Abemaciclib: Comprehensive Guide to Breast Cancer Treatment

Summary of Key Points

Abemaciclib is a prescription medication used to treat certain types of breast cancer, specifically hormone receptor-positive and HER2-negative breast cancers. It works by inhibiting proteins that promote the growth of cancer cells. Abemaciclib is often used in combination with other therapies. Common side effects include diarrhea, fatigue, and nausea. Always consult your healthcare provider before starting or adjusting your treatment. Our telemedicine providers are available to help manage your care.

Names of Medication

US Brand Name: Verzenio

Generic Name: Abemaciclib

The generic name refers to the active ingredient in the medication, while the brand name is assigned by the manufacturer. In this case, Abemaciclib is the generic name.

Pharmacologic Category

CDK 4/6 Inhibitor (Cyclin-Dependent Kinase 4 and 6 Inhibitor)

Abemaciclib Dosage

Abemaciclib is prescribed to treat various types of breast cancer in adults. The dosage may vary depending on the specific condition being treated. Below are common dosing guidelines for each indication. Always consult your doctor or one of our telemedicine providers before making any changes to your dose.

Breast Cancer (Hormone Receptor-Positive, HER2-Negative, Advanced or Metastatic): 150 mg taken orally twice daily, in combination with an aromatase inhibitor or fulvestrant.

Early-Stage Breast Cancer (Hormone Receptor-Positive, HER2-Negative): 150 mg taken orally twice daily, in combination with endocrine therapy for up to 2 years.

Triple-Negative Breast Cancer: 150 mg taken orally twice daily, in combination with other therapies as directed by your healthcare provider.

Invasive Lobular Breast Cancer: 150 mg taken orally twice daily, typically in combination with endocrine therapy.

Estrogen Receptor-Positive Breast Cancer: 150 mg taken orally twice daily, in combination with endocrine therapy or other treatments.

It is essential to follow your healthcare provider’s instructions carefully. If you have any questions about your dosage or treatment plan, our telemedicine providers are available to assist you.

Dosage Forms and Strengths

Tablets: 50 mg, 100 mg, 150 mg, 200 mg

Administration Instructions for Abemaciclib

Abemaciclib is taken orally, with or without food. Swallow the tablet whole with water; do not crush, chew, or break it. Take your doses at the same time each day to maintain consistent levels of the medication in your body. If you miss a dose, take it as soon as you remember, unless it is close to your next scheduled dose. Do not take two doses at once. Always follow your healthcare provider’s instructions.

Abemaciclib Side Effects and Adverse Reactions

Like all medications, Abemaciclib can cause side effects. Below are some of the most common and serious side effects. If you experience severe or concerning symptoms, contact your healthcare provider immediately.

Common Side Effects:

1. Diarrhea: Frequent, loose stools are common. Stay hydrated and consult your doctor if it becomes severe.
2. Fatigue: Feeling unusually tired or weak is common. Rest and consult your healthcare provider if it worsens.
3. Nausea: You may feel nauseous. Taking the medication with food may help reduce this symptom.
4. Decreased Appetite: You may experience a reduced desire to eat. Try to consume small, frequent meals.

Serious Side Effects:

1. Neutropenia: A decrease in white blood cells, which increases the risk of infection. Your doctor will monitor your blood counts regularly.
2. Liver Problems: Abemaciclib can affect liver function. Symptoms may include yellowing of the skin or eyes, dark urine, or upper abdominal pain. Notify your doctor immediately if you notice these symptoms.
3. Blood Clots: Abemaciclib may increase the risk of blood clots. Symptoms include swelling, pain, or redness in the legs, or sudden shortness of breath. Seek medical attention immediately if you experience these symptoms.

Contraindications for Abemaciclib Treatment

A contraindication is a specific situation where a medication should not be used because it may cause harm. If you have any of the following conditions, Abemaciclib may not be safe for you. Always consult your healthcare provider before starting or stopping any medication. Our telemedicine providers are available to help you make the best decision for your health.

1. Severe liver impairment: Abemaciclib is processed by the liver. If your liver is not functioning properly, the medication may accumulate in your body, leading to potentially dangerous side effects.
2. Allergic reaction to Abemaciclib: If you’ve had an allergic reaction to Abemaciclib or any of its ingredients, taking it again could cause a severe, life-threatening allergic response.
3. Severe neutropenia: Neutropenia is a condition where you have an abnormally low number of white blood cells, which are crucial for fighting infections. Abemaciclib can further reduce white blood cell counts, increasing the risk of serious infections.
4. Pregnancy: Abemaciclib can harm an unborn baby. If you are pregnant or planning to become pregnant, you should not take this medication.
5. Severe gastrointestinal issues: Abemaciclib can cause diarrhea and other gastrointestinal problems. If you already have severe gastrointestinal conditions, this medication may worsen your symptoms.

