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Asenapine Transdermal System: Benefits, Uses, and Dosage Guide
Key Points About the Asenapine Transdermal System
The Asenapine transdermal system, often referred to as the Asenapine patch, is a prescription medication designed to treat mental health conditions such as schizophrenia and bipolar disorder. This innovative antipsychotic treatment is applied directly to the skin, allowing the medication to be gradually absorbed into the bloodstream. It helps manage symptoms such as mood swings, hallucinations, and disorganized thinking. Always consult your healthcare provider before starting or adjusting your dose to ensure safe and effective use tailored to your needs.
Medication Names
US Brand Name: Secuado
The generic name for this medication is asenapine. The generic name refers to the official medical term for the drug’s active ingredient, while the brand name is the name given by the manufacturer for marketing purposes.
Pharmacologic Category
Category: Atypical Antipsychotic
Other medications in this category include aripiprazole (Abilify), risperidone (Risperdal), and olanzapine (Zyprexa). These medications are commonly prescribed to treat mental health conditions such as schizophrenia and bipolar disorder.
Recommended Dosing for the Asenapine Transdermal System
The Asenapine transdermal system is approved for treating several mental health conditions in adults. Below are the recommended doses for each condition. Always consult your healthcare provider before making any changes to your medication regimen. If needed, you can schedule a telemedicine appointment with us today.
Asenapine for Schizophrenia
Initial Dose: Apply one 3.8 mg/24 hours patch once daily. The dose may be increased to 5.7 mg/24 hours or 7.6 mg/24 hours based on your response to treatment and tolerability. Treatment is typically long-term and should be guided by your doctor.
Asenapine for Bipolar Disorder
Initial Dose: Apply one 3.8 mg/24 hours patch once daily. The dose may be adjusted to 5.7 mg/24 hours or 7.6 mg/24 hours depending on how well your symptoms are controlled and any side effects you may experience. Treatment is generally ongoing to effectively manage mood swings.
Off-Label Uses of the Asenapine Patch
The Asenapine transdermal system is sometimes prescribed off-label for other mental health conditions. Below are common off-label uses and typical dosing recommendations. Always consult your healthcare provider before using the Asenapine patch for any off-label purposes.
Major Depressive Disorder (MDD)
The typical dose is one 3.8 mg/24 hours patch applied once daily. This use should only be undertaken under the supervision of your healthcare provider.
Anxiety Disorders
The starting dose is generally 3.8 mg/24 hours. Speak with your doctor for personalized advice regarding the use of the Asenapine patch for anxiety disorders.
Post-Traumatic Stress Disorder (PTSD)
For PTSD, the usual dose is one 3.8 mg/24 hours patch applied daily. This is an off-label use and should be carefully discussed with your healthcare provider.
Obsessive-Compulsive Disorder (OCD)
The starting dose is typically 3.8 mg/24 hours. Always follow your doctor’s guidance when using the Asenapine transdermal system for OCD.
Attention-Deficit Hyperactivity Disorder (ADHD)
Although not FDA-approved for ADHD, the Asenapine transdermal system may be prescribed off-label. The usual dose is 3.8 mg/24 hours, but this should be determined by your healthcare provider based on your specific needs.
Borderline Personality Disorder (BPD)
For BPD, the typical dose is one 3.8 mg/24 hours patch applied daily. This is an off-label use and should be discussed thoroughly with your healthcare provider.
Psychotic Disorders
For other psychotic disorders, the initial dose is 3.8 mg/24 hours, with potential increases based on your response to treatment. Treatment is typically long-term and customized to the individual.
Substance Use Disorders
The Asenapine transdermal system may also be used off-label for substance use disorders. The starting dose is usually 3.8 mg/24 hours. Consult your healthcare provider for advice tailored to your situation.
Dosage Forms and Strengths
- Transdermal patch: 3.8 mg/24 hours
- Transdermal patch: 5.7 mg/24 hours
- Transdermal patch: 7.6 mg/24 hours
How to Use the Asenapine Transdermal System
Apply the Asenapine transdermal patch to clean, dry, and intact skin on areas such as the upper arm, upper back, abdomen, or hip. Rotate the application site daily to minimize the risk of skin irritation. Avoid applying the patch to areas with cuts, rashes, or other skin issues. The patch should be worn for 24 hours and then replaced with a new one. Be sure to avoid exposing the patch to direct heat sources, such as heating pads or hot baths, as this can increase the amount of medication absorbed into your body.
