Butoconazole Cream: Uses, Dosage, and Side Effects Explained

Summary of Key Points

Butoconazole is an antifungal medication used to treat vaginal yeast infections, also known as vaginal candidiasis. It works by inhibiting the growth of the fungus responsible for the infection. Butoconazole is available as a vaginal cream, typically applied once daily. Common side effects include mild burning or irritation. Always consult your healthcare provider before starting or adjusting your dose.

Names of Medication

US Brand Name: Gynazole-1 (Butoconazole)

The “generic name” refers to the active ingredient in the medication, which remains consistent across all brands. In this case, Butoconazole is the generic name.

Pharmacologic Category

Butoconazole belongs to the antifungal class of medications. Other related antifungal treatments include:

1. Clotrimazole
2. Miconazole
3. Terconazole
4. Tioconazole

Dosing

Butoconazole is prescribed for the treatment of various fungal infections, particularly those affecting the vaginal area. Below are the recommended dosages for each condition. Always consult your doctor before making any changes to your dose. For immediate medical advice, you can also consult one of our providers through telemedicine.

Vaginal Candidiasis (Yeast Infection)

Dosage: Apply one full applicator of 2% vaginal cream (Butoconazole) as a single dose.

Frequency: Single application.

Length of Treatment: One day.

Vulvovaginal Candidiasis

Dosage: Apply one full applicator of 2% vaginal cream (Butoconazole) as a single dose.

Frequency: Single application.

Length of Treatment: One day.

Fungal Infections (Candidiasis)

Dosage: Apply one full applicator of 2% vaginal cream (Butoconazole) as a single dose.

Frequency: Single application.

Length of Treatment: One day.

Dosage Forms and Strengths

Butoconazole cream is available in the following form:

1. Vaginal cream: 2% (available in pre-filled applicators)

How to Use Butoconazole Cream

Butoconazole is applied directly into the vagina using a pre-filled applicator. It is typically applied once, preferably at bedtime. To use, lie on your back with your knees bent, insert the applicator into the vagina, and press the plunger to release the cream. After use, discard the applicator. Avoid sexual intercourse during treatment, as the cream may weaken latex condoms or diaphragms. Always follow your healthcare provider’s instructions carefully.

Butoconazole Side Effects and Adverse Reactions

Like all medications, Butoconazole can cause side effects. Most are mild and resolve on their own, but some may require medical attention. If you experience any of the following, contact your healthcare provider:

1. Mild burning, itching, or irritation: These are common side effects that usually subside after the first few applications.
2. Headache: Some patients report mild headaches after using Butoconazole.
3. Abdominal pain: This is rare but possible. If the pain is severe, consult your doctor.
4. Allergic reaction: Though rare, serious allergic reactions can occur. Symptoms may include rash, itching, swelling, or difficulty breathing. Seek immediate medical attention if this happens.

Contraindications for Butoconazole Use

A contraindication is a specific situation or condition where a medication should not be used because it may cause harm. Before starting any medication, it’s important to know if there are reasons why it might not be safe for you. Below are the contraindications for using Butoconazole:

1. Allergy to Butoconazole or other antifungal medications: If you have had an allergic reaction to Butoconazole or similar antifungal medications in the past, using this medication could cause severe allergic reactions, such as rash, itching, swelling, or difficulty breathing.
2. Pregnancy (especially during the first trimester): While Butoconazole is generally considered safe during pregnancy, it is still important to consult your healthcare provider before using it, especially in the first trimester, as the medication may affect the developing fetus.
3. Open sores or wounds in the vaginal area: If you have open sores or wounds, Butoconazole may cause irritation or worsen the condition. Discuss this with your healthcare provider before use.

Drug Interactions with Butoconazole

Butoconazole may interact with other medications, potentially affecting its effectiveness or increasing the risk of side effects. Be sure to inform your healthcare provider about all the medications you are taking, including over-the-counter drugs, supplements, and herbal products. Below are some medications that may interact with Butoconazole:

1. Warfarin (Coumadin): Butoconazole may enhance the effects of Warfarin, a blood thinner, increasing the risk of bleeding.
2. Clotrimazole (Lotrimin): Using other antifungal medications like Clotrimazole alongside Butoconazole may increase the risk of side effects or reduce the effectiveness of treatment.
3. Progesterone (Prometrium): Butoconazole may interfere with hormone-based treatments, such as progesterone, potentially reducing their effectiveness.

