Balsalazide Medication: Uses, Dosage, and Side Effects Explained

Summary of Key Points

Balsalazide is a medication used to manage inflammatory bowel conditions, such as ulcerative colitis and other forms of colon inflammation. It works by reducing inflammation in the intestines, which helps alleviate symptoms like abdominal pain and chronic diarrhea. Balsalazide is available in both generic and brand-name versions. Always consult your healthcare provider before starting or adjusting your dosage. You can also connect with one of our telemedicine providers for personalized care.

Names of Medication

US Brand Name: Colazal (Balsalazide)

The “generic name” refers to the active ingredient in a medication, which remains consistent across all brands. In this case, the generic name is listed in parentheses.

Pharmacologic Category

Aminosalicylates (5-ASA): Balsalazide belongs to this class of anti-inflammatory medications used to treat bowel conditions.

Other medications in this category include mesalamine, sulfasalazine, and olsalazine.

Balsalazide Dosage

Balsalazide is prescribed for various inflammatory bowel conditions, and the dosage may vary depending on the specific condition being treated. Always follow your healthcare provider’s instructions and consult them before making any changes to your dose. You can also schedule a telemedicine visit with one of our providers to discuss your treatment plan.

Ulcerative Colitis (Adults)

The typical dose is 2.25 grams (three 750 mg capsules) taken orally three times a day for 8 to 12 weeks.

Crohn’s Disease

Although Balsalazide is not FDA-approved for Crohn’s disease, it may be prescribed off-label. Consult your doctor for specific dosing recommendations.

Inflammatory Bowel Disease (IBD)

The dosage is usually similar to that for ulcerative colitis, but your doctor will adjust the treatment based on your symptoms.

Gastrointestinal Inflammation

The dose and duration of treatment will depend on the severity of the inflammation. Your doctor will provide specific instructions tailored to your condition.

Colon Inflammation

The standard dose is typically 6.75 grams per day, divided into three doses.

Rectal Inflammation

Your doctor may prescribe a dose similar to that used for ulcerative colitis.

Bowel Disorders

The dosage will vary depending on the specific disorder and its severity.

Intestinal Inflammation

The standard dose is often 6.75 grams per day, divided into three doses.

Chronic Diarrhea

Balsalazide may be used off-label for chronic diarrhea related to inflammatory bowel conditions. Consult your doctor for appropriate dosing.

Abdominal Pain

Balsalazide may help relieve abdominal pain caused by inflammation. Your doctor will determine the appropriate dose based on your symptoms.

Dosage Forms and Strengths

Capsules: 750 mg

Administration Instructions for Balsalazide

Balsalazide should be taken orally, with or without food, as directed by your healthcare provider. If you have difficulty swallowing the capsules, they can be opened, and the contents sprinkled on applesauce. Be sure to swallow the mixture immediately without chewing. It’s important to drink plenty of fluids while taking this medication to help prevent kidney stones. Always follow your doctor’s instructions and consult them if you have any questions about how to take your medication.

Balsalazide Side Effects and Adverse Reactions

Like all medications, Balsalazide can cause side effects. While most are mild, some may be more serious. If you experience any of the following, contact your healthcare provider immediately.

Common Side Effects

1. Headache: Mild to moderate headaches are common and usually improve over time.
2. Abdominal Pain: Some patients may experience stomach discomfort or cramping.
3. Diarrhea: Loose stools may occur, especially when starting the medication.
4. Nausea: Feeling nauseous is a possible side effect.

Less Common Side Effects

1. Fatigue: Some patients report feeling unusually tired.
2. Joint Pain: Mild joint discomfort may occur.

Serious Side Effects (Rare)

1. Severe Allergic Reaction: Symptoms include rash, itching, swelling, and difficulty breathing. Seek emergency medical attention if these occur.
2. Liver Problems: Yellowing of the skin or eyes (jaundice), dark urine, or severe fatigue may indicate liver issues.
3. Kidney Problems: Symptoms include changes in urination or swelling in the legs and feet.

Contraindications for Balsalazide

A contraindication is a specific situation or condition where a particular treatment or medication should not be used because it may cause harm. For Balsalazide, there are several contraindications that patients should be aware of before starting treatment.

Allergy to Balsalazide or Its Components

If you have a known allergy to Balsalazide or any of its ingredients, taking the medication could lead to a severe allergic reaction, including rash, swelling, or difficulty breathing.

Allergy to Salicylates (e.g., Aspirin)

Balsalazide is chemically related to salicylates. If you are allergic to aspirin or other salicylate medications, you may also be allergic to Balsalazide, which could result in serious side effects like hives or anaphylaxis.

Severe Liver or Kidney Disease

Balsalazide is processed by the liver and kidneys. If you have severe liver or kidney disease, taking this medication could worsen your condition or lead to toxic buildup in your body.

If you have any of these conditions, it’s important to discuss them with your healthcare provider before starting Balsalazide. You can schedule a telemedicine appointment with one of our providers to review your medical history and determine if Balsalazide is safe for you.

