Indapamide Medication: Uses, Dosage, Side Effects & Interactions

Summary of Key Points

Indapamide is a prescription medication used to treat high blood pressure (hypertension) and fluid retention (edema). It belongs to a class of drugs known as diuretics, which help the body eliminate excess salt and water. Indapamide is commonly prescribed for managing conditions such as heart failure and chronic kidney disease. Always consult your healthcare provider before starting or adjusting your Indapamide dosage.

Names of Medication

US Brand Name: Lozol

Generic Name: Indapamide

The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. In this case, Indapamide is the generic name.

Pharmacologic Category

Thiazide-like diuretic

Other medications in this category include hydrochlorothiazide and chlorthalidone. These drugs help reduce fluid buildup and lower blood pressure by increasing urine output. Indapamide is often compared to hydrochlorothiazide for its effectiveness in treating hypertension.

Indapamide Dosage

Indapamide is used to treat various conditions, and the dosage may vary depending on the specific condition being treated. Always follow your doctor’s instructions and consult with one of our telemedicine providers before making any changes to your Indapamide dosage.

Indapamide for High Blood Pressure (Hypertension)

Initial dose: 1.25 mg orally once daily

Maintenance dose: 2.5 mg orally once daily if needed after 4 weeks

Indapamide for Edema (Fluid Retention)

Initial dose: 2.5 mg orally once daily

Maintenance dose: 5 mg orally once daily if needed

Indapamide for Congestive Heart Failure

Initial dose: 2.5 mg orally once daily

Maintenance dose: 5 mg orally once daily if needed

Indapamide for Chronic Kidney Disease

Initial dose: 1.25 mg orally once daily

Maintenance dose: 2.5 mg orally once daily if needed

Indapamide for Cirrhosis

Initial dose: 2.5 mg orally once daily

Maintenance dose: 5 mg orally once daily if needed

Indapamide for Diabetes Insipidus

Initial dose: 2.5 mg orally once daily

Maintenance dose: 5 mg orally once daily if needed

Indapamide for Heart Disease and Stroke Prevention

Initial dose: 1.25 mg orally once daily

Maintenance dose: 2.5 mg orally once daily if needed

Indapamide for Peripheral Edema

Initial dose: 2.5 mg orally once daily

Maintenance dose: 5 mg orally once daily if needed

Indapamide for Nephrotic Syndrome

Initial dose: 2.5 mg orally once daily

Maintenance dose: 5 mg orally once daily if needed

Always follow your healthcare provider’s instructions. If you have any questions or concerns about your Indapamide dosage, schedule a telemedicine visit with one of our providers today.

Dosage Forms and Strengths

Indapamide is available in the following forms:

1. Tablet: 1.25 mg, 2.5 mg
2. Extended-release tablet: 1.5 mg

How to Take Indapamide Safely

Indapamide is typically taken once daily, preferably in the morning to avoid frequent urination at night. It can be taken with or without food. Swallow the tablet whole with a glass of water. Do not crush or chew the tablet. If you miss a dose, take it as soon as you remember, but skip it if it’s almost time for your next dose. Never double up on doses.

Indapamide Side Effects

Like all medications, Indapamide can cause side effects. It’s important to be aware of these and contact your healthcare provider if you experience any concerning symptoms.

Common Side Effects (affecting more than 1 in 10 people):

Frequent urination: This is expected as the medication helps remove excess fluid from your body.

Dizziness or lightheadedness: Especially when standing up quickly, due to lower blood pressure.

Less Common Side Effects (affecting 1 in 100 people):

Low potassium levels (hypokalemia): This can cause muscle weakness, cramps, or irregular heartbeats.

Fatigue: Feeling unusually tired or weak.

Rare Side Effects (affecting fewer than 1 in 1,000 people):

Severe allergic reactions: Rash, itching, swelling, or difficulty breathing. Seek immediate medical attention if this occurs.

Severe dehydration: Extreme thirst, dry mouth, or confusion. This may require medical treatment.

If you experience any of these side effects or have concerns about your Indapamide medication, please contact your healthcare provider immediately. You can also schedule a telemedicine appointment with one of our providers for further guidance.

Contraindications for Indapamide

A contraindication is a specific situation or condition where a particular medication should not be used because it could cause harm. If you have any of the following conditions, it is important to avoid taking Indapamide. Always consult with a healthcare provider before starting or stopping any medication.

Severe Kidney Disease: Indapamide is processed by the kidneys. If your kidneys are not functioning properly, taking Indapamide could lead to a dangerous buildup of the drug in your body, worsening kidney function.

Severe Liver Disease: In patients with liver disease, Indapamide can cause an imbalance of electrolytes, which may lead to a condition called hepatic encephalopathy (a decline in brain function due to liver disease).

Allergy to Sulfonamides: Indapamide is a sulfonamide-based drug. If you have a known allergy to sulfonamides, taking Indapamide could trigger a serious allergic reaction, including rash, swelling, or difficulty breathing.

Low Potassium Levels (Hypokalemia): Indapamide can lower potassium levels in the blood. If you already have low potassium, taking this medication could make the condition worse, leading to muscle weakness, irregular heartbeats, or other complications.