Drug to Drug Interactions

Abemaciclib can interact with other medications, potentially altering its effectiveness or increasing the likelihood of side effects. It’s important to inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs, supplements, and herbal products. Below are some medications that may interact with Abemaciclib:

1. Ketoconazole (Nizoral): This antifungal can increase Abemaciclib levels in your body, raising the risk of side effects.
2. Rifampin (Rifadin): This antibiotic may reduce Abemaciclib’s effectiveness by accelerating its breakdown in the body.
3. Carbamazepine (Tegretol): Commonly used for seizures and nerve pain, this medication can lower Abemaciclib’s effectiveness.
4. St. John’s Wort: This herbal supplement, often used for depression, can decrease Abemaciclib levels, reducing its efficacy.
5. Clarithromycin (Biaxin): This antibiotic can increase Abemaciclib levels, heightening the risk of side effects.

Abemaciclib in Pregnancy

Is it Safe to Take Abemaciclib During Pregnancy?

No, Abemaciclib is not safe to use during pregnancy. It can harm an unborn baby, potentially leading to birth defects or pregnancy loss. If you are pregnant, planning to become pregnant, or suspect you might be pregnant, do not take Abemaciclib. Women of childbearing age should use effective contraception during treatment and for at least 3 weeks after the last dose. If you become pregnant while taking Abemaciclib, contact your healthcare provider immediately. Our telemedicine providers are available to guide you through your treatment options.

Abemaciclib While Breastfeeding

Is it Safe to Take Abemaciclib While Breastfeeding?

No, it is not recommended to take Abemaciclib while breastfeeding. Although it is unclear whether Abemaciclib passes into breast milk, the potential for serious side effects in a nursing infant means breastfeeding should be avoided during treatment and for at least 3 weeks after the last dose. If you are breastfeeding or plan to breastfeed, discuss alternatives with your healthcare provider. You can also consult our telemedicine providers to find the best solution for you and your baby.

Estimated Cost of Abemaciclib

The cost of a 30-day supply of Abemaciclib without insurance can range from $13,000 to $14,000, even with a GoodRX coupon. Prices may vary depending on the pharmacy and location. If you have concerns about the cost of Abemaciclib treatment, speak with your healthcare provider or pharmacist about financial assistance programs or potential generic alternatives.

Possible Alternatives to Abemaciclib

If Abemaciclib is not suitable for you, or if you are considering other treatment options, there are alternatives available. However, always consult your healthcare provider before making any changes to your treatment plan. Our telemedicine providers can help you explore these options.

1. Breast cancer: Other targeted therapies, such as Palbociclib (Ibrance) or Ribociclib (Kisqali), may be considered. Depending on the stage of cancer, chemotherapy, radiation, or surgery may also be options.
2. Hormone receptor-positive breast cancer: Hormonal therapies like Tamoxifen or Aromatase inhibitors (e.g., Letrozole or Anastrozole) may be recommended.
3. Metastatic breast cancer: In addition to Abemaciclib, options include chemotherapy, immunotherapy, or other targeted therapies like Everolimus (Afinitor).
4. Early-stage breast cancer: Common treatments include surgery, radiation, and hormonal therapy. Lifestyle changes, such as maintaining a healthy diet and regular exercise, can also support recovery.
5. Triple-negative breast cancer: Chemotherapy is often the first-line treatment. Immunotherapy, such as Pembrolizumab (Keytruda), may also be an option.
6. Lobular breast cancer: Treatment options may include surgery, radiation, chemotherapy, and hormonal therapy, depending on the stage of the cancer.
7. Invasive breast cancer: Surgery, radiation, chemotherapy, and targeted therapies are commonly used. Discuss with your provider which combination is best for your situation.
8. Estrogen receptor-positive breast cancer: Hormonal therapies like Tamoxifen or Fulvestrant (Faslodex) may be effective options.
9. HER2-negative breast cancer: In addition to Abemaciclib, other therapies like chemotherapy or hormonal therapy may be considered.

Recent Updates on Abemaciclib Research

Recent studies have shown promising results for Abemaciclib in treating early-stage breast cancer, particularly in patients with hormone receptor-positive, HER2-negative breast cancer. In 2021, the FDA approved Abemaciclib for use alongside endocrine therapy for early-stage breast cancer patients at high risk of recurrence. Ongoing research is also exploring Abemaciclib’s potential in combination with other therapies to improve outcomes for patients with metastatic breast cancer. New clinical trials are investigating its effectiveness in different breast cancer subtypes, including triple-negative breast cancer.

As research continues to evolve, staying informed about the latest developments is essential. If you have questions about how these updates may impact your treatment plan, our telemedicine providers are available to discuss your options.

James Kingsley

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