Front Desk: 469-391-0070
Amantadine Medication: Uses, Dosage, Side Effects & Interactions
Summary of Key Points
Amantadine is a medication used to treat a variety of conditions, including Parkinson’s disease, influenza, and drug-induced movement disorders. It works by influencing certain chemicals in the brain and is also prescribed to manage symptoms of multiple sclerosis and other neurological conditions. Always consult your healthcare provider before starting or adjusting your dose. You can also connect with one of our telemedicine providers for personalized care.
Names of Medication
US Brand Name: Symmetrel
Generic Name: Amantadine
The generic name refers to the active ingredient in the medication, while the brand name is assigned by the manufacturer. The generic name is listed in parentheses.
Pharmacologic Category
Dopamine Agonist
Antiviral Agent
NMDA Receptor Antagonist
Amantadine Dosage
Amantadine is prescribed for a range of conditions. The dosage, frequency, and duration of treatment depend on the specific condition being treated. Always consult your doctor before making any changes to your dose. You can also schedule a telemedicine appointment with one of our providers for further guidance.
Amantadine for Influenza
Adults: 200 mg once daily for 5-10 days.
Amantadine for Parkinson’s Disease
Adults: Start with 100 mg once daily. The dose may be increased to 100 mg twice daily after one week, depending on the response.
Amantadine for Drug-Induced Extrapyramidal Symptoms
Adults: 100 mg to 200 mg daily, depending on the severity of symptoms. Duration varies based on symptom control.
Amantadine for Multiple Sclerosis
Adults: 100 mg twice daily. Duration depends on symptom management.
Amantadine for Post-Polio Syndrome
Adults: 100 mg twice daily. Duration varies based on symptom control.
Amantadine for Restless Legs Syndrome
Adults: 100 mg to 200 mg daily, taken in the evening. Duration depends on symptom relief.
Amantadine for Herpes Simplex Virus
Adults: 200 mg daily for 5-10 days.
Amantadine for Traumatic Brain Injury
Adults: 100 mg twice daily. Duration depends on symptom improvement.
Amantadine for Chronic Fatigue Syndrome
Adults: 100 mg twice daily. Duration may vary based on symptom relief.
Amantadine for Cognitive Impairment
Adults: 100 mg to 200 mg daily. Duration depends on the severity of symptoms.
Dosage Forms and Strengths
Capsules: 100 mg
Tablets: 100 mg
Extended-Release Capsules: 129 mg, 193 mg, 258 mg
Oral Solution: 50 mg/5 mL
Administration Instructions for Amantadine
Amantadine can be taken with or without food. If you are using the extended-release form, swallow the capsule whole; do not crush or chew it. If you miss a dose, take it as soon as you remember, but skip it if it’s almost time for your next dose. Do not double the dose to make up for a missed one. Always follow your healthcare provider’s instructions and consult them if you have any concerns. You can also reach out to one of our telemedicine providers for advice.
Amantadine Side Effects and Adverse Reactions
Like all medications, Amantadine may cause side effects. It is important to be aware of these and contact your healthcare provider if they occur. Below are some potential side effects, categorized by frequency:
Common Side Effects (1-10%)
Dizziness: Feeling lightheaded or unsteady.
Dry Mouth: A decrease in saliva production, leading to a dry sensation in the mouth.
Nausea: A feeling of sickness in the stomach.
Insomnia: Difficulty falling or staying asleep.
Less Common Side Effects (0.1-1%)
Confusion: Trouble thinking clearly or focusing.
Hallucinations: Seeing or hearing things that are not present.
Swelling of the Legs or Feet: Fluid retention causing puffiness in the lower extremities.
Rare Side Effects (<0.1%)
Seizures: Sudden, uncontrolled electrical activity in the brain.
Heart Problems: Irregular heartbeat or other heart-related issues.
Contraindications for Amantadine
A contraindication is a specific condition or situation where a medication should not be used because it may cause harm. It’s important to know if any of these apply to you before starting a new medication like Amantadine. If you have any of the following conditions, you should not take Amantadine, or you should consult with a healthcare provider to discuss your options.
Severe kidney disease: Amantadine is cleared from the body by the kidneys. If your kidneys are not functioning properly, the drug can accumulate to dangerous levels, leading to toxicity.
Untreated angle-closure glaucoma: Amantadine can increase pressure in the eye, which can worsen this type of glaucoma and potentially lead to vision loss.
History of seizures: Amantadine can lower the seizure threshold, meaning it may increase the risk of seizures, especially in individuals with a history of epilepsy or other seizure disorders.
Heart failure or other serious heart conditions: Amantadine can cause changes in heart rhythm, which may be dangerous for people with pre-existing heart conditions.
Amantadine Drug Interactions
Amantadine can interact with other medications, which may increase the risk of side effects or reduce the effectiveness of either drug. It’s important to inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements. Some medications that may interact with Amantadine include:
Anticholinergic drugs (e.g., Benztropine [Cogentin], Trihexyphenidyl [Artane]): These medications can increase the risk of side effects such as confusion, dry mouth, and blurred vision when taken with Amantadine.
