Brodalumab Treatment: Uses, Dosing, Side Effects, and Costs

Summary of Key Points

Brodalumab is a prescription medication used to treat several inflammatory conditions, including psoriasis and psoriatic arthritis. It works by targeting specific proteins in the immune system that contribute to inflammation. Brodalumab is typically administered as an injection under the skin. While it is effective, it may cause side effects, so it’s important to follow your doctor’s instructions closely. Always consult a healthcare provider before starting or adjusting your Brodalumab treatment.

Names of Medication

US Brand Name: Siliq (Brodalumab)

The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. In this case, Brodalumab is the generic name.

Pharmacologic Category

Brodalumab belongs to a class of medications known as Interleukin-17 (IL-17) Receptor Antagonists.

Other medications in this category include Secukinumab (Cosentyx) and Ixekizumab (Taltz), which are also used to treat psoriasis and related conditions.

Dosing for Brodalumab Treatment

Brodalumab is prescribed for various conditions in adults, and the dosing schedule may differ depending on the specific condition being treated. Always consult your doctor before making any changes to your dose. You can also schedule a telemedicine appointment with one of our providers for personalized advice on Brodalumab treatment.

Brodalumab for Plaque Psoriasis

Initial Dose: 210 mg injected under the skin at weeks 0, 1, and 2.

Maintenance Dose: 210 mg every 2 weeks thereafter.

Brodalumab for Psoriatic Arthritis

Initial Dose: 210 mg injected under the skin at weeks 0, 1, and 2.

Maintenance Dose: 210 mg every 2 weeks thereafter.

Brodalumab for Ankylosing Spondylitis

Initial Dose: 210 mg injected under the skin at weeks 0, 1, and 2.

Maintenance Dose: 210 mg every 2 weeks thereafter.

Brodalumab for Atopic Dermatitis

Initial Dose: 210 mg injected under the skin at weeks 0, 1, and 2.

Maintenance Dose: 210 mg every 2 weeks thereafter.

Brodalumab for Hidradenitis Suppurativa

Initial Dose: 210 mg injected under the skin at weeks 0, 1, and 2.

Maintenance Dose: 210 mg every 2 weeks thereafter.

Brodalumab for Crohn’s Disease

Initial Dose: 210 mg injected under the skin at weeks 0, 1, and 2.

Maintenance Dose: 210 mg every 2 weeks thereafter.

Brodalumab for Ulcerative Colitis

Initial Dose: 210 mg injected under the skin at weeks 0, 1, and 2.

Maintenance Dose: 210 mg every 2 weeks thereafter.

Brodalumab for Rheumatoid Arthritis

Initial Dose: 210 mg injected under the skin at weeks 0, 1, and 2.

Maintenance Dose: 210 mg every 2 weeks thereafter.

Brodalumab for Multiple Sclerosis

Initial Dose: 210 mg injected under the skin at weeks 0, 1, and 2.

Maintenance Dose: 210 mg every 2 weeks thereafter.

Brodalumab for Systemic Lupus Erythematosus

Initial Dose: 210 mg injected under the skin at weeks 0, 1, and 2.

Maintenance Dose: 210 mg every 2 weeks thereafter.

Dosage Forms and Strengths

Brodalumab is available in the following forms:

1. 210 mg/1.5 mL solution in a single-dose prefilled syringe
2. 210 mg/1.5 mL solution in a single-dose autoinjector

Contraindications for Brodalumab

A contraindication is a specific condition where a treatment or medication should not be used because it may be harmful. Before starting Brodalumab, discuss any health conditions or medications with your healthcare provider to ensure it is safe for you.

Common Contraindications for Brodalumab

Active or untreated infections: Brodalumab can weaken the immune system, making it harder to fight infections. If you have an active infection, taking Brodalumab could worsen it.

History of Crohn’s disease: Brodalumab has been associated with worsening Crohn’s disease, a type of inflammatory bowel disease. If you have a history of Crohn’s disease, this medication may not be suitable for you.

Suicidal thoughts or behavior: Brodalumab has been linked to an increased risk of suicidal thoughts and behavior. If you have a history of depression or suicidal ideation, your healthcare provider may recommend an alternative treatment.

Allergic reactions to Brodalumab or its ingredients: If you have had an allergic reaction to Brodalumab or any of its components, you should not take this medication.

Drug-to-Drug Interactions

It is important to inform your healthcare provider about all medications you are currently taking, including prescription drugs, over-the-counter medications, and supplements. Some drugs may interact with Brodalumab, potentially increasing side effects or reducing the treatment’s effectiveness.

