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Deslorelin Implant: Uses, Dosage, and Side Effects Explained
Summary or Key Points
Deslorelin is a medication used to manage hormone-related conditions such as prostate cancer, endometriosis, and precocious puberty. It works by regulating hormone levels in the body. In veterinary medicine, Deslorelin is also used to treat conditions like hypersexuality in dogs. Always consult your healthcare provider before starting or adjusting your dosage. You can schedule a telemedicine appointment with one of our providers for personalized care.
Names of Medication
US Brand Name: Suprelorin
Generic Name: Deslorelin
The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. In this article, the generic name is listed in parentheses.
Pharmacologic Category
Gonadotropin-Releasing Hormone (GnRH) Agonist
Dosing for Deslorelin Implant
Deslorelin is prescribed for a variety of conditions, with the dosage tailored to the specific condition being treated. Always follow your healthcare provider’s instructions and consult them before making any changes to your dosage. You can also connect with one of our telemedicine providers for guidance.
Deslorelin for Prostate Cancer Treatment
Dose: 4.7 mg implant
Frequency: Every 6 months
Length of Treatment: Long-term, as directed by your doctor
Deslorelin for Endometriosis
Dose: 4.7 mg implant
Frequency: Every 6 months
Length of Treatment: Typically 6-12 months, depending on response
Deslorelin for Precocious Puberty
Dose: 4.7 mg implant
Frequency: Every 12 months
Length of Treatment: Until puberty is appropriately delayed
Deslorelin for Uterine Fibroids
Dose: 4.7 mg implant
Frequency: Every 6 months
Length of Treatment: As directed by your doctor
Deslorelin for Hormone-Responsive Tumors
Dose: 4.7 mg implant
Frequency: Every 6 months
Length of Treatment: Long-term, based on tumor response
Deslorelin for Dogs: Hypersexuality (Veterinary Use)
Dose: 4.7 mg implant
Frequency: Every 6-12 months
Length of Treatment: As needed, based on behavioral response
Deslorelin for Dogs: Cushing’s Disease (Veterinary Use)
Dose: 4.7 mg implant
Frequency: Every 6-12 months
Length of Treatment: As directed by your veterinarian
Deslorelin for Ovarian Cancer
Dose: 4.7 mg implant
Frequency: Every 6 months
Length of Treatment: Long-term, depending on response
Deslorelin for Testicular Cancer
Dose: 4.7 mg implant
Frequency: Every 6 months
Length of Treatment: Long-term, as directed by your doctor
Deslorelin for Anovulation (Failure to Ovulate)
Dose: 4.7 mg implant
Frequency: Every 6 months
Length of Treatment: Based on response to treatment
Dosage Forms and Strengths of Deslorelin
Implant: 4.7 mg
Administration Instructions for Deslorelin Implant
Deslorelin is administered as a subcutaneous implant, placed just under the skin. The implant is typically inserted by a healthcare provider in a medical setting and releases the medication gradually over time. Follow your doctor’s instructions carefully and attend all follow-up appointments to monitor your response. If you have any questions or concerns, consult one of our telemedicine providers.
Contraindications for Deslorelin Use
A contraindication is a specific condition where a medication should not be used due to potential harm. Below are the contraindications for Deslorelin:
- Pregnancy: Deslorelin is contraindicated during pregnancy as it can harm the developing fetus by altering hormone levels.
- Breastfeeding: Deslorelin is not recommended while breastfeeding, as it may affect milk production and could pass into breast milk, posing risks to the infant.
- Allergy to Deslorelin or similar medications: If you have a known allergy to Deslorelin or other GnRH agonists, taking this medication could cause a severe allergic reaction, including symptoms like rash, swelling, or difficulty breathing.
- Undiagnosed abnormal vaginal bleeding: Deslorelin should not be used until the cause of unexplained vaginal bleeding is identified, as it may worsen certain conditions.
