Front Desk: 469-391-0070
Dabigatran Medication: Uses, Dosage, and Side Effects Explained
Summary of Key Points
Dabigatran is a prescription medication used to prevent and treat blood clots. It is commonly prescribed for conditions such as atrial fibrillation, deep vein thrombosis (DVT), and pulmonary embolism (PE). By thinning the blood, Dabigatran helps reduce the risk of stroke and other serious complications. It is essential to take this medication exactly as prescribed and consult your healthcare provider before making any changes to your dosage or treatment plan.
Names of Medication
US Brand Name: Pradaxa
Generic Name: Dabigatran
The generic name refers to the active ingredient in the medication, which is listed in parentheses next to the brand name.
Pharmacologic Category
Category: Direct Thrombin Inhibitors
Dabigatran Dosage
Dabigatran is prescribed for various conditions. Always follow your healthcare provider’s instructions and never adjust your dose without consulting them. If you need to speak with a healthcare provider, you can schedule a telemedicine appointment with us.
Dabigatran for Atrial Fibrillation (Non-valvular)
Standard Dose: 150 mg taken orally twice daily.
For patients with severe kidney impairment, the dose may be reduced to 75 mg twice daily.
Dabigatran for Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE)
Standard Dose: 150 mg taken orally twice daily after 5 to 10 days of initial treatment with a parenteral anticoagulant (such as heparin).
Stroke and Systemic Embolism Prevention in Atrial Fibrillation
Standard Dose: 150 mg taken orally twice daily.
Venous Thromboembolism (VTE) Prevention after Surgery
Initial Dose: 110 mg taken orally on the first day after surgery, followed by 220 mg once daily thereafter.
Dabigatran for Coronary Artery Disease (CAD) and Peripheral Artery Disease (PAD)
Standard Dose: 150 mg taken orally twice daily in combination with aspirin.
Always consult your healthcare provider before making any changes to your medication. If you need immediate assistance, you can schedule a telemedicine consultation with one of our providers.
Dosage Forms and Strengths
Available Forms: Capsules: 75 mg, 110 mg, 150 mg
Administration Instructions for Dabigatran
Take Dabigatran exactly as prescribed by your healthcare provider. Swallow the capsules whole with a full glass of water. Do not crush, chew, or open the capsules, as this can affect how the medication is absorbed. Dabigatran can be taken with or without food. If you miss a dose, take it as soon as possible unless it is almost time for your next dose. Do not take two doses at once to make up for a missed dose. Always store the medication in its original container and keep it tightly closed to protect it from moisture.
Dabigatran Side Effects and Adverse Reactions
Like all medications, Dabigatran can cause side effects. Some are more common, while others are rare but serious. If you experience any side effects, contact your healthcare provider immediately. You can also schedule a telemedicine appointment with us to discuss your symptoms.
Common Dabigatran Side Effects
Indigestion: Some patients may experience stomach discomfort or heartburn.
Bleeding: Dabigatran increases the risk of bleeding, which may include nosebleeds, bruising, or bleeding gums.
Serious Dabigatran Side Effects
Severe Bleeding: Unusual bleeding, such as blood in the urine or stools, coughing up blood, or prolonged bleeding from cuts.
Allergic Reactions: Symptoms may include rash, itching, swelling, or difficulty breathing.
Stroke Symptoms: Sudden numbness, weakness, confusion, or trouble speaking.
If you experience any of these serious side effects, seek medical attention immediately. You can also contact our telemedicine team for urgent advice.
Contraindications for Dabigatran
A contraindication is a specific situation where a drug should not be used because it may cause harm. For Dabigatran, several conditions make taking this medication unsafe.
Active Bleeding: Dabigatran is a blood thinner, so taking it while you have active bleeding can worsen or prolong the bleeding.
Severe Kidney Impairment: Dabigatran is processed by the kidneys. If your kidneys are not functioning well, the drug can accumulate in your body, increasing the risk of bleeding.
Mechanical Heart Valves: Dabigatran is not recommended for people with mechanical heart valves, as it may increase the risk of blood clots and bleeding.
Allergy to Dabigatran or its Ingredients: If you have had an allergic reaction to Dabigatran in the past, you should not take it again, as it could cause a severe allergic reaction.
Liver Disease: Severe liver disease can affect how your body processes Dabigatran, increasing the risk of side effects such as bleeding.
Drug-to-Drug Interactions with Dabigatran
Some medications can interact with Dabigatran, either increasing the risk of side effects or reducing its effectiveness. It’s important to inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements. Below are some common medications that may interact with Dabigatran:
- Rifampin (Rifadin): This antibiotic can reduce the effectiveness of Dabigatran.
- Ketoconazole (Nizoral): This antifungal medication can increase Dabigatran levels in your blood, raising the risk of bleeding.
- Verapamil (Calan, Verelan): This blood pressure medication can increase Dabigatran levels, heightening the risk of bleeding.
