Front Desk: 469-391-0070
Dabrafenib Treatment: Uses, Dosage, and Common Side Effects
Summary of Key Points
Dabrafenib is a prescription medication used to treat certain types of cancer, including melanoma, non-small cell lung cancer, and thyroid cancer. It works by targeting specific mutations in cancer cells, helping to slow their growth. Dabrafenib is typically taken orally, and it’s essential to follow your doctor’s instructions carefully. Common side effects include fever, fatigue, and skin reactions. Always consult your healthcare provider before making any changes to your treatment plan.
Names of Medication
US Brand Name: Tafinlar (Dabrafenib)
The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. In this case, Dabrafenib is the generic name.
Pharmacologic Category
BRAF Kinase Inhibitor
Antineoplastic Agent
Dabrafenib Dosage
Dabrafenib is prescribed for various cancers, and the dosage may vary depending on the specific condition being treated. Always follow your doctor’s instructions and consult them before making any adjustments to your dose. You can also schedule a telemedicine appointment with one of our providers for personalized guidance.
Melanoma (BRAF V600E or V600K mutation-positive): 150 mg orally twice daily. Continue until disease progression or unacceptable toxicity.
Non-Small Cell Lung Cancer (BRAF V600E mutation-positive): 150 mg orally twice daily. Continue until disease progression or unacceptable toxicity.
Thyroid Cancer (BRAF V600E mutation-positive): 150 mg orally twice daily. Treatment duration will be determined by your healthcare provider.
Colorectal Cancer (BRAF V600E mutation-positive): 150 mg orally twice daily. Continue until disease progression or unacceptable toxicity.
Pancreatic Cancer (BRAF V600E mutation-positive): 150 mg orally twice daily. Continue as prescribed by your doctor.
BRAF-Mutant Cancer (other types): 150 mg orally twice daily. Duration depends on the specific cancer type and response to therapy.
Brain Cancer (BRAF V600E mutation-positive): 150 mg orally twice daily. Continue until disease progression or unacceptable toxicity.
Gastrointestinal Stromal Tumors (BRAF mutation-positive): 150 mg orally twice daily. Continue as directed by your healthcare provider.
Uveal Melanoma (BRAF mutation-positive): 150 mg orally twice daily. Continue until disease progression or unacceptable toxicity.
Metastatic Cancer (BRAF mutation-positive): 150 mg orally twice daily. Continue until disease progression or unacceptable toxicity.
Dosage Forms and Strengths
Capsules: 50 mg, 75 mg
Administration Instructions for Dabrafenib
Take Dabrafenib on an empty stomach, at least 1 hour before or 2 hours after a meal. Swallow the capsules whole with water; do not crush, chew, or open them. It’s important to take the medication at the same time each day. If you miss a dose, take it as soon as you remember, unless it’s close to your next scheduled dose. Do not take two doses at once to make up for a missed dose.
Adverse Reactions and Dabrafenib Side Effects
Like all medications, Dabrafenib can cause side effects. Some are common, while others are less frequent but more serious. Always report any unusual symptoms to your healthcare provider. You can also schedule a telemedicine visit with one of our providers to discuss any concerns.
Common Dabrafenib Side Effects:
- Fever: A frequent side effect that may require medical attention if it becomes severe.
- Fatigue: Feeling unusually tired or weak.
- Skin Reactions: Rash, redness, or peeling of the skin.
Less Common but Serious Side Effects:
- Heart Problems: Dabrafenib can affect heart function, leading to symptoms such as shortness of breath or swelling in the legs.
- Eye Problems: Blurred vision, eye pain, or other changes in vision may occur.
- Bleeding: Dabrafenib may increase the risk of bleeding, including in the brain or gastrointestinal tract.
Contraindications for Dabrafenib Treatment
A contraindication is a specific condition where a medication should not be used due to potential harm. For Dabrafenib, several situations make it unsuitable, as the risks outweigh the benefits.
Allergy to Dabrafenib: If you have a known allergy to Dabrafenib or any of its ingredients, taking this medication could cause a severe, life-threatening allergic reaction.
Severe Liver Disease: Dabrafenib is processed by the liver. If you have severe liver disease, your body may not metabolize the medication properly, increasing the risk of side effects or toxicity.
Severe Heart Conditions: Patients with a history of heart problems, such as heart failure or arrhythmias, should avoid Dabrafenib, as it can worsen these conditions by affecting heart rhythm and function.
Pregnancy: Dabrafenib can harm an unborn baby, so it is contraindicated during pregnancy. Women of childbearing age should use effective contraception while taking this medication.
Drug to Drug Interactions with Dabrafenib
It’s important to inform your healthcare provider about all medications you are taking, as Dabrafenib can interact with other drugs, potentially causing harmful effects or reducing the effectiveness of your treatment.
Warfarin (Coumadin): Dabrafenib may decrease the effectiveness of warfarin, a blood thinner, increasing the risk of blood clots.
Ketoconazole (Nizoral): This antifungal medication can increase Dabrafenib levels in your body, raising the risk of side effects.