Diuretics (e.g., Hydrochlorothiazide [Microzide], Furosemide [Lasix]): These medications can increase the concentration of Amantadine in the blood, raising the risk of toxicity.
Quinidine (Quinidex) and Quinine (Qualaquin): These medications can increase the amount of Amantadine in the bloodstream, potentially leading to an increased risk of side effects.
Memantine (Namenda): Both Memantine and Amantadine work on similar pathways in the brain, and taking them together may increase the risk of side effects such as confusion and dizziness.
Amantadine in Pregnancy
Is it safe to take Amantadine when pregnant?
Amantadine is classified as a Category C medication by the FDA for use during pregnancy. This means that while animal studies have shown potential risks to the fetus, there are no well-controlled studies in humans. In certain cases, the benefits of using Amantadine during pregnancy may outweigh the potential risks. It’s important to have a thorough discussion with your healthcare provider to weigh these factors. If you are pregnant or planning to become pregnant, consult one of our telemedicine providers to determine the most appropriate treatment plan for your condition.
Amantadine While Breastfeeding
Is it safe to take Amantadine while breastfeeding?
There is limited information available regarding the safety of Amantadine during breastfeeding. The medication may pass into breast milk and could potentially affect a nursing infant. If you are breastfeeding or planning to breastfeed, it’s essential to consult your healthcare provider to carefully consider the risks and benefits of continuing Amantadine. Our telemedicine providers are here to help you make an informed decision based on your individual circumstances.
Estimated Cost of Amantadine Medication
The estimated cost of a 30-day supply of Amantadine (100 mg capsules) without insurance ranges from approximately $20 to $30 when using a GoodRX coupon. Prices may vary depending on the pharmacy and location. Be sure to explore available discounts or speak with your provider about generic options to help manage costs effectively.
Possible Alternatives to Amantadine
If Amantadine is not the right medication for you, there are alternative treatments and lifestyle changes that may help manage your condition. Always consult your healthcare provider before making any changes to your treatment plan. Our telemedicine providers can guide you through these alternatives and help you find the best option for your needs.
Alternatives for Influenza
Other antiviral medications, such as Oseltamivir (Tamiflu) or Zanamivir (Relenza), may be used to treat or prevent influenza. Additionally, getting an annual flu vaccine is a key preventive measure to protect against the virus.
Alternatives for Parkinson’s Disease
For Parkinson’s disease, alternatives include Levodopa/Carbidopa (Sinemet), dopamine agonists like Pramipexole (Mirapex), or lifestyle changes such as regular exercise and physical therapy to help manage symptoms.
Alternatives for Drug-Induced Extrapyramidal Symptoms
Medications like Benztropine (Cogentin) or Diphenhydramine (Benadryl) may be considered as alternatives. Adjusting the dosage of the medication causing the symptoms may also provide relief.
Alternatives for Multiple Sclerosis
Disease-modifying therapies such as Interferon beta (Avonex) or Glatiramer acetate (Copaxone) may be considered for managing multiple sclerosis. Physical therapy and lifestyle changes, including a balanced diet and regular exercise, can also help alleviate symptoms.
Alternatives for Post-Polio Syndrome
While there is no specific cure for post-polio syndrome, physical therapy, pain management, and assistive devices can help improve quality of life. Consult with your healthcare provider for personalized recommendations based on your condition.
Alternatives for Restless Legs Syndrome
Medications such as Ropinirole (Requip) or Gabapentin (Neurontin) may be considered as alternatives. Lifestyle changes, including improving sleep hygiene and reducing caffeine intake, may also help manage symptoms.
Alternatives for Herpes Simplex Virus
Antiviral medications such as Acyclovir (Zovirax) or Valacyclovir (Valtrex) are commonly used to manage herpes simplex virus outbreaks and can help reduce the frequency and severity of symptoms.
Alternatives for Traumatic Brain Injury
Cognitive rehabilitation therapy and medications such as Methylphenidate (Ritalin) or Modafinil (Provigil) may help manage symptoms associated with traumatic brain injury, including difficulties with attention and fatigue.
Alternatives for Chronic Fatigue Syndrome
Treatment for chronic fatigue syndrome may include graded exercise therapy, cognitive behavioral therapy, and medications to manage symptoms such as pain or sleep disturbances. A comprehensive approach is often necessary to address the various aspects of this condition.
Alternatives for Cognitive Impairment
Medications such as Donepezil (Aricept) may help improve cognitive function. Additionally, lifestyle changes like engaging in mental exercises, maintaining a healthy diet, and staying physically active can support cognitive health.
Recent Updates on Amantadine Research
Recent studies have explored Amantadine’s potential in treating a broader range of neurological conditions. For example, ongoing research is investigating its use in managing symptoms of traumatic brain injury (TBI) and cognitive impairment. Some studies suggest that Amantadine may improve attention and reduce fatigue in TBI patients, though further research is needed to confirm these findings. Additionally, there is growing interest in Amantadine’s role in managing multiple sclerosis (MS) symptoms, particularly in reducing fatigue. As research continues to evolve, staying informed about new developments is important. If you have questions about whether Amantadine is right for you, our telemedicine providers are available to discuss your treatment options and provide personalized guidance.
