Olsalazine: A Comprehensive Guide

Names of Medication

Olsalazine is commonly known by the brand name Dipentum (Olsalazine).

Pharmacologic category

Olsalazine belongs to the category of medications known as Aminosalicylates. Other medications in this category include Mesalamine (Asacol, Lialda, Pentasa), Balsalazide (Colazal), and Sulfasalazine (Azulfidine).

Dosing

Ulcerative Colitis

For the treatment of ulcerative colitis, the usual dosage of Olsalazine is 500 mg taken orally twice a day. Treatment duration depends on individual response and disease severity. Always consult with your doctor for your specific dosing needs, and never adjust your dosage without first discussing it with your healthcare provider.

Dosage Forms and the strengths

Olsalazine is available in capsule form at a strength of 250 mg.

Administration Instructions

Olsalazine should be taken with food to decrease potential stomach upset. It is usually taken twice a day, with doses spaced evenly throughout the day.

Adverse Reactions and Side Effects

Diarrhea (Common)

Diarrhea is a common side effect of Olsalazine. This happens because Olsalazine increases intestinal activity. This side effect is typically temporary and may lessen over time as your body adjusts to the medication.

Abdominal Pain (Common)

Abdominal pain is another common side effect, possibly due to increased intestinal activity. If the pain persists or is severe, contact your healthcare provider.

Headache (Less Common)

Some people may experience headaches while taking Olsalazine. The exact reason for this is unknown, but it may be related to the body’s adjustment to the medication.

Rash (Rare)

A rash is a less common side effect of Olsalazine. This could be a sign of an allergic reaction. If you notice a rash while taking Olsalazine, contact your healthcare provider immediately.

Contraindications to taking Olsalazine

Allergy to Salicylates or Aminosalicylates

If you have a known allergy to salicylates or aminosalicylates, you should not take Olsalazine. An allergic reaction can cause symptoms such as rash, itching, swelling, severe dizziness, or trouble breathing.

Kidney Disease

If you have kidney disease, your doctor may advise against using Olsalazine, as it could potentially worsen kidney function.

Drug to Drug Interactions

Olsalazine can interact with several other medications, including:
Warfarin (Coumadin): Olsalazine can increase the effects of warfarin, leading to an increased risk of bleeding.
Methotrexate (Trexall): Olsalazine can potentially increase the toxicity of methotrexate.

Olsalazine in Pregnancy

Olsalazine should only be used during pregnancy if clearly needed and prescribed by a healthcare provider. Always discuss potential risks and benefits with your healthcare provider.

Olsalazine while Breastfeeding

It is not known if Olsalazine passes into breast milk. Consult your healthcare provider before breastfeeding while taking Olsalazine.

Estimated Cost of Medication

The estimated cost of a 30-day supply of Olsalazine (500 mg twice a day) without insurance, utilizing a GoodRX coupon, is approximately $250 to $300. Keep in mind that prices can vary depending on the pharmacy and location, and are subject to change based on negotiated agreements between pharmacies and pharmaceutical companies.

Brief Legal Disclaimer

This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.
Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.