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Delamanid Medication: Uses, Dosage, and Side Effects Explained
Summary or Key Points
Delamanid is a prescription medication used to treat various forms of tuberculosis, including drug-resistant strains. It works by inhibiting the growth of the bacteria responsible for tuberculosis. This medication is typically prescribed alongside other drugs for a more effective treatment plan. Always consult your healthcare provider before starting or adjusting your dose. Our telemedicine services offer quick and convenient access to care.
Names of Medication
US Brand Name: Deltyba
Generic Name: Delamanid
The generic name refers to the active ingredient in the medication and is listed in parentheses next to the brand name.
Pharmacologic Category
Antituberculosis Agents
Nitroimidazole Derivatives
Delamanid Dosage
Delamanid is used to treat several forms of tuberculosis. The dosage may vary depending on the specific condition being treated. Always follow your healthcare provider’s instructions and consult them before making any changes to your dose. You can also schedule a telemedicine appointment with one of our providers for personalized advice.
Multidrug-Resistant Tuberculosis (MDR-TB)
Adult Dose: 100 mg orally twice daily
Frequency: Every 12 hours
Length of Treatment: 24 weeks, in combination with other antituberculosis medications
Tuberculosis (TB)
Adult Dose: 100 mg orally twice daily
Frequency: Every 12 hours
Length of Treatment: 24 weeks, in combination with other antituberculosis medications
Pulmonary Tuberculosis
Adult Dose: 100 mg orally twice daily
Frequency: Every 12 hours
Length of Treatment: 24 weeks, in combination with other antituberculosis medications
Extrapulmonary Tuberculosis
Adult Dose: 100 mg orally twice daily
Frequency: Every 12 hours
Length of Treatment: 24 weeks, in combination with other antituberculosis medications
Latent Tuberculosis Infection
Adult Dose: 100 mg orally twice daily
Frequency: Every 12 hours
Length of Treatment: 24 weeks, in combination with other antituberculosis medications
Drug-Resistant Tuberculosis
Adult Dose: 100 mg orally twice daily
Frequency: Every 12 hours
Length of Treatment: 24 weeks, in combination with other antituberculosis medications
Chronic Tuberculosis
Adult Dose: 100 mg orally twice daily
Frequency: Every 12 hours
Length of Treatment: 24 weeks, in combination with other antituberculosis medications
Severe Tuberculosis
Adult Dose: 100 mg orally twice daily
Frequency: Every 12 hours
Length of Treatment: 24 weeks, in combination with other antituberculosis medications
Mycobacterial Infections
Adult Dose: 100 mg orally twice daily
Frequency: Every 12 hours
Length of Treatment: 24 weeks, in combination with other antituberculosis medications
Dosage Forms and Strengths
Tablet: 50 mg
Administration Instructions for Delamanid
Delamanid is taken orally, usually twice a day, with or without food. It is important to take this medication at the same time each day to maintain consistent levels in your bloodstream. Do not crush or chew the tablets. If you miss a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed dose. Do not double up on doses.
Delamanid Side Effects and Adverse Reactions
Like all medications, Delamanid can cause side effects. While not everyone will experience these, it is important to be aware of the potential risks. Contact your healthcare provider if you experience any side effects, and seek immediate medical attention for severe reactions. You can also consult one of our providers through telemedicine for advice on managing side effects.
Common Side Effects (Occur in more than 10% of patients)
Nausea: Feeling sick to your stomach.
Vomiting: Throwing up.
Headache: Pain or discomfort in the head.
Less Common Side Effects (Occur in 1-10% of patients)
Insomnia: Difficulty falling asleep or staying asleep.
Decreased appetite: Reduced desire to eat.
Dizziness: Feeling lightheaded or unsteady.
Rare Side Effects (Occur in less than 1% of patients)
QT Prolongation: A rare heart rhythm condition that can cause serious complications.
Allergic Reactions: Rash, itching, swelling, or difficulty breathing.
Contraindications for Delamanid
A contraindication is a specific situation or condition where a particular treatment or medication should not be used because it may be harmful to the patient. It’s important to know if you have any contraindications before starting a new medication like Delamanid.
Delamanid is contraindicated in the following situations:
Severe liver disease: Delamanid is processed by the liver. If you have severe liver disease, your body may not be able to break down the medication properly, leading to harmful side effects.
Severe kidney disease: If you have severe kidney disease, your body may not be able to eliminate Delamanid effectively, which could result in toxicity.
Prolonged QT interval: This heart condition affects the electrical activity of the heart. Delamanid can prolong the QT interval further, increasing the risk of life-threatening heart rhythm problems.
Allergy to Delamanid or its ingredients: If you have a known allergy to Delamanid or any of its components, taking the medication could trigger a severe allergic reaction.
