Front Desk: 469-391-0070
Calfactant: Surfactant Therapy for Newborn Lung Conditions
Summary of Key Points
Calfactant is a medication used to treat various lung conditions, particularly in newborns and premature infants. It works by replacing or supplementing surfactant, a substance that helps keep the lungs properly inflated. Calfactant is primarily used for conditions such as Respiratory Distress Syndrome (RDS) and other breathing difficulties. Always consult your healthcare provider before starting or adjusting any medication. You can also schedule a telemedicine appointment with one of our providers for more information.
Names of Medication
US Brand Name: Infasurf
Generic Name: Calfactant
The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. In this article, the generic name will be listed in parentheses.
Pharmacologic Category
Surfactant
Other medications in this category include Beractant (Survanta), Poractant Alfa (Curosurf), and Lucinactant (Surfaxin).
Calfactant Dosing Guidelines
Calfactant is used to treat several lung conditions, especially in newborns and premature infants. Below are the dosing guidelines for each condition. Always consult your healthcare provider before adjusting the dose, and feel free to schedule a telemedicine appointment with one of our providers for personalized advice.
Respiratory Distress Syndrome (RDS)
Initial dose: 3 mL/kg administered intratracheally (into the windpipe) as soon as possible after birth. Repeat doses may be given every 12 hours, up to a total of 3 doses.
Neonatal Respiratory Distress Syndrome
The dosing is the same as for RDS: 3 mL/kg intratracheally, with up to 3 doses in total.
Premature Birth
Calfactant is often used as a preventive measure for premature infants at risk of developing RDS. The dose is 3 mL/kg within 30 minutes of birth, followed by up to 2 additional doses every 12 hours.
Meconium Aspiration Syndrome
3 mL/kg intratracheally, repeated every 12 hours for up to 3 doses.
Bronchopulmonary Dysplasia
Calfactant may be used off-label for this condition. Consult your healthcare provider for specific dosing recommendations.
Acute Respiratory Distress Syndrome (ARDS)
Calfactant is sometimes used in adults with ARDS. The typical dose is 3 mL/kg intratracheally, repeated every 12 hours for up to 3 doses.
Pulmonary Edema
Calfactant may be used off-label for this condition. Consult your healthcare provider for specific dosing recommendations.
Congenital Diaphragmatic Hernia
Calfactant may be used in newborns with this condition. The dose is 3 mL/kg intratracheally, repeated every 12 hours for up to 3 doses.
Hypoxia
Calfactant may be used off-label for hypoxia. Consult your healthcare provider for specific dosing recommendations.
Atelectasis
Calfactant may be used off-label for this condition. Consult your healthcare provider for specific dosing recommendations.
Dosage Forms and Strengths
Suspension for intratracheal administration: 35 mg/mL in 6 mL vials
Calfactant Administration Instructions
Calfactant is administered intratracheally, meaning it is delivered directly into the windpipe through a tube. This procedure is typically performed in a hospital setting, often in the neonatal intensive care unit (NICU). A healthcare provider administers the medication, and the infant’s breathing and oxygen levels are closely monitored during and after the procedure.
Contraindications for Calfactant
A contraindication is a specific situation or condition where a medication should not be used because it may be harmful to the patient. For Calfactant, there are certain conditions where its use is not recommended.
Hypersensitivity to Calfactant or Its Components
If you or your baby have a known allergy to Calfactant or any of its ingredients, using this medication could trigger a severe allergic reaction, including rash, difficulty breathing, or swelling. In such cases, alternative treatments should be considered.
Severe Congenital Anomalies of the Lungs
In rare cases, babies born with severe lung defects may not benefit from Calfactant, as their lungs may not respond effectively to the medication.
Severe Infection (Sepsis)
If a newborn has a severe infection, the use of Calfactant may need to be delayed or reconsidered, as the infection could complicate the treatment of respiratory conditions.
Drug-to-Drug Interactions
Drug interactions occur when one medication affects how another works. While Calfactant is primarily administered in a hospital setting, it is important to be aware of potential interactions with other medications your baby may be receiving.
Survanta (Beractant)
Both Calfactant and Beractant are surfactants used to treat similar conditions. Using them together is not recommended, as they serve the same purpose, and combining them does not provide additional benefits.
Caffeine Citrate (Cafcit)
This medication is often used to treat apnea of prematurity. While it can be used alongside Calfactant, your healthcare provider will monitor your baby closely to ensure there are no adverse effects.
Antibiotics (Ampicillin, Gentamicin)
These antibiotics are commonly used in newborns with infections. While they do not directly interact with Calfactant, your healthcare provider will monitor your baby’s overall condition to ensure the best outcome.
