Carbenoxolone Treatment: Uses, Dosage, Benefits & Side Effects Guide

Summary of Key Points

Carbenoxolone is a medication used to treat various gastrointestinal and mucosal conditions, including peptic ulcers, gastritis, and esophagitis. It works by reducing inflammation and promoting healing in the affected areas. Additionally, Carbenoxolone is used to manage oral mucositis and canker sores. Always consult your healthcare provider before starting or adjusting your dose. Our telemedicine providers are available to assist with any questions or concerns you may have.

Names of Medication

US Brand Name: No specific brand name available in the US

Generic Name: Carbenoxolone

The generic name refers to the active ingredient in the medication. It is the scientific name used for the drug, while brand names are assigned by pharmaceutical companies.

Pharmacologic Category

Anti-inflammatory agents

Gastroprotective agents

Carbenoxolone Dosage

The dosage of Carbenoxolone varies depending on the condition being treated. Always consult your doctor before making any changes to your medication regimen. If you need assistance, our telemedicine providers are here to help.

1. Peptic Ulcer Disease: 100 mg to 300 mg orally, 2-3 times daily for 4-6 weeks.
2. Gastritis: 100 mg to 300 mg orally, 2-3 times daily for 4-6 weeks.
3. Esophagitis: 100 mg to 300 mg orally, 2-3 times daily for 4-6 weeks.
4. Inflammatory Bowel Disease: 100 mg to 300 mg orally, 2-3 times daily for 4-6 weeks.
5. Oral Mucositis: 100 mg to 300 mg orally, 2-3 times daily for 2-4 weeks.
6. Canker Sores (Aphthous Ulcers): 100 mg to 300 mg orally, 2-3 times daily for 2-4 weeks.
7. Erosive Esophagitis: 100 mg to 300 mg orally, 2-3 times daily for 4-6 weeks.
8. Stomatitis: 100 mg to 300 mg orally, 2-3 times daily for 2-4 weeks.
9. Dermatitis: Topical application of Carbenoxolone cream 2-3 times daily for 2-4 weeks.
10. Radiation-Induced Mucositis: 100 mg to 300 mg orally, 2-3 times daily for 2-4 weeks.

Dosage Forms and Strengths

Carbenoxolone is available in the following forms:

1. Oral Tablets: 50 mg, 100 mg, 300 mg
2. Topical Cream: 2%

Administration Instructions for Carbenoxolone

Carbenoxolone can be taken with or without food, depending on your doctor’s instructions. For oral use, swallow the tablet whole with water. For topical use, apply a thin layer of cream to the affected area and gently rub it in. Always follow your healthcare provider’s guidance. If you have any questions about how to take Carbenoxolone, our telemedicine providers are available to assist you.

Carbenoxolone Side Effects and Adverse Reactions

Like any medication, Carbenoxolone may cause side effects. It’s important to be aware of these potential reactions and contact your healthcare provider if you experience any concerning symptoms.

Common Side Effects (1-10%)

1. Fluid retention: Swelling in the legs or ankles due to water retention.
2. Increased blood pressure: A rise in blood pressure, which may require monitoring.
3. Electrolyte imbalances: Changes in potassium or sodium levels, which can cause muscle weakness or cramps.

Less Common Side Effects (<1%)

1. Headache: Mild to moderate headaches may occur.
2. Fatigue: Feeling unusually tired or weak.
3. Skin rash: Irritation or rash on the skin, especially with topical use.

Rare but Serious Side Effects

1. Severe allergic reactions: Swelling of the face, lips, or throat, difficulty breathing, or hives. Seek immediate medical attention if this occurs.
2. Severe electrolyte imbalances: Significant changes in potassium or sodium levels, which can lead to heart rhythm problems or muscle paralysis. Contact your doctor immediately if you experience these symptoms.

Contraindications for Carbenoxolone

A contraindication is a specific situation or condition where a medication should not be used because it may be harmful. Carbenoxolone has several contraindications where its use is not recommended, as it may worsen the patient’s health or interact negatively with existing conditions.

1. Severe kidney disease: Carbenoxolone can cause fluid retention and electrolyte imbalances, worsening kidney function in patients with pre-existing kidney disease.
2. Severe liver disease: Carbenoxolone may lead to fluid retention and increased pressure in the veins, which can be dangerous for individuals with liver disease, particularly those with cirrhosis.
3. Heart failure or other heart conditions: Carbenoxolone can cause fluid retention and increase blood pressure, which may exacerbate heart failure or other cardiovascular conditions.
4. Low potassium levels (hypokalemia): Carbenoxolone can further lower potassium levels, leading to dangerous heart rhythms and muscle weakness.
5. Uncontrolled high blood pressure (hypertension): Carbenoxolone may raise blood pressure, making it unsafe for individuals with poorly controlled hypertension.