Pregnancy: Indapamide is generally not recommended during pregnancy due to potential risks to the developing fetus (see more details in the section below).

Drug to Drug Interactions

Indapamide can interact with other medications, potentially increasing side effects or reducing the effectiveness of either drug. It’s important to inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements. Below are some common medications that may interact with Indapamide:

1. Digoxin (Lanoxin): Indapamide can lower potassium levels, which increases the risk of digoxin toxicity. This may lead to irregular heartbeats or other heart-related issues.
2. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) (Ibuprofen, Naproxen): NSAIDs can reduce Indapamide’s effectiveness in lowering blood pressure and may increase the risk of kidney damage.
3. ACE Inhibitors (Lisinopril, Enalapril): Combining Indapamide with ACE inhibitors can raise the risk of dangerously low blood pressure or kidney complications.
4. Loop Diuretics (Furosemide, Bumetanide): Using Indapamide alongside other diuretics can lead to excessive fluid and electrolyte loss, increasing the risk of dehydration and imbalances.
5. Lithium: Indapamide can raise lithium levels in the blood, potentially leading to lithium toxicity, which may cause tremors, confusion, and kidney damage.

Indapamide in Pregnancy

Is it safe to take Indapamide during pregnancy?

Indapamide is generally not recommended during pregnancy. Although research on its effects in pregnant women is limited, diuretics like Indapamide can reduce blood flow to the placenta, which may affect the baby’s growth and development. If you are pregnant or planning to become pregnant, discuss your treatment options with your healthcare provider. They may suggest alternative medications that are safer during pregnancy.

Indapamide while Breastfeeding

Is it safe to take Indapamide while breastfeeding?

There is limited information on whether Indapamide passes into breast milk. However, as a diuretic, it may reduce milk production. If you are breastfeeding or planning to breastfeed, consult your healthcare provider about the potential risks and benefits of taking Indapamide. They may recommend a safer alternative for both you and your baby.

Estimated Cost of Indapamide Medication

The cost of a 30-day supply of Indapamide without insurance can vary depending on the pharmacy and location. However, using a GoodRX coupon, the price for a 30-day supply of Indapamide (2.5 mg) typically ranges from $4 to $15. Check GoodRX or other discount programs for the most up-to-date pricing and savings options.

Possible Alternatives to Indapamide

For some patients, alternative treatments or lifestyle changes may be more appropriate. Always discuss any changes to your treatment plan with a healthcare provider before making adjustments. Our telemedicine providers are available to help you explore these options.

1. Hypertension (High Blood Pressure): Alternatives include other blood pressure medications such as ACE inhibitors (Lisinopril), ARBs (Losartan), or calcium channel blockers (Amlodipine). Lifestyle changes like reducing salt intake, regular exercise, and weight loss can also help manage blood pressure.
2. Edema (Fluid Retention): Other diuretics like Furosemide (Lasix) or Spironolactone may be used. Reducing salt intake and elevating the legs can also help reduce swelling.
3. Congestive Heart Failure: Medications such as beta-blockers (Metoprolol), ACE inhibitors, or ARBs may be prescribed. Lifestyle changes like reducing fluid intake and daily weight monitoring can help manage symptoms.
4. Chronic Kidney Disease: ACE inhibitors or ARBs are often preferred for managing blood pressure in patients with kidney disease. Reducing protein intake and controlling blood sugar levels (if diabetic) can help slow the progression of kidney disease.
5. Cirrhosis: Diuretics like Spironolactone may be used to manage fluid retention. Avoiding alcohol and following a low-sodium diet are important lifestyle changes for managing cirrhosis.
6. Diabetes Insipidus: Desmopressin is the preferred treatment for central diabetes insipidus. Managing fluid intake is also crucial.
7. Heart Disease: Beta-blockers, statins (Atorvastatin), and lifestyle changes such as quitting smoking, eating a heart-healthy diet, and exercising regularly can help manage heart disease.
8. Stroke Prevention: Antiplatelet medications like Aspirin or anticoagulants like Warfarin may be prescribed. Managing blood pressure and cholesterol levels through diet, exercise, and medication is also important.
9. Peripheral Edema: Other diuretics like Furosemide or Spironolactone may be used. Elevating the legs and wearing compression stockings can help reduce swelling.
10. Nephrotic Syndrome: Treatment may include corticosteroids or immunosuppressive drugs. Managing blood pressure and reducing salt intake are also important steps in managing this condition.

Recent Updates on Indapamide Research

Recent studies have focused on the long-term effects of Indapamide in managing hypertension and its potential benefits in reducing cardiovascular events. A 2021 study published in the Journal of Hypertension found that Indapamide, when used as part of combination therapy, significantly reduced the risk of heart attacks and strokes in patients with high blood pressure. Ongoing research is also exploring the use of Indapamide in patients with chronic kidney disease, with early results suggesting it may help slow kidney damage when combined with other medications.

As new research emerges, staying informed about the latest findings is important. If you have questions about how this research may affect your treatment plan, our telemedicine providers are available to discuss your options and provide personalized recommendations.

James Kingsley

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