Cilostazol Medication: Uses, Dosage, Side Effects & Interactions

Summary of Key Points

Cilostazol is a medication used to enhance blood flow in individuals with circulation problems, such as peripheral artery disease (PAD) and intermittent claudication. It helps alleviate symptoms like leg pain during physical activity. Cilostazol works by widening blood vessels and preventing blood clots. It is important to follow your doctor’s instructions closely when taking this medication. If you have any questions about your treatment, feel free to consult one of our telemedicine providers.

Names of Medication

US Brand Name: Pletal

Generic Name: Cilostazol

The generic name refers to the active ingredient, which remains consistent across all brands. It is listed in parentheses.

Pharmacologic Category

Phosphodiesterase-3 Inhibitor

Cilostazol Dosage

Cilostazol is prescribed for various conditions related to poor blood circulation. Below are the recommended doses for adults. Always consult your healthcare provider before making any changes to your dosage. For personalized advice, our telemedicine providers are available to assist you.

Cilostazol for Peripheral Artery Disease (PAD) and Intermittent Claudication

Dosage: 100 mg orally twice daily

Frequency: 30 minutes before or 2 hours after meals

Length of Treatment: Long-term, as directed by your doctor

Cilostazol for Coronary Artery Disease (CAD)

Dosage: 100 mg orally twice daily

Frequency: 30 minutes before or 2 hours after meals

Length of Treatment: As prescribed by your doctor

Cilostazol for Cerebrovascular Disease and Stroke Prevention

Dosage: 100 mg orally twice daily

Frequency: 30 minutes before or 2 hours after meals

Length of Treatment: Long-term, as directed by your doctor

Cilostazol for Atherosclerosis

Dosage: 100 mg orally twice daily

Frequency: 30 minutes before or 2 hours after meals

Length of Treatment: As prescribed by your doctor

Cilostazol for Raynaud’s Phenomenon

Dosage: 50 mg to 100 mg orally twice daily

Frequency: 30 minutes before or 2 hours after meals

Length of Treatment: As prescribed by your doctor

Cilostazol for Diabetic Neuropathy

Dosage: 100 mg orally twice daily

Frequency: 30 minutes before or 2 hours after meals

Length of Treatment: As prescribed by your doctor

Cilostazol for Chronic Venous Insufficiency

Dosage: 100 mg orally twice daily

Frequency: 30 minutes before or 2 hours after meals

Length of Treatment: As prescribed by your doctor

Cilostazol for Hypertension (High Blood Pressure)

Dosage: 100 mg orally twice daily

Frequency: 30 minutes before or 2 hours after meals

Length of Treatment: As prescribed by your doctor

Dosage Forms and Strengths

Tablet, Oral: 50 mg, 100 mg

Administration Instructions for Cilostazol

Take Cilostazol 30 minutes before or 2 hours after meals to ensure proper absorption. Avoid taking it with high-fat meals, as this can reduce its effectiveness. Always follow your healthcare provider’s instructions carefully. Do not stop taking Cilostazol without consulting your doctor, as this may worsen your condition. If you have any concerns, our telemedicine team is available to help manage your treatment plan.

Contraindications for Cilostazol

A contraindication is a condition where a medication should not be used because it may cause harm. If you have any of the following conditions, Cilostazol may not be safe for you. Always discuss your medical history with your healthcare provider before starting any new medication, including Cilostazol.

1. Heart failure: Cilostazol is contraindicated in patients with heart failure due to the increased risk of serious complications, including death, as it affects the heart’s ability to pump blood efficiently.
2. Allergy to Cilostazol: If you are allergic to Cilostazol or any of its ingredients, you should not take this medication. Allergic reactions may include rash, swelling, or difficulty breathing.
3. Bleeding disorders: Cilostazol can increase the risk of bleeding, making it unsuitable for individuals with bleeding disorders, such as hemophilia, or those at high risk for bleeding complications.
4. Severe kidney or liver disease: If you have severe kidney or liver disease, Cilostazol may not be processed properly, leading to increased side effects or toxicity.