Rifampin (Rifadin): This antibiotic can decrease Dabrafenib levels, making it less effective in treating cancer.
Atorvastatin (Lipitor): Dabrafenib can reduce the effectiveness of statins, which are used to lower cholesterol levels.
Phenytoin (Dilantin): This anti-seizure medication can lower Dabrafenib levels, reducing its effectiveness.
Dabrafenib in Pregnancy
Is it safe to take Dabrafenib when pregnant?
No, Dabrafenib is not considered safe during pregnancy. Research indicates that Dabrafenib can harm an unborn baby, potentially leading to birth defects or miscarriage. Women of childbearing age should use reliable contraception while undergoing Dabrafenib treatment and for at least two weeks after the final dose. If you are pregnant or planning to become pregnant, it is essential to discuss alternative treatment options with your healthcare provider. If you discover you are pregnant while taking Dabrafenib, contact your healthcare provider immediately for guidance.
Dabrafenib while Breastfeeding
Is it safe to take Dabrafenib while breastfeeding?
No, Dabrafenib is not recommended during breastfeeding. Although there is limited data on whether Dabrafenib passes into breast milk, there is a potential risk of serious side effects for a nursing infant. Therefore, breastfeeding should be avoided during Dabrafenib treatment and for at least two weeks after the last dose. If you are breastfeeding or planning to breastfeed, consult your healthcare provider to explore alternative treatments or feeding options.
Estimated Cost of Dabrafenib Treatment
The estimated cost of a 30-day supply of Dabrafenib (150 mg taken twice daily) without insurance ranges from $10,000 to $12,000. However, using a GoodRx coupon may reduce the cost to approximately $9,500. Prices can vary depending on the pharmacy and location. It is advisable to check with your pharmacy or use a coupon service like GoodRx for the most up-to-date pricing information.
Possible Alternatives to Dabrafenib
Depending on the type of cancer being treated, there may be alternative therapies or lifestyle changes available. Always consult your healthcare provider before making any changes to your treatment plan, or consider scheduling a telemedicine appointment with one of our specialists.
Melanoma
For melanoma, alternatives to Dabrafenib include immunotherapy (such as pembrolizumab or nivolumab) or other targeted therapies like vemurafenib. Additionally, lifestyle modifications, such as practicing sun protection and undergoing regular skin checks, are crucial for managing melanoma.
Non-Small Cell Lung Cancer
In the case of non-small cell lung cancer, other treatment options include chemotherapy, immunotherapy (such as atezolizumab), or radiation therapy. Quitting smoking and maintaining a healthy diet can also contribute to better outcomes.
Thyroid Cancer
For thyroid cancer, alternatives may include radioactive iodine therapy or surgery. Ensuring a balanced diet with adequate iodine intake is also important for maintaining thyroid health.
Colorectal Cancer
For colorectal cancer, chemotherapy, radiation therapy, or immunotherapy (such as pembrolizumab) may be considered. A high-fiber diet and regular screenings can also help reduce the risk of recurrence.
Pancreatic Cancer
In pancreatic cancer, surgery, chemotherapy (such as gemcitabine), or radiation therapy may be viable alternatives. Maintaining a healthy weight and avoiding smoking are important lifestyle changes that can support treatment.
BRAF-Mutant Cancer
For cancers with BRAF mutations, other targeted therapies like vemurafenib or encorafenib may be used as alternatives to Dabrafenib. Genetic counseling and regular monitoring are also recommended for patients with BRAF-mutant cancers.
Brain Cancer
For brain cancer, common alternatives include surgery, radiation therapy, or chemotherapy (such as temozolomide). Supporting cognitive health through brain exercises and a nutritious diet may also aid in treatment.
Gastrointestinal Stromal Tumors
For gastrointestinal stromal tumors, alternative treatments include imatinib or sunitinib. Regular physical activity and a balanced diet can help manage symptoms and improve overall health.
Uveal Melanoma
For uveal melanoma, radiation therapy or surgery may be considered as alternatives to Dabrafenib. Protecting your eyes from UV exposure is an important preventive measure for this type of cancer.
Metastatic Cancer
Treatment options for metastatic cancer vary widely and may include chemotherapy, immunotherapy, or radiation therapy. Maintaining a healthy lifestyle and managing stress are important for overall well-being during cancer treatment.
Recent Updates on Dabrafenib Research
Recent studies have explored combining Dabrafenib with other therapies to improve outcomes in patients with BRAF-mutant cancers. For instance, combining Dabrafenib with trametinib (another targeted therapy) has shown promising results in treating advanced melanoma and other cancers with BRAF mutations. Ongoing research is also investigating the use of Dabrafenib in combination with immunotherapies to enhance the body’s immune response against cancer cells. While these studies are still in progress, early findings are encouraging, suggesting that combination therapies may lead to better survival rates and fewer side effects. If you are interested in learning more about these emerging treatments, discuss them with your healthcare provider or schedule a telemedicine consultation with one of our specialists.