Adverse Reactions and Side Effects of the Asenapine Transdermal System
As with any medication, the Asenapine transdermal system (commonly referred to as the Asenapine patch) may cause side effects. While many of these are mild and manageable, others, though rare, can be more serious. If you experience any side effects, it’s important to contact your healthcare provider promptly. You can also schedule a telemedicine consultation with one of our providers for further evaluation and guidance.
Common Side Effects
- Drowsiness: A feeling of excessive sleepiness or fatigue.
- Weight gain: Some individuals may notice an increase in body weight over time.
- Application site reactions: Redness, itching, or irritation where the patch is applied.
Less Common Side Effects
- Dizziness: A sensation of lightheadedness or unsteadiness, which may occur occasionally.
- Dry mouth: A decrease in saliva production, leading to a persistent dry sensation in the mouth.
- Increased appetite: A noticeable increase in hunger or food cravings.
Serious Side Effects (Rare)
- Tardive dyskinesia: Involuntary, repetitive movements, particularly affecting the face, tongue, or jaw.
- Neuroleptic malignant syndrome: A rare but potentially life-threatening condition marked by symptoms such as high fever, severe muscle stiffness, and confusion.
- Severe allergic reactions: Signs may include swelling of the face, lips, or throat, as well as difficulty breathing. Seek immediate medical attention if these occur.
Contraindications for the Asenapine Transdermal System
Contraindications are specific conditions or circumstances in which a medication should not be used due to potential risks. Before starting the Asenapine transdermal system, it is essential to share your complete medical history with your healthcare provider, including any medications, supplements, or herbal products you are currently taking.
Conditions That May Prevent Use
- Severe liver impairment: Since Asenapine is processed in the liver, individuals with severe liver dysfunction may be at higher risk for side effects or toxicity.
- Allergic reaction to Asenapine: If you have previously experienced an allergic reaction to Asenapine or any of its components, you should avoid using the transdermal system. Symptoms of an allergic reaction may include rash, itching, swelling, or difficulty breathing.
- Heart conditions: Asenapine can cause QT prolongation, a change in heart rhythm that may be dangerous for individuals with pre-existing heart conditions such as arrhythmias.
- Severe hypotension: Asenapine may lower blood pressure, which could pose risks for individuals prone to fainting or those with significantly low blood pressure.
Drug-to-Drug Interactions with the Asenapine Transdermal System
The Asenapine transdermal system can interact with other medications, potentially increasing the likelihood of side effects or reducing the effectiveness of treatment. It is crucial to inform your healthcare provider about all medications you are taking, including prescription drugs, over-the-counter products, and dietary supplements. Below are some medications known to interact with Asenapine:
Medications That May Interact
- Fluoxetine (Prozac): This antidepressant may increase Asenapine levels in the body, raising the risk of side effects.
- Paroxetine (Paxil): Another antidepressant that can elevate Asenapine levels, potentially leading to heightened side effects.
- Quinidine: A medication used to treat heart rhythm disorders, which, when combined with Asenapine, may increase the risk of QT prolongation.
- Carbamazepine (Tegretol): Commonly prescribed for seizures and bipolar disorder, this drug can reduce the effectiveness of Asenapine by speeding up its breakdown in the liver.
- Ketoconazole (Nizoral): An antifungal medication that may raise Asenapine levels in the body, increasing the likelihood of side effects.
Asenapine Transdermal System in Pregnancy
Is the Asenapine transdermal system safe to use during pregnancy?
Asenapine is classified as a Category C medication for pregnancy. This means that while animal studies have shown potential risks to the fetus, there are no well-controlled studies in humans. In certain situations, the benefits of using Asenapine during pregnancy may outweigh the potential risks, particularly if the mother has a severe mental health condition that requires treatment. It is vital to have an open discussion with your healthcare provider to weigh the risks and benefits before starting or continuing Asenapine during pregnancy. If you are pregnant or planning to become pregnant, consider consulting one of our telemedicine providers to explore your treatment options and ensure the best possible care for you and your baby.
