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Ofatumumab Treatment: Uses, Dosage, and Side Effects Explained
Summary of Key Points
Ofatumumab is a prescription medication used to treat certain cancers and autoimmune conditions by targeting specific immune system cells. It is commonly prescribed for chronic lymphocytic leukemia (CLL), multiple sclerosis (MS), and other B-cell-related diseases. It’s important to follow your doctor’s instructions closely when taking this medication. If you have any questions, you can consult one of our telemedicine providers for further guidance.
Names of Medication
US Brand Name: Kesimpta
Generic Name: Ofatumumab
The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. The generic name is listed in parentheses.
Pharmacologic Category
Monoclonal Antibody
Anti-CD20 Antibody
Ofatumumab Dosing
Ofatumumab is prescribed for various conditions in adults, with the dosage depending on the specific disease being treated. Always consult your doctor before making any changes to your dose. You can also schedule a telemedicine appointment with one of our providers for personalized advice.
Chronic Lymphocytic Leukemia (CLL)
Initial dose: 300 mg intravenously (IV) on Day 1, followed by 1,000 mg IV on Day 8. After that, 1,000 mg IV every 4 weeks for up to 12 doses.
Ofatumumab for Multiple Sclerosis (MS)
Initial dose: 20 mg subcutaneously on Day 1, Day 7, and Day 14. Maintenance dose: 20 mg subcutaneously once a month starting on Day 29.
Non-Hodgkin Lymphoma (NHL)
Initial dose: 300 mg IV on Day 1, followed by 1,000 mg IV on Day 8. Then, 1,000 mg IV every 4 weeks for up to 8 doses.
Rheumatoid Arthritis (RA)
Initial dose: 700 mg IV on Day 1, followed by 700 mg IV every 4 weeks for up to 6 doses.
B-cell Malignancies
Initial dose: 300 mg IV on Day 1, followed by 1,000 mg IV on Day 8. Then, 1,000 mg IV every 4 weeks for up to 8 doses.
Follicular Lymphoma
Initial dose: 300 mg IV on Day 1, followed by 1,000 mg IV on Day 8. Then, 1,000 mg IV every 4 weeks for up to 8 doses.
Small Lymphocytic Lymphoma
Initial dose: 300 mg IV on Day 1, followed by 1,000 mg IV on Day 8. Then, 1,000 mg IV every 4 weeks for up to 8 doses.
Hairy Cell Leukemia
Initial dose: 300 mg IV on Day 1, followed by 1,000 mg IV on Day 8. Then, 1,000 mg IV every 4 weeks for up to 8 doses.
Primary Central Nervous System Lymphoma
Initial dose: 300 mg IV on Day 1, followed by 1,000 mg IV on Day 8. Then, 1,000 mg IV every 4 weeks for up to 8 doses.
Waldenström’s Macroglobulinemia
Initial dose: 300 mg IV on Day 1, followed by 1,000 mg IV on Day 8. Then, 1,000 mg IV every 4 weeks for up to 8 doses.
Dosage Forms and Strengths
Injection, solution: 20 mg/0.4 mL (subcutaneous)
Injection, solution: 100 mg/5 mL (intravenous)
Ofatumumab Administration Instructions
Ofatumumab can be administered either as an intravenous (IV) infusion or a subcutaneous injection. Your healthcare provider will determine the most appropriate method for you. If you are receiving an IV infusion, it will be done in a medical setting. If you are prescribed the subcutaneous form, your doctor may teach you how to administer the injection at home. Always follow your healthcare provider’s instructions carefully.
Contraindications for Ofatumumab
A contraindication is a condition where a treatment or medication should not be used due to potential harm. For Ofatumumab, certain conditions make its use inadvisable because of the risk of serious side effects or complications.
Hypersensitivity to Ofatumumab or its components: If you are allergic to Ofatumumab or any of its ingredients, taking it could trigger a severe allergic reaction, which may include symptoms like rash, difficulty breathing, or swelling.
Active infections: Ofatumumab can suppress the immune system, making it harder for your body to fight infections. If you have an active infection, taking Ofatumumab could worsen it or delay your recovery.
Hepatitis B infection: Ofatumumab can reactivate hepatitis B in patients with a history of the infection, potentially leading to serious liver problems. Your healthcare provider will likely screen for hepatitis B before starting treatment.
It’s essential to discuss your full medical history with your healthcare provider before starting Ofatumumab, especially if you have any of the above conditions. If you have concerns, one of our providers can assist you through a telemedicine consultation.
Drug-to-Drug Interactions with Ofatumumab
Ofatumumab may interact with other medications, increasing the risk of side effects or reducing the effectiveness of either drug. Be sure to inform your healthcare provider about all medications you are taking, including over-the-counter drugs, supplements, and herbal products. Known drug interactions include:
Immunosuppressants: Medications like Methotrexate (Trexall) or Azathioprine (Imuran) may increase the risk of infections when combined with Ofatumumab, as both suppress the immune system.
