Trametinib Medication: Uses, Dosage, Side Effects & Cost Overview

Trametinib Medication: Summary or Key Points

Trametinib is a prescription medication used to treat certain types of cancer, including melanoma, non-small cell lung cancer, and thyroid cancer. It works by inhibiting proteins that promote the growth of cancer cells. Trametinib is often used in combination with other treatments. Always consult your healthcare provider before starting or adjusting your dose. You can also reach out to one of our providers via telemedicine for more information.

Names of Trametinib Medication

US Brand Name: Mekinist

Generic Name: Trametinib

The generic name refers to the active ingredient in the medication and is listed in parentheses next to the brand name.

Pharmacologic Category of Trametinib

MEK Inhibitor

Kinase Inhibitor

Trametinib Dosage and Uses

Trametinib is prescribed for various cancers, with dosing tailored to the specific condition being treated. Always follow your doctor’s instructions and consult them before making any changes to your dose. You can also consult one of our telemedicine providers for personalized advice.

Trametinib Dosage for Specific Conditions

Melanoma: 2 mg orally once daily. Treatment continues until the disease progresses or side effects become intolerable.

Non-small cell lung cancer: 2 mg orally once daily, often in combination with other medications. The duration of treatment depends on the patient’s response and tolerance.

Thyroid cancer: 2 mg orally once daily. Treatment continues until the disease progresses or side effects become unmanageable.

Colorectal cancer: 2 mg orally once daily, typically in combination with other therapies. The length of treatment is based on individual response.

Pancreatic cancer: 2 mg orally once daily, often combined with other treatments. The duration of treatment depends on the patient’s tolerance.

Ovarian cancer: 2 mg orally once daily. Treatment continues as long as the patient responds and tolerates the medication.

Endometrial cancer: 2 mg orally once daily. Treatment continues until the disease progresses or severe side effects occur.

Biliary tract cancer: 2 mg orally once daily. The duration of treatment depends on the patient’s response and tolerance.

Uveal melanoma: 2 mg orally once daily. Treatment continues until the disease progresses or side effects become intolerable.

Neuroendocrine tumors: 2 mg orally once daily. The length of treatment depends on individual response and tolerance.

Trametinib Dosage Forms and Strengths

Tablet: 0.5 mg

Tablet: 2 mg

Trametinib Administration Instructions

Take Trametinib exactly as prescribed by your healthcare provider. It should be taken on an empty stomach, either 1 hour before or 2 hours after a meal. Swallow the tablet whole with water. Do not crush, chew, or break the tablet. If you miss a dose, take it as soon as you remember unless it is within 12 hours of your next scheduled dose. In that case, skip the missed dose and continue with your regular schedule.

Trametinib Side Effects and Adverse Reactions

Like all medications, Trametinib can cause side effects. Some are more common than others, and not everyone will experience them. If you notice any side effects, contact your healthcare provider immediately. You can also schedule a telemedicine appointment with one of our providers to discuss any concerns.

Common Trametinib Side Effects

Rash: Skin irritation or redness.

Diarrhea: Frequent, loose bowel movements.

Fatigue: Feeling unusually tired or weak.

Nausea: Feeling sick to your stomach.

Less Common Trametinib Side Effects

Fever: Elevated body temperature.

Swelling: Fluid retention, especially in the hands or feet.

Heart problems: Changes in heart function, such as a slow or irregular heartbeat.

Serious Trametinib Side Effects

Vision changes: Blurred vision or other eye problems.

Bleeding: Unusual bleeding or bruising.

Severe skin reactions: Painful skin rashes or blisters.

Trametinib Contraindications

A contraindication is a specific condition where a medication should not be used because it may be harmful. Several contraindications are associated with Trametinib that patients and healthcare providers need to be aware of.

Trametinib Contraindications to Be Aware Of

Allergic reaction to Trametinib: If you have had an allergic reaction to Trametinib, you should not take it again. Allergic reactions can cause serious symptoms, such as difficulty breathing, swelling, or rash.

Severe heart problems: Trametinib can affect the heart, especially in people with pre-existing heart conditions. If you have heart failure or other serious heart issues, Trametinib could worsen your condition.

Severe lung disease: Trametinib may cause or worsen lung problems, including interstitial lung disease (ILD). If you have a history of lung disease, your doctor may advise against using Trametinib.

Eye problems: Trametinib can cause serious eye issues, including retinal detachment or retinal vein occlusion. If you have a history of eye problems, particularly those affecting the retina, Trametinib may not be safe for you.

Pregnancy: Trametinib can harm an unborn baby. It is contraindicated during pregnancy unless no other treatment options are available and the potential benefits outweigh the risks.

