Cholestyramine Medication Profile

Summary or Key Points

Cholestyramine is a prescription medication used primarily to manage cholesterol levels and treat a variety of other conditions. It works by binding with bile acids in your digestive system, helping your body excrete them. This medication has several dosage forms and strengths, and can cause side effects such as constipation and stomach pain. Consult with your healthcare provider before adjusting your dose, and don’t hesitate to use our telemedicine service for instant guidance.

Names of Medication

US Brand Name: Questran (Cholestyramine)

A generic name, such as Cholestyramine in this case, is the official medical name for the active ingredient in the medication. It is standard across all brands of the medication and is placed in parentheses.

Pharmacologic Category

Cholestyramine belongs to a group of medications called bile acid sequestrants. Other medications in this category include Colesevelam (Welchol) and Colestipol (Colestid).

Dosing

The following are the indications for Cholestyramine, along with the typical dosing recommendations. Remember to always consult with your doctor or one of our telemedicine providers before adjusting your dose.

• Primary Biliary Cirrhosis: 4g orally, once or twice daily
• Hypercholesterolemia: 4g orally, 1-6 times daily
• Bile Acid Diarrhea: 4g orally, 1-3 times daily
• Pruritus due to Liver Disease: 4g orally, once daily
• Clostridium difficile Infection: 4g orally, 3 times daily as an adjunctive therapy
• Digitalis Toxicity: 4g orally, 1-2 times daily
• Thyrotoxicosis: 4g orally, 1-3 times daily
• Diarrhea from Rapid Gastric Emptying: 4g orally, 1-3 times daily
• Gilbert’s Syndrome: 4g orally, once or twice daily

Dosage Forms and Strengths

Cholestyramine is available in the following forms and strengths:

• Powder for oral suspension: 4g/packet or scoop

Administration Instructions

Cholestyramine should be taken exactly as prescribed by your healthcare provider. The powder should be mixed with water, fruit juice, or a soft food like applesauce. It’s essential to mix the powder thoroughly before swallowing. Always follow the specific instructions provided by your healthcare provider or pharmacist.

Adverse Reactions and Side Effects

Cholestyramine can cause several side effects. Here are some common ones:

• Constipation: This is the most common side effect, occurring in up to 10% of patients.
• Stomach pain: Some patients might experience stomach pain or discomfort.
• Nausea: Feeling sick can occur in some patients.
• Flatulence: Excess gas may be produced in the digestive system.

While most side effects are mild and temporary, if you experience persistent or severe side effects, consult your healthcare provider or take advantage of our telemedicine service for immediate consultation.

Contraindications

A contraindication is a condition or factor that serves as a reason to withhold a certain medical treatment due to the potential harm that it could cause the patient. Cholestyramine should not be taken by patients who:

• Have complete biliary obstruction. This is because Cholestyramine works by binding bile in the digestive tract and an obstruction would prevent bile flow.
• Are hypersensitive to Cholestyramine or any component of the formulation. An allergic reaction could occur in this situation.

Drug to Drug Interactions

Cholestyramine can interact with several other medications. Some notable ones include:

• Warfarin (Coumadin, Jantoven)
• Digoxin (Lanoxin)
• Thyroid hormones such as Levothyroxine (Synthroid, Levoxyl, Unithroid)

Cholestyramine in Pregnancy

Cholestyramine is generally considered safe to use during pregnancy. However, as with any medication, it should be used only when clearly needed and under the direction of a healthcare provider. Consider scheduling a telemedicine appointment with one of our providers to discuss this further.

Cholestyramine while Breastfeeding

Cholestyramine is considered compatible with breastfeeding by the American Academy of Pediatrics. However, always consult with your healthcare provider or one of our telemedicine providers to discuss the potential risks and benefits before taking any medication while breastfeeding.

Estimated Cost of Medication

The estimated cost of a 30-day supply of Cholestyramine, using a GoodRx coupon, is approximately $40 without insurance. Prices may vary depending on location and pharmacy.

Possible Alternatives

Here are some alternative treatments and lifestyle changes for the conditions Cholestyramine treats. Remember to consult your healthcare provider or our telemedicine providers before making any changes to your treatment plan.

• Primary Biliary Cirrhosis and Pruritus due to Liver Disease: Ursodiol (Actigall, Urso) can help by improving bile flow.
• Hypercholesterolemia: Statins such as Atorvastatin (Lipitor) and lifestyle changes like a healthy diet and regular exercise can help manage cholesterol levels.
• Bile Acid Diarrhea: Loperamide (Imodium) can help manage symptoms.
• Clostridium difficile Infection: Antibiotics such as Metronidazole (Flagyl) or Vancomycin (Vancocin) are primary treatments.

Recent Updates on Cholestyramine Research

Current research on Cholestyramine continues to validate its effectiveness for its approved uses. In addition, recent studies have explored its potential as a treatment for COVID-19 by binding to the virus in the gastrointestinal tract, potentially reducing the viral load and disease severity. As science progresses, we may find additional uses for this versatile medication.

Brief Legal Disclaimer

This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.
Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.