Medication Profile: Mesalamine
Summary or Key Points
Mesalamine, a key medication in the management of inflammatory bowel disease, is used primarily to treat conditions such as ulcerative colitis and Crohn’s disease. It works by reducing inflammation in the gut, helping to alleviate symptoms and enhance patient’s quality of life. Always consult with your healthcare provider or schedule a telemedicine appointment with us for dosing instructions and any concerns you may have about this medication.
Names of Medication
US Brand Name: Asacol, Lialda, Pentasa, Delzicol (Mesalamine).
Generic names refer to the active ingredient found in a medication. They are placed in parentheses to inform the reader about the standard non-proprietary name for the drug.
Pharmacologic Category
Mesalamine falls under the category of aminosalicylates, which also includes medications such as Sulfasalazine and Balsalazide.
Dosing
Mesalamine is used to treat the following conditions:
- Ulcerative Colitis: The typical dose is 1.2 grams to 4.8 grams per day in divided doses, depending on disease severity and the specific product used. This medication should be taken regularly for optimal results.
- Crohn’s Disease: The recommended dose varies between 2 grams to 4 grams per day in divided doses, depending on disease severity. Continuation of therapy is usually necessary to maintain remission.
Please remember, your personal dose may differ based on your condition and overall health. Always consult your healthcare provider or consider scheduling a telemedicine appointment with us for personalized dosing instructions.
Dosage Forms and Strengths
Mesalamine is available in the following forms and strengths:
- Delayed-Release Tablets: 1.2 grams
- Extended-Release Capsules: 0.375 grams
- Controlled-Release Capsules: 0.25 grams, 0.5 grams
- Gastro-resistant Tablets: 400mg, 800mg
Administration Instructions
Mesalamine should be taken as directed by your healthcare provider. It is usually taken with a full glass of water. The tablets or capsules should not be crushed, chewed, or broken. They should be swallowed whole. If you have any questions about how to take this medication, feel free to schedule a telemedicine appointment with our healthcare providers for guidance.
Adverse Reactions and Side Effects
While Mesalamine is generally well-tolerated, it may cause some side effects. These may include:
- Common: Headache, abdominal pain, and upset stomach.
- Less Common: Rash, fatigue, and back pain.
- Rare: Pancreatitis, liver and kidney problems, and allergic reactions.
If you notice any of these symptoms or have any concerns, consult your healthcare provider or schedule an appointment with us through telemedicine immediately.
Contraindications
Contraindications refer to conditions or factors that make a particular treatment or procedure potentially inadvisable. Mesalamine should not be used in the following situations:
- Allergy to Mesalamine or salicylates: Patients with known hypersensitivity to Mesalamine or other salicylates should avoid this medication due to the risk of severe allergic reactions.
- Severe kidney disease: Mesalamine is primarily excreted through the kidneys, so severe kidney disease could lead to drug accumulation and increased risk of adverse effects.
- Severe liver disease: Liver disease can affect the metabolism of Mesalamine, potentially leading to higher than intended levels of the drug in the body.
Always discuss your health history with your healthcare provider or consider scheduling a telemedicine appointment with us before starting new medication.
Drug to Drug Interactions
Medications that may interact with Mesalamine include:
- Nephrotoxic agents such as Ibuprofen (Advil), Naproxen (Aleve), or Acetaminophen (Tylenol).
- Anticoagulants such as Warfarin (Coumadin).
Mesalamine in Pregnancy
Mesalamine is generally considered safe to use during pregnancy. It is categorized as Pregnancy Category B, indicating no evidence of harm to the fetus in animal studies. However, always consult your healthcare provider or reach out to us through telemedicine before starting or continuing any medication during pregnancy.
Mesalamine while Breastfeeding
Mesalamine is excreted in breast milk in small quantities. It is generally considered safe to use while breastfeeding, but always consult with your healthcare provider or consider a telemedicine appointment with us if you have any concerns.
Estimated Cost of Medication
The estimated cost of a 30-day supply of Mesalamine, using a GoodRx coupon, is approximately $230, but prices can vary. Always consult your pharmacy for exact pricing.
Possible Alternatives
Possible alternative treatments or lifestyle changes that may help in managing Ulcerative Colitis and Crohn’s Disease include:
- Dietary Changes: A diet high in fiber and low in fat and processed foods may help manage symptoms.
- Other Medications: Other aminosalicylates, corticosteroids, and biologics may also be considered.
Before making any changes to your treatment plan, discuss these alternatives with your healthcare provider or consider scheduling a telemedicine appointment with us.
Recent Updates on Mesalamine Research
Recent research indicates that Mesalamine may have a role beyond reducing inflammation in the gut. Studies suggest that it could also have a positive effect on the gut microbiome, which could further aid in the management of Ulcerative Colitis and Crohn’s Disease. As always, consult with your healthcare provider or reach out to us through telemedicine for the most current information on this medication and your treatment plan.
Brief Legal Disclaimer
This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.
Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.