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Aripiprazole Medication: Uses, Dosage, Side Effects & More
Summary of Key Points
Aripiprazole is a prescription medication commonly used to manage several mental health conditions, including schizophrenia, bipolar disorder, and depression. It works by helping to restore the balance of certain natural chemicals in the brain, which can improve mood, behavior, and thinking. Aripiprazole is available in various forms and strengths, and it is crucial to take it exactly as prescribed by your healthcare provider.
Names of Aripiprazole Medication
Abilify (Aripiprazole)
Abilify Maintena (Aripiprazole)
Aristada (Aripiprazole Lauroxil)
The generic name refers to the active ingredient in the medication and is listed in parentheses.
Pharmacologic Category of Aripiprazole
Second-Generation (Atypical) Antipsychotics
Aripiprazole Dosage
Aripiprazole is prescribed for a variety of conditions in adults, with the dosage and frequency tailored to the specific condition being treated. Always consult your doctor before making any changes to your dose. You can also schedule a telemedicine appointment with one of our providers to discuss your treatment plan.
Aripiprazole for Schizophrenia
Initial dose: 10-15 mg once daily. The dose may be adjusted based on your response, with a target range of 10-30 mg per day.
Aripiprazole for Bipolar Disorder (Manic or Mixed Episodes)
Initial dose: 15 mg once daily. The dose may be adjusted, with a typical range of 15-30 mg per day.
Aripiprazole for Major Depressive Disorder (Adjunctive Treatment)
Initial dose: 2-5 mg once daily. The dose may be adjusted based on your response, with a maximum of 15 mg per day.
Aripiprazole for Irritability Associated with Autistic Disorder
Initial dose: 2 mg per day. The dose may be increased weekly by 5 mg, with a maximum of 15 mg per day.
Aripiprazole for Tourette’s Disorder
Initial dose: 2 mg daily for patients under 50 kg, and 5 mg daily for those over 50 kg. The dose may be adjusted based on response.
Aripiprazole for Obsessive-Compulsive Disorder (OCD)
Initial dose: 2-5 mg once daily, used as an adjunct to other treatments. The dose may be adjusted based on response, with a maximum of 15 mg per day.
Aripiprazole for Anxiety Disorders
Initial dose: 2-5 mg once daily. The dose may be adjusted based on response, with a typical range of 5-15 mg per day.
Aripiprazole for Depression
Initial dose: 2-5 mg once daily, used as an adjunct to other antidepressants. The dose may be adjusted based on response, with a maximum of 15 mg per day.
Aripiprazole for Psychosis
Initial dose: 10-15 mg once daily. The dose may be adjusted based on response, with a typical range of 10-30 mg per day.
Aripiprazole for Mood Disorders
Initial dose: 10-15 mg once daily. The dose may be adjusted based on response, with a typical range of 10-30 mg per day.
Aripiprazole Dosage Forms and Strengths
Tablets: 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg
Oral Solution: 1 mg/mL
Orally Disintegrating Tablets: 10 mg, 15 mg
Injection (Abilify Maintena): 300 mg, 400 mg (extended-release)
Injection (Aristada): 441 mg, 662 mg, 882 mg (extended-release)
Contraindications for Aripiprazole
A contraindication is a specific condition where a medication should not be used because it may cause harm. If you have any of the following conditions, you should avoid taking Aripiprazole or consult your healthcare provider before starting the medication.
Allergic reaction to Aripiprazole: If you have experienced an allergic reaction to Aripiprazole, taking it again could result in serious symptoms such as rash, itching, swelling, or difficulty breathing.
Severe liver disease: Aripiprazole is metabolized by the liver. If your liver is not functioning properly, the medication may not be processed effectively, leading to potentially harmful side effects.
Uncontrolled seizures: Aripiprazole may lower the seizure threshold, increasing the risk of seizures. If your seizures are not well-controlled, this medication may not be safe for you.
History of stroke or heart attack: Aripiprazole can increase the risk of cardiovascular events, particularly in older adults with dementia-related psychosis. If you have a history of stroke or heart attack, the risks may outweigh the benefits.
Dementia-related psychosis: Aripiprazole is not approved for treating dementia-related psychosis due to an increased risk of death in elderly patients with this condition.
Aripiprazole Drug Interactions
Aripiprazole can interact with other medications, which may increase side effects or reduce its effectiveness. Be sure to inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements. Some common medications that interact with Aripiprazole include:
Fluoxetine (Prozac): This antidepressant can raise Aripiprazole levels in your body, increasing the risk of side effects.
Paroxetine (Paxil): Another antidepressant that can elevate Aripiprazole levels, potentially leading to more side effects.