Medications That May Interact with Brodalumab

Live vaccines: Live vaccines (such as the MMR vaccine) should not be administered while taking Brodalumab, as it can weaken the immune system and increase the risk of infection from the vaccine.

Other immunosuppressants: Medications like methotrexate (Trexall) or cyclosporine (Neoral) may increase the risk of infections when taken with Brodalumab.

TNF inhibitors: Drugs such as adalimumab (Humira) or etanercept (Enbrel) may increase the risk of serious infections when used in combination with Brodalumab.

Brodalumab in Pregnancy

Is it safe to take Brodalumab during pregnancy?

The safety of Brodalumab during pregnancy has not been fully established. There is limited information on its effects in pregnant women and their unborn babies. While animal studies have not shown direct harm to the fetus, there is a lack of human studies to confirm these findings. If you are pregnant or planning to become pregnant, it is important to discuss the potential risks and benefits of Brodalumab with your healthcare provider. They may recommend alternative treatments during pregnancy to ensure the best outcome for both you and your baby.

Brodalumab while Breastfeeding

Is it safe to take Brodalumab while breastfeeding?

It is currently unknown whether Brodalumab passes into breast milk. Due to the potential risk of serious side effects in a nursing infant, it is essential to consult your healthcare provider before using this medication while breastfeeding. Your provider will help you carefully weigh the risks and benefits of continuing Brodalumab or breastfeeding, and guide you in making the best decision for your situation.

Estimated Cost of Brodalumab

The cost of Brodalumab can vary depending on your location and pharmacy. Without insurance, the estimated price for a 30-day supply using a GoodRx coupon ranges from approximately $5,000 to $6,000. To find the best available price, check with your pharmacy or consider using a discount program like GoodRx.

Possible Alternatives to Brodalumab

If Brodalumab is not the right treatment for you, there are several alternative therapies and lifestyle changes that may help manage your condition. Always consult with your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to discuss these options in more detail.

Psoriasis

1. Other biologic medications, such as adalimumab (Humira) or ustekinumab (Stelara)
2. Topical treatments, including corticosteroids or vitamin D analogs
3. Phototherapy (light therapy)
4. Stress management and maintaining a healthy diet

Psoriatic Arthritis

1. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil) or naproxen (Aleve)
2. Other biologics, including secukinumab (Cosentyx) or etanercept (Enbrel)
3. Physical therapy and regular exercise

Ankylosing Spondylitis

1. TNF inhibitors, such as infliximab (Remicade) or adalimumab (Humira)
2. Physical therapy and stretching exercises
3. NSAIDs for pain relief

Atopic Dermatitis

1. Topical corticosteroids or calcineurin inhibitors
2. Dupilumab (Dupixent), another biologic medication
3. Regular moisturizing and avoiding known triggers

Hidradenitis Suppurativa

1. Antibiotics, such as clindamycin or rifampin
2. Other biologics, including adalimumab (Humira)
3. Weight management and smoking cessation

Crohn’s Disease

1. TNF inhibitors, such as infliximab (Remicade) or adalimumab (Humira)
2. Immunomodulators, such as azathioprine (Imuran)
3. Dietary changes and stress management

Ulcerative Colitis

1. Aminosalicylates, such as mesalamine (Asacol)
2. Biologics, including vedolizumab (Entyvio)
3. Dietary adjustments and regular exercise

Rheumatoid Arthritis

1. DMARDs, such as methotrexate (Trexall) or sulfasalazine (Azulfidine)
2. Biologics, including tocilizumab (Actemra) or abatacept (Orencia)
3. Physical therapy and joint-friendly exercises

Multiple Sclerosis

1. Immunomodulatory drugs, such as interferon beta (Avonex) or glatiramer acetate (Copaxone)
2. Physical therapy and regular exercise
3. Managing stress and ensuring adequate rest

Systemic Lupus Erythematosus

1. Hydroxychloroquine (Plaquenil) or corticosteroids
2. Biologics, such as belimumab (Benlysta)
3. Sun protection and stress management

Recent Updates on Brodalumab Research

Recent studies continue to explore Brodalumab’s effectiveness in treating moderate to severe plaque psoriasis. Some research suggests that it may provide faster and more sustained skin clearance compared to other biologics. Additionally, ongoing studies are investigating its potential use in other inflammatory conditions, such as psoriatic arthritis and hidradenitis suppurativa. However, more research is needed to confirm its long-term safety and efficacy in these conditions. If you are interested in learning more about the latest research on Brodalumab or have questions about whether this medication is right for you, consider scheduling a telemedicine appointment with one of our providers.

James Kingsley

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