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Glycopyrrolate: Uses, Dosage, and Side Effects Overview
Summary of Key Points
Glycopyrrolate is a prescription medication used to manage a variety of conditions, including chronic obstructive pulmonary disease (COPD), peptic ulcer disease, hyperhidrosis (excessive sweating), and more. It works by reducing bodily secretions such as saliva, sweat, and stomach acid. Glycopyrrolate is available in different forms and strengths, with dosing tailored to the specific condition being treated. Always consult your healthcare provider before making any changes to your dosage.
Names of Glycopyrrolate Medication
US Brand Name: Robinul (Glycopyrrolate)
US Brand Name: Cuvposa (Glycopyrrolate)
US Brand Name: Seebri Neohaler (Glycopyrrolate)
The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. The generic name is listed in parentheses.
Pharmacologic Category of Glycopyrrolate
Anticholinergic Agent
Antispasmodic Agent
Glycopyrrolate Dosage
Glycopyrrolate is prescribed for various conditions, with the dosage depending on the specific condition being treated. Always follow your doctor’s instructions and consult them before making any changes to your dose. You can also schedule a telemedicine appointment with one of our providers for personalized advice.
Glycopyrrolate for Chronic Obstructive Pulmonary Disease (COPD)
Inhalation (Seebri Neohaler): 15.6 mcg inhaled twice daily.
Glycopyrrolate for Peptic Ulcer Disease
Oral (Robinul): 1 mg taken 2 to 3 times daily, with a maximum dose of 8 mg per day.
Glycopyrrolate for Hyperhidrosis (Excessive Sweating)
Oral (Robinul): 1 mg once or twice daily, adjusted based on response.
Glycopyrrolate for Salivary Gland Hypersecretion
Oral (Cuvposa): 0.02 mg/kg to 0.1 mg/kg three times daily, based on weight and response.
Glycopyrrolate as an Anesthesia Adjunct
Intravenous (IV): 0.004 mg/kg administered before surgery to reduce secretions.
Glycopyrrolate for Irritable Bowel Syndrome (IBS)
Oral (Robinul): 1 mg taken 2 to 3 times daily, adjusted based on symptoms.
Glycopyrrolate for Motion Sickness
Oral (Robinul): 1 mg taken 30 minutes before travel, repeated every 6 hours as needed.
Glycopyrrolate for Overactive Bladder
Oral (Robinul): 1 mg taken twice daily.
Glycopyrrolate for Parkinson’s Disease (to reduce drooling)
Oral (Robinul): 1 mg taken 2 to 3 times daily.
Glycopyrrolate for Cystic Fibrosis (to reduce excessive secretions)
Oral (Robinul): 1 mg taken 2 to 3 times daily.
Dosage Forms and Strengths of Glycopyrrolate
Tablets: 1 mg, 2 mg
Oral Solution (Cuvposa): 1 mg/5 mL
Inhalation Powder (Seebri Neohaler): 15.6 mcg per capsule
Injectable Solution: 0.2 mg/mL
Administration Instructions for Glycopyrrolate
Take Glycopyrrolate exactly as prescribed by your healthcare provider. Tablets and oral solutions can be taken with or without food. For inhalation, use the Seebri Neohaler device as directed. If using the injectable form, it will be administered by a healthcare professional. Do not crush or chew tablets unless instructed by your doctor. If you miss a dose, take it as soon as you remember unless it’s close to your next dose. In that case, skip the missed dose and continue with your regular schedule.
Glycopyrrolate Side Effects and Adverse Reactions
Like all medications, Glycopyrrolate may cause side effects. Not everyone will experience these, but it’s important to be aware of potential reactions. If you experience any severe side effects, contact your healthcare provider immediately or seek emergency care.
Common (1-10%): Dry mouth, constipation, blurred vision, difficulty urinating.
Less Common (0.1-1%): Drowsiness, dizziness, headache, nausea.
Rare (<0.1%): Severe allergic reactions, difficulty breathing, rapid heartbeat, confusion.
Contraindications for Glycopyrrolate
A contraindication is a specific situation or condition where a medication should not be used because it may cause harm. If you have any of the following conditions, Glycopyrrolate may not be safe for you. Always consult your healthcare provider before starting any new medication. If you have concerns, you can schedule a telemedicine appointment with one of our providers.
Glaucoma: Glycopyrrolate can increase eye pressure, worsening glaucoma.
Myasthenia Gravis: This medication can exacerbate muscle weakness in patients with this condition.
Urinary Retention: Glycopyrrolate can make urination more difficult, so it is not recommended for those with bladder-emptying issues.
Severe Ulcerative Colitis: Glycopyrrolate can slow intestinal movement, worsening symptoms in patients with this condition.
Tachycardia (fast heart rate): Glycopyrrolate may increase heart rate, which can be dangerous for those with an already elevated heart rate.
Obstructive gastrointestinal diseases: This medication may worsen blockages in the digestive system by slowing food movement through the intestines.
