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Amoxicillin-Clavulanate: Uses, Dosage, Side Effects & Interactions
Summary or Key Points
Amoxicillin-clavulanate is a combination antibiotic commonly prescribed to treat a variety of bacterial infections, such as sinusitis, pneumonia, and urinary tract infections. It works by inhibiting bacterial growth and helping to prevent antibiotic resistance. Available in multiple forms and strengths, it is important to consult a healthcare provider before starting or adjusting your dosage. You can schedule a telemedicine consultation with one of our providers for personalized advice.
Names of Medication
US Brand Name: Augmentin
The generic name for this medication is amoxicillin-clavulanate. The generic name refers to the active ingredients, while the brand name is assigned by the manufacturer. The generic name is typically listed in parentheses.
Pharmacologic Category
Penicillin Antibiotics
Beta-lactamase Inhibitors
Amoxicillin-Clavulanate Dosage
Amoxicillin-clavulanate is used to treat various infections in adults. The appropriate dosage depends on the specific condition being treated. Always consult your healthcare provider before making any changes to your dose. You can schedule a telemedicine visit for personalized guidance.
Amoxicillin-Clavulanate for Sinus Infection (Sinusitis)
500 mg/125 mg every 12 hours for 10-14 days
875 mg/125 mg every 12 hours for 5-7 days (for more severe cases)
Otitis Media (Ear Infection)
500 mg/125 mg every 12 hours for 10 days
Pneumonia
875 mg/125 mg every 12 hours for 7-10 days
Bronchitis
500 mg/125 mg every 12 hours for 7-10 days
Amoxicillin-Clavulanate for Urinary Tract Infection (UTI)
500 mg/125 mg every 12 hours for 5-7 days
Skin Infections
500 mg/125 mg every 12 hours for 7-10 days
Dental Infections
875 mg/125 mg every 12 hours for 5-7 days
Bacterial Conjunctivitis
500 mg/125 mg every 12 hours for 7 days
Intra-abdominal Infections
875 mg/125 mg every 12 hours for 7-14 days
Bone and Joint Infections
875 mg/125 mg every 12 hours for 4-6 weeks
Dosage Forms and Strengths
Tablets: 500 mg/125 mg, 875 mg/125 mg
Chewable Tablets: 200 mg/28.5 mg, 400 mg/57 mg
Oral Suspension: 125 mg/31.25 mg per 5 mL, 200 mg/28.5 mg per 5 mL, 250 mg/62.5 mg per 5 mL, 400 mg/57 mg per 5 mL
Administration Instructions
Take amoxicillin-clavulanate exactly as prescribed by your healthcare provider. Follow the dosing schedule and complete the entire course of treatment, even if you start feeling better. This is crucial to prevent antibiotic resistance. Taking the medication with food can help reduce stomach upset.
Contraindications
Contraindications are medical conditions that make it unsafe to take a particular medication. If you have any of the following conditions, you should avoid taking amoxicillin-clavulanate, as it could cause harm or worsen your condition. Always consult your healthcare provider before starting any new medication.
Allergy to Penicillin or Cephalosporins: If you have a known allergy to penicillin or cephalosporin antibiotics, taking amoxicillin-clavulanate may trigger a severe allergic reaction, which could include symptoms like rash, swelling, or difficulty breathing.
History of Cholestatic Jaundice or Liver Dysfunction: Amoxicillin-clavulanate can cause liver problems, particularly in individuals who have previously experienced liver issues or jaundice related to this medication.
Severe Renal Impairment: If your kidneys are not functioning properly, your body may struggle to eliminate the medication, potentially leading to toxic levels of the drug in your system.
Mononucleosis: People with mononucleosis (mono) who take amoxicillin-clavulanate are more likely to develop a rash. While this rash is not an allergic reaction, it can be mistaken for one.
Amoxicillin-Clavulanate Drug Interactions
Amoxicillin-clavulanate can interact with other medications, which may lead to side effects or reduce the effectiveness of either drug. Be sure to inform your healthcare provider about all medications you are currently taking, including over-the-counter drugs and supplements.
Allopurinol (Zyloprim): Taking allopurinol with amoxicillin-clavulanate may increase the likelihood of developing a rash.
Warfarin (Coumadin): Amoxicillin-clavulanate can enhance the effects of warfarin, a blood thinner, which may increase the risk of bleeding.
Probenecid (Benemid): Probenecid can reduce the body’s ability to eliminate amoxicillin, leading to higher concentrations of the drug in the bloodstream.