Carbenoxolone Drug Interactions

Carbenoxolone can interact with other medications, potentially leading to harmful effects or reducing the effectiveness of either drug. If you are taking any of the following medications, inform your healthcare provider before starting Carbenoxolone:

1. Diuretics (water pills): such as Furosemide (Lasix) or Hydrochlorothiazide (Microzide). These medications can lower potassium levels, and when combined with Carbenoxolone, the risk of dangerously low potassium levels increases.
2. Corticosteroids: such as Prednisone (Deltasone) or Dexamethasone (Decadron). These drugs can also reduce potassium levels, compounding the effect of Carbenoxolone.
3. Digoxin (Lanoxin): Carbenoxolone can increase the risk of digoxin toxicity by lowering potassium levels, which can lead to dangerous heart rhythms.
4. Antihypertensive medications: such as Lisinopril (Zestril) or Amlodipine (Norvasc). Carbenoxolone may reduce the effectiveness of these medications by raising blood pressure.

Carbenoxolone in Pregnancy

Is it safe to take Carbenoxolone when pregnant?

Carbenoxolone is generally not recommended during pregnancy. There is limited data on its safety for pregnant women, and it may affect fluid balance and blood pressure—both of which are crucial to monitor during pregnancy. If you are pregnant or planning to become pregnant, it’s important to discuss alternative treatments with your healthcare provider. Our telemedicine providers are available to help you find the safest options for both you and your baby.

Carbenoxolone while Breastfeeding

Is it safe to take Carbenoxolone while breastfeeding?

Carbenoxolone is not recommended for use while breastfeeding. There is insufficient information on whether Carbenoxolone passes into breast milk, and its potential effects on a nursing infant are unknown. If you are breastfeeding, consult your healthcare provider to explore safer alternatives. You can also schedule a telemedicine appointment with one of our providers to discuss your options.

Estimated Cost of Carbenoxolone Medication

The estimated cost of a 30-day supply of Carbenoxolone without insurance, using a GoodRx coupon, typically ranges from $50 to $70. Prices may vary depending on the pharmacy and your location. Be sure to check with your local pharmacy or use a GoodRx coupon to find the best available price.

Possible Alternatives to Carbenoxolone Treatment

If Carbenoxolone is not suitable for you, there are other treatment options and lifestyle changes that may help manage your condition. Always consult your healthcare provider before making any changes to your treatment plan. Our telemedicine providers are available to guide you through these alternatives.

Peptic Ulcer Disease

Proton pump inhibitors (PPIs), such as Omeprazole (Prilosec), or H2 blockers, like Ranitidine (Zantac), can help reduce stomach acid and promote healing. Lifestyle changes, such as avoiding NSAIDs, managing stress, and quitting smoking, can also be beneficial.

Gastritis

Antacids, PPIs, or H2 blockers may be prescribed to reduce stomach acid. Additionally, avoiding alcohol, spicy foods, and smoking can help alleviate symptoms.

Esophagitis

PPIs or H2 blockers are commonly used to treat esophagitis. Dietary changes, such as avoiding acidic or spicy foods, can also help manage symptoms.

Inflammatory Bowel Disease (IBD)

Medications like Mesalamine (Asacol) or biologics such as Infliximab (Remicade) may be prescribed to manage IBD. Dietary adjustments and stress management can also play a role in controlling symptoms.

Oral Mucositis

Topical treatments, such as mouthwashes containing lidocaine or corticosteroids, may provide relief. Maintaining good oral hygiene and avoiding irritants like alcohol and tobacco are also recommended.

Canker Sores

Over-the-counter topical treatments, such as Benzocaine (Orabase), or prescription medications like corticosteroids may help reduce discomfort. Avoiding acidic or spicy foods can also minimize irritation.

Erosive Esophagitis

PPIs are often the first line of treatment for erosive esophagitis. Lifestyle changes, such as weight loss, eating smaller meals, and avoiding lying down after eating, can also be effective in managing symptoms.

Stomatitis

Topical treatments, such as corticosteroid gels, may be used to manage stomatitis. Good oral hygiene and avoiding known irritants can help prevent flare-ups.

Dermatitis

Topical corticosteroids or antihistamines may be prescribed to manage dermatitis. Avoiding known irritants and using moisturizers regularly can help control symptoms.

Radiation-Induced Mucositis

Pain management with topical anesthetics and maintaining good oral hygiene are essential for managing radiation-induced mucositis. In some cases, low-level laser therapy may also be recommended.

Recent Updates on Carbenoxolone Research

Recent research on Carbenoxolone has explored its potential neuroprotective effects, particularly in conditions like Alzheimer’s disease and epilepsy. Some studies suggest that Carbenoxolone may help reduce brain inflammation and improve cognitive function, though further research is needed to confirm these findings. Additionally, ongoing studies are investigating its role in treating certain cancers, as it may inhibit specific enzymes that contribute to tumor growth. However, these studies are still in the early stages, and Carbenoxolone is not currently approved for these uses. If you’re interested in learning more, discuss these developments with your healthcare provider. You can also schedule a telemedicine appointment with one of our providers to explore whether Carbenoxolone is right for you.

James Kingsley

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