Carbamazepine (Tegretol): This medication, used for seizures and bipolar disorder, can reduce Aripiprazole’s effectiveness by lowering its levels in your body.
Ketoconazole (Nizoral): An antifungal medication that can increase Aripiprazole levels, raising the risk of side effects.
Quinidine (Quinidex): A medication used to treat heart rhythm problems, which can increase Aripiprazole levels and the likelihood of side effects.
Aripiprazole in Pregnancy
Is it safe to take Aripiprazole when pregnant?
Taking Aripiprazole during pregnancy may carry certain risks, particularly in the third trimester. Babies exposed to antipsychotic medications like Aripiprazole during this time may experience withdrawal symptoms, breathing difficulties, feeding challenges, or tremors after birth. However, untreated mental health conditions such as schizophrenia or bipolar disorder can also pose significant risks to both the mother and baby. It’s essential to have a thorough discussion with your healthcare provider to weigh the benefits of continuing Aripiprazole during pregnancy against the potential risks. If you are pregnant or planning to become pregnant, consult one of our telemedicine providers to create a treatment plan that prioritizes both your health and your baby’s well-being.
Aripiprazole while Breastfeeding
Is it safe to take Aripiprazole while breastfeeding?
Aripiprazole can pass into breast milk, and there is limited information on its safety for nursing infants. Some studies suggest that it may reduce milk production, and there is a potential for side effects in the baby, such as drowsiness or irritability. If you are breastfeeding or planning to breastfeed, it’s important to discuss the risks and benefits with your healthcare provider. Together, you can decide whether to continue breastfeeding while taking Aripiprazole or explore alternative treatment options that may be safer for you and your baby.
Estimated Cost of Aripiprazole Medication
The cost of a 30-day supply of Aripiprazole without insurance can vary depending on the dosage and the pharmacy. With a GoodRX coupon, the price for a 30-day supply of generic Aripiprazole (10 mg) typically ranges from $15 to $30. In contrast, brand-name Abilify can be significantly more expensive, often costing over $800 for a 30-day supply. Be sure to explore available discounts and coupons to help lower your medication costs.
Possible Alternatives to Aripiprazole
If Aripiprazole isn’t the right medication for you or if you experience side effects, there are alternative treatments available for the conditions it commonly treats. Always consult your healthcare provider before making any changes to your treatment plan. Our telemedicine providers can assist you in exploring these options.
Schizophrenia
Other antipsychotic medications, such as Risperidone (Risperdal) or Olanzapine (Zyprexa), may be considered. Additionally, cognitive behavioral therapy (CBT) and social skills training can provide further support.
Bipolar Disorder
Mood stabilizers like Lithium or anticonvulsants such as Valproate (Depakote) may be effective alternatives. Incorporating lifestyle changes, such as maintaining regular sleep patterns and managing stress, can also help control symptoms.
Major Depressive Disorder
Selective serotonin reuptake inhibitors (SSRIs) like Sertraline (Zoloft) or cognitive behavioral therapy (CBT) may offer effective alternatives for managing depression.
Irritability Associated with Autistic Disorder
Behavioral therapy and other antipsychotic medications, such as Risperidone (Risperdal), may be considered as alternatives.
Tourette’s Disorder
Medications such as Clonidine (Catapres) or behavioral therapy may be helpful alternatives for managing Tourette’s disorder.
Obsessive-Compulsive Disorder (OCD)
SSRIs like Fluoxetine (Prozac) or cognitive behavioral therapy (CBT) with exposure and response prevention (ERP) are commonly used alternatives for treating OCD.
Anxiety Disorders
SSRIs like Escitalopram (Lexapro) or cognitive behavioral therapy (CBT) are often recommended for treating anxiety disorders.
Depression
SSRIs or serotonin-norepinephrine reuptake inhibitors (SNRIs) like Venlafaxine (Effexor) may be effective alternatives for managing depression.
Psychosis
Other antipsychotic medications, such as Quetiapine (Seroquel) or Clozapine (Clozaril), may be considered for treating psychosis.
Mood Disorders
Mood stabilizers like Lamotrigine (Lamictal) or psychotherapy may be helpful alternatives for managing mood disorders.
Recent Updates on Aripiprazole Research
Recent research on Aripiprazole has focused on its long-term safety and effectiveness, particularly in treating schizophrenia and bipolar disorder. A 2022 study explored the use of long-acting injectable forms of Aripiprazole, which may improve medication adherence and reduce relapse rates in patients with schizophrenia. Additionally, ongoing research is investigating the potential use of Aripiprazole in treating other conditions, such as borderline personality disorder and substance use disorders. While these studies show promise, more research is needed to confirm the safety and effectiveness of Aripiprazole for these additional uses. Always consult your healthcare provider for the most current information regarding your treatment options.