Cilostazol Drug Interactions

Cilostazol can interact with other medications, increasing the risk of side effects or reducing the effectiveness of either drug. Inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements. Common medications that may interact with Cilostazol include:

1. Clopidogrel (Plavix): Taking Cilostazol with Clopidogrel can increase the risk of bleeding.
2. Aspirin: Combining Cilostazol with aspirin may also raise the risk of bleeding.
3. Ketoconazole (Nizoral): This antifungal medication can increase Cilostazol levels in your blood, potentially leading to more side effects.
4. Omeprazole (Prilosec): This acid reflux medication can raise Cilostazol levels, increasing the risk of side effects.
5. Warfarin (Coumadin): Taking Cilostazol with Warfarin can heighten the risk of bleeding complications.

Cilostazol in Pregnancy

Is it safe to take Cilostazol during pregnancy? The safety of Cilostazol during pregnancy has not been thoroughly studied. As a result, it is generally recommended to avoid using Cilostazol unless your healthcare provider determines that the potential benefits outweigh the risks. If you are pregnant or planning to become pregnant, it is important to consult your healthcare provider to discuss whether Cilostazol is appropriate for your situation.

Cilostazol while Breastfeeding

Is it safe to take Cilostazol while breastfeeding? There is limited information on whether Cilostazol passes into breast milk. Due to the lack of sufficient data, it is typically advised to avoid using Cilostazol while breastfeeding. If you are currently breastfeeding or planning to breastfeed, consult your healthcare provider to carefully weigh the potential risks and benefits.

Estimated Cost of Cilostazol Medication

The estimated cost of a 30-day supply of Cilostazol (100 mg tablets) without insurance ranges from $15 to $30 when using a GoodRx coupon. Prices may vary depending on the pharmacy. Be sure to explore available discounts or speak with one of our providers through telemedicine to discuss cost-saving options.

Possible Alternatives to Cilostazol

If Cilostazol is not suitable for you, there are other treatment options available. Always consult your healthcare provider before making any changes to your treatment plan. Below are some alternatives for conditions commonly treated with Cilostazol:

1. Peripheral artery disease (PAD): Lifestyle changes, such as quitting smoking, engaging in regular exercise, and adopting a healthy diet, can help manage PAD. Medications like statins or antiplatelet drugs (e.g., aspirin or clopidogrel) may also be recommended.
2. Intermittent claudication: In addition to Cilostazol, supervised exercise programs and medications like pentoxifylline may be considered. In more severe cases, surgical interventions may be necessary.
3. Coronary artery disease (CAD): Lifestyle modifications, including a heart-healthy diet and regular physical activity, along with medications such as beta-blockers, statins, or ACE inhibitors, may help manage CAD.
4. Cerebrovascular disease: Medications like aspirin or clopidogrel may help reduce the risk of stroke. Additionally, lifestyle changes, such as managing blood pressure and cholesterol levels, are crucial.
5. Atherosclerosis: Statins, lifestyle changes, and medications to control blood pressure and cholesterol are commonly used to manage atherosclerosis.
6. Raynaud’s phenomenon: Calcium channel blockers, such as nifedipine, may improve blood flow. Keeping hands and feet warm and managing stress can also help alleviate symptoms.
7. Diabetic neuropathy: Proper blood sugar management is essential. Medications like pregabalin (Lyrica) or duloxetine (Cymbalta) may be prescribed to relieve nerve pain.
8. Chronic venous insufficiency: Compression stockings, leg elevation, and regular exercise can be beneficial. In some cases, medications like diuretics or procedures to improve blood flow may be recommended.
9. Hypertension: Lifestyle changes, such as reducing salt intake, losing weight, and engaging in regular exercise, are key. Medications like ACE inhibitors, beta-blockers, or diuretics may also be prescribed.
10. Stroke prevention: Antiplatelet medications like aspirin or anticoagulants such as warfarin may be used. Managing risk factors like high blood pressure and cholesterol is also important.

Recent Updates on Cilostazol Research

Recent studies have explored the potential use of Cilostazol beyond its current indications. Some research suggests that Cilostazol may have neuroprotective effects, which could make it a potential treatment for conditions like Alzheimer’s disease or vascular dementia. However, further research is needed to confirm these findings. Additionally, ongoing studies are investigating the long-term safety and effectiveness of Cilostazol in preventing stroke recurrence in patients with a history of cerebrovascular disease. If you are interested in learning more about these developments, consider speaking with one of our providers through telemedicine to discuss the latest research and how it may apply to your treatment plan.

James Kingsley

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