosive esophagitis often outweigh the potential risks. Ongoing studies are exploring ways to minimize these risks, such as using the lowest effective dose for the shortest duration necessary.

If you have concerns about long-term PPI use, consult your healthcare provider. Our telemedicine providers are available to help you weigh the benefits and risks of Dexlansoprazole and explore other treatment options if needed.

James Kingsley

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