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Collagenase Clostridium Histolyticum: Uses, Dosing & Side Effects
Summary of Key Points
Collagenase clostridium histolyticum is an injectable medication used to treat fibrous tissue disorders such as Dupuytren’s contracture and Peyronie’s disease. It works by breaking down collagen, a protein that contributes to tissue thickening or hardening. This injection is administered by a healthcare provider, typically when other treatments have not been effective. Always consult your doctor before starting or adjusting any treatment.
Names of Medication
US Brand Name: Xiaflex
The generic name of a medication refers to its active ingredient. In this case, the generic name is Collagenase clostridium histolyticum.
Pharmacologic Category
Collagenase clostridium histolyticum belongs to the enzyme class of medications. These drugs work by breaking down specific proteins in the body. Other medications in this category include:
- Hyaluronidase
- Streptokinase
Dosing Information for Collagenase Clostridium Histolyticum
Collagenase clostridium histolyticum is used to treat various conditions in adults. The dosage depends on the condition being treated. Always consult your healthcare provider before adjusting your dose or starting a new treatment. If you need to speak to a doctor, you can schedule a telemedicine appointment with one of our providers.
Dupuytren’s Contracture Treatment
Dose: 0.58 mg injected into the affected cord in the hand.
Frequency: One injection per cord, followed by hand manipulation 24-72 hours after the injection.
Length of Treatment: Up to 3 injections per cord, with at least 4 weeks between injections.
Peyronie’s Disease Therapy
Dose: 0.58 mg injected into the plaque in the penis.
Frequency: Two injections per treatment cycle, with the second injection 1-3 days after the first.
Length of Treatment: Up to 4 treatment cycles, spaced approximately 6 weeks apart.
Plantar Fibromatosis
Dose: 0.58 mg injected into the fibrous tissue in the foot.
Frequency: One injection per affected area, with follow-up manipulation if necessary.
Length of Treatment: Varies based on the severity of the condition and response to treatment.
Other Fibrous Tissue Disorders
For conditions such as Dupuytren’s disease, finger contracture, hand contracture, fibrous tissue disorders, connective tissue disorders, and localized scleroderma, dosing is typically similar to that for Dupuytren’s contracture. Your healthcare provider will determine the exact dosage and treatment plan based on your specific condition.
Dosage Forms and Strengths
Injection: 0.58 mg per vial
Administration Instructions for Collagenase Injection
Collagenase clostridium histolyticum is administered as an injection by a healthcare provider. Do not attempt to self-administer this medication. The injection is given directly into the affected area, such as the hand or penis, depending on the condition being treated. After the injection, your doctor may perform tissue manipulation to enhance the effectiveness of the treatment. Follow all instructions from your healthcare provider and attend any scheduled follow-up appointments.
Adverse Reactions and Side Effects of Collagenase Clostridium Histolyticum
Like all medications, Collagenase clostridium histolyticum can cause side effects. Some are common and mild, while others are rare but more serious. If you experience any side effects, contact your healthcare provider immediately. If needed, you can schedule a telemedicine appointment with one of our providers.
Common Side Effects
These side effects are typically mild and tend to resolve on their own:
- Swelling at the injection site
- Bruising
- Pain in the treated area
- Itching or redness
Less Common Side Effects
These side effects may require medical attention:
- Allergic reactions (rash, itching, difficulty breathing)
- Severe pain or swelling
- Difficulty using the affected hand or penis
Rare but Serious Side Effects
Seek immediate medical attention if you experience any of the following:
- Rupture of the tendon in the hand
- Penile fracture (tear in the tissue of the penis)
- Severe allergic reaction (anaphylaxis)
Contraindications for Collagenase Clostridium Histolyticum
A contraindication is a specific situation where a medication should not be used because it may cause harm. Before starting any new medication, discuss your medical history with your healthcare provider to avoid potential risks.
Here are the contraindications for Collagenase clostridium histolyticum:
Allergy to Collagenase Clostridium Histolyticum
If you are allergic to this medication or any of its components, you should not take it. An allergic reaction could cause symptoms such as rash, itching, swelling, or difficulty breathing.
Bleeding Disorders
Patients with bleeding disorders, such as hemophilia, should avoid this medication. Collagenase clostridium histolyticum can increase the risk of bleeding or bruising, especially in those with clotting issues.
Infection at the Treatment Site
If you have an active infection at the injection site, this medication is contraindicated. Using it in an infected area could worsen the infection or delay healing.
Pregnancy
The safety of Collagenase clostridium histolyticum during pregnancy has not been fully established. It should be avoided unless the potential benefits outweigh the risks. Always consult your healthcare provider if you are pregnant or planning to become pregnant.
Drug Interactions with Collagenase Clostridium Histolyticum
Collagenase clostridium histolyticum may interact with other medications, which could either reduce its effectiveness or increase the likelihood of side effects. It’s important to inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs and supplements.