- Amiodarone (Pacerone): This heart rhythm medication can increase the risk of bleeding when taken with Dabigatran.
- Clopidogrel (Plavix): This blood thinner, when combined with Dabigatran, can increase the risk of bleeding.
- Nonsteroidal Anti-inflammatory Drugs (NSAIDs) like ibuprofen (Advil, Motrin) or naproxen (Aleve): These medications can increase the risk of bleeding when taken with Dabigatran.
Dabigatran in Pregnancy
Is it safe to take Dabigatran when pregnant?
Dabigatran is generally not recommended during pregnancy due to the heightened risk of bleeding complications for both the mother and baby. If you are pregnant or planning to become pregnant, it’s essential to consult your healthcare provider. They may suggest safer alternatives during this time. If you are currently taking Dabigatran and discover you are pregnant, contact one of our telemedicine providers immediately to discuss your options and ensure the best care for you and your baby.
Dabigatran While Breastfeeding
Is it safe to take Dabigatran while breastfeeding?
There is limited information on whether Dabigatran passes into breast milk. Due to the potential risk to a nursing infant, it is generally advised to avoid Dabigatran while breastfeeding. If you require anticoagulation therapy during this period, your healthcare provider may recommend alternative medications that are safer for both you and your baby. Consult one of our telemedicine providers to determine the most appropriate treatment plan for your situation.
Estimated Cost of Dabigatran Medication
The estimated cost of a 30-day supply of Dabigatran (Pradaxa) without insurance typically ranges from $400 to $500, depending on the pharmacy. However, with a GoodRx coupon, the price may be reduced to around $350. Prices can vary, so it’s a good idea to check with your local pharmacy or use a discount service like GoodRx to find the most affordable option.
Possible Alternatives to Dabigatran
If Dabigatran is not suitable for you, there are other treatment options available for the conditions it treats. Below are some alternatives for specific conditions. Always consult your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to explore these alternatives in more detail.
Atrial Fibrillation (AFib)
Alternatives include other blood thinners such as warfarin (Coumadin) or apixaban (Eliquis). Additionally, lifestyle changes—like managing high blood pressure, reducing alcohol consumption, and maintaining a healthy weight—can help manage AFib and reduce associated risks.
Deep Vein Thrombosis (DVT)
Alternatives include rivaroxaban (Xarelto) or enoxaparin (Lovenox). Regular physical activity and wearing compression stockings may also help prevent DVT by improving circulation and reducing clot formation.
Pulmonary Embolism (PE)
Treatment alternatives include anticoagulants such as apixaban (Eliquis) or warfarin (Coumadin). Staying active and avoiding prolonged periods of immobility are important steps in reducing the risk of PE.
Myocardial Infarction (Heart Attack)
Alternatives may include medications like aspirin, clopidogrel (Plavix), or beta-blockers. In addition to medication, lifestyle changes such as quitting smoking, adopting a heart-healthy diet, and engaging in regular exercise are crucial for recovery and prevention of future heart attacks.
Stroke
Alternatives include aspirin, clopidogrel (Plavix), or other anticoagulants like apixaban (Eliquis). Managing high blood pressure and cholesterol, along with regular physical activity, can significantly reduce the risk of stroke.
Thromboembolism
Alternatives include warfarin (Coumadin) or rivaroxaban (Xarelto). Staying physically active and maintaining a healthy weight are also important strategies to lower the risk of thromboembolism.
Venous Thromboembolism (VTE)
Alternatives include enoxaparin (Lovenox) or rivaroxaban (Xarelto). Regular exercise and avoiding extended periods of sitting or inactivity can help prevent VTE.
Non-Valvular Atrial Fibrillation
Alternatives include apixaban (Eliquis) or warfarin (Coumadin). Lifestyle modifications, such as reducing stress and managing high blood pressure, can also play a key role in managing this condition.
Post-Operative Venous Thromboembolism
Alternatives include enoxaparin (Lovenox) or rivaroxaban (Xarelto). Early mobilization after surgery and the use of compression stockings can help prevent post-operative VTE by promoting healthy blood flow.
Coronary Artery Disease (CAD)
Alternatives include aspirin, statins, or beta-blockers. In addition to medication, lifestyle changes such as eating a heart-healthy diet, exercising regularly, and quitting smoking are essential for managing CAD and improving overall heart health.
Recent Updates on Dabigatran Research
Recent studies have continued to evaluate the safety and effectiveness of Dabigatran compared to other anticoagulants. A 2022 study found that Dabigatran is as effective as warfarin in preventing strokes in patients with atrial fibrillation, with a lower risk of major bleeding. Ongoing research is also exploring Dabigatran’s use in patients with chronic kidney disease and its potential role in preventing recurrent venous thromboembolism in cancer patients. As new research emerges, it’s important to stay informed and discuss any updates with your healthcare provider. You can easily schedule a telemedicine appointment with one of our providers to review the latest findings and how they may impact your treatment plan.