Butoconazole in Pregnancy

Is it safe to take Butoconazole when pregnant?

Butoconazole is generally considered safe to use during pregnancy, particularly in the second and third trimesters. However, it’s essential to consult your healthcare provider before starting this medication, especially during the first trimester. Your provider will carefully weigh the potential benefits and risks to ensure the treatment is appropriate for both you and your baby.

Butoconazole while Breastfeeding

Is it safe to take Butoconazole while breastfeeding?

There is limited information regarding the safety of Butoconazole during breastfeeding. Since it is applied topically, the amount that may pass into breast milk is likely to be minimal. Nevertheless, it’s important to speak with your healthcare provider before using Butoconazole while breastfeeding to ensure it is safe for both you and your baby.

Estimated Cost of Butoconazole Cream

The cost of a 30-day supply of Butoconazole cream without insurance can vary. With a GoodRx coupon, the estimated price typically ranges from $50 to $70. Prices may differ depending on the pharmacy and location. Be sure to explore available discounts or coupons to help reduce the cost.

Possible Alternatives to Butoconazole

If Butoconazole isn’t the right treatment for you, there are alternative options and lifestyle changes that may help manage fungal infections. Always consult your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to discuss your options.

Vaginal Candidiasis

Alternatives include other antifungal creams such as Miconazole (Monistat) or oral antifungal medications like Fluconazole (Diflucan). Maintaining good hygiene and wearing breathable cotton underwear can also help prevent infections.

Vulvovaginal Candidiasis

Similar to vaginal candidiasis, Miconazole or Clotrimazole (Gyne-Lotrimin) are common alternatives. Additionally, probiotics and avoiding scented hygiene products may help reduce the risk of recurrence.

Fungal Infections

Oral antifungals like Terbinafine (Lamisil) or topical treatments such as Clotrimazole can be effective. Keeping the affected area clean and dry is crucial for preventing fungal growth.

Yeast Infections

In addition to Butoconazole, Fluconazole (Diflucan) is a common oral alternative. Wearing loose-fitting clothing and using unscented soaps may help lower the risk of future infections.

Candidiasis

Oral antifungals like Itraconazole (Sporanox) or topical treatments such as Nystatin can be effective. Maintaining a balanced diet and reducing sugar intake may help prevent yeast overgrowth.

Dermatophytosis

Topical antifungals like Terbinafine (Lamisil) or oral medications such as Griseofulvin can be used. Keeping the skin dry and avoiding the sharing of personal items like towels can help prevent the spread of infection.

Tinea Pedis (Athlete’s Foot)

Terbinafine (Lamisil) or Clotrimazole (Lotrimin) creams are commonly used treatments. Wearing moisture-wicking socks and keeping feet dry can help prevent recurrence.

Tinea Corporis (Ringworm)

Topical antifungals like Miconazole (Monistat) or oral medications such as Fluconazole (Diflucan) can be effective. Avoiding direct contact with infected individuals or animals is important for prevention.

Tinea Cruris (Jock Itch)

Topical antifungals like Clotrimazole (Lotrimin) or oral medications such as Itraconazole (Sporanox) can be effective. Keeping the groin area dry and wearing loose-fitting clothing can help prevent infections.

Onychomycosis (Fungal Nail Infection)

Oral antifungals like Terbinafine (Lamisil) or topical treatments such as Ciclopirox (Penlac) can be used. Keeping nails trimmed and dry is essential for preventing fungal growth.

Recent Updates on Butoconazole Research

Recent studies on Butoconazole have focused on its effectiveness in treating recurrent vaginal yeast infections. Research indicates that Butoconazole remains a highly effective option for uncomplicated vaginal candidiasis, with fewer side effects compared to oral antifungals. Ongoing studies are also exploring its potential in treating other fungal infections, including those resistant to traditional antifungal medications. Always consult your healthcare provider to determine the best treatment for your condition. If you have any questions or concerns, you can schedule a telemedicine visit with one of our providers to discuss the latest research and how it may apply to your treatment plan.

James Kingsley

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