Drug to Drug Interactions with Deslorelin
Deslorelin may interact with other medications, potentially reducing its effectiveness or increasing the risk of side effects. Inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements. Below are some medications that may interact with Deslorelin:
- Warfarin (Coumadin): Deslorelin may increase the risk of bleeding when taken with blood thinners like Warfarin.
- Insulin or oral diabetes medications: Deslorelin can affect blood sugar levels, so adjustments to diabetes medications may be necessary.
- Hormonal therapies: Medications like estrogen or testosterone supplements may interfere with how Deslorelin works, as it alters hormone levels.
- Anticonvulsants: Medications such as phenytoin (Dilantin) or carbamazepine (Tegretol) may reduce Deslorelin’s effectiveness by speeding up its metabolism in the liver.
Deslorelin in Pregnancy
Is it safe to take Deslorelin when pregnant?
No, Deslorelin is not considered safe during pregnancy. It can interfere with hormone levels that are essential for maintaining a healthy pregnancy. If you are pregnant or planning to become pregnant, it is important to avoid using Deslorelin. Be sure to inform your healthcare provider if you are pregnant or suspect you might be before starting this medication.
Deslorelin while Breastfeeding
Is it safe to take Deslorelin while breastfeeding?
No, Deslorelin is not recommended for use while breastfeeding. The medication may pass into breast milk and could potentially affect the nursing infant. Additionally, it may reduce milk production. If you are breastfeeding, consult your healthcare provider to discuss alternative treatment options.
Estimated Cost of Deslorelin Medication
The cost of a 30-day supply of Deslorelin without insurance can vary depending on the pharmacy and location. With a GoodRx coupon, prices typically range from $150 to $300. Since prices may fluctuate, it’s a good idea to check with your pharmacy for the most up-to-date pricing.
Possible Alternatives to Deslorelin
Depending on the condition being treated, there are several alternative treatments or lifestyle changes that may be considered. Always consult your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to explore these alternatives.
Prostate Cancer
Alternatives include other hormone therapies such as leuprolide (Lupron) or goserelin (Zoladex). In some cases, radiation therapy or surgery may also be viable options.
Endometriosis
Non-hormonal treatments like NSAIDs (ibuprofen or naproxen) can help manage pain, while hormonal treatments such as oral contraceptives may also be effective. In more severe cases, surgery may be considered.
Precocious Puberty
Other GnRH agonists, such as leuprolide (Lupron) or triptorelin (Trelstar), may be used to delay the onset of early puberty.
Uterine Fibroids
Alternatives include medications like ulipristal acetate (Esmya) or surgical options such as myomectomy or hysterectomy, depending on the size and symptoms of the fibroids.
Hormone-Responsive Tumors
Other hormone therapies, such as tamoxifen or aromatase inhibitors, may be considered depending on the specific type of tumor.
Hypersexuality in Dogs
Behavioral therapy and medications like medroxyprogesterone acetate (Depo-Provera) may serve as alternatives.
Cushing’s Disease
Other treatment options include medications like trilostane (Vetoryl) or surgery to remove the adrenal gland tumor responsible for the disease.
Ovarian Cancer
Treatment options may include chemotherapy, surgery, or targeted therapies such as bevacizumab (Avastin), depending on the stage of the cancer.
Testicular Cancer
Surgery (orchiectomy) is often the first line of treatment, followed by chemotherapy or radiation therapy, depending on the stage of the cancer.
Anovulation
Lifestyle changes, such as weight management and regular exercise, may help restore ovulation. Medications like clomiphene (Clomid) or letrozole (Femara) may also be used to induce ovulation.
Recent Updates on Deslorelin Research
Recent studies have been exploring Deslorelin’s potential in treating various hormone-related conditions, including its role in managing hormone-responsive tumors and reproductive disorders. Ongoing research is also examining its long-term safety and effectiveness in conditions such as prostate cancer and endometriosis. Additionally, new formulations of Deslorelin are being developed to enhance patient convenience and minimize side effects. Stay informed about the latest research, and discuss any new treatment options with your healthcare provider. You can also schedule a telemedicine appointment with one of our providers to learn more about the latest advancements in Deslorelin therapy.
