US Brand Name:
{Lovenox} ({Enoxaparin})
Pharmacologic Category:
Low Molecular Weight Heparin (LMWH) Other medications in this category include: {Dalteparin} ({Fragmin}) and {Tinzaparin} ({Innohep})
Diseases Treated, Dosing, and Treatment Duration
{Deep Vein Thrombosis (DVT)}: Initial dose of 1 mg/kg subcutaneously every 12 hours or 1.5 mg/kg once daily for at least 5 days and until an oral anticoagulant is effective.
{Pulmonary Embolism (PE)}: Same dosing as DVT treatment.
{Venous Thromboembolism (VTE)} Prophylaxis: 40 mg subcutaneously once daily for 7-10 days or until risk is reduced.
{Acute Coronary Syndrome (ACS)}: 1 mg/kg subcutaneously every 12 hours in combination with {aspirin} for 2-8 days or until stable.
{Myocardial Infarction (MI)}: Same dosing as ACS treatment.
{Unstable Angina}: Same dosing as ACS treatment.
Prophylaxis of {Thromboembolic Complications} in Surgery Patients: 40 mg subcutaneously once daily, starting 2 hours prior to surgery and continuing for 7-10 days or until risk is reduced.
{Atrial Fibrillation (AFib)} Stroke Prevention: Dosing varies based on individual factors; consult with a healthcare provider for personalized recommendations.
Dosage Forms and Strengths:
30 mg/0.3 mL 40 mg/0.4 mL 60 mg/0.6 mL 80 mg/0.8 mL 100 mg/mL 120 mg/0.8 mL 150 mg/mL
Administration Instructions:
Inject subcutaneously (under the skin) in the fatty tissue of the abdomen, rotating injection sites. Do not expel the air bubble from the syringe before injection. Do not inject into a muscle. Do not mix with other medications.
Adverse Reactions and Side Effects:
{Dizziness} (5-12%): A sensation of lightheadedness or feeling faint, which may increase the risk of falls.
{Headache} (3-10%): Pain or discomfort in the head or neck region.
{Cough} (1-10%): A dry, persistent cough resulting from the medication’s effect on the lungs.
{Hypotension} (1-5%): Low blood pressure, which can cause dizziness, lightheadedness, and fainting.
{Hyperkalemia} (1-5%): Elevated potassium levels in the blood, which can cause irregular heartbeats or other heart-related issues.
{Angioedema} (less than 1%): Swelling of the face, lips, tongue, or throat, which can cause difficulty breathing and requires immediate medical attention.
Contraindications:
Active major bleeding History of {heparin-induced thrombocytopenia (HIT)} Hypersensitivity to {enoxaparin}, {heparin}, or pork products
Drug to Drug Interactions:
{Warfarin} ({Coumadin}, {Jantoven}): Increased risk of bleeding {Aspirin} or other nonsteroidal anti-inflammatory drugs ({NSAIDs}): Increased risk of bleeding {Clopidogrel} ({Plavix}): Increased risk of bleeding {Dipyridamole} ({Persantine}): Increased risk of bleeding
Pregnancy:
Enoxaparin is classified as pregnancy category B. While no adequate and well-controlled studies in pregnant women have been conducted, animal studies have not shown any adverse effects on the fetus. Enoxaparin should only be used during pregnancy if the potential benefits outweigh the potential risks to the fetus. Consult with a healthcare provider before using enoxaparin during pregnancy.
Breastfeeding:
Enoxaparin has not been studied in human breast milk. However, it is not expected to be excreted in breast milk due to its large molecular weight. While the risk to the nursing infant appears to be low, consult with a healthcare provider before using enoxaparin while breastfeeding.
Estimated Price of a 30-Day Supply:
The price of a 30-day supply of enoxaparin varies based on dosage, frequency, and the specific needs of the patient. Using a GoodRx coupon, the estimated cost for a 30-day supply of enoxaparin 40 mg/0.4 mL syringes ranges from $45 to $100. It’s important to note that prices may vary by location, pharmacy, and dosage.
Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.