Asenapine Transdermal System While Breastfeeding
Is it safe to use the Asenapine transdermal system while breastfeeding?
Currently, it is unclear whether the Asenapine patch passes into breast milk. Due to the potential risk of serious side effects in nursing infants, breastfeeding is generally not recommended while using the Asenapine transdermal system. If you are breastfeeding or planning to breastfeed, it is important to consult your healthcare provider. Together, you can carefully weigh the potential risks and benefits of continuing this medication. Our telemedicine providers are here to help you make an informed decision that prioritizes both your health and your baby’s well-being.
Estimated Cost of the Asenapine Transdermal System
The cost of a 30-day supply of the Asenapine transdermal system without insurance typically ranges between $400 and $600. However, using a GoodRx coupon may lower the price to approximately $350 to $450, depending on the pharmacy. For the most accurate pricing, it’s a good idea to check with your local pharmacy and explore available discount programs.
Possible Alternatives to the Asenapine Transdermal System
If the Asenapine transdermal system is not the right fit for you, there are other treatment options to consider. Below are some alternatives for conditions commonly treated with the Asenapine patch. Always consult your healthcare provider before making any changes to your treatment plan. Our telemedicine providers are available to assist you in exploring these options.
Schizophrenia: Alternative antipsychotic medications include Risperidone (Risperdal) and Olanzapine (Zyprexa). Additionally, incorporating lifestyle changes such as stress management techniques and cognitive behavioral therapy (CBT) can provide valuable support.
Bipolar Disorder: Mood stabilizers like Lithium or Valproate, as well as atypical antipsychotics such as Quetiapine (Seroquel), are potential alternatives. Psychotherapy and lifestyle adjustments, such as maintaining a consistent sleep schedule, can also play a key role in managing symptoms.
Major Depressive Disorder: Antidepressants like Sertraline (Zoloft) or Escitalopram (Lexapro) may be effective options. Therapy and lifestyle changes, including regular physical activity and mindfulness practices, can further help alleviate symptoms.
Anxiety Disorders: Medications such as Buspirone (Buspar) or selective serotonin reuptake inhibitors (SSRIs) like Fluoxetine (Prozac) may be beneficial. Cognitive behavioral therapy (CBT) and relaxation techniques are also widely recommended for managing anxiety.
Post-Traumatic Stress Disorder (PTSD): SSRIs such as Sertraline (Zoloft) or Paroxetine (Paxil) are commonly prescribed. Trauma-focused therapy and mindfulness practices can also be highly effective in addressing PTSD symptoms.
Obsessive-Compulsive Disorder (OCD): SSRIs like Fluoxetine (Prozac) or Fluvoxamine (Luvox) are frequently used. Cognitive behavioral therapy (CBT), particularly with exposure and response prevention (ERP), is a cornerstone of OCD treatment.
Attention-Deficit Hyperactivity Disorder (ADHD): Stimulant medications such as Methylphenidate (Ritalin) or Amphetamine (Adderall) are commonly prescribed. Behavioral therapy and structured routines can also help manage symptoms effectively.
Borderline Personality Disorder: Dialectical behavior therapy (DBT) is a highly effective treatment approach. In some cases, medications like mood stabilizers or antipsychotics may be used to address specific symptoms.
Psychotic Disorders: Other antipsychotic medications, such as Aripiprazole (Abilify) or Clozapine (Clozaril), may be considered. Therapy and supportive care are also essential components of a comprehensive treatment plan.
Substance Use Disorders: Medications like Naltrexone or Buprenorphine can help manage cravings and withdrawal symptoms. Counseling, support groups, and lifestyle changes are critical for long-term recovery.
Recent Updates on Asenapine Transdermal System Research
Recent studies have explored the efficacy and safety of the Asenapine transdermal system, particularly for individuals with schizophrenia and bipolar disorder. A 2022 study highlighted that the transdermal system delivers a steady release of medication, which may help reduce side effects such as sedation and weight gain compared to oral formulations. Additionally, ongoing research is investigating the use of the Asenapine patch in combination with other medications to improve outcomes for patients with treatment-resistant schizophrenia and bipolar disorder.
As new research continues to emerge, staying informed about your treatment options is crucial. If you have questions or concerns about your current medication, our telemedicine providers are available to discuss the latest findings and how they may influence your care plan.
