Talazoparib: A Comprehensive Medication Profile

Summary or Key Points

Talazoparib, sold under the brand name Talzenna, is an oral medication used to treat certain types of breast cancer in adults. It functions by inhibiting specific enzymes that help repair damaged DNA in cancer cells, leading to their death. This article provides an in-depth look at Talazoparib, including dosing, potential side effects, interactions, and more.

Names of Medication

Brand Name: Talzenna

Generic Name: Talazoparib

The term ‘generic name’ refers to the chemical or official name of the drug that isn’t subject to being trademarked, unlike the brand name. The generic name is given in parentheses.

Pharmacologic Category

Talazoparib belongs to a group of drugs known as poly (ADP-ribose) polymerase (PARP) inhibitors. Other drugs in this category include Olaparib (Lynparza), Niraparib (Zejula), and Rucaparib (Rubraca).

Dosing

Breast Cancer:
The usual adult dose of Talazoparib is 1 mg taken orally once daily. The duration of treatment depends on the patient’s response and tolerance to the medication. Remember to consult your doctor or one of our telemedicine providers before adjusting your dose.

Dosage Forms and Strengths

Talazoparib comes in a capsule form, available in one strength: 1 mg.

Administration Instructions

Talazoparib is taken by mouth, with or without food. If you vomit after taking a dose, do not take an extra dose; take your next dose at your regular scheduled time.

Adverse Reactions and Side Effects

• Fatigue: Feeling unusually tired or weak is common, affecting more than 1 in 10 people.
• Decreased appetite: Some patients may experience a decreased appetite.
• Anemia: Low levels of red blood cells can occur, leading to tiredness and breathlessness.
• Neutropenia: A decrease in the number of white blood cells, which can make you more prone to infections.
• Headache: Some patients may experience headaches.

Contraindications

A contraindication is a specific situation in which a drug, procedure, or surgery should not be used because it may be harmful to the patient. Talazoparib should not be used in patients who are allergic to it or any of its components. It should also not be used in patients who have severe kidney impairment, as this can lead to increased levels of the drug in the body.

Drug to Drug Interactions

Talazoparib can interact with the following medications:

• Phenytoin (Dilantin, Phenytek)
• Rifampin (Rifadin, Rimactane)
• St. John’s Wort

Talazoparib in Pregnancy

Talazoparib may cause harm to an unborn baby if used during pregnancy. It is recommended to use effective contraception during treatment and for at least 7 months after the final dose.

Talazoparib while Breastfeeding

It’s not known whether Talazoparib passes into breast milk. Due to the potential for serious adverse reactions in a breastfed child, women should not breastfeed during treatment and for at least 1 month after the last dose.

Estimated Cost of Medication

The estimated cost of a 30-day supply of Talazoparib without insurance, using a GoodRx coupon, is approximately $12,400. Please note that prices may vary based on your location and the pharmacy you visit.

Possible Alternatives

For breast cancer, possible alternative treatments include other PARP inhibitors like Olaparib (Lynparza), Niraparib (Zejula), and Rucaparib (Rubraca). Additionally, chemotherapy, hormone therapy, and targeted therapy might be appropriate. Lifestyle changes such as maintaining a healthy diet, regular exercise, and cessation of smoking might help. Always discuss these alternatives with your healthcare provider or one of our telemedicine providers before making any changes to your treatment plan.

Recent Updates on Talazoparib Research

Recent research indicates Talazoparib’s effectiveness in treating certain types of prostate cancer, expanding its potential uses. Another study is investigating its use alongside immunotherapy for treating advanced solid tumors. However, these studies are ongoing, and their results should not influence current treatment without healthcare provider’s advice.

Remember, this information is intended to supplement, not substitute for, the expertise and judgement of your healthcare provider. Always consult your healthcare provider or one of our telemedicine providers to ensure the information displayed on this page applies to your personal circumstances.

Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.