Live vaccines: Vaccines such as MMR (measles, mumps, rubella) or Varicella (chickenpox) should be avoided while on Ofatumumab because your immune system may not respond appropriately, increasing the risk of infection.
Other monoclonal antibodies: Medications like Rituximab (Rituxan) or Ocrelizumab (Ocrevus) may have similar effects on the immune system and should not be combined with Ofatumumab without careful medical supervision.
If you are taking any of these medications, your healthcare provider may need to adjust your treatment plan. You can discuss your medication list with one of our telemedicine providers for personalized advice.
Ofatumumab in Pregnancy
Is it safe to take Ofatumumab when pregnant?
There is limited information regarding the safety of Ofatumumab during pregnancy. While animal studies suggest potential risks, there is not enough data from human studies to confirm its safety. Ofatumumab treatment may affect the developing baby’s immune system, so it is generally not recommended during pregnancy unless the potential benefits outweigh the risks. If you are pregnant or planning to become pregnant, it is important to consult your healthcare provider. They can help you weigh the risks and benefits and explore alternative treatments if necessary.
Ofatumumab while Breastfeeding
Is it safe to take Ofatumumab while breastfeeding?
It is not yet clear whether Ofatumumab passes into breast milk or how it might affect a nursing infant. Due to the potential risk of immune system suppression in the baby, breastfeeding is generally not recommended while undergoing Ofatumumab treatment. If you are breastfeeding or planning to breastfeed, discuss your options with your healthcare provider to determine the best course of action for both you and your baby.
Estimated Cost of Ofatumumab Treatment
The cost of a 30-day supply of Ofatumumab can vary depending on the pharmacy and location. Without insurance, the estimated cost using a GoodRx coupon ranges from $6,000 to $7,000 per month. Prices may fluctuate, so it’s a good idea to check with your pharmacy or use a coupon service like GoodRx to find the most affordable option.
Possible Alternatives to Ofatumumab
If Ofatumumab is not the right treatment for you, there are alternative therapies available for the conditions it commonly treats. Always consult your healthcare provider before making any changes to your treatment plan. Our telemedicine providers are also available to help you explore these options.
Chronic Lymphocytic Leukemia (CLL)
Alternatives include Ibrutinib (Imbruvica), Venetoclax (Venclexta), or chemotherapy regimens. In addition, lifestyle changes such as maintaining a healthy diet and taking steps to avoid infections can help manage symptoms.
Multiple Sclerosis (MS)
Other disease-modifying therapies include Ocrelizumab (Ocrevus), Alemtuzumab (Lemtrada), or oral medications like Dimethyl fumarate (Tecfidera). Regular exercise and physical therapy can also play a role in managing symptoms. Ofatumumab for multiple sclerosis is a newer option, but alternatives should be considered based on your individual needs.
Non-Hodgkin Lymphoma
Treatment options may include Rituximab (Rituxan), chemotherapy, or radiation therapy. Your healthcare provider may also recommend lifestyle adjustments to support your immune system.
Rheumatoid Arthritis (RA)
Alternatives include Methotrexate (Trexall), Adalimumab (Humira), or other biologic therapies. Physical therapy and anti-inflammatory diets may also help manage symptoms.
B-cell Malignancies
Treatment options may include targeted therapies like Ibrutinib (Imbruvica) or chemotherapy. Discuss with your provider the best approach for your specific condition.
Follicular Lymphoma
Rituximab (Rituxan) or chemotherapy may be considered as alternatives. Maintaining a healthy lifestyle and managing stress can also support your treatment plan.
Small Lymphocytic Lymphoma (SLL)
Similar to CLL, treatments like Ibrutinib (Imbruvica) or chemotherapy may be appropriate. Regular monitoring and healthy lifestyle choices can also be beneficial.
Hairy Cell Leukemia
Cladribine (Leustatin) or Pentostatin (Nipent) are commonly used treatments. Your healthcare provider may also recommend supportive care to help manage symptoms.
Primary Central Nervous System Lymphoma
Treatment options may include high-dose methotrexate or radiation therapy. Consult with your provider to determine the best approach for your treatment.
Waldenström’s Macroglobulinemia
Ibrutinib (Imbruvica) or Rituximab (Rituxan) are common alternatives. Regular monitoring and lifestyle changes may also help manage the condition.
Recent Updates on Ofatumumab Research
Recent studies have focused on the use of Ofatumumab in treating multiple sclerosis (MS). A 2020 study demonstrated that Ofatumumab treatment significantly reduced relapses in patients with relapsing forms of MS compared to other therapies. Ongoing research is also exploring its potential in treating other autoimmune conditions and B-cell malignancies. As more data becomes available, Ofatumumab may become an increasingly common option for these conditions.
Stay informed by discussing the latest research with your healthcare provider. Our telemedicine team is available to provide up-to-date information and help you make the best decisions for your health.