Below are some medications that may interact with Collagenase clostridium histolyticum:
- Blood thinners (anticoagulants): Medications such as warfarin (Coumadin), heparin, or enoxaparin (Lovenox) can heighten the risk of bleeding when used alongside Collagenase clostridium histolyticum.
- Nonsteroidal anti-inflammatory drugs (NSAIDs): Drugs like ibuprofen (Advil, Motrin) and aspirin may increase the risk of bruising or bleeding when combined with this medication.
- Platelet inhibitors: Medications such as clopidogrel (Plavix) can interfere with blood clotting, raising the risk of complications when used with Collagenase clostridium histolyticum.
Collagenase Clostridium Histolyticum and Pregnancy
Is it safe to take Collagenase clostridium histolyticum during pregnancy?
The safety of Collagenase clostridium histolyticum during pregnancy has not been thoroughly studied. Due to potential risks to the developing baby, it is generally recommended to avoid this medication during pregnancy unless absolutely necessary. If you are pregnant or planning to become pregnant, consult your healthcare provider to carefully weigh the risks and benefits. Our telemedicine providers are available to help you make an informed decision.
Collagenase Clostridium Histolyticum While Breastfeeding
Is it safe to take Collagenase clostridium histolyticum while breastfeeding?
There is limited information on whether Collagenase clostridium histolyticum passes into breast milk or affects a nursing infant. Given the lack of conclusive research, caution is advised when using this medication while breastfeeding. Discuss your specific situation with your healthcare provider to determine the best course of action for both you and your baby. Our telemedicine team is available to provide personalized advice tailored to your needs.
Estimated Cost of Collagenase Clostridium Histolyticum
The estimated cost of a 30-day supply of Collagenase clostridium histolyticum without insurance can vary depending on the pharmacy and location. With a GoodRX coupon, the cost typically ranges from $3,500 to $4,000 per treatment. Since this medication is often administered in a clinical setting, the total cost may also include additional procedure fees. For the most accurate pricing information, check with your healthcare provider or pharmacy.
Possible Alternatives to Collagenase Clostridium Histolyticum
If Collagenase clostridium histolyticum is not suitable for you, there are alternative treatments and lifestyle changes that may help manage your condition. Always consult your healthcare provider before making any changes to your treatment plan. Our telemedicine providers are available to help you explore your options.
- Dupuytren’s contracture treatment: Alternatives include physical therapy, splinting, or surgical interventions such as fasciotomy or fasciectomy. Steroid injections may also help reduce inflammation and slow disease progression.
- Peyronie’s disease therapy: Treatment options include oral medications like pentoxifylline, intralesional injections of verapamil, or surgical correction. Lifestyle changes, such as avoiding trauma to the penis, may also help manage symptoms.
- Plantar fibromatosis: Conservative treatments like orthotics, physical therapy, or corticosteroid injections may alleviate symptoms. In severe cases, surgery may be necessary to remove fibrous tissue.
- Fibromatosis: Depending on the location and severity, treatment may include observation, radiation therapy, or surgery. NSAIDs may help manage pain and inflammation.
- Dupuytren’s disease: Similar to Dupuytren’s contracture, treatment options include physical therapy, steroid injections, or surgery to release affected tissue.
- Contracture of the fingers: Physical therapy, splinting, or surgical release may be recommended depending on the severity of the contracture.
- Hand contracture: Treatment options include physical therapy, splinting, or surgery to release contracted tissue.
- Fibrous tissue disorders: Depending on the specific disorder, treatment may include medications to reduce inflammation, physical therapy, or surgery to remove or release fibrous tissue.
- Connective tissue disorders: Treatment depends on the underlying condition and may include medications to manage symptoms, physical therapy, or lifestyle changes to reduce strain on affected tissues.
- Localized scleroderma: Treatment options include topical or systemic corticosteroids, immunosuppressive medications, or phototherapy. Physical therapy may help maintain mobility in affected areas.
Recent Updates on Collagenase Clostridium Histolyticum Research
Recent studies are investigating the expanded use of Collagenase clostridium histolyticum for other fibrous tissue disorders beyond Dupuytren’s contracture and Peyronie’s disease. Ongoing clinical trials are exploring its effectiveness in treating conditions such as adhesive capsulitis (frozen shoulder) and cellulite. Preliminary results suggest that the medication may help break down fibrous tissue in these conditions, but further research is needed to confirm its safety and efficacy.
Additionally, researchers are studying the long-term outcomes of patients treated with Collagenase clostridium histolyticum to better understand its potential benefits and risks over time. As new findings emerge, it is important to stay informed and discuss any updates with your healthcare provider. Our telemedicine providers are available to answer any questions you may have about the latest research and how it may impact your treatment plan.
