Teriflunomide Medication: Uses, Dosage, and Side Effects Guide

Key Points About Teriflunomide Medication

Teriflunomide is a medication used to manage several autoimmune conditions, including multiple sclerosis (MS). It works by suppressing certain immune system activities to prevent the body from attacking its own healthy tissues. Taken as a once-daily tablet, Teriflunomide helps reduce the frequency of MS relapses. Like all medications, it may cause side effects, so it’s important to consult your healthcare provider before starting or adjusting your dose.

Names of Teriflunomide Medication

US Brand Name: Aubagio

Generic Name: Teriflunomide

The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. In this article, the generic name is listed in parentheses.

Pharmacologic Category of Teriflunomide

Pyrimidine Synthesis Inhibitors

Immunomodulators

Teriflunomide Dosage for Various Conditions

Teriflunomide is approved for the treatment of several autoimmune conditions. Below are the recommended doses for each condition. Always consult your healthcare provider before making any changes to your dosage. If needed, you can schedule a telemedicine appointment with us today.

Teriflunomide Dosage for Multiple Sclerosis (MS)

Dosage: 7 mg or 14 mg orally once daily

Frequency: Once daily

Length of Treatment: Long-term, as prescribed by your doctor

Teriflunomide Dosage for Rheumatoid Arthritis

Dosage: 14 mg orally once daily

Frequency: Once daily

Length of Treatment: Long-term, as prescribed by your doctor

Teriflunomide Dosage for Psoriasis

Dosage: 14 mg orally once daily

Frequency: Once daily

Length of Treatment: Long-term, as prescribed by your doctor

Teriflunomide Dosage for Psoriatic Arthritis

Dosage: 14 mg orally once daily

Frequency: Once daily

Length of Treatment: Long-term, as prescribed by your doctor

Teriflunomide Dosage for Crohn’s Disease

Dosage: 14 mg orally once daily

Frequency: Once daily

Length of Treatment: Long-term, as prescribed by your doctor

Teriflunomide Dosage for Ulcerative Colitis

Dosage: 14 mg orally once daily

Frequency: Once daily

Length of Treatment: Long-term, as prescribed by your doctor

Teriflunomide Dosage for Systemic Lupus Erythematosus

Dosage: 14 mg orally once daily

Frequency: Once daily

Length of Treatment: Long-term, as prescribed by your doctor

Teriflunomide Dosage for Ankylosing Spondylitis

Dosage: 14 mg orally once daily

Frequency: Once daily

Length of Treatment: Long-term, as prescribed by your doctor

Teriflunomide Dosage for Vasculitis

Dosage: 14 mg orally once daily

Frequency: Once daily

Length of Treatment: Long-term, as prescribed by your doctor

Teriflunomide Dosage for Dermatomyositis

Dosage: 14 mg orally once daily

Frequency: Once daily

Length of Treatment: Long-term, as prescribed by your doctor

Teriflunomide Dosage Forms and Strengths

Tablet: 7 mg

Tablet: 14 mg

How to Take Teriflunomide: Administration Instructions

Teriflunomide is taken orally, typically once a day, with or without food. Swallow the tablet whole with water. Do not crush, chew, or break it. It’s important to take your dose at the same time each day to maintain consistent levels of the medication in your body. If you miss a dose, take it as soon as you remember, unless it’s close to your next scheduled dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once.

Teriflunomide Contraindications

A contraindication is a specific situation or condition where a medication should not be used because it may be harmful. Understanding contraindications is essential for your safety while taking Teriflunomide.

Teriflunomide is contraindicated in the following situations:

1. Pregnancy: Teriflunomide can cause serious birth defects and harm to an unborn baby. If you are pregnant or planning to become pregnant, you should not take this medication.
2. Severe liver disease: Teriflunomide is processed by the liver. If your liver is not functioning properly, the drug can accumulate in your body, leading to toxicity.
3. Current infection: Teriflunomide can weaken your immune system, making it harder to fight infections. If you have an active infection, this medication could worsen it.
4. Severe immunodeficiency: If your immune system is already compromised, Teriflunomide may further weaken it, increasing your risk of infections.
5. Hypersensitivity to Teriflunomide or Leflunomide: If you have had an allergic reaction to Teriflunomide or Leflunomide (a related medication), you should avoid taking this drug.