Drug-to-Drug Interactions with Glycopyrrolate
Glycopyrrolate can interact with other medications, increasing the risk of side effects or reducing the effectiveness of either drug. Here are some medications that may interact with Glycopyrrolate:
Anticholinergic medications: These include drugs like Benztropine (Cogentin) or Trihexyphenidyl (Artane). Taking these with Glycopyrrolate can increase the risk of side effects such as dry mouth, constipation, and difficulty urinating.
Potassium supplements: Glycopyrrolate can slow digestive movement, increasing the risk of irritation from potassium supplements.
Opioid pain medications: Drugs such as Oxycodone (OxyContin) or Hydrocodone (Vicodin) can also slow the digestive system, increasing the risk of constipation when taken with Glycopyrrolate.
Antihistamines: Medications like Diphenhydramine (Benadryl) or Cetirizine (Zyrtec) can enhance Glycopyrrolate’s drying effects, leading to excessive dryness in the mouth, eyes, and skin.
Medications for Parkinson’s disease: Drugs like Levodopa (Sinemet) may interact with Glycopyrrolate, potentially worsening side effects such as confusion or hallucinations.
Glycopyrrolate in Pregnancy
Is it safe to take Glycopyrrolate during pregnancy?
There is limited information regarding the safety of Glycopyrrolate during pregnancy. While animal studies have not shown harm to the fetus, there are no well-controlled studies in pregnant women. As a result, Glycopyrrolate should only be used during pregnancy if the potential benefits outweigh the risks. If you are pregnant or planning to become pregnant, it is important to discuss this with your healthcare provider. You can also schedule a telemedicine appointment with one of our providers to review your treatment options.
Glycopyrrolate While Breastfeeding
Is it safe to take Glycopyrrolate while breastfeeding?
There is no definitive evidence on whether Glycopyrrolate passes into breast milk. However, because Glycopyrrolate can reduce bodily secretions, it may potentially decrease milk production. If you are breastfeeding or planning to breastfeed, consult your healthcare provider before starting Glycopyrrolate. You can also connect with one of our providers through telemedicine to discuss your options.
Estimated Cost of Glycopyrrolate Medication
The cost of a 30-day supply of Glycopyrrolate without insurance can vary. With a GoodRX coupon, the price typically ranges from $20 to $40 for a 30-day supply, depending on the dosage and the pharmacy. Prices may fluctuate, so it’s a good idea to check with your local pharmacy or use a coupon service like GoodRX to find the best available price.
Possible Alternatives to Glycopyrrolate
If Glycopyrrolate is not the right option for you, there are alternative treatments and lifestyle changes that may help manage your condition. Always consult your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to explore your options.
Alternatives for Chronic Obstructive Pulmonary Disease (COPD)
Alternatives include inhaled bronchodilators such as Albuterol (ProAir, Ventolin) or Tiotropium (Spiriva). Pulmonary rehabilitation and quitting smoking are also crucial lifestyle changes that can improve symptoms.
Alternatives for Peptic Ulcer Disease
Proton pump inhibitors (PPIs) like Omeprazole (Prilosec) or H2 blockers such as Ranitidine (Zantac) may be effective alternatives. Additionally, avoiding triggers like spicy foods, alcohol, and smoking can help manage symptoms.
Alternatives for Hyperhidrosis (Excessive Sweating)
Topical treatments like Aluminum Chloride (Drysol) or oral medications such as Oxybutynin (Ditropan) may be considered. Botox injections or lifestyle adjustments, such as wearing breathable fabrics, may also provide relief.
Alternatives for Salivary Gland Hypersecretion
Alternatives include Botulinum toxin injections or other anticholinergic medications like Scopolamine.
Alternatives for Anesthesia Adjunct
Other medications, such as Atropine or Scopolamine, may be used as alternatives during anesthesia.
Alternatives for Irritable Bowel Syndrome (IBS)
Medications like Dicyclomine (Bentyl) or lifestyle changes, such as adopting a low-FODMAP diet, may help manage symptoms.
Alternatives for Motion Sickness
Alternatives include Scopolamine patches or over-the-counter medications like Meclizine (Dramamine).
Alternatives for Overactive Bladder
Medications such as Oxybutynin (Ditropan) or behavioral therapies like bladder training may be effective alternatives.
Alternatives for Parkinson’s Disease
Medications like Levodopa (Sinemet) or other anticholinergics such as Benztropine (Cogentin) may be used. Physical therapy and regular exercise are also important components of managing the condition.
Alternatives for Cystic Fibrosis
Inhaled medications like Dornase alfa (Pulmozyme) or chest physiotherapy may be used to help manage symptoms.
Recent Updates on Glycopyrrolate Research
Recent research has focused on Glycopyrrolate’s role in treating chronic obstructive pulmonary disease (COPD) and hyperhidrosis. In COPD, new inhalation formulations of Glycopyrrolate have been developed, which may improve lung function and reduce symptoms. For hyperhidrosis, ongoing studies are evaluating the long-term safety and effectiveness of Glycopyrrolate in managing excessive sweating. Additionally, research is exploring its use in combination with other medications for conditions like overactive bladder and irritable bowel syndrome. As always, it’s important to discuss any new treatment options with your healthcare provider. If you have questions about Glycopyrrolate or want to learn more about the latest research, you can schedule a telemedicine appointment with one of our providers.