Oral Contraceptives (Birth Control Pills): Amoxicillin-clavulanate may decrease the effectiveness of birth control pills, raising the risk of unintended pregnancy. It is advisable to use an additional form of contraception while taking this medication.
Amoxicillin-Clavulanate in Pregnancy
Is it safe to take Amoxicillin-clavulanate during pregnancy?
Amoxicillin-clavulanate, also known as Amoxicillin and clavulanate potassium, is generally considered safe to use during pregnancy, particularly when the benefits outweigh any potential risks. The FDA classifies it as a Category B medication, meaning that animal studies have not shown harm to the fetus, although there are no well-controlled studies in pregnant women. If you are pregnant or planning to become pregnant, it’s important to discuss the risks and benefits of this medication with your healthcare provider. Our telemedicine providers are available to help you make an informed decision about using Amoxicillin-clavulanate during pregnancy.
Amoxicillin-Clavulanate While Breastfeeding
Is it safe to take Amoxicillin-clavulanate while breastfeeding?
Amoxicillin-clavulanate is generally considered safe for use while breastfeeding. Although small amounts of the medication may pass into breast milk, it is typically not enough to cause harm to a nursing infant. However, some babies may experience mild side effects, such as diarrhea or yeast infections. If you notice any unusual symptoms in your baby, contact your healthcare provider. You can also consult one of our telemedicine providers for personalized advice on managing any side effects related to Amoxicillin-clavulanate while breastfeeding.
Estimated Cost of Amoxicillin-Clavulanate
The cost of a 30-day supply of Amoxicillin-clavulanate without insurance can vary depending on the dosage and the pharmacy. With a GoodRx coupon, the estimated price for a 30-day supply of the generic version typically ranges from $13 to $20. For the most accurate pricing, check with your local pharmacy. If you are prescribed Amoxicillin-clavulanate for a sinus infection or another condition, comparing prices across pharmacies may help you find the best deal.
Possible Alternatives to Amoxicillin-Clavulanate
Depending on the condition being treated, there may be alternative medications to Amoxicillin-clavulanate. Always consult your healthcare provider before making any changes to your treatment plan. Our telemedicine providers can assist you in exploring alternatives, especially if you have concerns about side effects or potential drug interactions.
- Sinusitis: Alternatives may include other antibiotics like doxycycline or using a nasal saline rinse to help clear the sinuses. In some cases, sinusitis may resolve without the need for antibiotics.
- Otitis Media (Ear Infection): For mild cases, watchful waiting may be an option. Other antibiotic alternatives include cefdinir or azithromycin.
- Pneumonia: Depending on the type of pneumonia, alternatives may include azithromycin or levofloxacin. Rest, fluids, and supportive care are also essential components of treatment.
- Bronchitis: Since many cases of bronchitis are viral, antibiotics may not be necessary. Alternatives include rest, fluids, and over-the-counter medications to manage symptoms.
- Urinary Tract Infection (UTI): Alternatives include antibiotics such as nitrofurantoin or trimethoprim-sulfamethoxazole. Drinking plenty of water and urinating frequently can also help flush out bacteria.
- Skin Infections: Depending on the type of infection, alternatives may include topical antibiotics or oral antibiotics like cephalexin.
- Dental Infections: Alternatives may include antibiotics like clindamycin or metronidazole, along with dental procedures to address the source of the infection.
- Bacterial Conjunctivitis: Alternatives include antibiotic eye drops such as erythromycin or polymyxin B/trimethoprim.
- Intra-abdominal Infections: Depending on the severity, alternatives may include antibiotics like metronidazole or ciprofloxacin. In some cases, surgery may be required.
- Bone and Joint Infections: Alternatives may include antibiotics like vancomycin or ceftriaxone, depending on the bacteria involved. Surgery may also be necessary to remove infected tissue.
Recent Updates on Amoxicillin-Clavulanate Research
Recent research on Amoxicillin-clavulanate has focused on its effectiveness in treating resistant bacterial infections. Studies indicate that while Amoxicillin-clavulanate remains effective for many common infections, the rise of antibiotic-resistant bacteria is an increasing concern. Researchers are exploring ways to enhance the drug’s efficacy, such as combining it with other antibiotics or developing new formulations. Ongoing studies are also investigating the long-term effects of using Amoxicillin-clavulanate, particularly in children and pregnant women. If you have concerns about antibiotic resistance or want to learn more about the latest research on Amoxicillin-clavulanate, our telemedicine providers can guide you through the most current treatment options.
