Beraprost Medication: Uses, Dosage, and Side Effects Explained

Summary of Key Points

Beraprost is a medication used to manage conditions related to poor blood flow, such as pulmonary arterial hypertension (PAH), Raynaud’s phenomenon, and peripheral artery disease (PAD). It works by widening blood vessels, which improves circulation. Beraprost is available in tablet form and is typically taken several times a day. It is essential to follow your healthcare provider’s instructions carefully and consult them before making any changes to your dosage.

Names of Medication

US Brand Name: Beraprost

Generic Name: Beraprost sodium

The generic name refers to the active ingredient in the medication, while the brand name is assigned by the manufacturer. In this case, “Beraprost sodium” is the generic name.

Pharmacologic Category

Prostacyclin Analog

Vasodilator

Beraprost Dosage

Beraprost is prescribed for various conditions, and the dosage will depend on the specific condition being treated. Always follow your healthcare provider’s guidance and consult them before adjusting your dose. If you need to speak with a healthcare provider, you can schedule a telemedicine appointment with us today.

Beraprost for Pulmonary Arterial Hypertension (PAH)

The typical dose is 20 mcg taken orally 3 to 4 times per day. Treatment is usually long-term, but your doctor will determine the best course for you.

Beraprost for Raynaud’s Phenomenon

The usual dose is 20 mcg taken orally 3 times per day. The duration of treatment depends on the severity of your symptoms.

Beraprost for Peripheral Artery Disease (PAD)

The recommended dose is 20 mcg taken 3 times per day. Treatment may be long-term, depending on your condition.

Beraprost for Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

The typical dose is 20 mcg taken 3 to 4 times per day. Long-term treatment may be required.

Beraprost for Ischemic Heart Disease

The usual dose is 20 mcg taken 3 times per day. Your healthcare provider will determine the appropriate treatment duration.

Beraprost for Heart Failure

The recommended dose is 20 mcg taken 3 to 4 times per day. Treatment is typically long-term.

Beraprost for Diabetes-Related Complications

The typical dose is 20 mcg taken 3 times per day. The duration of treatment will depend on the severity of the complications.

Beraprost for Scleroderma

The usual dose is 20 mcg taken 3 times per day. Treatment duration will vary based on your symptoms.

Beraprost for Atherosclerosis

The recommended dose is 20 mcg taken 3 times per day. Long-term treatment may be necessary.

Beraprost for Hypertension

The typical dose is 20 mcg taken 3 times per day. Your healthcare provider will determine the appropriate treatment duration.

Dosage Forms and Strengths

Tablets: 20 mcg

Administration Instructions for Beraprost

Beraprost should be taken orally, with or without food, as directed by your healthcare provider. It is important to take the medication at evenly spaced intervals throughout the day to maintain consistent levels in your bloodstream. If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not take two doses at once. Always consult your healthcare provider if you have any questions or concerns about how to take Beraprost.

Beraprost Side Effects and Adverse Reactions

Like all medications, Beraprost can cause side effects. Most are mild, but some may be more serious. If you experience any side effects, contact your healthcare provider immediately. You can also schedule a telemedicine appointment with us to discuss your symptoms.

Common Side Effects (affecting more than 1 in 10 patients)

1. Headache: A frequent side effect, usually mild and temporary.
2. Flushing: Redness or warmth in the face, neck, or chest.
3. Nausea: A feeling of sickness in the stomach, which may improve over time.

Less Common Side Effects (affecting 1 in 100 patients)

1. Dizziness: A sensation of light-headedness or unsteadiness.
2. Diarrhea: Loose or watery stools.
3. Low Blood Pressure (Hypotension): A drop in blood pressure that may cause fainting or dizziness.

Rare Side Effects (affecting fewer than 1 in 1,000 patients)

1. Bleeding: Unusual bleeding or bruising, which may indicate a more serious condition.
2. Allergic Reactions: Rash, itching, swelling, or difficulty breathing. Seek medical attention immediately if you experience these symptoms.

Contraindications for Beraprost

A contraindication is a specific situation or condition where a medication should not be used because it may cause harm. If you have any of the following conditions, you should not take Beraprost, or you should discuss it with your healthcare provider before starting the medication.

Severe Liver Disease

Beraprost is processed by the liver. If your liver is not functioning properly, the medication may not be cleared efficiently, leading to increased side effects or toxicity.

Severe Kidney Disease

Like the liver, the kidneys help eliminate Beraprost from your system. If you have severe kidney issues, the drug could accumulate in your body, causing harmful effects.

Active Bleeding Disorders

Beraprost can increase the risk of bleeding because it affects blood clotting. If you have a condition that causes bleeding, such as hemophilia, or if you are on blood thinners, taking Beraprost could worsen this risk.