Trametinib Drug Interactions

Trametinib can interact with other medications, increasing the risk of side effects or reducing its effectiveness. Some known drug interactions include:

Common Trametinib Drug Interactions

Warfarin (Coumadin): Trametinib may increase the risk of bleeding when taken with blood thinners like Warfarin.

Ketoconazole (Nizoral): This antifungal medication can increase Trametinib levels in your body, potentially leading to more side effects.

Rifampin (Rifadin): This antibiotic can decrease Trametinib’s effectiveness by lowering its levels in the blood.

Carbamazepine (Tegretol): This seizure medication may reduce Trametinib’s effectiveness by speeding up its breakdown in the body.

Phenytoin (Dilantin): Similar to Carbamazepine, Phenytoin may reduce Trametinib levels, making it less effective.

Trametinib in Pregnancy

Is it safe to take Trametinib when pregnant? No, Trametinib is not considered safe during pregnancy. It can harm an unborn baby, potentially leading to birth defects or pregnancy loss. If you are pregnant or planning to become pregnant, it is essential to discuss alternative treatments with your healthcare provider. Women of childbearing age should use effective contraception while taking Trametinib and for at least four months after the last dose. If you become pregnant while taking Trametinib, contact your healthcare provider immediately to discuss your options.

Trametinib While Breastfeeding

Is it safe to take Trametinib while breastfeeding? No, Trametinib is not recommended during breastfeeding. Although it is unclear whether Trametinib passes into breast milk, the potential for serious side effects in a nursing infant means it should be avoided. If you are breastfeeding or planning to breastfeed, consult your healthcare provider to explore safer alternatives.

Estimated Cost of Trametinib Medication

The cost of a 30-day supply of Trametinib without insurance can be substantial. With a GoodRx coupon, the estimated price for a 30-day supply of Trametinib (0.5 mg or 2 mg tablets) ranges from $10,000 to $12,000. Prices may vary depending on the pharmacy and location. If you are concerned about the cost of Trametinib, speak with your healthcare provider or pharmacist about financial assistance programs that may be available to help manage expenses.

Possible Alternatives to Trametinib

If Trametinib is not suitable for you, or if you are exploring other treatment options, there are alternatives available for the conditions it treats. Always consult your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to discuss your options in more detail.

Melanoma

Alternatives may include other targeted therapies such as Vemurafenib (Zelboraf) or immunotherapy options like Pembrolizumab (Keytruda). Surgery, radiation, and lifestyle changes, such as sun protection, can also play a role in a comprehensive treatment plan.

Non-Small Cell Lung Cancer

Other treatment options may include targeted therapies like Osimertinib (Tagrisso) or chemotherapy. Quitting smoking and maintaining a healthy diet can also contribute to better outcomes.

Thyroid Cancer

Radioactive iodine therapy, surgery, or other targeted therapies such as Lenvatinib (Lenvima) may be considered as alternatives.

Colorectal Cancer

Chemotherapy, immunotherapy, or targeted therapies like Cetuximab (Erbitux) may be used. Dietary changes and regular screenings are also important in managing this condition.

Pancreatic Cancer

Alternatives include chemotherapy, radiation, or surgery. In some cases, targeted therapies like Olaparib (Lynparza) may be an option.

Ovarian Cancer

Treatment options may include chemotherapy, surgery, or targeted therapies such as Bevacizumab (Avastin). Maintaining a healthy lifestyle and undergoing regular screenings are also important aspects of care.

Endometrial Cancer

Hormone therapy, chemotherapy, or surgery may be considered. Weight management and regular exercise can help reduce risk factors and improve overall health.

Biliary Tract Cancer

Chemotherapy, radiation, or targeted therapies like Pembrolizumab (Keytruda) may be alternatives. Maintaining a healthy diet and avoiding alcohol can support overall well-being.

Uveal Melanoma

Radiation therapy, surgery, or other targeted therapies may be used. Regular eye exams are crucial for early detection and effective management.

Neuroendocrine Tumors

Somatostatin analogs like Octreotide (Sandostatin) or chemotherapy may be considered. Dietary adjustments and regular monitoring are also important for managing this condition.

Recent Updates on Trametinib Research

Recent studies on Trametinib have focused on its use in combination with other therapies to improve outcomes in various cancers. For instance, research indicates that combining Trametinib with Dabrafenib (Tafinlar) can enhance survival rates in patients with BRAF-mutated melanoma. Additionally, ongoing clinical trials are investigating the effectiveness of Trametinib in combination with immunotherapies for cancers such as non-small cell lung cancer and colorectal cancer. While these studies are promising, further research is needed to fully understand the long-term benefits and potential risks of these combinations.

If you are interested in learning more about the latest research or clinical trials involving Trametinib, speak with your healthcare provider or schedule a telemedicine appointment with one of our providers today.

James Kingsley

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