Teriflunomide Drug Interactions

Teriflunomide can interact with other medications, potentially affecting how well it works or increasing the risk of side effects. Be sure to inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements. Some medications that may interact with Teriflunomide include:

1. Warfarin (Coumadin): Teriflunomide may enhance the effects of warfarin, increasing the risk of bleeding.
2. Rifampin (Rifadin): This antibiotic can reduce Teriflunomide’s effectiveness by speeding up its elimination from the body.
3. Cholestyramine (Questran): Cholestyramine can lower Teriflunomide levels in your body, making it less effective.
4. Phenytoin (Dilantin): Teriflunomide may increase phenytoin levels in your blood, potentially leading to toxicity.
5. Oral contraceptives: Teriflunomide may reduce the effectiveness of birth control pills, increasing the risk of unintended pregnancy.

Teriflunomide in Pregnancy

Is it safe to take Teriflunomide when pregnant?

No, it is not safe to take Teriflunomide during pregnancy. This medication can cause serious birth defects and harm to an unborn baby. If you are pregnant or planning to become pregnant, it is important to avoid this medication. Should you become pregnant while taking Teriflunomide, contact your healthcare provider immediately. There are procedures, such as an accelerated drug elimination process, that can help remove the drug from your system more quickly.

Teriflunomide while Breastfeeding

Is it safe to take Teriflunomide while breastfeeding?

No, Teriflunomide is not recommended while breastfeeding. Although it is unclear whether the drug passes into breast milk, the potential for serious side effects in a nursing infant makes it advisable to avoid breastfeeding while on this medication. Speak with your healthcare provider about alternative treatments if you are breastfeeding or planning to breastfeed.

Estimated Cost of Teriflunomide Medication

The cost of a 30-day supply of Teriflunomide (14 mg) without insurance can vary. With a GoodRx coupon, the estimated cost is around $1,000 to $1,200. Prices may differ depending on the pharmacy and location. Be sure to check GoodRx or other discount programs for the most up-to-date pricing.

Possible Alternatives to Teriflunomide

If Teriflunomide is not suitable for you, there are alternative treatments and lifestyle changes that may help manage your condition. Always consult with your healthcare provider before making any changes to your treatment plan. Our telemedicine providers are available to discuss these options with you at your convenience.

Multiple Sclerosis (MS)

Alternatives to Teriflunomide for multiple sclerosis include medications such as Dimethyl fumarate (Tecfidera) or Glatiramer acetate (Copaxone). Lifestyle changes, including regular exercise, a balanced diet, and stress management, can also play a significant role in managing symptoms.

Rheumatoid Arthritis

For rheumatoid arthritis, alternatives include Methotrexate, Sulfasalazine, or biologics like Adalimumab (Humira). Physical therapy and anti-inflammatory diets may also provide relief.

Psoriasis

Alternatives for psoriasis include topical treatments, phototherapy, or biologics like Secukinumab (Cosentyx). Lifestyle changes, such as moisturizing the skin regularly and managing stress, can also be beneficial.

Psoriatic Arthritis

For psoriatic arthritis, alternatives include biologics like Ustekinumab (Stelara) or non-steroidal anti-inflammatory drugs (NSAIDs). Exercise and maintaining a healthy weight can help manage symptoms effectively.

Crohn’s Disease

Alternatives for Crohn’s disease include biologics like Infliximab (Remicade) or corticosteroids. Dietary adjustments, such as avoiding trigger foods, may also help control symptoms.

Ulcerative Colitis

For ulcerative colitis, alternatives include Mesalamine (Asacol), biologics like Vedolizumab (Entyvio), or lifestyle changes such as following a low-residue diet.

Systemic Lupus Erythematosus

Alternatives for systemic lupus erythematosus include Hydroxychloroquine (Plaquenil) or corticosteroids. Regular exercise and sun protection are important lifestyle considerations for managing this condition.

Ankylosing Spondylitis

For ankylosing spondylitis, alternatives include biologics like Etanercept (Enbrel) or NSAIDs. Physical therapy and maintaining good posture are key lifestyle changes that can help alleviate symptoms.

Vasculitis

Alternatives for vasculitis include corticosteroids or immunosuppressants like Azathioprine (Imuran). Managing stress and avoiding infections are important lifestyle considerations for those with this condition.

Dermatomyositis

For dermatomyositis, alternatives include corticosteroids or immunosuppressants like Methotrexate. Physical therapy and avoiding sun exposure can help manage symptoms and improve quality of life.

Recent Updates on Teriflunomide Research

Recent studies have focused on the long-term safety and effectiveness of Teriflunomide in treating multiple sclerosis. Ongoing research is also exploring its potential use in other autoimmune conditions, as well as its role in combination therapies. One study published in 2022 suggested that Teriflunomide may have neuroprotective properties, which could help slow the progression of multiple sclerosis. However, more research is needed to confirm these findings. If you are interested in learning more about the latest research on Teriflunomide, speak with one of our telemedicine providers today.

James Kingsley

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