Understanding Balsalazide: A Comprehensive Guide

Names of Medication

The drug in question is Balsalazide, sold under the brand name Colazal in the United States.

Pharmacologic Category

Balsalazide falls under the category of anti-inflammatory drugs, specifically, it is an Aminosalicylate. Other medications in this category include Mesalamine (Asacol, Lialda, Pentasa), Sulfasalazine (Azulfidine), and Olsalazine (Dipentum).

Dosing

Balsalazide is primarily used to treat two diseases: Ulcerative Colitis and Crohn’s Disease.

Ulcerative Colitis

For adults with Ulcerative Colitis, the usual dosage is 2250 mg (three 750 mg capsules) taken orally three times daily for up to 8 weeks. Always follow your doctor’s instructions as dosages can vary based on the severity of the disease.

Crohn’s Disease

The use of Balsalazide for the treatment of Crohn’s Disease is considered off-label. This means that while it’s not officially approved for this use, some doctors may prescribe it if they believe it will be beneficial. The dosage would likely mirror that of Ulcerative Colitis, but always consult your doctor for personalized advice.
Remember, never adjust your dose without first consulting your doctor.

Dosage Forms and Strengths

Balsalazide (Colazal) comes in a capsule form and is available in a strength of 750 mg.

Administration Instructions

Balsalazide is typically taken orally with a full glass of water, three times a day. It does not need to be taken with food.

Adverse Reactions and Side Effects

Balsalazide can cause a variety of side effects. These include:

Abdominal Pain

(common): This is likely due to the drug’s activity in the gut as it works to reduce inflammation.

Headache

(common): This can occur due to changes in the body as it adjusts to the medication.

Nausea

(less common): This can be a direct effect of the drug on the stomach lining.

Diarrhea

(less common): While the drug works to treat inflammatory bowel conditions, it may paradoxically cause diarrhea in some individuals.

Rash

(rare): This is likely an allergic reaction to the medication.

Contraindications to Taking Balsalazide

Contraindication means a condition or factor that serves as a reason to withhold a certain medical treatment due to the harm it would cause the patient. Balsalazide is contraindicated in patients with a known hypersensitivity to salicylates (like aspirin) or aminosalicylates, or to any of the components of the balsalazide formulation.
Remember, before starting any new medication, always inform your healthcare provider about all your existing medical conditions and any other medications you are currently taking.

Drug to Drug Interactions

Balsalazide may interact with certain other medications, leading to increased side effects or decreased effectiveness. Here are a few significant interactions:

Warfarin (Coumadin)

: Balsalazide can potentially increase the effects of Warfarin, leading to an increased risk of bleeding.

Thiopurines (Azathioprine, Mercaptopurine)

: Combined use with Balsalazide can potentially increase the risk of blood disorders.

Nephrotoxic drugs

: Concurrent use with drugs that are harmful to the kidneys, like Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), could increase the risk of kidney damage.
Always inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs and supplements.

Balsalazide in Pregnancy

There is limited data on the use of Balsalazide during pregnancy. As a precaution, it should be used during pregnancy only if clearly needed and under the supervision of a healthcare provider.

Balsalazide while Breastfeeding

Balsalazide and its metabolites may be excreted in breast milk. Therefore, caution should be exercised when Balsalazide is administered to a nursing woman. Always consult your healthcare provider to discuss the potential risks and benefits.

Estimated Cost of Medication

As of writing, the estimated cost for a 30-day supply of Balsalazide (Colazal) 750mg without insurance is around $550-$600 when utilizing a GoodRx coupon. However, the actual price you pay will depend on your pharmacy, your location, and any insurance coverage you may have. Please note that prices may change over time due to negotiated agreements between pharmacies and pharmaceutical companies.

Brief Legal Disclaimer

This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.

Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.