Calfactant in Pregnancy
Is it Safe to Take Calfactant When Pregnant?
Calfactant is not typically used during pregnancy, as it is specifically designed for newborns with respiratory distress. However, if you are pregnant and concerned about your baby’s lung development, it’s important to discuss your concerns with your healthcare provider. They can help you understand the potential risks and benefits, guiding you toward the safest options for your baby’s health.
Calfactant While Breastfeeding
Is it Safe to Take Calfactant While Breastfeeding?
Calfactant is not absorbed into the bloodstream when administered to newborns and is unlikely to pass into breast milk. Therefore, it is generally considered safe for breastfeeding mothers. However, if you have any concerns about breastfeeding while your baby is receiving Calfactant, it’s always a good idea to consult your healthcare provider for reassurance and guidance.
Estimated Cost of Calfactant
The cost of Calfactant can vary depending on location and availability. Without insurance, the estimated cost of a 30-day supply using a GoodRx coupon ranges from approximately $1,500 to $2,000. However, since this medication is typically administered in a hospital setting, the cost may be included in the overall hospital care fees. Be sure to check with your healthcare provider and hospital for specific pricing information.
Possible Alternatives to Calfactant
Several alternative treatments and lifestyle changes may help manage conditions treated by Calfactant. It’s essential to discuss these options with your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to explore these alternatives in more detail.
Respiratory Distress Syndrome (RDS)
In addition to surfactant therapy like Calfactant, other treatments for RDS include oxygen therapy, mechanical ventilation, and continuous positive airway pressure (CPAP). Prenatal steroids may also be given to mothers at risk of premature delivery to help the baby’s lungs mature before birth.
Neonatal Respiratory Distress Syndrome
Similar to RDS, treatment options for neonatal respiratory distress syndrome include surfactant replacement therapy, oxygen support, and mechanical ventilation. Early prenatal care and timely intervention are crucial in managing this condition effectively.
Premature Birth
Preventative measures such as administering prenatal steroids, receiving proper prenatal care, and avoiding risk factors like smoking can help reduce the likelihood of premature birth. After birth, premature infants may require specialized care, including surfactant therapy, oxygen support, and nutritional support to promote healthy development.
Meconium Aspiration Syndrome
Treatment for meconium aspiration syndrome may involve suctioning the baby’s airways, oxygen therapy, and, in severe cases, mechanical ventilation. In some instances, surfactant therapy like Calfactant may also be used to improve lung function.
Bronchopulmonary Dysplasia (BPD)
Treatment options for bronchopulmonary dysplasia include oxygen therapy, diuretics to reduce fluid in the lungs, and nutritional support to promote lung healing. Preventing premature birth and minimizing the use of mechanical ventilation can help lower the risk of developing BPD.
Acute Respiratory Distress Syndrome (ARDS)
Treatment for ARDS often involves oxygen therapy, mechanical ventilation, and addressing the underlying cause of the condition, such as infection or trauma. In some cases, surfactant therapy may be considered as part of the treatment plan.
Pulmonary Edema
Treatment for pulmonary edema may include diuretics to reduce fluid buildup in the lungs, oxygen therapy, and addressing the underlying cause, such as heart failure or infection, to prevent further complications.
Congenital Diaphragmatic Hernia
Treatment for congenital diaphragmatic hernia typically involves surgery to repair the diaphragm, along with respiratory support, which may include oxygen therapy and, in some cases, surfactant therapy to assist with breathing.
Hypoxia
Treatment for hypoxia focuses on increasing oxygen levels in the blood. This may involve oxygen therapy, mechanical ventilation, or addressing the underlying cause of low oxygen levels to restore normal breathing function.
Atelectasis
Treatment for atelectasis may include deep breathing exercises, chest physiotherapy, and, in more severe cases, mechanical ventilation or surgery to help re-expand the collapsed areas of the lung.
Recent Updates on Calfactant Research
Recent research on Calfactant continues to focus on improving outcomes for premature infants and those with respiratory distress. Studies have shown that early administration of surfactants like Calfactant can significantly improve survival rates and reduce complications in newborns with respiratory distress syndrome (RDS). Researchers are also exploring the potential use of Calfactant in treating other conditions, such as acute respiratory distress syndrome (ARDS) in adults, though further studies are needed in this area.
Ongoing clinical trials are investigating the optimal timing and dosage of Calfactant to maximize its benefits while minimizing potential side effects. As new research emerges, it may lead to updated guidelines for the use of Calfactant in both neonatal and adult populations.
If you have questions about recent research or would like to discuss the latest treatment options for your baby’s condition, our telemedicine providers are available to help. Schedule an appointment today to receive personalized advice and care.