Allergy to Beraprost or Its Ingredients

If you have had an allergic reaction to Beraprost in the past, you should avoid taking it again, as it could lead to serious allergic reactions, including anaphylaxis.

Drug to Drug Interactions

Certain medications may interact with Beraprost, potentially increasing side effects or reducing the effectiveness of one or both drugs. It’s important to inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements. Below is a list of medications that may interact with Beraprost:

1. Warfarin (Coumadin): Beraprost can increase the risk of bleeding when combined with blood thinners like warfarin.
2. Aspirin (Bayer, Ecotrin): Both aspirin and Beraprost thin the blood, which can heighten the risk of bleeding.
3. Clopidogrel (Plavix): Taking this antiplatelet drug with Beraprost may further raise the risk of bleeding.
4. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve): These medications can increase the likelihood of gastrointestinal bleeding when used with Beraprost.
5. Heparin: Like warfarin, heparin is a blood thinner that can elevate the risk of bleeding when taken with Beraprost.

Beraprost in Pregnancy

Is it Safe to Take Beraprost When Pregnant?

There is limited information on the safety of Beraprost during pregnancy. While animal studies have shown some risks, there is not enough data from human studies to determine its safety. If you are pregnant or planning to become pregnant, it’s essential to discuss the potential risks and benefits of Beraprost with your healthcare provider. They can help you weigh the possible risks to your baby against the benefits of treating your condition.

Beraprost While Breastfeeding

Is it Safe to Take Beraprost While Breastfeeding?

It is currently unknown whether Beraprost passes into breast milk. Due to the potential for serious side effects in a nursing infant, it is generally recommended to avoid breastfeeding while taking Beraprost. If you are breastfeeding or plan to breastfeed, consult your healthcare provider to explore alternative treatments or discuss whether you should stop breastfeeding while using this medication.

Estimated Cost of Beraprost Medication

The cost of Beraprost can vary depending on your location and pharmacy. Without insurance, the estimated price for a 30-day supply using a GoodRx coupon ranges from $300 to $500. Prices may fluctuate, so it’s a good idea to check with your pharmacy or use a prescription discount service like GoodRx for the most up-to-date pricing.

Possible Alternatives to Beraprost

If Beraprost is not suitable for you, or if you are exploring alternative treatments, several other medications or lifestyle changes may help manage your condition. Always consult your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to discuss your options.

1. Pulmonary arterial hypertension: Other medications such as sildenafil (Revatio), tadalafil (Adcirca), or bosentan (Tracleer) may be considered. Lifestyle changes, including regular exercise and a low-sodium diet, can also help manage symptoms.
2. Raynaud’s phenomenon: Calcium channel blockers like nifedipine (Procardia) or lifestyle adjustments, such as avoiding cold temperatures and managing stress, may help reduce symptoms.
3. Peripheral artery disease: Medications like cilostazol (Pletal) or lifestyle changes, such as quitting smoking, exercising regularly, and following a heart-healthy diet, can improve blood flow.
4. Chronic thromboembolic pulmonary hypertension: Surgical options like pulmonary thromboendarterectomy or medications such as riociguat (Adempas) may be considered.
5. Ischemic heart disease: Medications like nitroglycerin or beta-blockers, along with lifestyle changes like a heart-healthy diet and regular exercise, can help manage symptoms.
6. Heart failure: ACE inhibitors, beta-blockers, and diuretics are commonly prescribed. Lifestyle changes, such as reducing salt intake and monitoring fluid levels, can also be beneficial.
7. Diabetes-related complications: Managing blood sugar levels through medications like metformin (Glucophage) and lifestyle changes, such as a healthy diet and regular exercise, can help prevent complications.
8. Scleroderma: Immunosuppressive drugs like methotrexate or lifestyle changes, such as protecting the skin from cold and injury, may help manage symptoms.
9. Atherosclerosis: Statins like atorvastatin (Lipitor) or lifestyle changes, such as quitting smoking, eating a heart-healthy diet, and exercising regularly, can slow disease progression.
10. Hypertension: Medications like lisinopril (Zestril) or lifestyle changes, such as reducing salt intake, losing weight, and exercising regularly, can help lower blood pressure.

Recent Updates on Beraprost Research

Recent studies on Beraprost have focused on its potential benefits in treating pulmonary arterial hypertension (PAH) and other vascular diseases. A 2022 study found that Beraprost may improve exercise capacity and reduce symptoms in patients with PAH. Ongoing research is also exploring the use of Beraprost in combination with other medications to enhance its effectiveness and minimize side effects. However, more large-scale clinical trials are needed to confirm these findings and better understand Beraprost’s long-term safety across various patient populations.

If you are interested in learning more about the latest research on Beraprost or want to discuss whether this medication is right for you, schedule a telemedicine appointment with one of our providers today.

James Kingsley

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