Natalizumab Medication Profile

Names of Medication

US Brand Name: Tysabri (Natalizumab)

Pharmacologic Category

Natalizumab belongs to the class of medications called monoclonal antibodies.

Dosing

Natalizumab is used to treat the following conditions in adults:

Multiple Sclerosis (MS)

: The standard dose for treating MS is 300 mg of Natalizumab, administered intravenously every 4 weeks. The length of treatment depends on the individual patient and the severity of the disease.

Crohn’s Disease

: For treating Crohn’s Disease, the dose is also 300 mg of Natalizumab, administered intravenously every 4 weeks. The duration of treatment varies based on patient response and disease severity.
Always consult your healthcare provider before making any changes to your medication regimen.

Dosage Forms and Strengths

Natalizumab is available in the following form and strength: – Injection: 300 mg/15 mL single-dose vial

Administration Instructions

Natalizumab is administered by a healthcare professional as an intravenous infusion over approximately one hour. It is given once every 4 weeks.

Adverse Reactions and Side Effects

Some side effects and adverse reactions that may occur when taking Natalizumab include:

Headache (common)

: Natalizumab may cause headaches in some patients. These headaches are typically mild and may be related to the drug’s effects on the immune system.

Fatigue (common)

: Fatigue is another common side effect of Natalizumab. This could be due to the body’s response to the medication or the underlying disease being treated.

Infusion-related reactions (less common)

: Some patients may experience reactions during or shortly after the infusion, such as itching, rash, fever, or difficulty breathing. Inform your healthcare provider if you experience any of these symptoms during or after your infusion.

Progressive Multifocal Leukoencephalopathy (PML) (rare)

: Natalizumab has been associated with a rare, but serious, viral infection of the brain called PML. PML can cause severe disability or death. The risk of PML increases with the duration of treatment and previous use of immunosuppressant medications.

Contraindications to Taking Natalizumab

A contraindication refers to a situation where a medication should not be used because it may be harmful. Natalizumab is contraindicated in:

Patients with a history of Progressive Multifocal Leukoencephalopathy (PML)

: Due to the increased risk of PML in patients treated with Natalizumab, it should not be used in patients with a history of this condition.

Patients with severe active infections

: Natalizumab may further weaken the immune system, increasing the risk of serious infections. It should not be used in patients with severe active infections until these conditions are adequately treated.

Patients with known hypersensitivity to Natalizumab or any of its components

: Patients with known hypersensitivity reactions to Natalizumab or any of its ingredients should avoid this medication.

Drug to Drug Interactions

While Natalizumab has no significant drug-drug interactions known, it is important to inform your healthcare provider of all medications you are currently taking, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Natalizumab in Pregnancy

Natalizumab is classified as a Category C medication by the FDA, which means it could potentially cause harm to an unborn baby. If you are pregnant, planning to become pregnant, or if you become pregnant while taking Natalizumab, immediately inform your healthcare provider.

Natalizumab while Breastfeeding

It is not known whether Natalizumab passes into breast milk. Therefore, breastfeeding mothers should discuss with their healthcare provider whether to discontinue breastfeeding or the medication, considering the importance of the drug to the mother’s health.

Estimated Cost of Medication

The estimated cost of a 30-day supply of Natalizumab can vary greatly based on the pharmacy and location. As of 2023, without insurance and with the use of a GoodRx coupon, the cost is around $7,000-$8,000 per infusion. Remember, this is an estimate and prices may vary.

Legal Disclaimer

This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.
Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.