Drug to Drug Interactions
Delamanid can interact with other medications, which may increase the risk of side effects or reduce the effectiveness of either Delamanid or the other drugs. Be sure to inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements.
Medications that may interact with Delamanid include:
Rifampin (Rifadin): This common antibiotic for tuberculosis can reduce the effectiveness of Delamanid by speeding up its breakdown in the liver.
Ketoconazole (Nizoral): This antifungal medication can increase Delamanid levels in your blood, raising the risk of side effects.
Amiodarone (Pacerone): This heart medication can further prolong the QT interval, increasing the risk of dangerous heart rhythm problems when taken with Delamanid.
Fluoroquinolones (e.g., Ciprofloxacin, Levofloxacin): These antibiotics can also prolong the QT interval, which may increase the risk of heart issues when combined with Delamanid.
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Delamanid in Pregnancy
Is it safe to take Delamanid when pregnant?
Currently, there is limited information on the safety of Delamanid during pregnancy. While animal studies suggest potential risks, there is not enough evidence to determine its effects on human pregnancies. If you are pregnant or planning to become pregnant, it is crucial to discuss the potential risks and benefits of taking Delamanid with your healthcare provider. In some cases, the benefits of treating multidrug-resistant tuberculosis (MDR-TB) may outweigh the possible risks to the fetus. Always consult your provider before starting or stopping any medication during pregnancy.
Delamanid while Breastfeeding
Is it safe to take Delamanid while breastfeeding?
There is insufficient data on whether Delamanid passes into breast milk or its effects on a breastfeeding infant. Due to the potential for serious side effects, including heart rhythm disturbances, it is generally recommended that women avoid breastfeeding while taking Delamanid. If you are breastfeeding or planning to breastfeed, discuss your options with your healthcare provider. They may suggest alternative treatments or recommend temporarily stopping breastfeeding while on the medication.
Estimated Cost of Delamanid Medication
The estimated cost of a 30-day supply of Delamanid without insurance can vary. With a GoodRX coupon, the price typically ranges from $2,000 to $5,000, depending on the pharmacy. Be sure to check with your pharmacy for the most accurate pricing and explore financial assistance options if needed.
Possible Alternatives to Delamanid
If Delamanid is not suitable for you or if you are exploring alternative treatments, other options are available. Always consult your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to discuss these alternatives.
Multidrug-Resistant Tuberculosis (MDR-TB)
Alternatives include bedaquiline (Sirturo), linezolid (Zyvox), and clofazimine. In some cases, a combination of antibiotics may be used to treat MDR-TB. Lifestyle changes, such as improving nutrition and avoiding smoking, can also support your treatment.
Tuberculosis
Standard first-line treatments include a combination of isoniazid, rifampin, pyrazinamide, and ethambutol. These medications are typically taken for 6 to 9 months. It is important to complete the full course of antibiotics to prevent the development of resistance.
Pulmonary Tuberculosis
Similar to standard TB treatment, a combination of antibiotics is used. In some cases, surgery may be considered if there is significant lung damage.
Extrapulmonary Tuberculosis
Treatment generally involves the same antibiotics used for pulmonary TB, but the duration may be longer, depending on the site of infection.
Latent Tuberculosis Infection
Treatment options include isoniazid or rifampin for several months to prevent the infection from becoming active. Regular follow-ups with your healthcare provider are essential to monitor your condition.
Drug-Resistant Tuberculosis
In addition to Delamanid, other options include bedaquiline and linezolid. Treatment may be more complex and require a longer duration of therapy.
Chronic Tuberculosis
This form of TB may require a longer course of antibiotics or alternative medications if resistance has developed. Supportive care, including proper nutrition and rest, is also important.
Severe Tuberculosis
Hospitalization and a combination of antibiotics are often necessary. In some cases, surgery may be required to remove damaged lung tissue.
Mycobacterial Infections
Depending on the type of mycobacteria, treatment may involve a combination of antibiotics such as clarithromycin, ethambutol, and rifabutin. It is essential to follow your healthcare provider’s recommendations closely.
Recent Updates on Delamanid Research
Recent studies have focused on the effectiveness of Delamanid in combination with other medications for treating multidrug-resistant tuberculosis (MDR-TB). A 2022 study found that Delamanid, when used alongside bedaquiline and linezolid, showed promising results in shortening the treatment duration for MDR-TB. Additionally, ongoing research is exploring the use of Delamanid in pediatric populations and its potential for treating other drug-resistant mycobacterial infections. However, more data is needed to confirm its safety and efficacy in these groups.
As research continues, it is important to stay informed about new developments. If you have questions about Delamanid or your treatment plan, consider scheduling a telemedicine appointment with one of our providers to discuss the latest research and how it may impact your care.
