Ursodiol: An Overview

Summary or Key Points

Ursodiol, also known as ursodeoxycholic acid, is a medication primarily used to treat certain liver diseases and gallstones. It can provide relief by reducing the production of cholesterol in your liver and helping your body to absorb and dissolve gallstones. As with any medication, it is essential to consult with your healthcare provider or one of our trusted telemedicine providers before starting or adjusting a dose of Ursodiol.

Names of Medication

US Brand Name: Actigall (Ursodiol)

A ‘generic name’ is the official medical name for the active ingredient in a medication. It is standardized and used universally by healthcare professionals. The generic name is listed in parenthesis.

Pharmacologic Category

Ursodiol belongs to a category of medications known as bile acids. Other medications in this group include Cholic Acid and Chenodiol.

Dosing

Ursodiol is used to treat various conditions, and the dose may vary accordingly. Always consult with your healthcare provider or our telemedicine professionals before adjusting your dose. Indications and typical dosing are as follows:

• Gallstones: 8-10 mg/kg/day in 2-3 divided doses, typically until the gallstones are dissolved.
• Primary Biliary Cirrhosis (PBC): 13-15 mg/kg/day in 2-3 divided doses, treatment continues indefinitely.
• Primary Sclerosing Cholangitis (PSC): Dosing varies and should be individualized under the guidance of a healthcare provider.

Dosage Forms and Strengths

Ursodiol is available in the following dosage forms and strengths:

• Tablets: 250mg and 500mg
• Capsules: 300mg

Administration Instructions

Ursodiol is typically taken orally with food to improve absorption. If taking multiple doses per day, they should be distributed evenly. If a dose is missed, take it as soon as possible, unless it is near the time of the next dose. Never double up on doses. Consult with your healthcare provider or one of our available telemedicine professionals for any questions about administration.

Adverse Reactions and Side Effects

While Ursodiol is generally well-tolerated, some patients may experience side effects. As with any medication, if you experience any symptoms or reactions that concern you, consult with your healthcare provider or one of our telemedicine professionals immediately. Common side effects may include:

• Diarrhea: (Common) loose or watery stools.
• Upset stomach or nausea: (Less common) may include a general feeling of discomfort or illness.
• Rash: (Rare) may present as red, itchy, or irritated skin.

Adverse Reactions and Side Effects (continued)

While the above side effects are more common, some individuals may experience other side effects. It is important to note that everyone’s body responds differently to medications, so if you have any concerns or experience any unusual symptoms, always contact a healthcare provider immediately. Less common side effects can include:

• Back pain: (Less common) discomfort or pain located in the back region.
• Constipation: (Less common) difficult or infrequent bowel movements.
• 
  : (Less common) a continuous pain in the head.
• Dizziness: (Less common) a sensation of unsteadiness, imbalance or light-headedness.
• Indigestion: (Less common) discomfort or pain in the stomach associated with difficulty in digesting food.

Summary

Ursodiol can be a beneficial medication for those suffering from gallstones or certain liver diseases. However, as with all medications, it’s important to understand the dosing instructions, potential side effects, and to have ongoing conversations with your healthcare provider. At our telemedicine practice, we’re committed to providing our patients with this level of comprehensive care and advice.

Remember, never hesitate to consult one of our telemedicine providers if you have any questions or concerns about your medication. Our mission is to ensure your healthcare experience is convenient, secure, and personalized to your needs.

Contraindications

A ‘contraindication’ is a situation in which a drug should not be used, because it may be harmful to the patient. Ursodiol should not be used in the following situations:

• Allergy to Ursodiol or bile acids: If you have had an allergic reaction to Ursodiol or other bile acids, taking Ursodiol could trigger another allergic reaction.
• Non-functioning gallbladder: Ursodiol works by helping the gallbladder dissolve gallstones, so it is not effective if the gallbladder is not working properly or has been removed.
• Gallstones with calcification: Ursodiol is not effective at dissolving calcified gallstones, and could potentially lead to complications.

Drug to Drug Interactions

Ursodiol may interact with other medications, which could change how your medications work or increase your risk for side effects. Some medications that could interact with Ursodiol include:

• Cholestyramine (Questran)
• Colestipol (Colestid)
• Estrogens (Premarin, Estrace)
• Oral contraceptives containing estrogens

Ursodiol in Pregnancy

There is limited data on the use of Ursodiol in pregnancy, but no definitive evidence that it is harmful. If you are pregnant or planning to become pregnant, please consult your healthcare provider or one of our telemedicine professionals for advice.

Ursodiol while Breastfeeding

It is not known if Ursodiol is excreted into breast milk. If you are breastfeeding or planning to breastfeed, please consult your healthcare provider or one of our telemedicine professionals for advice.

Estimated Cost of Medication

The estimated cost of a 30-day supply of Ursodiol without insurance, using a GoodRX coupon, is approximately $30 to $80. Prices may vary depending on pharmacy location and dosage required.

Possible Alternatives

For each condition treated by Ursodiol, there may be alternative treatments or lifestyle changes that could help. Please discuss these with your healthcare provider or one of our telemedicine professionals before making any changes to your treatment plan.

• Gallstones: Alternatives may include watchful waiting for asymptomatic stones, surgery for symptomatic stones, and dietary modifications.
• Primary Biliary Cirrhosis (PBC): Other treatment options include obeticholic acid, fibrates, or liver transplantation in severe cases.
• Primary Sclerosing Cholangitis (PSC): There are currently limited medical therapies available. Liver transplantation may be an option in severe cases.

Recent Updates on Ursodiol Research

Current research on Ursodiol is examining its effectiveness in treating a wider range of liver conditions, such as Non-Alcoholic Fatty Liver Disease (NAFLD) and liver damage associated with Cystic Fibrosis. Another ongoing study is investigating the impact of Ursodiol on the progression of Alzheimer’s Disease, as there is some evidence that it could have a protective effect on neurons. As always, consult with your healthcare provider or one of our telemedicine professionals for the most up-to-date information.

Brief Legal Disclaimer

This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.
Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.