Drug to Drug Interactions with Balsalazide

Some medications may interact with Balsalazide, potentially affecting its effectiveness or increasing the risk of side effects. It’s important to inform your healthcare provider about all the medications you’re taking, including over-the-counter drugs, supplements, and herbal remedies. Below are some medications that may interact with Balsalazide:

1. Azathioprine (Imuran): Using Balsalazide alongside azathioprine may increase the risk of bone marrow suppression, which can lead to low blood cell counts.
2. Mercaptopurine (Purinethol): Similar to azathioprine, combining mercaptopurine with Balsalazide could heighten the risk of bone marrow suppression.
3. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) or naproxen (Aleve): Taking NSAIDs with Balsalazide may raise the risk of gastrointestinal bleeding or ulcers.
4. Blood thinners such as warfarin (Coumadin): Balsalazide may increase the risk of bleeding when used with blood thinners.

Always consult your healthcare provider before starting or stopping any medications. If you have concerns about potential drug interactions, our telemedicine providers can help you review your current medications and determine if Balsalazide is the right choice for you.

Balsalazide in Pregnancy

Is it Safe to Take Balsalazide When Pregnant?

There is limited data on the use of Balsalazide during pregnancy. While animal studies have not shown harmful effects on the fetus, there is insufficient research in humans to fully assess the risks. If you are pregnant or planning to become pregnant, it’s essential to discuss the potential benefits and risks of Balsalazide with your healthcare provider. In some cases, untreated inflammatory bowel disease (IBD) may pose a greater risk to both the mother and baby than the medication itself. Our telemedicine providers can help you make an informed decision based on your specific situation.

Balsalazide While Breastfeeding

Is it Safe to Take Balsalazide While Breastfeeding?

There is limited information about the safety of Balsalazide while breastfeeding. It is unclear whether Balsalazide passes into breast milk or if it could affect a nursing infant. If you are breastfeeding or plan to breastfeed, it’s important to discuss the potential risks and benefits with your healthcare provider. They may recommend monitoring your baby for any signs of side effects, such as diarrhea or irritability. Our telemedicine providers are available to guide you through this decision.

Estimated Cost of Balsalazide Medication

The cost of Balsalazide can vary depending on the pharmacy and location. Without insurance, the estimated cost for a 30-day supply of Balsalazide using a GoodRx coupon ranges from approximately $100 to $200. Prices may fluctuate, so it’s a good idea to check with your local pharmacy or use a discount service like GoodRx to find the best price.

Possible Alternatives to Balsalazide

If Balsalazide is not suitable for you, other treatment options and lifestyle changes may help manage your condition. Always consult your healthcare provider before making any changes to your treatment plan. Our telemedicine providers can help you explore these alternatives.

1. Ulcerative colitis: Alternatives include mesalamine (Asacol, Lialda), sulfasalazine (Azulfidine), or corticosteroids. Dietary adjustments, such as avoiding high-fiber foods during flare-ups, may also provide relief.
2. Crohn’s disease: Other medications include biologics like infliximab (Remicade) or adalimumab (Humira). A low-residue diet may also help reduce symptoms.
3. Inflammatory bowel disease (IBD): In addition to medications, stress management techniques and regular exercise may help minimize flare-ups.
4. Gastrointestinal inflammation: Proton pump inhibitors (PPIs) or H2 blockers may be used if the inflammation is related to acid reflux. Avoiding spicy or acidic foods may also help.
5. Colon inflammation: Other anti-inflammatory medications, such as corticosteroids, may be prescribed. A high-fiber diet may help prevent future inflammation.
6. Rectal inflammation: Topical treatments like mesalamine suppositories or hydrocortisone enemas may be effective.
7. Bowel disorders: Depending on the specific disorder, treatments may include antispasmodics, fiber supplements, or probiotics.
8. Intestinal inflammation: Biologics or immunosuppressants may be used for severe cases. A low-fiber diet during flare-ups may help alleviate symptoms.
9. Chronic diarrhea: Antidiarrheal medications like loperamide (Imodium) or bile acid binders may provide relief. Staying hydrated and avoiding trigger foods is also important.
10. Abdominal pain: Pain relievers like acetaminophen (Tylenol) may be used, but NSAIDs should be avoided. Heat therapy or relaxation techniques may also offer relief.

Recent Updates on Balsalazide Research

Recent studies on Balsalazide have focused on its long-term safety and effectiveness in treating ulcerative colitis and other inflammatory bowel diseases. A 2022 study found that Balsalazide is generally well-tolerated for long-term use, with fewer gastrointestinal side effects compared to other treatments like sulfasalazine. Ongoing research is also exploring the potential of Balsalazide in treating other inflammatory conditions, such as Crohn’s disease, though more evidence is needed before it can be widely recommended for these conditions.

As new research emerges, staying informed about the latest treatment options is essential. Our telemedicine providers can help you stay up-to-date and make adjustments to your treatment plan as needed.

James Kingsley

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